The international journal of cardiovascular imaging最新文献

{"title":"Intracavitary blood flow dynamics in the systemic right ventricle after atrial switch operation: a shift from transverse to longitudinal systolic pattern.","authors":"Giulia Pasqualin, Alessandra Riva, Francesco Sturla, Francesca Bevilacqua, Massimo Chessa, Mauro Lo Rito, Antonia Camporeale, Paolo Ferrero, Daniel Giese, Mario Carminati, Antonio Saracino, Alessandro Giamberti, Alberto Redaelli, Emiliano Votta, Massimo Lombardi","doi":"10.1007/s10554-025-03377-y","DOIUrl":"10.1007/s10554-025-03377-y","url":null,"abstract":"<p><p>Failure of the systemic right ventricle (SRV) is based on morphological differences between right and left ventricles (RVs and LVs). RV adaptation to systemic afterload includes increased circumferential myocardial strain with an unknown impact on intracavitary hemodynamics. The study aimed to explore the SRV pattern of intracavitary blood flow, expressed as hemodynamic force (HDF), and its relationship with wall mechanics. 4D Flow MRI was acquired for twelve adults with transposition of great arteries after atrial switch operation (TGA/AS) SRVs and for twelve healthy subjects. HDF was projected onto the apical-basal, lateral-septal and inferior-anterior directions. The ratio of the root mean square between transverse (sum of HDF_{inferior-anterior} and HDF_{lateral-septal}) and longitudinal HDF (HDF_apical-basal) was evaluated (R_RMS). SRVs of patients with TGA/AS showed R_RMS systolic values (0.94 ± 0.19) comparable to LVs (0.85 ± 0.33, p = 0.82), and significantly lower than RVs (1.85 ± 0.51, p < 0.0001). Concomitantly, averaged systolic HDF_apical-basal magnitude (r=-0.77, p = 0.004) and R_RMS systolic values (r = 0.84, p = 0.0007) showed a strong correlation with free-wall circumferential strain (FWCS). During diastole, TGA/AS SRVs had significantly lower HDF_apical-basal than control LVs (p = 0.002), revealing a diastolic R_RMS (0.72 ± 0.19) similar to RVs (0.96 ± 0.25, p = 0.17). In TGA/AS patients, SRVs structural and functional features impact on intracavitary hemodynamics, being different from that of healthy LVs and RVs. During systole, SRVs displayed a HDF shift towards LV, possibly as a result of increased FWCS. Inversely, the SRV diastolic filling appeared to be closely related to ventricular morphology, as suggested by R_RMS comparable to RVs during diastole.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"943-954"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of left ventricular myocardial work in patients undergoing surgery for primary mitral regurgitation.","authors":"Takeru Nabeta, Ferande Peters, Hoi W Wu, Aileen Paula Chua, Meindert Palmen, Anton Tomšič, Nina Ajmone Marsan, Jeroen J Bax, Pieter van der Bijl","doi":"10.1007/s10554-025-03386-x","DOIUrl":"10.1007/s10554-025-03386-x","url":null,"abstract":"<p><strong>Purpose: </strong>Echocardiography-based, left ventricular myocardial work (LVMW) can assess LV function by incorporating LV afterload. This study aims to evaluate the prognostic value of LVMW indices in patients with primary mitral regurgitation (MR) undergoing mitral valve surgery.</p><p><strong>Methods and results: </strong>A total of 306 patients (mean age 63 ± 12 years, 68% male) with severe, primary MR who underwent surgery, were included. All patients underwent transthoracic echocardiography and LVMW indices were assessed with commercially available ultrasound equipment before surgery. The mean LV global work index (LVGWI) was 1979 ± 537 mmHg% and 130 (42%) patients had impaired LVGWI (≤ 1900 mmHg%). During a median follow-up of 5.0 years (interquartile range, 2.5-8.9), 27 (8.8%) patients died after mitral valve surgery. Patients with impaired LVGWI or LV global longitudinal strain (LVGLS) (≤ 20%) had lower survival rates compared to the group with preserved (p < 0.01 and p = 0.02, respectively). While the likelihood ratio test suggests that LVGWI ≤ 1900 mmHg% provides additional prognostic information beyond the model including LVGLS (p < 0.05) for all-cause mortality, no significant improvement was observed in area under the curve, the C-index, or net-reclassification index.</p><p><strong>Conclusions: </strong>In patients with severe, primary MR who underwent surgery, impaired pre-operative LVGWI was associated with a higher mortality risk, and may have incremental value beyond LVGLS, but requires further study for validation.