The international journal of cardiovascular imaging最新文献

{"title":"Agatston scoring for assessment of coronary artery disease in patients undergoing transcatheter aortic valve implantation.","authors":"Karim Mostafa, Jakob Christoph Voran, Markus Müller, Anka Pohlmeyer, Marie Noormalal, Mostafa Salem, Mohammed Saad, Patrick Langguth, Derk Frank, Carmen Wolf, Hatim Seoudy","doi":"10.1007/s10554-025-03471-1","DOIUrl":"https://doi.org/10.1007/s10554-025-03471-1","url":null,"abstract":"<p><p>Computed tomography (CT) angiography remains a cornerstone of pre-interventional assessment for transaortic valve implantation (TAVI). CT imaging prior to TAVI further allows for evaluation of the coronary arteries, with the simplest method being the calculation of the coronary Agatston score. Following the expansion of TAVI to lower risk patients, non-invasive coronary diagnostics in the framework of TAVI gain importance as they may allow patients to avoid unnecessary invasive coronary angiography (ICA) before the procedure. This study evaluates the diagnostic performance of coronary Agatston score values on pre-TAVI CT scans for the assessment of coronary artery disease. A total of 285 patients received a standard TAVI evaluation CT scan and routine ICA prior to the TAVI procedure. Agatston score values of the coronary tree and the proximal coronary segments (1, 5, 6, 11) were calculated separately by two radiologists. Reference for the AUC analysis was performance of PCI or stenting of the corresponding coronary segment following the recommendation of the Heart Team. ROC-analysis was performed for evaluation of the Agatston score at the level of the heart, the coronary arteries and the proximal coronary vessel segments (1, 5, 6 and 11) level to determine cutoff-values for optimal sensitivity and specificity. A total of 285 patients received a standard TAVI evaluation CT scan and routine ICA prior to the TAVI procedure. Agatston score values of the coronary tree and the proximal coronary segments (1, 5, 6, 11) were calculated separately by two radiologists. Reference for the AUC analysis was performance of PCI or stenting of the corresponding coronary segment following the recommendation of the Heart Team. ROC-analysis was performed for evaluation of the Agatston score at the level of the heart, the coronary arteries and the proximal coronary vessel segments (1, 5, 6 and 11) level to determine cutoff-values for optimal sensitivity and specificity. Coronary artery disease requiring intervention was present in 61 patients upon ICA (17.9%). In predicting the need of performance of a coronary intervention at a sensitivity of >89%, Agatston values of the full coronary tree >170 allow for a sensitivity of 90% (AUC 0.76, NPV 0.93). The sum Agatston score of the proximal segments >117 enables a sensitivity of 90% (AUC 0.74, NPV 0.93) and >47 a sensitivity of 98% (NPV 0.98). On the segmental level, Agatston values of >22 in the proximal RCA and >30 in the proximal LAD and CX allow for a sensitivity of 90% (AUC RCA 0.74, NPV 0.98; LAD 0.71, NPV 0.94; CX 0.75, NPV 0.99). Aiming for 98% sensitivity or higher, Agatston values of >2 for the RCA, >3 for the LAD and >27 for the CX apply (RCA NPV 1; LAD NPV 0.97; CX NPV 1). Coronary artery Agatston scoring on TAVI evaluation CT scans can serve as a predictor for the need of coronary interventions in the workup leading up to TAVI and it provides valuable information for identification of patients without s","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart-Brain axis: is microvascular dysfunction the link between stroke and Takotsubo syndrome?","authors":"Riccardo Cau, Michele Porcu, Jasjit S Suri, Filippo Cademartiri, Mahmud Mossa-Basha, Luca Saba","doi":"10.1007/s10554-025-03477-9","DOIUrl":"https://doi.org/10.1007/s10554-025-03477-9","url":null,"abstract":"<p><p>Takotsubo syndrome (TS) is characterized by transient left ventricular dysfunction, often triggered by psychological or physiological stress. Increasing evidence highlights the critical role of the brain-heart axis in TS, with small blood vessels acting as central mediators. Recent data indicate a significant association between TS and cerebrovascular events, particularly ischemic stroke. Studies show that the incidence of stroke in TS patients is 1-2% per patient-year, which may occur during the acute phase or later due to ongoing autonomic and microvascular dysfunction. This underscores the shared mechanisms of microvascular impairment between the heart and brain in TS. Imaging techniques are essential for detecting microvascular abnormalities in both the heart and brain, providing valuable insights into the interconnected nature of microvascular dysfunction across the heart-brain axis. The aim of this review is to investigate the potential shared pathophysiological