The journal of international advanced otology最新文献

{"title":"Long-Term Audiological Outcomes of Ossiculoplasty Using Glass Ionomer Cement: A 12-Year Cohort Study.","authors":"Arda Er, Muhammed Dagkiran, Ilda Tanrısever Pehlivan, Caglar Eker, Elvan Onan, Ozgur Surmelioglu, Suleyman Ozdemir, Mustafa Mete Kiroglu","doi":"10.65717/iao.2026.262562","DOIUrl":"https://doi.org/10.65717/iao.2026.262562","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the long-term functional hearing outcomes of ossicular chain reconstruction using glass ionomer cement (GIC) by comparing preoperative, early postoperative, and late postoperative audiological results. This study presents one of the limited series in the literature reporting very long-term (up to 12 years) audiological outcomes of ossiculoplasty using GIC.</p><p><strong>Methods: </strong>This retrospective cohort study included 45 patients who underwent ossicular chain reconstruction using GIC between 2012 and 2024. Audiological outcomes, including air conduction (AC), bone conduction (BC), pure tone average, and air-bone gap (ABG), were evaluated preoperatively, early postoperatively (3-12 months), and late postoperatively. Patients were grouped according to follow-up duration as 1-5 years (n=19), 5-10 years (n=12), and ≥10 years (n=14). Changes in audiological parameters were analyzed statistically.</p><p><strong>Results: </strong>A total of 45 patients were included. Significant improvement in AC thresholds and ABG values was observed in the early postoperative period compared to preoperative values (P < .05). In the 1- to 10-year follow-up group, early postoperative ABG results were largely preserved at late follow-up. However, in patients with ≥10 years of follow-up, a statistically significant deterioration in ABG was observed over time.</p><p><strong>Conclusion: </strong>Ossicular reconstruction using GIC provides significant early hearing improvement, and these gains are largely maintained in medium-term (1-5 years) and long-term (5-10 years) follow-up. Limited impairment is observed only in very long-term follow-up (≥10 years). Glass ionomer cement remains a highly viable option for limited ossicular defects, offering functional stability for at least 10 years.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 3","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translabyrinthine Fistula Closure in Inner Ear Malformations with Otogenic Cerebrospinal Fluid Leak.","authors":"Keisuke Tsuchida, Masahiro Takahashi, Yuka Okawa, Takara Nakazawa, Motoki Hirabayashi, Kazuhisa Yamamoto, Yutaka Yamamoto, Hiromi Kojima","doi":"10.65717/iao.2026.262426","DOIUrl":"10.65717/iao.2026.262426","url":null,"abstract":"<p><strong>Unlabelled: </strong>Inner ear malformations can cause abnormal communication between the inner ear and subarachnoid space, leading to otogenic cerebrospinal fluid (CSF) leakage and subsequent bacterial meningitis. Persistent leakage may result in recurrent meningitis, which is associated with neurological sequelae and poor prognosis; thus, early diagnosis and surgical intervention are essential. Various surgical strategies have been reported, commonly termed middle ear obliteration and inner ear obliteration. However, their definitions remain ambiguous, and techniques vary widely in approach and effectiveness. This study describes 2 pediatric cases of incomplete partition type I (IP-I) malformation complicated by recurrent meningitis that were treated with translabyrinthine fistula closure via the lateral semicircular canal, a form of inner ear obliteration. Both patients exhibited high vestibular CSF pressure due to hypoplasia of the internal auditory canal fundus. Patient 1 had undergone 4 previous window closure surgeries elsewhere without success, whereas Patient 2 had no residual hearing and required prompt management. In both cases, the fistula was directly identified and sealed with a three-layer construct under direct visualization, allowing secure closure. Postoperative follow-up revealed no recurrence of meningitis for >8 years in Case 1 and more than 1 year in Case 2, without complications. This technique may represent a reasonable treatment option for controlling CSF leakage in severe inner ear malformations, including cases refractory to conventional treatments, even at the cost of sacrificing inner ear function. Using 2 representative pediatric cases, this study presents a case-based review that clarifies the classification, indications, and limitations of current surgical strategies for otogenic CSF leakage associated with inner ear malformations.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 2","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Interactions During Shared Book Reading in Children with Cochlear Implant and Their Typically Developing Peers: A Comparative Study.","authors":"Sneha Mareen Varghese, Arunima Santhosh, Jeffy Philip","doi":"10.65717/iao.2026.251987","DOIUrl":"10.65717/iao.2026.251987","url":null,"abstract":"<p><strong>Objective: </strong>Shared book reading (SBR) is a pivotal activity in early childhood language development. However, children using cochlear implants (CIs) face challenges due to their auditory difficulties and the need for adapted communication strategies. This study aims to compare the maternal interactions during SBR by mothers of children with CIs and typically developing (TD) children.