Jordan H Chamberlin, Sameer Abrol, James Munford, Jim O'Doherty, Dhiraj Baruah, U Joseph Schoepf, Jeremy R Burt, Ismail M Kabakus
{"title":"Artificial intelligence-derived coronary artery calcium scoring saves time and achieves close to radiologist-level accuracy accuracy on routine ECG-gated CT.","authors":"Jordan H Chamberlin, Sameer Abrol, James Munford, Jim O'Doherty, Dhiraj Baruah, U Joseph Schoepf, Jeremy R Burt, Ismail M Kabakus","doi":"10.1007/s10554-024-03306-5","DOIUrl":"10.1007/s10554-024-03306-5","url":null,"abstract":"<p><p>Artificial Intelligence (AI) has been proposed to improve workflow for coronary artery calcium scoring (CACS), but simultaneous demonstration of improved efficiency, accuracy, and clinical stability have not been demonstrated. 148 sequential patients who underwent routine calcium-scoring computed tomography were retrospectively evaluated using a previously validated AI model (syngo. CT CaScoring VB60, Siemens Healthineers, Forscheim, Germany). CACS was performed by manual (Expert alone), semi-automatic (AI + expert review), and automatic (AI alone) methods. Time to complete and intraclass correlation coefficients were the primary endpoints. Secondary endpoints included differences in multiethnic study of atherosclerosis (MESA) percentiles and stratification by calcium severity. AI and expert CACS agreement was excellent (ICC = 0.951; 95% CI 0.933-0.964). The global median time was 15 ± 2 s for AI (\"Automatic\"), 38 ± 13 s for the AI + manual review (\"Semiautomatic\") and 45 ± 24 s for the manual segmentation. Automatic segmentation was faster than manual segmentation for all CACS severities (P < 0.001). AI computational time was independent of calcium burden. Global mean bias in Agatston score across all patients was 7.4 ± 102.6. The mean bias for global MESA score percentile was 2.1% ± 12%. 95% of error corresponded to a ± 10% difference in MESA score. The use of AI for CACS performs excellent accuracy, saves approximately 60% of time in comparison to manual review, and demonstrates low bias for clinical risk profiles. Time benefits are magnified for patients with high CACS. However, a semi-automatic approach is still recommended to minimize potential errors while maintaining efficiency.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"269-278"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of magnetic field strength and segmentation variability on the reproducibility and repeatability of radiomic texture features in cardiovascular magnetic resonance parametric mapping.","authors":"Pascal Yamlome, Jennifer H Jordan","doi":"10.1007/s10554-024-03312-7","DOIUrl":"10.1007/s10554-024-03312-7","url":null,"abstract":"<p><p>Our study aims to assess the robustness of myocardial radiomic texture features (RTF) to segmentation variability and variations across scanners with different field strengths, addressing concerns about reliability in clinical practices. We conducted a retrospective analysis on 45 pairs of CMR T1 maps from 15 healthy volunteers using 1.5 T and 3 T Siemens scanners. Manual left ventricular myocardium segmentation and a deep learning-based model with Monte Carlo Dropout generated masks with different levels of variability and 1023 RTFs extracted from each region of interest (ROI). Reproducibility: the extent to which RTFs extracted from 1.5 T and 3 T images are consistent, and repeatability: the extent to which RTFs extracted from multiple segmentation runs at the same field strength agree with each other, were measured by the intraclass correlation coefficient (ICC). We categorized ICC values as excellent, good, moderate, and poor. We reported the proportion of RTFs that fell in each category. The proportion of RTFs with excellent repeatability decreased as the proportion of ROI pixels in congruence across segmentation runs decreased. Up to 31% of RTFs showed excellent repeatability, while 35% showed good repeatability across segmentation runs from the manually generated masks. Across scanners (i.e., 1.5 T vs 3 T), only 7% exhibited good reproducibility. While our results demonstrate RTF sensitivity to differences in field strength and segmentation variability, we identified certain preprocessing filters and feature classes that are less sensitive to these variations and, as such, may be good candidates for imaging biomarkers or building machine-learning models.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"325-337"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marta Leite, Gustavo Pires-Morais, Ana Isabel Azevedo, Rita Faria
