Giuseppe Romano, Pietro Pieri, Elio Pieri, Vincenzo Polizzi
{"title":"Giant left atrial appendage closure with the 40 mm watchman FLX pro: overcoming challenging anatomy and transseptal access.","authors":"Giuseppe Romano, Pietro Pieri, Elio Pieri, Vincenzo Polizzi","doi":"10.1007/s10554-026-03718-5","DOIUrl":"10.1007/s10554-026-03718-5","url":null,"abstract":"","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"2045-2046"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jon Zubiaur, Sara Río Sánchez, Ignacio Fernández Herrero, Leire Unzué
{"title":"Multimodality imaging in right coronary aneurysm.","authors":"Jon Zubiaur, Sara Río Sánchez, Ignacio Fernández Herrero, Leire Unzué","doi":"10.1007/s10554-026-03720-x","DOIUrl":"10.1007/s10554-026-03720-x","url":null,"abstract":"","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"2047-2049"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147871119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaoqin Xue, Yuting Bai, Huijuan Li, Huiling An, Wenxia Chen, Xiaoling Su
{"title":"Repositioning of exercise treadmill testing in contemporary chest pain management.","authors":"Xiaoqin Xue, Yuting Bai, Huijuan Li, Huiling An, Wenxia Chen, Xiaoling Su","doi":"10.1007/s10554-026-03728-3","DOIUrl":"10.1007/s10554-026-03728-3","url":null,"abstract":"<p><strong>Background: </strong>Chest pain evaluation has become increasingly imaging-led with widespread use of coronary CT angiography (CTCA) and stress imaging (e.g., CMR, stress echocardiography). In this context, the clinical role of exercise treadmill testing (ETT) is debated because its accuracy for obstructive coronary artery disease (CAD) is generally lower than that of contemporary imaging.</p><p><strong>Objective: </strong>This narrative review reassesses the value of ETT in current chest pain care by summarizing diagnostic performance, exercise-derived prognostic/functional information, cost and resource implications, and its positioning in major society guidelines, to clarify where ETT remains clinically useful.</p><p><strong>Methods: </strong>PubMed, Embase, and the Cochrane Library were searched for English-language studies published from 2010 onward. Priority was given to major clinical guidelines, diagnostic meta-analyses, prognostic cohort studies, and cost-effectiveness evaluations relevant to stable or low-to-intermediate risk chest pain assessment.</p><p><strong>Results: </strong>Contemporary evidence shows that ETT has modest sensitivity for obstructive CAD but retains reasonable specificity when used in appropriately selected patients with an interpretable baseline ECG and adequate exercise capacity. Beyond diagnostic classification, ETT yields physiologic and functional markers-exercise capacity, chronotropic response, heart rate recovery, blood pressure response, symptom reproduction, and arrhythmia provocation-that are strongly associated with future cardiovascular outcomes and are not fully captured by anatomic testing alone. As an inexpensive, widely available test that avoids radiation and iodinated contrast, ETT remains a pragmatic option for low-risk patients and for systems with limited access to advanced imaging. Current ESC and AHA/ACC guidance continues to reserve a role for exercise ECG within risk-adapted pathways, particularly for functional assessment and selected diagnostic scenarios.</p><p><strong>Conclusion: </strong>ETT should be viewed as complementary to advanced imaging rather than competitive. When embedded in risk-stratified pathways and applied to the right population, it provides clinically meaningful functional and prognostic information at low cost. Its utility is greatest in low-risk stable chest pain, for exercise physiology assessment, and in resource-constrained settings.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1845-1854"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147871068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luísa Pinheiro, Tamara Pereira, Emídio Mata, Bárbara Lage Garcia, Raquel Menezes Fernandes, Filipa Cordeiro, Marina Fernandes, António Lourenço, Olga Azevedo
{"title":"Differential diagnosis of hypertrophic cardiomyopathy, fabry cardiomyopathy and cardiac amyloidosis: insights from right ventricular strain imaging echocardiography.","authors":"Luísa Pinheiro, Tamara Pereira, Emídio Mata, Bárbara Lage Garcia, Raquel Menezes Fernandes, Filipa Cordeiro, Marina Fernandes, António Lourenço, Olga Azevedo","doi":"10.1007/s10554-026-03750-5","DOIUrl":"10.1007/s10554-026-03750-5","url":null,"abstract":"<p><p>Purpose This study aims to evaluate the diagnostic value of right ventricular (RV) myocardial assessment using two-dimensional speckle-tracking echocardiography (2D-STE) in differentiating hypertrophic cardiomyopathy (HCM), Fabry cardiomyopathy (FC), and wild-type transthyretin amyloidotic cardiomyopathy (ATTR-CM), given the clinical importance of accurate diagnosis for guiding treatment and prognosis. Methods A retrospective study was performed involving ninety consecutive patients with nonobstructive sarcomeric HCM, FC or wild-type ATTR-CM, thirty from each