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"991-1000"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular diastolic and systolic functions by cardiac magnetic resonance in beta-thalassemia major: correlation with clinical findings and cardiac complications.","authors":"Antonella Meloni, Luca Saba, Vincenzo Positano, Mauro Taccori, Laura Pistoia, Emanuela De Marco, Paola Maria Grazia Sanna, Filomena Longo, Piera Giovangrossi, Calogera Gerardi, Angelica Barone, Domenico Visceglie, Valerio Barra, Alberto Clemente, Riccardo Cau","doi":"10.1007/s10554-025-03352-7","DOIUrl":"10.1007/s10554-025-03352-7","url":null,"abstract":"<p><p>This cross-sectional study explored the association of left ventricular (LV) fractional area change (FAC) with demographic characteristics, clinical data, cardiovascular magnetic resonance (CMR) findings, and cardiac complications (heart failure and arrythmias) in patients with beta-thalassemia major (β-TM). We included 292 β-TM patients (151 females, 36.72 ± 11.76 years) consecutively enrolled in the Extension-Myocardial Iron Overload in Thalassemia project and 20 healthy controls (8 females, 36.97 ± 3.54 years). CMR was used to assess FAC and derive LV systolic and diastolic indexes, to quantify myocardial iron overload (MIO) by the T2* technique and LV volumes and ejection fraction, and to detect late gadolinium enhancement (LGE). Healthy subjects and β-TM patients showed comparable LV systolic and diastolic indexes. In β-TM, the LV systolic index was significantly correlated with global heart T2* values, and patients with significant MIO (T2*<20ms) were more likely to have a reduced LV systolic index compared to those without MIO (odds ratio-OR = 3.13; p = 0.013). In multivariate analysis, global heart T2* values and positive LGE emerged as independent determinants of the LV systolic index. The number of segments with LGE inversely correlated with the LV systolic index (p = 0.003). Patients with a reduced LV systolic index were more likely to have cardiac diseases than those with a normal LV systolic index (OR = 5.34; p < 0.0001). No significant correlates were found for the LV diastolic index. In well-treated β-TM patients, MIO and LGE were the strongest determinants of the LV systolic index, and a reduced LV systolic index was associated with an increased risk of cardiac complications.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"847-857"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated generation of echocardiography reports using artificial intelligence: a novel approach to streamlining cardiovascular diagnostics.","authors":"Finn Syryca, Christian Gräßer, Teresa Trenkwalder, Philipp Nicol","doi":"10.1007/s10554-025-03382-1","DOIUrl":"10.1007/s10554-025-03382-1","url":null,"abstract":"<p><p>Accurate interpretation of echocardiography measurements is essential for diagnosing cardiovascular diseases and guiding clinical management. The emergence of large language models (LLMs) like ChatGPT presents a novel opportunity to automate the generation of echocardiography reports and provide clinical recommendations. This study aimed to evaluate the ability of an LLM (ChatGPT) to 1) generate comprehensive echocardiography reports based solely on provided echocardiographic measurements, and when enriched with clinical information 2) formulate accurate diagnoses, along with appropriate recommendations for further tests, treatment, and follow-up. Echocardiographic data from n = 13 fictional cases (Group 1) and n = 8 clinical cases (Group 2) were input into the LLM. The model's outputs were compared against standard clinical assessments conducted by experienced cardiologists. Using a dedicated scoring system, the LLM's performance was evaluated and stratified based on its accuracy in report generation, diagnostic precision, and the appropriateness of its recommendations. Patterns, frequency and examples of misinterpretations by LLM were analysed. Across all cases, mean total score was 6.86 (SD = 1.12). Group 1 had a mean total score of 6.54 (SD = 1.13) and accuracy of 3.92 (SD = 0.86), while Group 2 scored 7.38 (SD = 0.92) and 4.38 (SD = 0.92), respectively. Recommendations were 2.62 (SD = 0.51) for Group 1 and 3.00 (SD = 0.00) for Group 2, with no significant differences (p = 0.096). Fully acceptable reports were 85.7%, borderline acceptable 14.3%, and none were not acceptable. Of 299 parameters, 5.3% were misinterpreted. The LLM demonstrated a high level of accuracy in generating detailed echocardiography reports, mostly correctly identifying normal and abnormal findings, and making accurate diagnoses across a range of cardiovascular conditions. ChatGPT, as an LLM, shows significant potential in automating the interpretation of echocardiographic data, offering accurate diagnostic insights and clinical recommendations. These findings suggest that LLMs could serve as valuable tools in clinical practice, assisting and streamlining clinical workflow.