The journal of international advanced otology最新文献

{"title":"The Effectiveness and Cost Analysis of a Pilot Newborn Hearing Screening Program at a Hospital in a Low- to Middle-Income Country.","authors":"Pariya Lertbussarakam, Pittayapon Pitathawatchai","doi":"10.5152/iao.2024.231109","DOIUrl":"10.5152/iao.2024.231109","url":null,"abstract":"<p><strong>Background: </strong>When a universal newborn hearing screening program is not feasible, particularly in the early stages of its establishment when it requires a great deal of effort and resources, a smaller scale in screening, such as a specific geographical subset or targeted group, is suggested rather than doing nothing. This study aims to pilot a newborn hearing screening program at a hospital in a low- to middle-income country and determine its effectiveness and costs in the context of a lack of qualified audiologists.</p><p><strong>Methods: </strong>All high-risk births at Hatyai Hospital were recruited for newborn hearing screening between January and December 2021. Newborns who failed 2 stages of transient evoked otoacoustic emissions screening were referred for diagnostic assessment and subsequent interventions. The program's effectiveness was assessed based on the standards of the American Academy of Pediatrics. All costs related to screening, diagnostic, and intervention stages were also evaluated.</p><p><strong>Results: </strong>Out of 883 newborns, 792 newborns were screened, resulting in a 95.1% screening coverage. The referral rate regarding the diagnostic stage was 3.9%. Also, 28.3% and 12.9% lost-to-follow-up rates were observed in the secondscreening and diagnostic assessment stages, respectively. Ten children were confirmed as having permanent hearing loss, with a prevalence of 1.3%. The total cost was US$13 611, and the cost (for the screening stage) per case screened was US$4.</p><p><strong>Conclusion: </strong>The program was considered effective with 2 out of 3 benchmarks achieved.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"20 6","pages":"477-483"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Quality of Life in Patients with Small Vestibular Schwannomas.","authors":"Matthias Scheich, Lisa Schultes, Manuel Stöth, Jens-Holger Krannich, Rudolf Hagen, Stephan Hackenberg, Miriam Bürklein","doi":"10.5152/iao.2024.241481","DOIUrl":"10.5152/iao.2024.241481","url":null,"abstract":"<p><strong>Background: </strong>Vestibular schwannomas (VS) are benign tumors arising from the eighth cranial nerve. They often cause no symptoms for a long period of time. Due to the improved availability and quality of magnetic resonance imaging diagnostics, even small tumors can be diagnosed at an early stage. The fact that the diagnosis of a VS might negatively affect a patient's quality of life (QoL) should be taken into consideration when informing patients about various treatment options. However, little is known about the level of QoL in patients with small VS prior to scheduled surgery.</p><p><strong>Methods: </strong>One hundred forty- one patients with a T1 or T2 VS that had been scheduled for microsurgery via the middle cranial fossa (MCF) approach between 01/2013 and 12/2018 were included. Quality of life was evaluated using the Short-Form-36 (SF-36) survey. Eighty-one patients completed the questionnaire. Additionally, audiological and clinical data were collected.</p><p><strong>Results: </strong>When compared to the German normative QoL data, VS patients showed a significant deterioration in quality of life in 6 of the 8 SF-36 subscales, whereas only 4 of 8 subscales were affected when compared to the normative group of patients with hearing loss. The analysis of predictors did not show any significant relationship between tumor volume, facial nerve function, and QoL. Only preoperative hearing status and sex had a slight impact on one subscale each (emotional health and physical health, respectively).</p><p><strong>Conclusion: </strong>This study shows that patients with small VS have an impairment in QoL before surgical treatment. Most of the examined clinical predictors did not have a significant impact on the QoL.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"20 6","pages":"472-476"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consideration of Sufficient and Insufficient Benefits in Hearing Aid Fitting.","authors":"Yoshihiro Nitta, Hajime Sano, Shogo Furuki, Sachie Umehara, Yuki Hara, Taku Yamashita","doi":"10.5152/iao.2024.241565","DOIUrl":"10.5152/iao.2024.241565","url":null,"abstract":"<p><strong>Background: </strong>During hearing aid (HA) fitting, individuals may experience better speech discrimination at normal speech levels and worse discrimination at loud speech levels than without an HA. Therefore, we investigated factors that worsen speech discrimination when the speech sound level increases.</p><p><strong>Methods: </strong>Speech discrimination was measured in patients aged >20 years who had average hearing thresholds <90 dB on pure-tone audiometry. An insufficient benefit was defined as speech discrimination being better at 65 dB sound pressure level (SPL) with HAs than without HAs and worse at 80 dB SPL.