disease, referred to a tertiary cardiomyopathy consultation. Thirty matched healthy individuals served as controls. All participants underwent echocardiographic evaluation of RV morphology and RV myocardial mechanics using 2D-STE. RV global longitudinal strain, RV free wall longitudinal strain, and the RV apical sparing ratio were derived and diagnostic performance of RV parameters for differentiating ATTR-CM, FC, and HCM was assessed using receiver operating characteristic (ROC) curve analysis. Inter- and intra-observer reproducibility was assessed using Bland-Altman analysis. Results RV hypertrophy was significantly more prevalent in ATTR-CM and FC (100% and 97%, respectively) than in HCM (60%). ATTR-CM patients exhibited the most substantial RV strain impairment compared to FC and HCM. RV strain analysis led to significant reclassification of RV systolic dysfunction prevalence in all groups. RV global longitudinal strain, RV free wall longitudinal strain and RV apical sparing ratio emerged as effective parameters for distinguishing ATTR-CM from FC (AUC 0.91, AUC 0.89 and AUC 0.85; respectively). RV wall thickness (RVWT) was the best discriminative parameter for distinguishing ATTR-CM from HCM (AUC 0.98) and FC from HCM (AUC 0.91), followed by RV apical sparing ratio (AUC 0.94 and AUC 0.75, respectively). Excellent inter- and intra-observer agreement was observed. Conclusions Our study underscores the importance of RV assessment in differentiating HCM phenocopies. RV strain parameters and RVWT may play pivotal roles in distinguishing these conditions, facilitating earlier diagnostic and specific treatment initiation. Further research is required to assess their clinical implications.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1855-1867"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huihui Zhou, Dan Zhu, Shangci Hao, Yongjia Shao, Nan Xu, Qian Xi
{"title":"Cardiac MRI-based strain analysis for the assessment of left atrial dysfunction in patients with atrial fibrillation.","authors":"Huihui Zhou, Dan Zhu, Shangci Hao, Yongjia Shao, Nan Xu, Qian Xi","doi":"10.1007/s10554-026-03762-1","DOIUrl":"10.1007/s10554-026-03762-1","url":null,"abstract":"<p><p>Atrial fibrillation (AF) involves changes in atrial myocardium and early left atrial (LA) dysfunction, which are difficult to identify using conventional static measurements. This study aimed to investigate the value of cardiac magnetic resonance feature tracking (CMR-FT) derived LA strain parameters for assessing LA dysfunction in AF patients and to identify sensitive indicators for early detection of impaired LA function.This retrospective study included 113 AF patients and 52 age- and sex-matched healthy controls. LA structural (LAD, LAVI) and functional parameters (LAEF, εs, εe, εa) were measured. AF patients were divided into AF1 (abnormal LAVI/LAEF, n = 92) and AF2 (normal LAVI/LAEF, n = 21). Group comparisons, correlation analysis, ROC analysis, and univariate and multivariate logistic regression analyses were performed.AF patients showed significantly increased LAD and LAVI, decreased LAEF, and impaired LA strain (all P < 0.001). Even in the AF2 subgroup with normal LAVI/LAEF, LA strain remained significantly impaired (all P < 0.001). LA strain was positively correlated with LVEF and LAEF, and negatively correlated with LAD and LAVI (all P < 0.001). εs showed the strongest correlation with total LAEF (r = 0.902). ROC analysis showed high efficacy for identifying LA dysfunction (AUC > 0.80), with εs achieving the highest AUC (0.917).CMR-FT enables non-invasive quantitative assessment of LA function. LA strain is more sensitive than conventional static parameters for detecting established LA dysfunction in AF patients, although patients already exhibited structural remodeling and reduced LVEF. The small AF2 subgroup limits the robustness of early-detection claims. εs is a promising imaging biomarker for assessing LA dysfunction.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1925-1932"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mengyu Fei, Federico Caobelli, Hengbin Zhang, Kaitao Wang, Chong Xu, Wenliang Che, Fei Yu, Han Zhang
{"title":"The value of myocardial perfusion CZT-SPECT in the assessment of coronary microvascular dysfunction in INOCA patients: a comparative study with caIMR.","authors":"Mengyu Fei, Federico Caobelli, Hengbin Zhang, Kaitao Wang, Chong Xu, Wenliang Che, Fei Yu, Han Zhang","doi":"10.1007/s10554-026-03769-8","DOIUrl":"10.1007/s10554-026-03769-8","url":null,"abstract":"<p><strong>Background: </strong>In this exploratory diagnostic study, although our previous study demonstrated the strong prognostic value of CZT-SPECT-derived stress myocardial blood flow (sMBF) and myocardial flow reserve (MFR) in patients with ischemia and non-obstructive coronary artery disease (INOCA), their diagnostic value and optimal cut-off values for coronary microvascular dysfunction (CMD) remain unclear.