The international journal of cardiovascular imaging最新文献

{"title":"Two coronary tails, one tale: mirror-image distal origin anomalies.","authors":"Scott P David, Stefan Gherca, Michael J Zellweger, Maurice Pradella, Philip Haaf","doi":"10.1007/s10554-026-03696-8","DOIUrl":"10.1007/s10554-026-03696-8","url":null,"abstract":"","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1831-1832"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13658312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastro-pericardial fistula with pneumopericardium.","authors":"Melisa Prieto Peralta, Arzu Canan","doi":"10.1007/s10554-026-03714-9","DOIUrl":"10.1007/s10554-026-03714-9","url":null,"abstract":"","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1825-1826"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of impaired flow-mediated epicardial vasodilation among different types of coronary flow regulation.","authors":"Ines Valenta, Mohammad Alavi, Ashwin S Parihar, Sudhir Jain, Thomas Hellmut Schindler","doi":"10.1007/s10554-026-03736-3","DOIUrl":"10.1007/s10554-026-03736-3","url":null,"abstract":"<p><p>To assess the prevalence of impairment of flow-mediated epicardial vasodilation (IEV) in the presence of normal and abnormal coronary microvascular function. In 332 consecutive symptomatic patients, global and longitudinal myocardial blood flow (MBF) at rest and during pharmacologically stimulated hyperemia was evaluated with ¹³N-ammonia positron emission tomography/computed tomography (PET/CT). Normal coronary microvascular function (nCMF) was defined by a myocardial flow reserve (MFR = MBFstress/MBFrest) of ≥ 2.0 (group 1; n = 210 (G1)), while an abnormal MFR of < 2.0 (predominantly due to decreases in hyperemic MBF) denoted classical CMD (group 2; n = 83 (G2)) or (predominantly related to increases in resting MBF ≥ 1.0mL/g/min) signified endogen CMD (group 3; n = 39 (G3)), respectively. Furthermore, normal flow-mediated epicardial vasodilation (NEV) was defined as longitudinal hyperemic MBF gradient < -0.10 mL/g/min, whereas a value ≥ -0.10 mL/g/min signified IEV.In the entire study population, IEV was present in 34.6.% (115/332). IEV was highest in group 1 (46.2%), while there was a comparable low prevalence between group 2 and group 3 (13.3% vs. 17.9%; p = 559). The hyperemic longitudinal MBF gradient was significantly higher in G1 compared to G2 (-0.28 ± 0.10 vs. -0.19 ± 0.08 mL/g/min; p ≤ 0.008), but comparable between group 1 and group 3 (-0.28 ± 0.10 and - 0.27 ± 0.10 mL/g/min; p = 0.795). The hyperemic longitudinal MBF gradient and ΔMBF Gradient correlated inversely with the global hyperemic MBF, respectively (r = 0.41, SEE = 0.09 and r = 0.34, SEE = 0.09, both p ≤ 0.001). Nearly half of symptomatic patients with normal global MFR may have IEV. As IEV carries important diagnostic and prognostic information, it may further optimize prognostication on cardiovascular individuals deserving further clinical testing.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1749-1763"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The roles of quantitative doppler echocardiography in optimizing guideline-directed medical therapy in Post-STEMI patients.","authors":"Juan Lei, Tou Kun Chong, Jingwei Gao, Jian Chen, Kan Liu","doi":"10.1007/s10554-026-03722-9","DOIUrl":"10.1007/s10554-026-03722-9","url":null,"abstract":"","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1667-1674"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography-guided PCI in left anterior descending versus non-left anterior descending lesions: a prespecified substudy of the OCCUPI trial.","authors":"Soo-Jin Kim, Seung-Jun Lee, Sung-Jin Hong, Sang-Hyup Lee, Jong-Young Lee, Deok-Kyu Cho, Jin Won Kim, Sang Min Kim, Seung-Ho Hur, Ji-Yong Jang, Jin Sin Koh, Hoyoun Won, Jun-Won Lee, Soon Jun Hong, Dong-Kie Kim, Jeong Cheon Choe, Jin Bae Lee, Tae-Hyun Yang, Jung-Hee Lee, Young Joon Hong, Jong-Hwa Ahn, Yong-Joon Lee, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung Ho Heo, Byeong-Keuk Kim","doi":"10.1007/s10554-026-03734-5","DOIUrl":"10.1007/s10554-026-03734-5","url":null,"abstract":"<p><p>The OCCUPI trial demonstrated the clinical benefit of optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI). However, whether the effect of OCT guidance differs according to diseased coronary vessel remains unclear. This prespecified substudy evaluated the consistency of clinical outcomes with OCT-guided PCI in left anterior descending (LAD) versus non-LAD lesions. Among 1,375 patients without left main disease, 888 had LAD lesions and 487 had non-LAD lesions. Patients were randomized to undergo PCI guided by either OCT or conventional angiography. The primary endpoint