The American journal of Chinese medicine最新文献_第2页

Targeting EGFR-Mcl-1 Axis by Piperlongumine as a Novel Strategy for Non-Small Cell Lung Cancer Therapy. 哌隆明靶向EGFR-Mcl-1轴治疗非小细胞肺癌的新策略

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-03-27 DOI: 10.1142/S0192415X25500235

Wen Liu, Zhibin Jiang, Ruirui Wang, Xiongjian Zhang, Xiaoqing Jiang, Can Chen, Pengfei Guo, Ming Yi, Wei Li

{"title":"Targeting EGFR-Mcl-1 Axis by Piperlongumine as a Novel Strategy for Non-Small Cell Lung Cancer Therapy.","authors":"Wen Liu, Zhibin Jiang, Ruirui Wang, Xiongjian Zhang, Xiaoqing Jiang, Can Chen, Pengfei Guo, Ming Yi, Wei Li","doi":"10.1142/S0192415X25500235","DOIUrl":"10.1142/S0192415X25500235","url":null,"abstract":"Non-small cell lung cancer (NSCLC) is a malignancy that faces serious resistance challenges in treatment. In this study, we identified Piperlongumine as a promising therapeutic candidate to overcome Osimertinib resistance in NSCLC. We systematically investigated the inhibitory effect of Piperlongumine on NSCLC cells and confirmed that it could effectively inhibit the in vitro kinase activity of wild-type (WT), exon 19 deletion, and L858R/T790M-mutated EGFR. We also found that Piperlongumine-induced intrinsic apoptosis by interfering with the EGFR signaling pathway, which was characterized by the down-regulation of the anti-apoptotic protein Mcl-1. Further mechanistic studies revealed that Piperlongumine-induced degradation of Mcl-1 was dependent on the Akt-GSK3β signaling pathway. Additionally, Piperlongumine-promoted interaction between Mcl-1 and β-TRCP, thereby enhancing β-TRCP-mediated ubiquitination and the degradation of Mcl-1. Furthermore, Piperlongumine significantly inhibited tumor growth in both Osimertinib-sensitive and resistant NSCLC xenograft models. These findings highlight the potential of Piperlongumine as an effective agent in overcoming EGFR-targeted therapy resistance and suggest new avenues for its clinical application in NSCLC treatment.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"597-619"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gambogic Acid Induces Ferroptosis via miR-1291/FOXA2 Axis in Gastric Cancer. 藤黄酸通过miR-1291/FOXA2轴诱导胃癌铁下垂。

The American journal of Chinese medicine Pub Date : 2025-01-01 DOI: 10.1142/S0192415X25500363

Chun-Mei Qian, Liu Yang, Yi-Ying Wang, Zi-Liang Wang, Zi-Hang Xu, Mi-Die Xu, Xing Zhang, Xiao-Yu Wang

{"title":"Gambogic Acid Induces Ferroptosis via miR-1291/FOXA2 Axis in Gastric Cancer.","authors":"Chun-Mei Qian, Liu Yang, Yi-Ying Wang, Zi-Liang Wang, Zi-Hang Xu, Mi-Die Xu, Xing Zhang, Xiao-Yu Wang","doi":"10.1142/S0192415X25500363","DOIUrl":"https://doi.org/10.1142/S0192415X25500363","url":null,"abstract":"Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, posing a significant threat to human health. Recently, gambogic acid (GA) has garnered attention for its anticancer properties in GC. However, it remains unclear whether GA can regulate other forms of cell death beyond apoptosis. In this study, we found that GA inhibited proliferation and induced ferroptosis in GC cells. Western blot analysis was employed to assess ferroptosis and endoplasmic reticulum (ER) stress-related proteins, as well as forkhead box A2 (FOXA2) expression. Additionally, malondialdehyde (MDA) and glutathione (GSH) levels were measured following GA treatment, and quantitative real-time polymerase chain reaction (RT-qPCR) was used to evaluate miR-1291 expression. Our findings revealed that GA treatment elevated reactive oxygen species (ROS) levels and promoted intracellular Fe[Formula: see text], MDA, and GSH accumulation. Furthermore, GA upregulated SLC7A11 and ferritin expression while suppressing glutathione peroxidase 4 (GPX4) in AGS and HGC27 cells, suggesting its role in ferroptosis induction. Notably, GA increased miR-1291 levels and downregulated FOXA2 expression. Subsequent analyses showed FOXA2 as a direct target of miR-1291. Functional experiments involving miR-1291 and FOXA2 knockdown or overexpression further suggested that the miR-1291/FOXA2 axis mediates ferroptosis. Finally, tumor xenograft models showed that GA effectively inhibited tumor growth by inducing ferroptosis. In conclusion, our study provides compelling evidence that GA induces ferroptosis in GC through the miR-1291/FOXA2 axis, highlighting its potential as a novel therapeutic strategy and preventive target for gastric cancer treatment.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 3","pages":"951-971"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Panax notoginseng Saponins Alleviate Inflammatory Bowel Disease via Alteration of Gut Microbiota-Bile Acid Metabolism. 三七皂苷通过改变肠道微生物-胆汁酸代谢减轻炎症性肠病。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-03-29 DOI: 10.1142/S0192415X25500223