</p><p><strong>Methods: </strong>Fifteen mothers of children with CIs and 20 mothers of TD children participated in the study. Each of them was given a picture-salient and a print-salient book to read to their child in any order. The interactions were video recorded and analyzed.</p><p><strong>Results: </strong>Mothers of children with CIs exhibited significantly more verbal and nonverbal behaviors compared to mothers of TD counterparts, particularly nonverbal references, which displayed a large effect size. Notably, while mothers of children with CIs showed significant differences in nonverbal references across both book types, mothers of TD children showed marked differences in verbal behaviors, including non-immediate talk, written text, and engagement with books. Additionally, analysis revealed that the correlation between the language proficiency of the mother and various verbal behaviors in both groups highlighted its importance in language development. Furthermore, the duration of therapy was significantly linked to the use of nonverbal references and providing text by mothers of children with CIs.</p><p><strong>Conclusion: </strong>The study sheds light on the variations in maternal interaction in accordance with the types of books and also highlights the use of decontextualized language during SBR.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 2","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Various Surgical Techniques for Cochlear Implantation in an Ossified Cochlea: A Systematic Review.","authors":"Isra Aljazeeri, Alhassan Alghazlan, Tawfiq Khurayzi, Ibrahim Shami, Ahmad M Aldhafeeri, Yassin Abdelsamad, Abdulrahman Hagr, Farid Alzhrani","doi":"10.65717/iao.2026.252060","DOIUrl":"10.65717/iao.2026.252060","url":null,"abstract":"<p><strong>Background: </strong>Cochlear ossification, otherwise known as labyrinthitis ossificans, is not an uncommon encounter in candidates for cochlear implantation (CI) that may necessitate alternative surgical approaches due to the insertion difficulties. We aimed to review the literature for the documented approaches for CI in cases with cochlear ossification.</p><p><strong>Methods: </strong>This review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines on articles that described their surgical approach for CI in cases with cochlear ossification. A comprehensive search of the electronic medical databases was conducted through Feb 2025.</p><p><strong>Results: </strong>A total of 31 reports on 492 patients were included. The following approaches were documented: the facial recess approach, facial recess approach with removal of the incus buttress, combined facial recess and transcanal approach, subtotal petrosectomy/or radical mastoidectomy approach. The insertion was carried out through round window (RW), extended RW, scala tympani (ST) cochleostomy, scala vestibuli (SV) cochleostomy, double cochleostomy (basal turn with apical or middle turn cochleostomies), retrograde array insertion (through middle or apical turn cochleostomy) and partial or complete drill-out procedure. Alternative electrode designs used were short, double/split, triple, and stiff electrode arrays. In some instances, there was a need for alternative techniques to enable CI, including partial insertion technique, retrograde insertion, and robotic-assisted cochlear implant surgery.</p><p><strong>Conclusions: </strong>This review suggests numerous approaches and techniques for CI in an ossified cochlea, providing alternative approaches when the RW is inaccessible through the standard facial recess approach.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 2","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Cholesteatoma: The Role of Early Diagnosis in Surgical Outcomes.","authors":"Mariapaola Guidi, Ruggero Lapenna, Francesco Zappoli Thyrion, Letizia Flammia, Antonio Sarno, Franco Trabalzini","doi":"10.65717/iao.2026.251577","DOIUrl":"10.65717/iao.2026.251577","url":null,"abstract":"<p><strong>Background: </strong>This study presents the clinical experience in the management of pediatric cholesteatoma, specifically evaluating whether a delay in surgical intervention following symptom onset negatively affects prognosis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted of children who underwent surgical treatment for chronic otitis media with cholesteatoma between March 2017 and July 2018, with a minimum follow-up of 24 months. For staging purposes and to correlate disease severity with clinical outcomes, the 2017 European Academy of Otology and Neurotology/Japan Otological Society Joint Consensus guidelines were applied.</p><p><strong>Results: </strong>A total of 64 patients were included. Disease-free survival was 100% at 9 months and 83% at 41 months.