was 1-year major adverse cardiovascular events (MACE), defined as a composite of cardiac death, myocardial infarction, stent thrombosis, or ischemia-driven target-vessel revascularization (TVR). Outcomes were assessed by time-to-event analysis. In the LAD group, 1-year MACE occurred in 4.5% of patients treated with OCT-guided PCI and 5.5% treated with angiography-guided PCI, with no statistically significant difference (p = 0.456). In the non-LAD group, corresponding MACE rates were 4.6% and 7.7%, respectively (p = 0.099). There was no significant interaction between diseased vessel and PCI guidance strategy (p for interaction = 0.351). Ischemia-driven TVR occurred less frequently with OCT-guided PCI in both LAD and non-LAD lesions, without significant heterogeneity (p for interaction = 0.872). In complex coronary lesions, the clinical effect of OCT-guided PCI was consistent between LAD and non-LAD vessels, with fewer repeat revascularizations observed across diseased-vessel subgroups.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1737-1747"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148059257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventilation-perfusion (V/Q) scans: trends from medicare part B (2013-2023).","authors":"Alaaeddine El Ghazawi, Ahmad El Yaman, Maria Alwan, Mahmoud Al Rifai, Mouaz H Al-Mallah","doi":"10.1007/s10554-026-03739-0","DOIUrl":"10.1007/s10554-026-03739-0","url":null,"abstract":"<p><p>Ventilation-Perfusion (V/Q) scan has been established as a nuclear imaging modality for diagnosis of pulmonary embolism (PE), especially in patients with contraindications computed tomography pulmonary angiography (CTPA). However, its use in United States is declining. We analyzed national Medicare data (2013-2023) to assess V/Q and Q scan utilization and physician procedure volumes. Our analysis shows that annual V/Q scans have been declining over the period from 2013 to 2023, with a marked drop occurring between 2019 and 2020 (COVID-19 era). Most of the V/Q scans have been read by low volume readers (< 11/ year). Low-volume readers percentage increased from 20.3% in 2013 to 43.4% in 2023. These trends may impact diagnostic quality and highlight the need to reassess training, competency, and access to V/Q imaging for patients contraindicated for CTPA.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1765-1768"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148255232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related changes in lysosomal abundance in mouse hearts assessed by Lysotracker fluorescence imaging and autophagy gene expression analysis.","authors":"Jawaher Albulushi, Hannah Coghlan, Mohesh Moothanchery, Aiswarya Dev, Emily Akerman, Jasmine Heenan, Nordine Helassa, Oluwatobi Adegbite, Parveen Sharma, Fenil Patel, Libby Harrison, Mahon L Maguire, Gary R Mirams, Pawel Swietach, Harish Poptani, Rebecca Ab Burton","doi":"10.1007/s10554-026-03719-4","DOIUrl":"10.1007/s10554-026-03719-4","url":null,"abstract":"<p><strong>Purpose: </strong>Lysosomal function is essential for cardiac proteostasis and cellular health, yet its regulation during ageing remains poorly defined. We aimed to determine whether whole-organ, fluorescence imaging using an In Vivo Imaging System (IVIS) provides a novel, rapid and scalable approach for quantifying lysosomal abundance in intact ex vivo hearts prior to deeper molecular analysis.</p><p><strong>Methods: </strong>Ex vivo hearts from young (2-4 months) and aged (18 months) mice were labelled with Lysotracker™ Red and imaged using IVIS, to quantify whole-heart acidic-vesicle-associated fluorescence signals. Expression of lysosomal and autophagy-related genes (Lamp2, Atp6v1a, Sqstm1, Cd63, Atg12, Nfe2l2, M6pr) was assessed by RT-qPCR.</p><p><strong>Results: </strong>Whole-heart Lysotracker fluorescence did not differ significantly between age groups, indicating preservation of overall acidic-vesicle pool. Expression of Atp6v1a and Lamp2 was unchanged, suggesting maintained acidification capacity and lysosomal structure, whereas minor, upregulation of Sqstm1 might indicate increased autophagic demand and altered vesicle trafficking, which warrants further investigation. No statistically significant changes in M6pr, Atg12, or Nfe2l2 were detected, suggesting transcriptional stability in enzyme trafficking, core autophagy, and oxidative stress pathways. Regionally, atria showed higher Lysotracker signal than ventricles, consistent with known enrichment of acidic vesicular stores in atrial physiology.