Lin Wang, Li Shao, Yong-Chao Gao, Jing Liu, Xu-Dong Li, Jie Zhou, Shuang-Feng Li, Yue-Lin Song, Bo Liu, Wei Zhang, Wei-Hua Huang

{"title":"Panax notoginseng Saponins Alleviate Inflammatory Bowel Disease via Alteration of Gut Microbiota-Bile Acid Metabolism.","authors":"Lin Wang, Li Shao, Yong-Chao Gao, Jing Liu, Xu-Dong Li, Jie Zhou, Shuang-Feng Li, Yue-Lin Song, Bo Liu, Wei Zhang, Wei-Hua Huang","doi":"10.1142/S0192415X25500223","DOIUrl":"10.1142/S0192415X25500223","url":null,"abstract":"Bile acid metabolism mediated by gut microbiota is significantly related to immunity regulation that plays an important role in the development and treatment of inflammatory bowel disease (IBD). Our previous study has demonstrated that Panax notoginseng saponins (PNS) alleviate colitis due to the regulation of T helper 17/Regulatory T cells (Th17/Treg) balance via gut microbiota. However, the effects and mechanism of PNS on colitis pertinent to bile acid metabolism mediated by gut microbiota remain elusive. This study aims to investigate the anti-colitis mechanism of PNS by regulating the Th17/Treg balance pertinent to gut microbiota-bile acid metabolism. Results showed that PNS significantly decreased the relative abundance of Allobaculum, Dubosiella, Muribaculum, and Alistipes, and up-regulated the relative contents of conjugated bile acids, such as TCA and TCDCA. Fecal microbiota transplantation (FMT) showed that the gut microbiota remodeled by PNS had a regulatory effect on bile acid metabolism, and up-regulated the relative contents of TCA and TCDCA, which alleviated IBD and promoted Treg cell expression in vivo and in vitro. Taken together, PNS could reshape the profiling of gut microbiota to generate more TCA and TCDCA, which improve the balance of Th17/Treg to exert anti-IBD effects.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"567-596"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geniposide Suppresses Tumor Progression Through DUOX1-Mediated Ferroptosis in Hepatocellular Carcinoma. 京尼平苷通过duox1介导的肝癌铁下垂抑制肿瘤进展。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-07 DOI: 10.1142/S0192415X25500600

Mei Luo, Yuelian Wang, Xiaodong Liu, Lin Liu, Li Zhu, Guo Chen, Qing Ye, Chengshi He, Xujue Xiao, Jike Li