</p><p><strong>Conclusion: </strong>In pediatric cases, a conservative surgical approach is often preferable to preserve quality of life. Early-stage diagnosis plays a crucial role, as delayed detection may adversely affect both the choice of surgical technique and auditory outcomes.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 2","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Idiopathic Sequential Neuritis: Case Report and Literature Review.","authors":"Fabio Pedretti, Silvia Quaglieri, Marco Benazzo, Pietro Canzi, Elena Carlotto","doi":"10.65717/iao.2026.251819","DOIUrl":"10.65717/iao.2026.251819","url":null,"abstract":"<p><strong>Unlabelled: </strong>Bilateral sequential vestibular neuritis is a rare condition reported in literature involving the vestibular nerve sequentially. Nowadays, the video head impulse test (vHIT) and vestibular-evoked myogenic potentials provide specific patterns of reduced vestibulo-ocular reflex (VOR) that allow differentiation between complete and partial nerve involvement. These tests are essential in cases of bilateral vestibular loss to monitor vestibular compensation. The case of a 56-year-old man who presented to a tertiary vestibular center with acute left-sided vestibular loss, following a documented contralateral acute vestibular loss 4 years earlier. To the best of current knowledge, this report presents, for the first time in the literature, vHIT in Suppression Head Impulse Paradigm modality data as an expression of compensation. A review of the literature was also performed according to PRISMA statements.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 2","pages":"1-3"},"PeriodicalIF":1.2,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Sensorineural Hearing Loss in Adults: Consideration of Lifestyle Practices from a Mitochondrial Perspective.","authors":"Wong Kein Low","doi":"10.65717/iao.2026.252231","DOIUrl":"10.65717/iao.2026.252231","url":null,"abstract":"<p><strong>Unlabelled: </strong>The physiological processes of sensorineural hearing in the cochlea have high energy demands. As energy is provided mainly by mitochondria housed in cochlear cells, mitochondrial dysfunction can possibly lead to sensorineural hearing loss (SNHL). Consequently, hearing benefits can potentially be derived if measures that can potentially enhance mitochondrial health are implemented. Unhealthy lifestyle practices have led to an increased risk of developing systemic oxidative stress and chronic inflammation. These, in turn, may result in persistent mitochondrial dysfunction in the body. Together, they could possibly lead to the development of SNHL and other non-communicable chronic diseases (NCDs). Factors such as micro-nutrient deficiencies, obstructive sleep apnea, and gut dysfunction could result in mitochondrial dysfunction. On the other hand, mitochondrial function could be enhanced by interventions such as better food choices and hormetic strategies like intermittent fasting. Conventional treatments of SNHL focus on steroid therapy in acute loss and hearing rehabilitation with hearing devices in chronic loss. By integrating personalized healthy lifestyle strategies, it is postulated that the chances of hearing recovery in acute SNHL could be enhanced in some patients. In chronic SNHL, they could help to prevent/slow down its progression and possibly also the progression of concomitant NCDs. Further research is warranted to substantiate these postulations.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 2","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Minocycline on Traumatic Facial Nerve Injury: An Experimental Study.","authors":"Bugra Celik, Ozge Caglar Cil, Erkan Tezcan, Oguz Guclu","doi":"10.65717/iao.2026.252065","DOIUrl":"10.65717/iao.2026.252065","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the efficacy of minocycline (M) and methylprednisolone (MP) in the treatment of trauma to the facial nerve (FN).</p><p><strong>Methods: </strong>The study was conducted on 35 male Wistar albino rats. The subjects were randomly divided into 5 groups. Buccal branches were traumatized except those in the sham group. Group 2 received 3 mg/day saline intramuscularly, the third group (M group) 90 mg/day M intraperitoneally, the fourth group (MP group) 1 mg/kg/day MP intramuscularly, the fifth group (M + MP group) 90 mg/day M intraperitoneally and 1 mg/kg/day MP treatment for 14 days. Electrophysiological tests were performed before and after the trauma, and the results were recorded. Then, the relevant nerve parts in the buccal branches of the subjects were removed and sent for histopathological examination.</p><p><strong>Results: </strong>The best results were observed in Group 1 and Group 5, while Group 2 had the worst results in terms of axonal diameter measurement, myelin sheath degeneration, and mast cell count parameters measured in histopathological examinations. In the electrophysiological analyses, the differences between the third week (posttreatment) and the first measured (pre-traumatic) NET (nerve excitability test) and MST (maximum stimulation test)values were observed to be significantly lower in Groups 1, 4, and 5 compared to Group 2. This was statistically significant.