</p><p><strong>Conclusion: </strong>IVIS-based Lysotracker imaging provides a rapid whole-organ approach for assessing acidic vesicle distribution in intact hearts, enabling scalable screening of lysosome-associated physiology. While limited by depth-dependent optical attenuation and lack of organelle specificity, this approach complements molecular analysis and supports integrated investigation of lysosomal and autophagy pathways during cardiac ageing.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1685-1696"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NASCI case of the month: coral reef thoracic aorta and subclavian artery.","authors":"Sanaz Moghaddamimonaghi, Ali Fuat Tekin, Stefan L Zimmerman","doi":"10.1007/s10554-026-03749-y","DOIUrl":"10.1007/s10554-026-03749-y","url":null,"abstract":"<p><p>Coral reef aorta (CRA) is a rare and severe form of atherosclerotic disease, marked by dense, irregular calcifications that project into the aortic lumen [1]. CRA exhibits an exophytic growth pattern, resulting in pronounced intraluminal obstruction [2]. Mechanisms of CRA are not understood; however, extent of calcification is usually out of proportion to atherosclerosis and probably related to abnormal calcium metabolism and systemic inflammatory state [1]. CRA more commonly affects women, presents with symptoms related to vascular compromise, is often found in the suprarenal and juxtarenal segments of the aorta, and is challenging to treat, often requiring open repair [2, 3].We report a case of CRA involving both the thoracic aorta and subclavian artery, resulting in symptoms of subclavian steal.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1827-1828"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The double threat: imaging manifestations of thoracic sarcoidosis with miliary nodules and myocardial involvement with radiologic-pathologic correlation.","authors":"Shweta Kataria, Muthu Kumar Sakthivel, Surekha Bantumilli","doi":"10.1007/s10554-026-03698-6","DOIUrl":"10.1007/s10554-026-03698-6","url":null,"abstract":"<p><p>A middle-aged man presented with near syncope and complete heart block. Multimodality thoracic and cardiac imaging, together with histology, established the diagnosis of thoracic sarcoidosis with myocardial involvement. This case highlights an uncommon miliary pattern of pulmonary sarcoidosis and underscores the value of combined cardiac MRI and FDG PET-CT in identifying active cardiac sarcoid as the cause of conduction block, prompting timely immunosuppressive and implantable cardiac defibrillator placement.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1833-1834"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of formalin fixation on biventricular parameters in cardiac diffusion tensor imaging: A pilot study in a miniature swine model.","authors":"Leyi Zhu, Jing Xu, Chen Cui, Peng Sun, Xinyang Wu, Xuejing Duan, Huaying Zhang, Tingting Zheng, Mengdi Jiang, Di Zhou, Wenjing Yang, Yining Wang, Gang Yin, Wenli Zhou, Xinqiao Lian, Arlene Sirajuddin, Andrew E Arai, Qiang Zhang, Li Li, Shihua Zhao, Minjie Lu","doi":"10.1007/s10554-026-03730-9","DOIUrl":"10.1007/s10554-026-03730-9","url":null,"abstract":"<p><p>Purpose To examine the impact of formalin fixation on biventricular cardiac diffusion tensor imaging (cDTI) parameters in a miniature swine model, using histological findings as the reference standard. Methods High-resolution ex-vivo cDTI data of one healthy miniature swine were acquired at baseline and on days 5 and 9 after formalin fixation. Histology with hematoxylin and eosin staining was employed to assess helix angle (HA) and HA transmurality on day 10 following fixation. In total, 64 myocardial segments, including 48 left ventricular (LV) and 16 right ventricular (RV) segments, were analyzed in head-to-head comparison. Results For this heart, subepicardial HA became more negative after formalin fixation on cDTI, and subendocardial HA showed a positive increase, which led to a significant elevation in HA transmurality (all P < .05). Mean diffusivity decreased in LV and RV walls during the first 5 days of fixation (P < .05 and P < .01, respectively), with a further marked decrease in the LV wall over the next 4 days (P < .001) but no significant change in the RV wall. HAs derived from cDTI at baseline and on days 5 and 9 following fixation exhibited excellent consistencies in the LV wall and poor-to-good consistencies in the RV wall with those assessed with histology, among which baseline HA yielded the highest interclass correlation coefficient of 0.968 in the LV wall and 0.812 in the RV wall. Conclusion In this pilot study, formalin fixation had an impact on both cardiomyocyte orientations and diffusion properties derived from cDTI.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1723-1735"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}