The international journal of cardiovascular imaging最新文献

{"title":"The double threat: imaging manifestations of thoracic sarcoidosis with miliary nodules and myocardial involvement with radiologic-pathologic correlation.","authors":"Shweta Kataria, Muthu Kumar Sakthivel, Surekha Bantumilli","doi":"10.1007/s10554-026-03698-6","DOIUrl":"10.1007/s10554-026-03698-6","url":null,"abstract":"<p><p>A middle-aged man presented with near syncope and complete heart block. Multimodality thoracic and cardiac imaging, together with histology, established the diagnosis of thoracic sarcoidosis with myocardial involvement. This case highlights an uncommon miliary pattern of pulmonary sarcoidosis and underscores the value of combined cardiac MRI and FDG PET-CT in identifying active cardiac sarcoid as the cause of conduction block, prompting timely immunosuppressive and implantable cardiac defibrillator placement.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1833-1834"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of formalin fixation on biventricular parameters in cardiac diffusion tensor imaging: A pilot study in a miniature swine model.","authors":"Leyi Zhu, Jing Xu, Chen Cui, Peng Sun, Xinyang Wu, Xuejing Duan, Huaying Zhang, Tingting Zheng, Mengdi Jiang, Di Zhou, Wenjing Yang, Yining Wang, Gang Yin, Wenli Zhou, Xinqiao Lian, Arlene Sirajuddin, Andrew E Arai, Qiang Zhang, Li Li, Shihua Zhao, Minjie Lu","doi":"10.1007/s10554-026-03730-9","DOIUrl":"10.1007/s10554-026-03730-9","url":null,"abstract":"<p><p>Purpose To examine the impact of formalin fixation on biventricular cardiac diffusion tensor imaging (cDTI) parameters in a miniature swine model, using histological findings as the reference standard. Methods High-resolution ex-vivo cDTI data of one healthy miniature swine were acquired at baseline and on days 5 and 9 after formalin fixation. Histology with hematoxylin and eosin staining was employed to assess helix angle (HA) and HA transmurality on day 10 following fixation. In total, 64 myocardial segments, including 48 left ventricular (LV) and 16 right ventricular (RV) segments, were analyzed in head-to-head comparison. Results For this heart, subepicardial HA became more negative after formalin fixation on cDTI, and subendocardial HA showed a positive increase, which led to a significant elevation in HA transmurality (all P < .05). Mean diffusivity decreased in LV and RV walls during the first 5 days of fixation (P < .05 and P < .01, respectively), with a further marked decrease in the LV wall over the next 4 days (P < .001) but no significant change in the RV wall. HAs derived from cDTI at baseline and on days 5 and 9 following fixation exhibited excellent consistencies in the LV wall and poor-to-good consistencies in the RV wall with those assessed with histology, among which baseline HA yielded the highest interclass correlation coefficient of 0.968 in the LV wall and 0.812 in the RV wall. Conclusion In this pilot study, formalin fixation had an impact on both cardiomyocyte orientations and diffusion properties derived from cDTI.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1723-1735"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Evaluation of the diagnostic value of dual-time-point, multiparameter 99mTc-PYP imaging in diagnosing Transthyretin Cardiac Amyloidosis\".","authors":"Deepti M Sati, Vanashri Dhananjay Shinde, Chhaya Agarwal","doi":"10.1007/s10554-026-03742-5","DOIUrl":"10.1007/s10554-026-03742-5","url":null,"abstract":"","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1821-1822"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial fibrosis is associated with worse left ventricular strain and synchrony assessed by novel CMR imaging in the general population: data from the Akershus Cardiac examination 1950 study.","authors":"Thakshani Wimalanathan, Joanna Sulkowska, Aklilu Woldegabriel Melles, Michael Fredrik Paus, Julia Brox Skranes, Trygve Berge, Arnljot Tveit, Helge Røsjø, Torbjørn Omland, Magnus Nakrem Lyngbakken, Siri Lagethon Heck","doi":"10.1007/s10554-026-03746-1","DOIUrl":"10.1007/s10554-026-03746-1","url":null,"abstract":"<p><p>Investigate the relationship between myocardial fibrosis and left ventricular (LV) deformation and mechanical