</p><p><strong>Results: </strong>Of the 251 participants (296 ears), 229 and 25 had sufficient benefit and insufficient benefit, respectively. Functional gains (FGs) of sufficient benefit were approximately 1/3 gain (1/3 G) at 500 and 4000 Hz and slightly larger at 1000 and 2000 Hz. Functional gains of insufficient benefit were approximately 1/2 G at 1000 and 2000 Hz, smaller at 500 and 4000 Hz, and approximately 1/3 G at 250 Hz. Moreover, the difference between 1/2 G and FG was significantly larger in the sufficient benefit group at 250 500, and 4000 Hz than in the insufficient benefit group. Additionally, the average compression ratio at 50-80 dB SPL in the insufficient benefit group was approximately 1.1 to 1.2, slightly lower than the standard values.</p><p><strong>Conclusion: </strong>Adjusting the compression ratio and lowering the FG to approximately 1.5 and 1/3 G, respectively, may help improve speech discrimination if it worsens with increasing sound levels during HA fitting.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"20 6","pages":"502-506"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thiol-Disulfide Homeostasis in Noise-Induced Hearing Loss in Rats.","authors":"Enes Aydın, Serpil Mungan Durankaya, Osman Yilmaz, Günay Kirkim, Safiye Aktaş, Salim Neşelioğlu, Özcan Erel, Yüksel Olgun, Abdullah Dalgıç","doi":"10.5152/iao.2024.241555","DOIUrl":"10.5152/iao.2024.241555","url":null,"abstract":"<p><strong>Background: </strong>This study was designed to assess if thiol-disulfide homeostasis could be used as diagnostic biomarker in noise-induced hearing loss (NIHL) in a laboratory animal model.</p><p><strong>Methods: </strong>The study was carried out with a total of 28 female albino rats in 4 groups: group 1 (control group) included rats that were not exposed to noise or any study treatment; in group 2, following noise exposure, rats received 2 mg of dexamethasone per kilogram of body weight via the intramuscular route for 5 days; in Group 3, rats were exposed to noise and received a saline solution for 5 days, in a volume (0.15 cc) matched to that of dexamethasone administered in group 2; and in group 4, rats were exposed to noise, and blood samples were collected during the early phase to assess thiol-disulfide homeostasis without administering any treatment. Rats in groups 2, 3, and 4 were exposed to 120 dB noise in the 4 kHz octave band for 4 hours. The auditory brainstem response (ABR) test was performed in all groups on day 1 after noise exposure and was repeated in groups 1, 2, and 3 on day 5. Auditory brainstem response thresholds were recorded at 8, 12, 16, 20, and 32 kHz frequencies. Groups 1, 2, and 3 rats were sacrificed on day 5, and group 4 rats were sacrificed by exsanguination on day 1 after noise exposure. Venous blood samples collected from the caudal vena cava were centrifuged and sent to the corresponding laboratory for thiol-disulfide homeostasis studies. After sacrificing the rats, the right and left temporal bones of each rat were removed and stained with hematoxylin eosin for histological studies to explore any pyknotic changes in spiral ganglion cells.</p><p><strong>Results: </strong>Intergroup comparisons by frequency on day 5 of noise exposure showed statistically significantly lower responses in ABR measurements at 8 kHz, 12 kHz, and 16 kHz in group 2 compared to group 3 (P = .003, P=.006, and P=.002). Improvements were observed with dexamethasone administered for therapeutic purposes, particularly if the hearing loss was induced by low-frequency noise. In the assessment of the parameters of thiol-disulfide homeostasis, disulfide/native thiol and disulfide/total thiol ratios and ischemia-modified albumin (IMA) levels were higher in group 4 than in other groups, although only the differences between group 1 and group 4 reached statistical significance.</p><p><strong>Conclusion: </strong>According to this study, thiol-disulfide homeostasis and IMA can be shown as diagnostic biomarkers in NIHL, especially in the early period. The results from our study suggest that these markers may be used as adjunctive diagnostic tools in NIHL, in addition to audiological studies. However, this issue can be clarified with further clinical studies.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"20 6","pages":"466-471"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling Cochlear Dynamics: The Effect of Clicks, Tone Burst Frequencies, Polarity, and Stimulus Rates on Cochlear Microphonics in Individuals with Normal Hearing.","authors":"Prajwal Kumar Eranna, Gowtham Varma, Animesh Barman","doi":"10.5152/iao.2024.241662","DOIUrl":"10.5152/iao.2024.241662","url":null,"abstract":"<p><strong>Background: </strong>Despite cochlear microphonic's potential clinical application, especially in ANSD diagnosis, the optimal parameters to record cochlear microphonics and the effect of various stimulus parameters are not well understood yet, which makes its recording a difficult procedure. The present study was undertaken to determine the effect of stimulus polarity, rate, stimulus type, and stimulus frequency on different aspects of cochlear microphonics, which could help to decide an optimal stimulus parameter that can be used to record CM.