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"967-977"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-traumatic pulmonary artery pseudonaneurysm.","authors":"Thomas Saliba, David Rotzinger","doi":"10.1007/s10554-025-03343-8","DOIUrl":"10.1007/s10554-025-03343-8","url":null,"abstract":"","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1013-1014"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of echocardiographic and computed-tomography assessment of Sano shunt stenosis on need for percutaneous intervention.","authors":"Natalie Soszyn, Prashant K Minocha, Benjamin Frank, Ernesto Mejia, Jenny E Zablah, Gareth J Morgan","doi":"10.1007/s10554-025-03355-4","DOIUrl":"10.1007/s10554-025-03355-4","url":null,"abstract":"<p><p>The decision for Sano re-intervention is made on the patient's clinical condition and imaging suggestive of conduit stenosis; however, no consensus exists on what imaging parameters best identify patients requiring re-intervention. We undertook a single center retrospective cohort study of patients who underwent a Norwood-Sano procedure to understand which echocardiographic and CT parameters were associated with intervention prior to second-stage palliation. Proximal and distal Sano Doppler velocity and peak gradients (PG) were recorded from TTE performed prior to Sano stenting or second-stage palliation if no intervention performed. Measured CT parameters included minimum and maximum diameter (mm), perimeter (mm), and cross-sectional area (mm²). Seventy-seven were identified. All had echocardiographic conduit assessment and 44 (57%) had a CT. Thirty-one (40%) required Sano stenting: 5 (16%) proximal, 16 (52%) distal and 10 (32%) both. Higher mean proximal Sano velocity and PG was associated with proximal Sano intervention (2 vs. 3 m/s, p = 0.001; 18 vs. 41mmHg, p = 0.001) while lower mean proximal Sano velocity and PG was associated with distal intervention (2.4 vs. 3.4 m/s, p = 0.03; 25 vs. 49mmHg, p = 0.03). Smaller distal Sano CT measurements were associated with distal stenting (minimum diameter: 4.1 vs. 4.9 mm,p = 0.007; maximum diameter: 5 vs. 6.2 mm, p = 0.003; perimeter: 14.8 vs. 17.7 mm, p = 0.003; CSA: 17.2 vs. 24.1mm², p = 0.003). Higher median reduction in Sano conduit minimum diameter from nominal (22% vs. 5%, p = 0.01), perimeter (25% vs. 13%, p = 0.001), and CSA (44% vs. 26%, p = 0.006) was seen if stenting was required. Though Doppler-derived gradients remain a useful screening tool, obtaining cross-sectional CT imaging in patients demonstrating clinical concern regarding Sano shunt stenosis can be beneficial in identifying patients with distal Sano stenosis.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"859-868"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of hematopoietic stem cell transplantation on cardiac mechanics in systemic sclerosis.","authors":"Chen Chen, Arvind Nishtala, Emily Li, William M Schultz, Abigail S Baldridge, Jacob W Groenendyk, Daniel C Lee, Sanjiv J Shah, Richard K Burt, Benjamin H Freed","doi":"10.1007/s10554-025-03365-2","DOIUrl":"10.1007/s10554-025-03365-2","url":null,"abstract":"<p><p>Systemic sclerosis (SSc) is an autoimmune disease that causes inflammation and fibrosis. Cardiac involvement in SSc is often subclinical and portends a worse prognosis. Autologous hematopoietic stem cell transplant (HSCT) improves survival in SSc but its effect on cardiac function is unknown. This study aimed to assess HSCT's effect on cardiac mechanics in SSc. Participants with SSc who received HSCT at a single academic center between 2009 and 2018 were identified from a prospective registry. All participants underwent comprehensive conventional and speckle-tracking echocardiography (STE) pre- and post-HSCT, and right heart catheterization before HSCT. Baseline and follow-up clinical and echocardiographic variables were compared. Among 88 HSCT recipients (age 51±11 years, 75% female), there was significant improvement of right ventricular (RV) strain globally (18.1±3.9% versus 20.0±4.5%, p < 0.01) and within the RV free wall (20.7±5.3% versus 23.2±5.6%, p < 0.01). Regionally, RV free wall strain improved in the mid (20.4±9.5% versus 23.7±8.0%, p = 0.04) and apical (15.3±8.6% versus 20.9±9.0%, p < 0.01) segments, but not the basal segment. While left ventricular (LV) strain did not change, left atrial (LA) reservoir strain improved (35.9±8.7% versus 47.8±11.4%, p < 0.01) and LA stiffness index (0.24±0.12 versus 0.18±0.08, p < 0.01) decreased post-HSCT. RV and LA mechanics significantly improve after HSCT among patients with SSc. This suggests a favorable effect of HSCT on the underlying myocardial pathology caused by SSc.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"879-887"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose dobutamine stress cardiovascular magnetic resonance imaging to assess aortic stenosis severity in left ventricular systolic dysfunction and severe mitral annular calcification.","authors":"Clement Lau, Nomathemba Nyathi, Brian Jere, Jamal Nasir Khan","doi":"10.1007/s10554-025-03376-z","DOIUrl":"10.1007/s10554-025-03376-z","url":null,"abstract":"<p><p>We present a case of a patient with symptomatic heart failure and chronic kidney disease in which severe mitral valve calcification prevented accurate assessment of aortic stenosis (AS) severity using conventional guideline-directed imaging modalities. We used a novel technique of low dose dobutamine stress cardiovascular magnetic resonance (LD-dCMR) imaging to elucidate and confirm severe AS, allowing the patient to subsequently proceed to have a successful transcatheter aortic valve implantation. To our knowledge, this is the first reported case in the literature base of LD-dCMR confirming severe AS in left ventricular systolic dysfunction where conventional imaging modalities were limited by dystrophic cardiac calcification.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1009-1010"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future challenges of imaging in cardiac amyloidosis.","authors":"Laurenz Hauptmann, Maximilian Autherith, Andreas Kammerlander, Franz Duca, Christian Nitsche","doi":"10.1007/s10554-025-03353-6","DOIUrl":"10.1007/s10554-025-03353-6","url":null,"abstract":"","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1001-1003"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143461137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between left ventricular hypertrophy, myocardial fibrosis, and left atrial function in non-obstructive hypertrophic cardiomyopathy: insights from CMR-FT imaging.","authors":"Yan Zheng, Ma Liyuan, Qian Wu, Huairong Zhang, Yuan Li, Rui Li, Li Zhu","doi":"10.1007/s10554-025-03363-4","DOIUrl":"10.1007/s10554-025-03363-4","url":null,"abstract":"<p><p>Nonobstructive hypertrophic cardiomyopathy (NOHCM) is associated with left ventricular (LV) hypertrophy and myocardial fibrosis, which progressively impair left atrial (LA) function. This study evaluated the impact of LV hypertrophy and fibrosis on LA dysfunction using cardiac magnetic resonance (CMR) imaging and feature-tracking (FT) strain analysis in 99 NOHCM patients, who were stratified into four groups based on the extent of late gadolinium enhancement (LGE): no fibrosis (LGE < 7%), mild fibrosis (7% ≤ LGE < 15%), moderate fibrosis (15% ≤ LGE < 30%), and severe fibrosis (LGE ≥ 30%). LA functional parameters, including reservoir strain (εs), conduit strain (εe), and pump strain (εa), showed significant reductions with increasing LGE burden (P < 0.05), with functional decline detectable even in mild fibrosis cases despite preserved LV ejection fraction. LV morphological and functional indices, such as global peak wall thickness (GPWT), LV end-systolic volume (LVESV), and LGE percentage, negatively correlated with LA strain metrics (r = -0.2 to -0.7, P < 0.05). Strain analysis demonstrated high reproducibility (ICC > 0.75). These findings highlight the clinical significance of CMR-FT as a sensitive and reliable tool for early detection of LA dysfunction in NOHCM patients, even before significant LV structural changes occur. The ability of CMR-FT to identify subtle changes in LA mechanics could provide valuable insights for risk stratification and guide early intervention strategies, ultimately improving clinical outcomes in this patient population.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"869-878"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}