mechanisms that link TS and stroke, with a specific emphasis on microvascular dysfunction as a common factor. By examining the role of the heart-brain axis in both conditions and emphasizing the crucial role of advanced imaging techniques, this review seeks to clarify how microvascular abnormalities can simultaneously affect the cardiovascular and cerebrovascular systems. Additionally, it provides insights into the clinical implications of these findings, highlighting the importance of viewing TS and stroke as interconnected conditions within a shared pathological framework. Understanding these mechanisms may not only improve early detection but also pave the way for novel therapeutic strategies targeting both cardiac and cerebral microvascular health, potentially enhancing outcomes for TS patients.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of thoracic aortic calcification and its effects on thoracic aortic size.","authors":"Long Cao, Longteng Ma, Tianfeng Ma, Guoyi Sun, Zelin Niu, Hongpeng Zhang, Jianping Bai, Wei Guo","doi":"10.1007/s10554-025-03481-z","DOIUrl":"https://doi.org/10.1007/s10554-025-03481-z","url":null,"abstract":"<p><p>Thoracic aortic calcification (TAC) is a valuable predictor for assessing the risk of cardiovascular disease. However, there is limited evidence clarifying the specific determinants of TAC and its impact on the thoracic aortic diameter. A total of 446 patients who underwent lung nodule screening between August 2020 and April 2023 were included. TAC volume and thoracic aortic diameter were measured separately based on three predefined aortic segments on unenhanced computed tomography. Univariate analysis and regression models were used to identify independent determinants of TAC volume. Additionally, univariate and multivariate generalized linear regression analyses were conducted to explore the association between TAC volume and thoracic aortic diameter. The mean age of the patients was 55.6 years, and 45.5% were men. Using the absence of TAC as a reference, age, hypertension, smoking, elevated blood urea nitrogen, and increased circulating alkaline phosphatase levels were identified as independent risk factors for the presence of TAC (all P < 0.05). Independent of age and other factors, total TAC volume was positively correlated with aortic diameter across three different thoracic aortic planes (all P < 0.05). Notably, each TAC segment contributed differently to thoracic aortic dilation. Beyond traditional risk factors, serum alkaline phosphatase concentrations emerge as a novel predictor of TAC burden. Increased TAC volume leads to enlargement of thoracic aortic segments in a characteristic pattern, where an increased TAC volume in the lower aortic segment appears to drive the expansion of the upper aortic segment.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved prediction of permanent pacemaker implantation in TAVR for aortic regurgitation: integrating Self-expanding valve implants with 3D printed Patient-specific aortic root models and sensors.","authors":"Yuanting Yang, Hongning Song, Ji Zhang, Sheng Cao, Tuantuan Tan, Shixin Tao, Bing Huang, Changwu Xu, Zheng Hu, Jing Chen, Qing Zhou","doi":"10.1007/s10554-025-03461-3","DOIUrl":"https://doi.org/10.1007/s10554-025-03461-3","url":null,"abstract":"<p><p>The aim of this study is to develop a comprehensive predictive model for PPMI after transcatheter aortic valve replacement (TAVR) in patients with aortic regurgitation by reflecting pressure changes in the critical region post-TAVR using 3D-printed root models equipped with pressure sensors, in conjunction with clinical baseline characteristics, MDCT findings, procedural factors. A retrospective analysis was performed on seventy-two patients with aortic regurgitation who performed pre-TAVR CT evaluation using self-expandable valves. The study excluded patients with a pre-existing PPMI or those who underwent surgical aortic valve replacement. The primary endpoint was in-hospital PPMI following TAVR. Pressure sensors integrated into 3D printed models of aortic root were utilized to visualize pressure in critical regions during TAVR simulation.Additionally, Baseline data, MDCT, and procedural outcomes were collected and analyzed according to established criteria. Multivariable logistic regression models were employed to identify the relationship between variables and the risk of PPMI. The new PPMI rate was 17.9%.The study validated the efficacy of using 3D-printed aortic root models with pressure sensors in predicting the risk of PPMI. On multivariate analysis, the maximum contact pressure, LVOT/annulus area ratio,△MSID and pre-existing RBBB were independent predictors of PPMI. A combination of these factors significantly increased the risk of PPMI post-TAVR. The 3D-printed model of aortic root with pressure sensors provides a valuable tool for visualizing pressure in critical regions and enhancing risk assessment in TAVR procedures.The study highlights the significance of integrating various clinical, anatomical, and procedural factors to predict PPMI risk accurately.