{"title":"A rare presentation of an accessory mitral valve chordae.","authors":"Marta Leite, Gustavo Pires-Morais, Ana Isabel Azevedo, Rita Faria","doi":"10.1007/s10554-024-03213-9","DOIUrl":"10.1007/s10554-024-03213-9","url":null,"abstract":"<p><p>The mitral subvalvular apparatus can exhibit complex and unique anatomical variations. Accessory mitral valve chordae (AMVC) typically present as additional thin strands in the left ventricle. Their appearance in the atrium is rare. In the clinical case described, the AMVC was an incidental and intriguing finding during a routine transthoracic echocardiography.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"393-394"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expanding the volume on 4D flow CMR : Editorial for \"Robustness of 4D flow MRI derived aortic wall shear stress and pulse wave velocity across different protocols in healthy controls and in patients with bicuspid aortic valve\".","authors":"Kady Fischer, Jessica A M Bastiaansen","doi":"10.1007/s10554-025-03335-8","DOIUrl":"10.1007/s10554-025-03335-8","url":null,"abstract":"","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"181-183"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yujiro Ide, Dominik Daniel Gabbert, Jan Hinnerk Hansen, Anselm Uebing, Inga Voges
{"title":"Liver T1 mapping in Fontan patients and patients with biventricular congenital heart disease - insights into the effects of venous congestions on diffuse liver disease.","authors":"Yujiro Ide, Dominik Daniel Gabbert, Jan Hinnerk Hansen, Anselm Uebing, Inga Voges","doi":"10.1007/s10554-024-03314-5","DOIUrl":"10.1007/s10554-024-03314-5","url":null,"abstract":"<p><p>T1 relaxation time quantification on parametric maps is routinely used in cardiac imaging and may serve as a non-invasive biomarker for diffuse liver disease. In this study, we aimed to investigate the relationship between liver T1 values and cardiac function in patients with congenital heart disease (CHD) and compared patients with a biventricular circulation (BVC) to those with a Fontan circulation (FC). Magnetic resonance images from patients with CHD, obtained between June and December 2023 on a 1.5 T machine, were retrospectively reviewed. The examinations included cardiac cine sequences to assess ventricular mass and volumes, along with liver T1 mapping. T1 values were measured in eight liver segments and were compared with ventricular mass and volumes in patients with BVC and FC. In total, 104 patients (75 with BVC and 29 with FC) were included. T1 values varied significantly among the eight liver segments in both patient groups. In an age-matched comparison, patients with FC had significantly higher T1 values in all liver segments. In patients with BVC and right ventricular (RV) enlargement, a positive correlation between RV volume and T1 values in the right liver lobe was found (R > 0.504, p < 0.033). In patients with FC, the T1 values did not differ between patients with an extracardiac conduit or a lateral tunnel. Liver T1 mapping suggests more severe liver affection in patients with FC compared to those with BVC. It seems a valuable addition to cardiovascular magnetic resonance for patients who are at risk of systemic venous congestion.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"347-358"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Riccardo Cau, Alessandro Pinna, Roberta Montisci, Luigia d'Errico, Jasjit S Suri, Marco Francone, Giuseppe Muscogiuri, Luca Saba
{"title":"Impact of papillary muscle infarction on atrial and ventricular myocardial deformation in non-anterior STEMI patients.","authors":"Riccardo Cau, Alessandro Pinna, Roberta Montisci, Luigia d'Errico, Jasjit S Suri, Marco Francone, Giuseppe Muscogiuri, Luca Saba","doi":"10.1007/s10554-024-03317-2","DOIUrl":"10.1007/s10554-024-03317-2","url":null,"abstract":"<p><p>The purpose of this study was to explore the impact of papillary muscle (PPM) infarction on left atrial and ventricular strain parameters in patients with non-anterior ST-segment elevation myocardial infarction (NA-STEMI) using cardiovascular magnetic resonance (CMR). This retrospective study performed CMR scans on 88 consecutive patients with NA-STEMI (68 males, 65 ± 10.05 years). Among them, 30 demonstrated PPM infarction (25 males, 67.12 ± 9.49 years), defined as late gadolinium enhancement (LGE) in a papillary muscle head in two contiguous LGE CMR slices, and confirmed on the long-axis LGE CMR slices. Atrial and ventricular strain were analyzed by CMR feature tracking with dedicated post-processing software. Patients with PPM infarction were older (p = 0.001), with lower left ventricular ejection fraction (p = 0.040), higher indexed left ventricular end-diastolic volume (p = 0.020), and end-systolic volume (p = 0.044) compared to patients without LGE in the papillary muscle. Additionally, patients with PPM infarction showed impaired reservoir strain, booster strain, global longitudinal strain (GLS), and higher LGE extent compared to NA-STEMI patients without PPM involvement (p = 0.001, p = 0.004, p = 0.001, and p = 0.003, respectively). In multivariable analysis, GLS, global radial strain, reservoir strain, and booster strain parameters were the only independent determinants of PPM infarction (p = 0.001, p = 0.041, p = 0.002, and p = 0.027, respectively). The presence of PPM infarction assessed by CMR is independently linked to atrial and ventricular strain impairment in patients with NA-STEMI.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"359-368"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yingqian Zhang, Hui Hui, Xiangjun Wu, Jing Jing, Lei Gao, Jie Tian, Yundai Chen