synchrony using state-of-the-art cardiac magnetic resonance imaging (CMR) in an elderly general population. In 200 participants without known coronary artery disease, all born in 1950, diffuse fibrosis was quantified by septal extracellular volume (ECV) fraction and focal fibrosis by late gadolinium enhancement (LGE). LV global longitudinal and circumferential strain (GLS, GCS) and mechanical dispersion (MD) were derived by CMR-feature tracking (CMR-FT). Myocardial deformation was also assessed using fast strain-encoded MR (fSENC) percentage of LV segments with normal longitudinal and circumferential strain (≤ -17%). The associations between myocardial fibrosis and bothstrain and mechanical dispersion were examined using regression analyses. Median age was 69.0 (interquartile range (IQR) 68.6-69.3) years and 52% were male. In adjusted models, LGE presence and volume were associated with worse GLS (presence: β = 0.83, 95% CI 0.02 to 1.63; volume: β = 0.17, 95% CI 0.04 to 0.30) and lower fSENC % normal myocardium (presence: β = -6.68, 95% CI -13.33 to -0.04; volume: β = -1.66, 95% CI -3.14 to -0.18). The association between LGE (presence and volume) and GCS was attenuated when adjusting for indexed LV end diastolic volume. ECV values above 26% were associated with worse GLS, GCS and lower fSENC % normal myocardium. Participants with focal scars had significantly higher median MD (89.0 ms (IQR 71.2, 121.1) vs 78.0 ms (IQR 60.4, 97.3)), and focal scars were associated with MD above the sex specific upper quartile (OR 2.64, 95% CI (1.18, 5.94) for LGE presence and 1.22, 95% CI (1.05, 1.42) for LGE volume). In this elderly general population, focal myocardial fibrosis was associated with worse LV deformation and synchrony. There was a threshold effect with a non-linear association between diffuse fibrosis and strain.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1801-1815"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148280622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary artery remodeling and wall shear stress in repaired tetralogy of fallot: insights from 4D flow MRI before and after transcatheter pulmonary valve implantation.","authors":"Hirozumi Mori, Michinobu Nagao, Tomohito Kogure, Seiji Asagai, Kei Inai, Akihiro Inoue, Atsushi Yamamoto, Junichi Yamaguchi, Takeshi Shinkawa, Masahiro Jinzaki","doi":"10.1007/s10554-026-03726-5","DOIUrl":"10.1007/s10554-026-03726-5","url":null,"abstract":"<p><p>To investigate hemodynamic factors associated with pulmonary artery (PA) remodeling in repaired tetralogy of Fallot (rTOF), focusing on wall shear stress (WSS) and pulmonary regurgitation (PR), and to assess pre- and post-procedural changes following transcatheter pulmonary valve implantation (TPVI) using 4D flow MRI. Thirty rTOF patients undergoing TPVI were analyzed using pre- and 3-month post-procedural 4D flow MRI. Regurgitant fraction (RF-4D), ventricular parameters, and WSS along the main pulmonary artery (MPA) were quantified. Pre-TPVI, RF-4D correlated with MPA dilation (r = 0.567, p = 0.001), whereas no association was observed with mean pulmonary arterial pressure. Both systolic and diastolic WSS showed significant negative correlations with MPA area. Multivariable analysis demonstrated that RF-4D (β = 11.52, p < 0.001) and diastolic WSS (β = -0.54, p = 0.003) were independently associated with MPA dilation, while age was not significant. Post-TPVI, RF-4D decreased markedly with right ventricular reverse remodeling. Early diastolic WSS significantly decreased, while systolic WSS remained unchanged, resulting in resolution of the biphasic WSS pattern. In rTOF, pulmonary artery dilation was more strongly associated with pulmonary regurgitation-derived flow metrics than with pressure, suggesting a dominant role of flow-related hemodynamic stress. Diastolic WSS decreased after TPVI in parallel with reduction of PR and may reflect the stage of vascular remodeling. These findings suggest that WSS may serve as a mechanistic marker of pulmonary artery remodeling and may provide additional value for risk stratification in patients with progressive pulmonary regurgitation and PA dilation.