</p><p><strong>Methods: </strong>We prospectively recruited 56 INOCA patients referred from cardiovascular medicine to nuclear medicine. Each underwent CZT-SPECT and coronary angiography-derived index of microcirculatory resistance (caIMR) within one week. CMD was defined as caIMR > 25 U. Bonferroni correction was applied for multiple comparisons of regional coronary physiological parameters.</p><p><strong>Results: </strong>Based on caIMR, CMD was present in 42 INOCA patients (75%). After correction, regional MFR (LAD: 2.9 ± 0.9 vs. 3.7 ± 0.7, p =0.02; LCX: 2.8 ± 1.0 vs. 4.0 ± 1.5, p = 0.02; RCA: 2.9 ± 1.1 vs. 3.9 ± 0.7, p = 0.04) and global MFR (3.0 ± 0.9 vs. 3.9 ± 0.8, p < 0.01) were significantly lower in the CMD group, while no significant difference was observed in regional sMBF. Only global sMBF (r=-0.43, p < 0.01) and global MFR (r=-0.32, p = 0.02) showed moderate inverse correlations with caIMR. The optimal diagnostic cut-offs were global sMBF ≤ 3.8 mL/min/g (AUC = 0.68, 95%CI 0.55-0.80, p = 0.02) and global MFR ≤ 2.9 (AUC = 0.80, 95%CI 0.68-0.90, p < 0.01). DeLong test showed no statistically significant difference in diagnostic efficacy between the two parameters (95%CI for AUC difference: -0.06 to 0.30, p = 0.19). Conclusions These preliminary results demonstrate that CZT-SPECT-derived global sMBF and MFR provide modest diagnostic accuracy for identifying CMD in INOCA patients. This non-invasive approach may support identification of CMD and help guide clinical decision-making.</p><p><strong>Trial registration: </strong>ChiCTR2000037112. Registered 27 August 2022, https://www.chictr.org.cn/.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1945-1955"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148414388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriel Cavalcante Lima Chagas, Thomaz Alexandre Costa, Raymundo Quintana Quezada, John Jeffrey Carr, Bruno Bezerra Lima
{"title":"Where is the plaque signal? Colchicine and coronary atherosclerosis by CCTA.","authors":"Gabriel Cavalcante Lima Chagas, Thomaz Alexandre Costa, Raymundo Quintana Quezada, John Jeffrey Carr, Bruno Bezerra Lima","doi":"10.1007/s10554-026-03735-4","DOIUrl":"10.1007/s10554-026-03735-4","url":null,"abstract":"","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"2031-2032"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antonia Petersen, P Kamieniarz, D Meteva, T Walter-Rittel, T Elgeti, L-A Schaafs
{"title":"Influence of left bundle branch block on left atrial strain parameters in patients with ischaemic and non-ischaemic dilated cardiomyopathy.","authors":"Antonia Petersen, P Kamieniarz, D Meteva, T Walter-Rittel, T Elgeti, L-A Schaafs","doi":"10.1007/s10554-026-03773-y","DOIUrl":"10.1007/s10554-026-03773-y","url":null,"abstract":"<p><p>Left atrial (LA) strain parameters predict mortality in patients with ischaemic/non-ischaemic dilated cardiomyopathy (DCM). Left bundle branch block (LBBB) is a common conduction abnormality in those patients. To date, the impact of LBBB on LA strain parameters assessed by cardiovascular magnetic resonance imaging (cMRI) has not been studied systematically. In this retrospective single-centre study, we included 20 (10 female) controls without DCM or LBBB, 21 (11 female) patients with LBBB without DCM, 20 (7 female) patients with DCM without LBBB, and 20 (9 female) patients with DCM and LBBB. LA volumes and strain were assessed semi-automatically using the cvi42<sup>®</sup> and Segment<sup>®</sup> software. LA reservoir/conduit strain and corresponding strain rates were significantly impaired in patients with DCM (p = 0.003/0.022 respectively < 0.001/0.004) in comparison to controls. The presence of LBBB did not lead to significant changes of LA reservoir/conduit strain in controls (p = 0.919/0.391) nor in patients with DCM (p = 0.862/0.999), same was true for LA reservoir/conduit strain rate in patients with DCM (p = 0.999/0.812). LA conduit strain rate of patients with LBBB was significantly impaired in comparison to controls (p = 0.005). Left ventricular dilatation was associated with significantly impaired LA reservoir/conduit strain/strain rates. The presence of LBBB was not associated with additional impairment in LA strain/strain rate parameters in patients with ischaemic/non-ischaemic DCM, supporting the robustness of LA functional parameters in the presence of this common conduction abnormality. However, in patients with LBBB without dilatation LA conduit strain rate was significantly impaired in comparison to controls and further studies are needed to evaluate the impact of this finding.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1999-2009"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Massive cardiac echinococcosis.","authors":"Pranjal Rai, Yashant Aswani","doi":"10.1007/s10554-026-03732-7","DOIUrl":"10.1007/s10554-026-03732-7","url":null,"abstract":"<p><p>Cardiac Echinococcosis is an extremely rare presentation of systemic hydatid cyst disease and may present with atypical symptoms like chest pain or breathlessness. We briefly describe a case with its associated multimodal imaging findings, including chest radiograph, CT and cardiac MRI.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"2051-2052"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}