</p><p><strong>Methods: </strong>The study involved 32 normal-hearing adults. CM was recorded from these individuals using extratympanic CM measurement from the ear canal independently for tone burst frequencies (500 Hz, 1 kHz, 4 kHz & 8 kHz) and click stimuli having rarefaction and condensation polarity at 30.1/sec and 59.1/sec repetition rates. Amplitude and latency were measured from the recorded waveforms and compared across and between stimulus conditions.</p><p><strong>Results: </strong>Results reveal that stimulus frequency and stimulus type have a significant effect on different parameters of CM. However, there was no significant effect of stimulus polarity and rate of stimulus on the amplitude and latency of cochlear microphonics. The amplitude and latency of the cochlear microphonics are inversely proportional to the stimulus frequency.</p><p><strong>Conclusion: </strong>Hence, the study suggests the use of low-frequency tone burst (500 Hz/1 kHz) to elicit robust CM, which has greater application in the assessment of cochlear functioning over OAE as the latter gets affected by environmental and physiological noise and also due to middle ear pathology.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"20 6","pages":"494-501"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Round Window Accessibility Prediction in Cochlear Implant Surgery.","authors":"Salah-Eddine Youbi, Omar Oulghoul, Youssef Lakhdar, Atmane Zaroual, Mohamed Chehbouni, Othmane Benhoummad, Youssef Rochdi, Abdelaziz Raji","doi":"10.5152/iao.2024.231368","DOIUrl":"10.5152/iao.2024.231368","url":null,"abstract":"<p><strong>Background: </strong>Clear identification of the round window (RW) through the facial recess is a key surgical step for successful cochlear implantation (CI) surgery, which may be very challenging in some cases. Objective is to predict round window (RW) accessibility during CI surgery using high-resolution computed tomography (HRCT).</p><p><strong>Methods: </strong>We retrospectively reviewed preoperative HRCT scans of 142 patients who underwent CI surgery via the standard posterior tympanotomy approach at our ENT Head and Neck Surgery department. Surgical accessibility of the RW was assessed according to 2 methods, similar to the ones introduced by Mandour et al and Elzayat et al. Pre-operative imaging findings were then compared to the actual surgical accessibility of the RW by reviewing surgical notes and video recordings.</p><p><strong>Results: </strong>Difficult surgical access to the RW was correctly predicted in our series by Mandour's method in 81.8% of the cases, with a sensitivity and specificity of 56.3% and 96.4%, respectively, and by Elzayat's method in 72.2% of the cases, with a sensitivity and specificity of 50% and 94.5%, respectively. Combining both methods showed an increase in sensitivity levels (Se=71.9%). When the 2 methods both predicted difficult RW access, there was a strong probability that drilling a cochleostomy would be necessary for safe electrode insertion along the scala tympani of the basal turn of the cochlea (P < .001).</p><p><strong>Conclusion: </strong>These 2 methods are both simple and reliable tools that can help the surgeon anticipate difficult surgical access and prepare for the potential use of alternative techniques.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"20 6","pages":"489-493"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Strategy for Bone Conduction Device Adoption: Study of Non-Usage Challenges, Skin-Deep Insights and Patient Satisfaction.","authors":"","doi":"10.5152/iao.2024.241585","DOIUrl":"10.5152/iao.2024.241585","url":null,"abstract":"","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"20 6","pages":"523-530"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Ear, the Hidden Threat of Paecilomyces Neuro-Otological Infection: A Case Report.","authors":"Jing Hern Khoo, Izny Hafiz Zainon, Hafizah Husna Johari, Ida Sadja'ah Sachlin","doi":"10.5152/iao.2024.231331","DOIUrl":"10.5152/iao.2024.231331","url":null,"abstract":"<p><strong>Background: </strong>Paecilomyces spp. are thermo-tolerant fungi found in decaying vegetables and soil. They can cause ocular, cutaneous, and miscellaneous infections. In otorhinolaryngology, most infections occur in the paranasal sinuses, while otological infection is uncommon.</p><p><strong>Methods: </strong>We report a case of 41-year-old diabetic, male army officer with warm, fluctuant left temporal swelling and reduced hearing. Otoscopy revealed an edematous external auditory canal (EAC) with posterior wall sagging and bulging tympanic membrane. Computed tomography revealed subperiosteal temporal abscess extending intracranially. The pus was drained surgically via an otological and a neurosurgical approach, and pus sent for culture grew paecilomyces. He showed clinical improvement after receiving oral antifungal treatment postoperatively. Retrospectively, his occupation as an army officer and his diabetic immunocompromised state may have predisposed him to the infection.</p><p><strong>Results: </strong>Paecilomyces middle ear infection leading to intracranial involvement of such magnitude is yet to be reported, and we showcase its successful management through a combined surgical neuro-otology approach and oral antifungal therapy. Fungal ear infections can lead to severe extracranial and intracranial complications if inadequately treated. Differentiating it from cholesteatoma also presents a diagnostic challenge clinically and radiologically. While both can lead to intracranial complications, our patient's brief history and lack of prior ear symptoms contrast with that of cholesteatoma.