{"title":"Geniposide Suppresses Tumor Progression Through DUOX1-Mediated Ferroptosis in Hepatocellular Carcinoma.","authors":"Mei Luo, Yuelian Wang, Xiaodong Liu, Lin Liu, Li Zhu, Guo Chen, Qing Ye, Chengshi He, Xujue Xiao, Jike Li","doi":"10.1142/S0192415X25500600","DOIUrl":"10.1142/S0192415X25500600","url":null,"abstract":"Among the spectrum of digestive system cancers, hepatocellular carcinoma (HCC) poses a particularly formidable challenge due to its poor prognosis. Geniposide, an iridoid glucoside extracted from the fruit of Gardenia jasminoides Ellis, exhibits a diverse array of biological activities. The goal of this study is to delineate the specific roles and underlying mechanisms of geniposide on the progression of HCC. Cell viability, apoptosis and migration of Huh7 and HepG2 cells were, respectively, assessed via CCK-8, flow cytometry and trans-well assays. The level of reactive oxygen species (ROS) was assessed with a dihydroethidium (DHE) probe. The measurement of mitochondrial membrane potential (MMP) was conducted using JC-1 staining. Ferroptosis-related markers were evaluated by Western Blot assay. Transcriptome sequencing was performed in HCC cells both treated and untreated with geniposide. In vivo experiments were applied with the subcutaneous xenograft tumor model. In vitro experiments revealed that geniposide exerted a concentration-dependent suppression on cell viability and migration, concurrently eliciting apoptosis in HCC cells. Ferroptosis was identified as the main form of geniposide-induced cell death in HCC. Geniposide promoted the iron ions levels, ROS accumulation, and the expression of ferroptosis markers, which were partially reversed by the addition of deferoxamine (DFO, ferroptosis inhibitor). Intersection analysis was applied between upregulated genes of HCC cells and ferroptosis-related genes. DUOX1 was proven to be involved in geniposide-mediated roles in HCC. In vivo experiments further clarified the suppressive effects of geniposide on tumors. Geniposide treatment increased intracellular iron ions and induced ferroptosis in HCC. Geniposide attenuated tumor progression and oxidative stress via DUOX1-mediated ferroptosis.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"1573-1589"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Traditional Chinese Medicine in Targeting NF-[Formula: see text]B Ubiquitination Against Ischemic Stroke. 中药靶向NF- B泛素化对缺血性脑卒中的作用。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-16 DOI: 10.1142/S0192415X25500521

Jieyu Ding, Yi Qiu, Fang Yan, Xi Peng

{"title":"The Role of Traditional Chinese Medicine in Targeting NF-[Formula: see text]B Ubiquitination Against Ischemic Stroke.","authors":"Jieyu Ding, Yi Qiu, Fang Yan, Xi Peng","doi":"10.1142/S0192415X25500521","DOIUrl":"https://doi.org/10.1142/S0192415X25500521","url":null,"abstract":"Ischemic Stroke (IS) is a severe neurological disease with high mortality rates worldwide, involving a complex cascade reaction in which the ubiquitination process of nuclear factor kappa B (NF-[Formula: see text]B) pathway has been proposed as a therapeutic target for IS on account of the fact that NF-[Formula: see text]B can be suppressed by the Ubiquitin-Proteasome System (UPS). This review systematically discusses the epidemiology of IS, the NF-[Formula: see text]B signaling pathway, and the anti-inflammatory and anti-apoptotic effects that TCM monomers and formulations exert by regulating the ubiquitination process of the NF-[Formula: see text]B signaling pathway. We initially offer an overview of the incidence and treatment of IS, following which the canonical pathway and non-canonical pathway of NF-[Formula: see text]B are introduced. Next, the ubiquitination mechanisms of NF-[Formula: see text]B when using traditional Chinese medicine (TCM) to treat IS were highlighted. We also discussed the involvement of MyD88, an upstream protein, in the herb-based treatment of IS. Finally, we proposed future research directions for screening advantageous herbal components. Given previous research, we anticipate that TCM drugs will present promising candidates for IS treatment in clinical medicine.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 5","pages":"1355-1378"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of Gut Microbiota by Traditional Chinese Medicine: A Novel Therapeutic Approach for Chronic Inflammatory Airway Diseases. 中药调节肠道微生物群：治疗慢性炎症性气道疾病的新途径。

IF 5.5

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-09-15 DOI: 10.1142/S0192415X25500764

Linxin Zheng, Yi Fu, Jiawang Wu, Ting Liu, Xinting Zhang, Chongchang Qu, Bingqian Zeng, Ningyuan Zhang, Shuanglan Xu, Jiao Yang, Xiqian Xing