{"title":"Neovascularization restructuring patterns in diabetic patients with coronary in stent restenosis: an in-vivo optical coherence tomography study.","authors":"Yingqian Zhang, Hui Hui, Xiangjun Wu, Jing Jing, Lei Gao, Jie Tian, Yundai Chen","doi":"10.1007/s10554-024-03301-w","DOIUrl":"10.1007/s10554-024-03301-w","url":null,"abstract":"<p><p>Patients with diabetes mellitus (DM) have an increased risk of in stent restenosis (ISR). Neovascularization (NV) is considered as a unique pathophysiology factor of ISR in diabetic patients. However, the restructuring patterns of in vivo human coronary NV and their relationship with ISR, especially in diabetic patients remain unclear. In this study, we aimed to investigate the NV structure differentiations between patients with and without DM after coronary stent implantation using optical coherence tomography (OCT). We included 136 patients with ISR (70 patients in DM group and 66 patients in non-DM group) who underwent OCT during coronary angiography follow-up. NVs were manually segmented, after which three-dimensional (3D) rendering of OCT images was conducted. NVs greater than 1 mm in length were classified as longitudinal running or coral tree types based on their 3D structures. NV structures were compared between DM and non-DM patients. The prevalence of the coral tree pattern NV in the DM group was 2.14-fold higher than in the non-DM group(p = 0.012). 47.14% of patients in the DM group and 51.51% of patients in the non-DM group presented longitudinal running NV (p = 0.610). The number of coral tree pattern NV was relatively higher in DM patients than in the non-DM patients (p = 0.019). However, the number of longitudinal running NV showed no difference between the two groups (p = 0.872). The normalized NV volume was significantly larger in the DM group (p = 0.008). Patients with coral tree pattern NV have thinner minimum fibrous cap thickness (p = 0.030). DM was the risk factor for coral tree pattern NV formation in ISR lesions after adjustment for other factors. NV with specific restructuring patterns, such as longitudinal running and coral tree patterns, can be identified in ISR lesions. NV with a coral tree pattern, characterized by higher leakiness and immaturity, is more commonly found in patients with DM and is associated with tissue instability in ISR. Accurate and feasible imaging modalities for NV might offer promising opportunities to evaluate NV and prevent progression of ISR in diabetic patients.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"225-235"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correlation of right ventricular outflow tract residual disease on post-op transesophageal echocardiography and discharge transthoracic echocardiography after tetralogy of fallot repair.","authors":"Christine Sawda, Soichiro Henmi, Pallavi Dwivedi, Mitchell Haverty, Yves d'Udekem, Yue-Hin Loke, Michelle Udine","doi":"10.1007/s10554-024-03302-9","DOIUrl":"10.1007/s10554-024-03302-9","url":null,"abstract":"<p><p>Post-operative transesophageal echocardiography (TEE) is standard of care to evaluate for residual disease and quality of surgical repair. The residual lesion score (RLS) as defined by the pediatric heart network explored the impact of residual lesions on outcomes using discharge transthoracic echocardiogram (TTE). In tetralogy of fallot with pulmonary stenosis (TOF/PS), the residual right ventricular outflow tract (RVOT) gradient is one marker of quality of repair. Given peri-operative differences in hemodynamics, this study aims to define the correlation between TEE and discharge TTE RVOT gradient. This single center retrospective study included patients with TOF/PS undergoing primary repair with accompanying perioperative TEE and discharge TTE. TEE and TTE measurements were compared. An RLS based on the type of repair was assigned to the post-operative TEE based on the RVOT doppler velocity. TEE RVOT peak velocity and VTI correlated with TTE RVOT peak velocity (Spearman rank correlation coefficient = 0.62 (p < 0.001)) and VTI (Spearman rank correlation coefficient = 0.66 (p < 0.001)) at time of discharge. Application of RLS at the time of the TEE does not accurately reflect RLS at the time of discharge based on current criteria (p-value based on McNemar's Chi-squared test = 0.24). The ability of post-op TEE measurement to predict need for re-intervention is just as effective as TTE. On ROC analysis, the TEE RVOT peak velocity had similar AUC (0.672) compared to discharge TTE RVOT peak velocity (0.721) on predicting need for re-intervention. After surgical repair of TOF/PS, there is a strong correlation between post-op TEE and discharge RVOT peak velocity. TEE offers a chance to guide immediate re-intervention if needed and may be applied to severe residual post-op RVOT peak velocity. Further studies are needed to identify RLS based on TEE and its relationship to outcomes and intraoperative management.