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prognostically meaningful definition of non-dilated left ventricular cardiomyopathy.","authors":"Alberto Aimo, Ignazio Alessio Gueli, Bianca Alderotti, Irina Bellisario, Giancarlo Todiere, Chrysanthos Grigoratos, Carmelo De Gori, Alberto Clemente, Giorgia Panichella, Giuseppe Vergaro, Alberto Giannoni, Nicoletta Botto, Simona Vittorini, Claudio Passino, Giovanni Donato Aquaro, Filippo Cademartiri, Michele Emdin, Andrea Barison","doi":"10.1007/s10554-025-03474-y","DOIUrl":"https://doi.org/10.1007/s10554-025-03474-y","url":null,"abstract":"<p><p>Non-dilated left ventricular cardiomyopathy (NDLVC) has been defined as non-ischemic LV scarring and/or fatty replacement and/or hypokinesia, without LV dilation. We tried to identify specific criteria for LV dilation and dysfunction to implement this definition. We identified all non-ischemic cardiomyopathy patients undergoing a cardiovascular magnetic resonance scan from 2012 to 2022 with LV ejection fraction (LVEF) < 55% and/or non-ischemic late gadolinium enhancement (LGE) and/or fatty replacement, and without specific etiologies. The primary endpoint was a composite of all-cause death, sustained ventricular tachycardia or fibrillation. The cohort included 388 patients (32% women, median age 55 years [interquartile range 43-63]). Over 4.3 years (1.9-7.0), 59 patients (15%) developed a primary endpoint event. The risk increased exponentially with LVEDVi values, with inflection points approaching the upper reference limit of LVEDVi (< 96 mL/m² in women, < 105 mL/m² in men). Using these criteria, we identified NDLVC in 237 patients (61%). Among them, LVEF was the only univariate predictor of outcome. Patients with LVEF ≥ 45% (n = 212) or ≥ 40% (n = 223) had a longer survival than those with LVEF < 45% or < 40% (p = 0.025 and p < 0.001, respectively). NDLVC patients, identified by non-ischemic LV scarring and/or fatty replacement and/or hypokinesia and LVEDVi < 96 mL/m² (women) or < 105 mL/m² (men), have a lower risk of death or ventricular arrhythmias than patients with dilated cardiomyopathy. LVEF < 45% or < 40% further stratified outcome. The definition of NDLVC could incorporate these LVEDVi and LVEF cut-points to identify a population of patients with a homogeneous risk of death or ventricular arrhythmias.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photon-counting CT for coronary stent evaluation: OCT-validated case of severe in-stent restenosis.","authors":"Lili Száraz, Péter Kulyassa, Pál Maurovich-Horvat, Bálint Szilveszter","doi":"10.1007/s10554-025-03484-w","DOIUrl":"https://doi.org/10.1007/s10554-025-03484-w","url":null,"abstract":"<p><p>Photon-counting detector CT (PCD-CT) has the potential to transform stent assessment by improving visualization of stent patency and in-stent restenosis (ISR) characterization utilizing improved spatial resolution. This report presents a case of ISR evaluated using PCD-CT, with direct comparison to optical coherence tomography (OCT), as the current gold standard.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double outlet left atrium with right atrial outlet atresia.","authors":"Damandeep Singh, Niraj Nirmal Pandey, Vineeta Ojha, Sivasubramanian Ramakrishnan","doi":"10.1007/s10554-025-03473-z","DOIUrl":"https://doi.org/10.1007/s10554-025-03473-z","url":null,"abstract":"","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left atrial volume quantification by transthoracic echocardiography versus cardiovascular magnetic resonance: a systematic review and meta-analysis.","authors":"Masliza Mahmod, Sacha Bull, Tushy Kailayanathan, Tom A Davis, Alessandra Borlotti, Iulia A Popescu, Indrajeet Das, Malgorzata Wamil, Helena Thomaides Brears, Rajarshi Banerjee, Amitava Banerjee","doi":"10.1007/s10554-025-03455-1","DOIUrl":"https://doi.org/10.1007/s10554-025-03455-1","url":null,"abstract":"<p><p>Heart failure (HF) with preserved ejection fraction (HFpEF) is diagnosed by symptoms and/ or markers of congestion with cardiac dysfunction despite 'normal' (preserved) left ventricular (LV) EF. Of the criteria, left atrial volume (LAV) is being increasingly used, with cardiovascular magnetic resonance (CMR) recognised as the gold standard for volumetric assessment. We searched databases for studies with LAV and indexed (LAVi) measurements obtained through both transthoracic echocardiography (TTE) and CMR. We identified 17 articles, encompassing 1203 individuals with cardiac disease. TTE showed more frequent measurement failure (6% [95% CI 2, 11]) compared to CMR (1% [0, 5]). TTE underestimated values compared to CMR, with a bias of -20mL [95% CI -30, -11] for LAV and - 9 mL/m² [95% CI -13, -5] for LAVi (p < 0.001). TTE misclassified LA enlargement in 38% [95%CI 25, 52) of cases diagnosed by CMR. TTE systematically underestimates LAV and should be used with caution.