</p><p><strong>Conclusion: </strong>The rarity of neuro-otological paecilomyces infections emphasizes the need for awareness and early identification. It is vital to recognize such infections, and prompt surgical management with appropriate antifungal drugs is warranted to prevent disastrous outcomes.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"20 6","pages":"536-539"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Otologic Manifestations in Patients with Achondroplasia: A Multicenter Study.","authors":"Dohee Kim, Joonsik Yoon, Myung-Whan Suh, Jun Ho Lee, Moo Kyun Park","doi":"10.5152/iao.2024.241523","DOIUrl":"10.5152/iao.2024.241523","url":null,"abstract":"<p><strong>Background: </strong>Achondroplasia, the most prevalent form of skeletal dysplasia involving short stature, necessitates a multidisciplinary approach that includes otology and auditory rehabilitation. Despite this, the clinical characteristics of hearing loss and otologic manifestations in achondroplasia patients remain poorly defined. This study aimed to explore the prevalence and treatment outcomes of otologic disease in individuals with achondroplasia.</p><p><strong>Methods: </strong>A retrospective review of medical records was conducted for 70 patients who visited the otolaryngology clinic at 3 institutions in South Korea from 1999 to 2023. Demographic and clinical characteristics, including audiometric findings, imaging studies, treatment modalities, and outcomes, were analyzed.</p><p><strong>Results: </strong>Among 53 patients who underwent audiometry, 26 showed conductive hearing loss, 2 had mixed-type hearing loss, and 4 had sensorineural hearing loss. Fifty-one patients (72.9%) had middle ear effusion at least once. Myringotomy or ventilation tube insertion was performed on 33 patients (47.1%), and 16 patients (22.9%) required multiple insertions. Eighteen patients (25.7%) had adenoid hypertrophy, and 16 (22.9%) underwent adenoidectomy. Temporal bone computed tomography (TBCT) scans were taken in 9 patients (12.9%) for middle ear evaluation. Computed tomography (CT) scans showed a high jugular bulb and rotated inner ear structures. Chronic otitis media with cholesteatoma was diagnosed in 2 patients (2.9%), in whom tympanomastoidectomy was performed.</p><p><strong>Conclusion: </strong>Half of the children with achondroplasia experienced hearing loss, most commonly due to conductive hearing loss. Threequarters of these children exhibited otitis media with effusions, often necessitating the insertion of a ventilation tube and adenoidectomy. Given the anatomical variations present in these children, such as a high jugular bulb and rotated structures of the inner ear and facial nerve, a cautious approach is essential when performing middle ear surgery.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"20 6","pages":"517-522"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Ebselen in Facial Nerve Crush Injury: An Experimental Study.","authors":"Lütfü Şeneldir, Veysel Alparslan Gölcük, Gökçe Tanyeri Toker, Ayşegül Verim, Pembegül Güneş","doi":"10.5152/iao.2024.231360","DOIUrl":"10.5152/iao.2024.231360","url":null,"abstract":"<p><strong>Background: </strong>Ebselen is a neuroprotective drug that protects cellular components from oxidative damage by modulating enzymatic cofactors, metalloproteins, gene expression, antioxidant-anti-inflammatory effects, and immunological systems. Our goal was to compare the efficacy of Ebselen and methylprednisolone on rat facial nerve crush injury.</p><p><strong>Methods: </strong>Thirty healthy male Wistar rats (mean weight of 245 g) were used in this study. The rats were randomly divided into four groups: Group 1 (ebselen group), Group 2 (methylprednisolone group), Group 3 (control group), and Group 4 (sham group (the right side of the control group)). Except for the sham group, all groups had their left facial nerve crushed. Three weeks after surgery, prospective functional, histologic, and electrophysiologic recovery was reported.</p><p><strong>Results: </strong>The ebselen group and methylprednisolone group had similar and more significant recovery at Nerve Excitability Thresholds (NET) at the end of three weeks. These groups also showed similar features in terms of histopathological parameters such as axonal degeneration, vascular congestion, axon diameter, and myelin thickness. Except for the macrovacuolization parameter, both showed statistically better results than the control group. Although there was an earlier improvement in the whiskers and blink tests in the ebselen group compared to the methylprednisolone and control groups, complete recovery was observed in all groups on the 21st day.</p><p><strong>Conclusion: </strong>Ebselen was found to be similarly effective to methylprednisolone in nerve regeneration in a rat model of experimental facial nerve crush. Considering that methylprednisolone has serious systemic side effects, ebselen may be a good alternative.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"20 6","pages":"507-516"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}