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"237-245"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pamela Piña, Daniel Lorenzatti, Annalisa Filtz, Andrea Scotti, Elena Virosta Gil, Juan Duarte Torres, Cristina Morante Perea, Leslee J Shaw, Carl J Lavie, Daniel S Berman, Gianluca Iacobellis, Piotr J Slomka, Philippe Pibarot, Marc R Dweck, Damini Dey, Mario J Garcia, Azeem Latib, Leandro Slipczuk
{"title":"Epicardial adipose tissue, cardiac damage, and mortality in patients undergoing TAVR for aortic stenosis.","authors":"Pamela Piña, Daniel Lorenzatti, Annalisa Filtz, Andrea Scotti, Elena Virosta Gil, Juan Duarte Torres, Cristina Morante Perea, Leslee J Shaw, Carl J Lavie, Daniel S Berman, Gianluca Iacobellis, Piotr J Slomka, Philippe Pibarot, Marc R Dweck, Damini Dey, Mario J Garcia, Azeem Latib, Leandro Slipczuk","doi":"10.1007/s10554-024-03307-4","DOIUrl":"10.1007/s10554-024-03307-4","url":null,"abstract":"<p><p>Computed tomography (CT)-derived Epicardial Adipose Tissue (EAT) is linked to cardiovascular disease outcomes. However, its role in patients undergoing Transcatheter Aortic Valve Replacement (TAVR) and the interplay with aortic stenosis (AS) cardiac damage (CD) remains unexplored. We aim to investigate the relationship between EAT characteristics, AS CD, and all-cause mortality. We retrospectively included consecutive patients who underwent CT-TAVR followed by TAVR. EAT volume and density were estimated using a deep-learning platform and CD was assessed using echocardiography. Patients were classified according to low/high EAT volume and density. All-cause mortality at 4 years was compared using Kaplan-Meier and Cox regression analyses. A total of 666 patients (median age 81 [74-86] years; 54% female) were included. After a median follow-up of 1.28 (IQR 0.53-2.57) years, 11.7% (n = 77) of patients died. The EAT volume (p = 0.017) decreased, and density increased (p < 0.001) with worsening AS CD. Patients with low EAT volume (< 49cm<sup>3</sup>) and high density (≥-86 HU) had higher all-cause mortality (log-rank p = 0.02 and p = 0.01, respectively), even when adjusted for age, sex, and clinical characteristics (HR 1.71, p = 0.02 and HR 1.73, p = 0.03, respectively). When CD was added to the model, low EAT volume (HR 1.67 p = 0.03) and CD stages 3 and 4 (HR 3.14, p = 0.03) remained associated with all-cause mortality. In patients with AS undergoing TAVR, CT-derived low EAT volume, and high density were independently associated with increased 4-year mortality and worse CD stage. Only EAT volume remained associated when adjusted for CD.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"279-290"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Raskin, Levester Kirksey, Michael Bergen, Sameer Gadani, Abraham Levitin, Jon G Quatromoni, Sean P Lyden, Hans Michell, Cassandra Kovach, Sasan Partovi
{"title":"Translumbar and Transhepatic Tunneled Dialysis Catheter Placements in the End Stage Renal Disease Population.","authors":"Daniel Raskin, Levester Kirksey, Michael Bergen, Sameer Gadani, Abraham Levitin, Jon G Quatromoni, Sean P Lyden, Hans Michell, Cassandra Kovach, Sasan Partovi","doi":"10.1007/s10554-024-03313-6","DOIUrl":"10.1007/s10554-024-03313-6","url":null,"abstract":"<p><p>For end-stage renal disease (ESRD) patients requiring hemodialysis, reliable vascular access is crucial, especially when conventional supradiaphragmatic options are exhausted. This study reviews the technical aspects, clinical outcomes, and complications of translumbar and transhepatic tunneled dialysis catheter (TDC) placements. These alternative infradiaphragmatic approaches provide essential hemodialysis access for patients with central venous occlusions. Translumbar catheter placement is associated with high technical success rates and prolonged patency, while the transhepatic approach serves as a last resort for patients with both superior and inferior vena cava occlusions. Careful patient selection and operator expertise are critical for placement of these advanced infradiaphragmatic dialysis catheter approaches.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"339-346"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}