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic arch calcification in relation to cigarette smoking: results from the multi-ethnic study of atherosclerosis (MESA).","authors":"Salman Ansari, Robert Trujillo, Robyn L McClelland, Matthew J Budoff","doi":"10.1007/s10554-025-03462-2","DOIUrl":"https://doi.org/10.1007/s10554-025-03462-2","url":null,"abstract":"<p><p>Cigarette smoking is a known contributor to cardiovascular disease (CVD) and is associated with increased prevalence of coronary artery calcium. However, despite this clinical significance, calcium deposition in other vascular beds, specifically the aortic arch, has yet to be thoroughly investigated among cigarette smokers.The study population comprised participants who underwent non-contrast chest CT scans in MESA exam 5 (2010-2012). Aortic arch calcium (AAC) is defined as calcification in the transverse aortic arch, as measured using the Agatston method on chest CT scans. Log-transformed AAC scores were used for all analyses. Multivariable linear regression models were fit to assess the relationship between log-AAC and cigarette smoking status (never-smoked, former smoker, current smoker). Cox proportional hazard models were fit to investigate the relationship between log-AAC and incident CVD and mortality for those with a history of smoking (former & current smokers). All models were adjusted for demographic and traditional clinical risk factors. After excluding those with missing variables or prevalent CVD prior to the chest CT, 2,191 participants were included in the final analysis, of which 1,091 self-identified as never smokers, 918 as former smokers, and 182 as current smokers. Estimated mean log-AAC was 0.58 (p < 0.001) log-Agatston units higher in former smokers compared with never smokers [95% CI: 0.40-0.77], and 1.10 (p < 0.001) log-Agatston units higher in current smokers compared with never smokers [95% CI: 0.76-1.40]. Among ever-smokers (current or former smokers), a one log-Agatston unit increase in AAC was associated with a 20.6% (p = 0.002) greater risk for CVD events [95% CI: 7.4 - 35.5%] and a 12% (p = 0.020) greater risk for mortality [95% CI: 2 - 23%]. This study demonstrated an association between cigarette smoking and AAC scores, with significant differences in AAC among current, former, and never smokers. Furthermore, AAC is associated with incident cardiovascular events and mortality among those with a history of smoking.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of an interactive CTCA/FFR_CT interventional stent planning tool on patient management.","authors":"David Murphy, Anil Gurung, Daniel McKenzie, Robert Lowe, Sri Raveen Kandan, Thomas Burchell, Kevin Carson, Ali Khavandi, Jonathan C L Rodrigues, Jcl Rodrigues","doi":"10.1007/s10554-025-03464-0","DOIUrl":"https://doi.org/10.1007/s10554-025-03464-0","url":null,"abstract":"<p><p>Fractional flow reserve (FFR) post percutaneous coronary intervention (PCI) is an important determinant of patient outcomes. A new virtual stent planning tool allows users to model PCI and obtain post PCI FFR_CT. We hypothesised that where a sub-optimal post PCI FFR_CT was predicted theoretical management may be altered prior to invasive angiography. Single-centre retrospective review of patients listed for PCI with preceding CTCA(+ FFR_CT), (Jan 2023-Sep 2024). Interventional cardiologists (ICs) at our institution determined a theoretical management strategy of (1) medical therapy (GDMT) (2) PCI or (3) multi-disciplinary team meeting (MDT) ± coronary artery bypass grafting (CABG) on a per-patient and per-vessel basis. The virtual stent planning tool was then unblinded and decision making repeated. Changes to management were compared with Wilcoxon-signed rank test and inter-rater agreement with Fleiss' free marginal kappa. 335 patients had a CTCA(+ FFR_CT), 96 clinically listed for angiography, 74 included in the study. 73% male, 66 ± 11 years. On a per-patient basis using CTCA(+ FFR_CT) data PCI was chosen in 95% of cases, GDMT in 4% and MDT ± CABG in 1%. The addition of the virtual planning tool changed management strategy to PCI in 59% of cases, GDMT in 30% and MDT in 11%, Wilcoxon-signed rank test P = 0.04. In patients scheduled to undergo clinically indicated PCI with preceding CTCA(+ FFR_CT) the use of the virtual stent planning tool significantly altered ICs theoretical management strategy upstream of invasive angiography, with a reduction in PCI, predominantly in favour of GDMT.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}