{"title":"Modulation of Gut Microbiota by Traditional Chinese Medicine: A Novel Therapeutic Approach for Chronic Inflammatory Airway Diseases.","authors":"Linxin Zheng, Yi Fu, Jiawang Wu, Ting Liu, Xinting Zhang, Chongchang Qu, Bingqian Zeng, Ningyuan Zhang, Shuanglan Xu, Jiao Yang, Xiqian Xing","doi":"10.1142/S0192415X25500764","DOIUrl":"10.1142/S0192415X25500764","url":null,"abstract":"The gut microbiota serves as a crucial modulator of host immunity and plays a pivotal role in regulating airway inflammation, maintaining immune balance, and affecting the course of associated diseases through gut-lung axis interactions. Recent studies increasingly demonstrate that patients with chronic inflammatory airway diseases (CIAD) commonly exhibit gut dysbiosis. This imbalance in gut microbiota can promote pulmonary inflammation and airway remodeling by affecting the synthesis of short-chain fatty acids (SCFAs), impairing intestinal mucosal barrier integrity, and disrupting immune regulation. With increasing attention to the gut-lung axis, microbiota-targeted therapeutic strategies have attracted growing attention. Traditional Chinese medicine (TCM), characterized by its multi-component composition, multi-target approach, and holistic regulatory properties, holds unique advantages in restoring gut microbial balance for the treatment of CIAD. This paper systematically reviews the therapeutic potential of TCMs and their bioactive constituents in managing CIAD through gut microbiota modulation. By regulating gut microbial composition and stimulating the generation of SCFAs, TCMs exert anti-inflammatory, immunomodulatory, and gut barrier-protective effects. TCMs thus offer novel perspectives and promising therapeutic strategies for CIAD treatment.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"2043-2070"},"PeriodicalIF":5.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cordycepin: A Promising Anticancer Compound from Traditional Chinese Medicine. 冬虫夏草：一种很有前途的中药抗癌化合物。

IF 5.5

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-09-05 DOI: 10.1142/S0192415X2550079X

Yibang Li, Youyan Han, Nanmiao Wang, Yao Bi, Wanshan Yang, Yang Yang, Xiangshan Ren

{"title":"Cordycepin: A Promising Anticancer Compound from Traditional Chinese Medicine.","authors":"Yibang Li, Youyan Han, Nanmiao Wang, Yao Bi, Wanshan Yang, Yang Yang, Xiangshan Ren","doi":"10.1142/S0192415X2550079X","DOIUrl":"10.1142/S0192415X2550079X","url":null,"abstract":"As cancer continues to pose a significant threat to human health, the search for effective therapeutic agents has become a critical focus in medical research. Cordyceps is a fungus used in traditional Chinese medicine (TCM) valued for its potential health benefits, which include boosting energy, supporting the immune system, and acting as an anti-oxidant. Cordycepin, also known as 3[Formula: see text]-deoxyadenosine, is a bioactive nucleoside derived from Cordyceps. This compound recently has garnered widespread attention for its potential anticancer properties. Through systematic integration of our prior experimental evidence with literature retrieval from PubMed, we confirmed its efficacy in inducing apoptosis, suppressing proliferation, and blocking metastasis across a broad range of cancer types. These effects are primarily attributed to its modulation of key signaling pathways, such as MAPK, AMPK, mTOR, and Wnt/[Formula: see text]-catenin, all of which play crucial roles in various malignant conditions. In addition, cordycepin's ability to modulate immune responses through the regulation of adenosine receptor (AR), and in particular the A3 adenosine receptor (A3AR), has gained attention as an innovative strategy for enhancing the effectiveness of immunotherapy. Recent advancements in improving cordycepin's biostability, bioavailability, and transport efficiency within the body system have further supported the clinical application of this compound in medical oncology. This review highlights key research findings and explores promising future directions with the aim of contributing to ongoing studies in cancer management.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"2137-2165"},"PeriodicalIF":5.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlorogenic Acid Ameliorates Acetaminophen-Induced Liver Injury Through AMPK/mTOR/ULK1-Mediated Autophagy Activation. 绿原酸通过AMPK/mTOR/ ulk1介导的自噬激活改善对乙酰氨基酚诱导的肝损伤

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-03-27 DOI: 10.1142/S0192415X2550020X

Yu-Xin Yao, Chen-Hao Yao, Chao-Yang Zhang, Xian-Zhi Peng, Shu Dai, Yu-Jie Yu, Yan-Zhi Li, Sheng-Lin Zhang, Yun-Xia Li