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1697-1707"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147871101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the diagnostic value of dual-time-point, multi-parameter 99mTc-PYP imaging in diagnosing Transthyretin Cardiac Amyloidosis.","authors":"Jinyong Luo, Lihua Ji, Qingfei Dong, Qingqian Kong, Ting Chen, Weihong Yuan","doi":"10.1007/s10554-026-03727-4","DOIUrl":"10.1007/s10554-026-03727-4","url":null,"abstract":"<p><p>Objective To assess the clinical value of dual-time-point planar imaging and SPECT/CT tomographic imaging of 99mTc-PYP in diagnosing transthyretin cardiac amyloidosis (ATTR-CA), and to compare the diagnostic performance of different imaging time points and methods. Methods A retrospective analysis of 98 suspected CA patients (ATTR-CA 12; AL-CA 23; non-CA 63). Early imaging at 1 h and delayed imaging at 3 h included planar and tomographic imaging. Evaluations used the Perugini visual grading, heart-to-contralateral lung uptake ratio (H/CL), and tomographic semi-quantitative scoring. Pathology biopsy and genetic testing served as the gold standard. Sensitivity, specificity, and accuracy were compared across methods. Results Delayed tomographic imaging for ATTR-CA achieved a sensitivity of 100.0%, specificity of 96.5%, and accuracy of 96.9%, the best among all methods. The earliest Perugini scoring method had the lowest accuracy (80.6%), and early imaging using the H/CL method had the lowest diagnostic sensitivity (58.3%). SPECT/CT imaging at 3 h provides significant incremental diagnostic value compared to planar imaging and offers the greatest benefits, Cases that were missed during the initial review have been reclassified.Delayed imaging was superior to early imaging overall, and tomographic imaging significantly reduced false positives caused by blood-pool artifacts. Conclusion Dual-time-point 99mTc-PYP imaging with tomographic imaging can significantly improve the diagnostic accuracy for ATTR-CA, with delayed SPECT/CT performing best. For cases with atypical early imaging or diagnostic difficulty due to blood-pool tracer distribution, when Perugini grade is 2, early H/CL ≤ 1.5 or delayed H/CL ≤ 1.3, or in highly suspected cases where early imaging provides insufficient diagnostic evidence, routine inclusion of delayed SPECT/CT in the imaging workflow for suspected ATTR-CA is recommended to optimize subtyping and guide subsequent therapy.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1709-1721"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal imaging in left main and bifurcation revascularization: contemporary evidence and comparative modalities review.","authors":"Inderbir Padda, Harshan Atwal, Inderjeet Bharaj, Khushal Choudhary, Pruthvi C Revaiah, Charles Sineri","doi":"10.1007/s10554-026-03710-z","DOIUrl":"10.1007/s10554-026-03710-z","url":null,"abstract":"<p><p>Left main (LM) and bifurcation coronary artery disease (CAD) are anatomically complex lesions which require detailed planning and precise execution for successful revascularization. Conventional angiography has limited ability to characterize plaque burden and complex bifurcation anatomy, prompting the use of adjunctive imaging. These limitations have driven the adoption of advanced intravascular imaging (IVI) modalities to enhance diagnostic accuracy and guide intervention. This review evaluates and compares the roles of intravascular ultrasound (IVUS), optical coherence tomography (OCT), computed tomography coronary angiography (CTCA), and angiography in LM and bifurcation disease. A comprehensive analysis of anatomical challenges, lesion complexity, hemodynamic implications, and modality-specific advantages is provided. Key randomized controlled trials (ULTIMATE, ILUMIEN, OCTOBER, RENOVATE-COMPLEX-PCI) and real-world data are reviewed. IVUS remains the preferred modality for LM percutaneous coronary intervention (PCI), particularly for ostial and proximal lesions, due to its superior tissue penetration and correlation with physiologic indices such as minimal lumen area (MLA). OCT offers unmatched resolution and is valuable in distal LM bifurcations and complex bifurcation strategies. CTCA enhances preprocedural planning, especially for ostial and ambiguous lesions, while hybrid imaging techniques enable anatomical-physiological integration. Contemporary trials consistently demonstrate improved stent expansion, reduced major adverse cardiac events (MACE), and lower target vessel failure (TVF) with imaging-guided PCI versus angiography alone. While IVUS remains the gold standard, OCT and CTCA play complementary roles. Future directions include broader adoption of artificial intelligence (AI) enhanced imaging, fusion technologies, and standardized algorithms to improve outcomes, reduce variability, and promote cost-effectiveness in complex coronary interventions.