</p><p><strong>Conclusion: </strong>Positive effects on nerve fibers were observed when M was used alone and together with MP. It is suggested that M, whose effectiveness in traumatic FN injury has not been previously investigated in the literature, be used as a treatment in humans for this purpose, and that more diverse and advanced comparative studies be conducted.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 2","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benign Paroxysmal Positional Vertigo in Patients with Mild Traumatic Brain Injury: A Multidisciplinary Study.","authors":"Johan C M L Dao, Ilja Van der Geest, Seher Makineli, Benjamin L Emmink, Tjasse D Bruintjes, Tjard R Schermer, Stephanie M Winters","doi":"10.65717/iao.2026.252084","DOIUrl":"10.65717/iao.2026.252084","url":null,"abstract":"<p><strong>Background: </strong>Benign paroxysmal positional vertigo (BPPV) is a common vestibular disorder. Previous studies have reported diverse and conflicting results regarding the incidence of BPPV after head trauma (t-BPPV). The aims of this study were to determine the incidence of t-BPPV in patients presenting at a hospital emergency department (ED) with mild traumatic brain injury (TBI) and to assess its risk factors.</p><p><strong>Methods: </strong>A single-center prospective cohort study was conducted. Patients with mild TBI were included at the ED of the teaching hospital. Dix-Hallpike and supine roll-tests were used to diagnose t-BPPV. Data on demographic and clinical characteristics were collected. The t-BPPV patients were contacted by telephone 1 month after the initial diagnosis and treatment. The t-BPPV rates were calculated. Univariable and multivariable logistic regression models were used to assess risk factors for t-BPPV.</p><p><strong>Results: </strong>Among the 156 patients included (mean age 65 (SD 17) years), 20 had t-BPPV (incidence of 12.8% (95% CI 7.7-17.9)). Female sex (odds ratio (OR) 4.66 (95% CI 1.45-14.97); P =.010) and high energy trauma (OR 3.80 (95% CI 1.11-12.92); P=.033) were statistically significant risk factors for the occurrence of t-BPPV after mild TBI.</p><p><strong>Conclusion: </strong>The incidence of t-BPPV in a Dutch population that presents at the ED with mild TBI was 12.8%. Female sex and undergoing high-energy trauma were shown to be risk factors for the occurrence of t-BPPV.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 2","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Sacculo-collic and Otolith-ocular Pathway Dysfunction in Individuals with Vestibular Migraine.","authors":"Prajeesh Thomas, Sujeet Kumar Sinha","doi":"10.65717/iao.2026.252189","DOIUrl":"10.65717/iao.2026.252189","url":null,"abstract":"<p><strong>Background: </strong>Vestibular migraine is the second most common cause of dizziness and is characterized by variability in migraine symptom presentation, duration, and temporal relationship to vestibular symptoms. Studies have reported alterations in amplitude and latency of vestibular-evoked myogenic potentials among individuals with vestibular migraine. But these reports have limitations in terms of sample size, number of tests, and confirmation of the diagnosis.</p><p><strong>Methods: </strong>A prospective standard group comparison design was employed for this study. Seventy-six individuals with confirmed vestibular migraine and 76 healthy age-matched subjects participated in this study. All of them underwent cervical vestibular-evoked myogenic potential (cVEMP) and ocular vestibular-evoked myogenic potential (oVEMP) test with a 500 Hz tone burst stimulus. The response rate, latency, and amplitude parameters were analyzed.</p><p><strong>Results: </strong>A significantly lower response rate of VEMPs was noted in vestibular migraine participants compared to the healthy group which had a 100% response rate. Among the vestibular migraine individuals, the oVEMP response rate was lower than the cVEMP response rate. There was no main effect of ear on VEMPs' latency and amplitude; hence, right and left ear responses were combined for analysis. The latency of cVEMP and oVEMP was prolonged, and the amplitude of cVEMP was reduced in vestibular migraine compared to healthy individuals.</p><p><strong>Conclusion: </strong>The otolithic dysfunction in vestibular migraine could arise from vasospasm of the labyrinthine artery, disproportionately affecting the saccule and utricle. The otolith-ocular pathway dysfunction is more predominant in vestibular migraine than sacculo-collic pathway dysfunction. Reduced cVEMP amplitude and prolonged cVEMP and oVEMP latencies suggest involvement of both peripheral and central components in vestibular migraine. The heterogeneous nature of the condition explains the variety of response patterns.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 2","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}