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1647-1666"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAPIRE score predicts long-term major cardiac events.","authors":"Daniele Andreini, Edoardo Conte, Marco Magnoni, Saima Mushtaq, Alice Bonomi, Roberto Latini, Marco Gorini, Felicita Andreotti, Eleuterio Ferrannini, Giuseppe Mercuro, Antonio L Bartorelli, Fabrizio Montecucco, Aldo P Maggioni","doi":"10.1007/s10554-026-03716-7","DOIUrl":"10.1007/s10554-026-03716-7","url":null,"abstract":"","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1675-1684"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Carvalho et al.: CT-derived extracellular volume and the prediction target in severe aortic stenosis.","authors":"Shinya Yamaguchi, Tadao Aikawa, Toshiki Kuno","doi":"10.1007/s10554-026-03755-0","DOIUrl":"10.1007/s10554-026-03755-0","url":null,"abstract":"","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1817-1818"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Murray law-based quantitative flow ratio for functional assessment of coronary lesions: a systematic review and meta-analysis.","authors":"Ioannis Skalidis, Wesley Bennar, Dorian Garin, Thais Pittet, Peter Wenaweser, Julius Jelisejevas, Giacomo Maria Cioffi, Pascal Meier, Lisa Simioni, Mesmine Mawa Kamdem, Giulia S Beretta, Mariama Akodad, Thomas Hovasse, Philippe Garot, Serban Puricel, Mario Togni, Stephane Cook","doi":"10.1007/s10554-026-03740-7","DOIUrl":"10.1007/s10554-026-03740-7","url":null,"abstract":"<p><p>Angiography-derived coronary physiology has emerged as an attractive alternative to pressure-wire-based fractional flow reserve (FFR) for functional lesion assessment. Murray law-based quantitative flow ratio (µQFR) represents a simplified, single-view approach, but its diagnostic performance across diverse clinical settings remains incompletely defined. To evaluate the diagnostic accuracy of µQFR for identifying functionally significant coronary lesions using invasive FFR as the reference standard. We performed a systematic review and diagnostic accuracy meta-analysis in accordance with PRISMA-DTA recommendations. Studies assessing µQFR against invasive FFR (≤ 0.80) with extractable lesion-level data were included. Sensitivity and specificity were pooled using a bivariate random-effects model. Secondary analyses explored performance in patients undergoing transcatheter aortic valve implantation (TAVI) and in calcified coronary lesions. Seven studies comprising 1,826 coronary lesions were included. µQFR demonstrated a pooled sensitivity of 0.807 (95% CI 0.690-0.888) and specificity of 0.944 (95% CI 0.893-0.971), with a positive likelihood ratio of 14.41, negative likelihood ratio of 0.20, and diagnostic odds ratio of 70.6. Specificity remained consistently high, whereas sensitivity showed substantial variability. In exploratory subgroup analyses, sensitivity was 0.77 (95% CI 0.64-0.87) in TAVI patients (2 studies; 236 lesions) and 0.72 (95% CI 0.66-0.78) in calcified lesions (2 studies; 691 lesions); these findings are hypothesis-generating only. µQFR demonstrates promising diagnostic accuracy with consistently high specificity. However, its moderate sensitivity, negative likelihood ratio of 0.20, and reduced performance in calcified lesions limit its ability to safely exclude functionally significant disease. Prospective validation is required before µQFR can be recommended as a standalone decision-making tool.</p>","PeriodicalId":94227,"journal":{"name":"The international journal of cardiovascular imaging","volume":" ","pages":"1769-1777"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148255257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}