{"title":"Chlorogenic Acid Ameliorates Acetaminophen-Induced Liver Injury Through AMPK/mTOR/ULK1-Mediated Autophagy Activation.","authors":"Yu-Xin Yao, Chen-Hao Yao, Chao-Yang Zhang, Xian-Zhi Peng, Shu Dai, Yu-Jie Yu, Yan-Zhi Li, Sheng-Lin Zhang, Yun-Xia Li","doi":"10.1142/S0192415X2550020X","DOIUrl":"10.1142/S0192415X2550020X","url":null,"abstract":"Acetaminophen (APAP)-induced liver injury (AILI) is a universal liver disease and the predominant cause of acute liver failure in clinical practice. Autophagy is a highly conserved intracellular degradation pathway, with accumulating evidence indicating its involvement in APAP hepatotoxicity. Notably, the serine/threonine AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/unc-51-like kinase 1 (ULK1) pathway serves as the most classical autophagy pathway and engages in autophagy activation. Thus, pharmacological activation of the AMPK/mTOR/ULK1 pathway has emerged as a critical strategy for addressing AILI. Chlorogenic acid (CGA), a main bioactive constituent isolated from Lonicera japonica Thunb., is an autophagy regulator with potential for AILI therapy. However, whether and how CGA modulates autophagy to antagonize AILI has not yet been elucidated. In the present study, we aim to explore the impact of CGA on AILI, as well as the underlying mechanisms in vitro and in vivo. The results demonstrated that CGA could protect the mice and LO2 cells from oxidative stress and liver injury induced by APAP. Regarding mechanisms, CGA activated the AMPK/mTOR/ULK1 pathway, thereby promoting autophagy. This was evidenced by the degradation of p62/SQSTM1 (hereafter referred to as p62), as well as the up-regulation of LC3B, ATG5, and Beclin1. It is worth noting that the aforementioned, CGA-provided beneficial effects were abrogated by pharmacological inhibition of AMPK with Compound C (CC, an AMPK inhibitor). These [Formula: see text] that CGA alleviates oxidative stress and liver injury induced by APAP, which is contingent upon the regulatory effect of CGA on the AMPK/mTOR/ULK1 axis.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"523-542"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Chinese Medicine in the Treatment of Chronic Hepatitis B. 中医在慢性乙型肝炎治疗中的作用。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-18 DOI: 10.1142/S0192415X25500508

Shihao Zheng, Qiuyue Wang, Wenying Qi, Jinchi Xie, Xiaobin Zao, Xiaoke Li, Peng Zhang, Yongan Ye

{"title":"The Role of Chinese Medicine in the Treatment of Chronic Hepatitis B.","authors":"Shihao Zheng, Qiuyue Wang, Wenying Qi, Jinchi Xie, Xiaobin Zao, Xiaoke Li, Peng Zhang, Yongan Ye","doi":"10.1142/S0192415X25500508","DOIUrl":"https://doi.org/10.1142/S0192415X25500508","url":null,"abstract":"The pathogenesis of chronic hepatitis B (CHB) involves complex mechanisms, and hepatitis B virus (HBV)-induced immune responses play a central role in hepatocyte injury and inflammatory necrosis. CHB infection not only drives liver pathology but also demonstrates significant extrahepatic associations which include depression, cognitive dysfunction, diabetes mellitus, insomnia, non-alcoholic fatty liver disease, and thrombocytopenia. Conventional Western medicine primarily employs antiviral therapy but faces limitations which include low hepatitis B surface antigen clearance rates and frequent adverse drug reactions. In contrast, traditional Chinese medicine demonstrates therapeutic advantages in CHB management which are exemplified by Artemisia capillaris, Xiaochaihu Decoction and Fuzheng Huayu Tablet. Through its modulation of immune pathways and intervention in key HBV lifecycle targets, traditional Chinese medicine achieves a tripartite therapeutic synergy that combines immune reconstitution, viral suppression, and hepatic repair. Chinese medical interventions exhibit characteristic multi-ingredient, multi-target mechanisms that possess immunomodulatory effects in CHB management. Future research should employ modern technologies to elucidate these mechanisms further and thus facilitate the development of optimized treatment protocols. Standardized therapeutic approaches derived from such evidence will hold significant clinical value.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 5","pages":"1285-1307"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traditional Chinese Medicine for Cerebral Ischemia-Reperfusion Injury Prevention: Molecular Mechanisms and Future Perspectives. 中药预防脑缺血再灌注损伤的分子机制及未来展望

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-06-20 DOI: 10.1142/S0192415X25500387

Liuding Wang, Yifan Chen, Yue Liu, Jingjing Wei, Lina Miao, Ze Chang, Min Jia, Longtao Liu, Xiao Liang, Yunling Zhang

{"title":"Traditional Chinese Medicine for Cerebral Ischemia-Reperfusion Injury Prevention: Molecular Mechanisms and Future Perspectives.","authors":"Liuding Wang, Yifan Chen, Yue Liu, Jingjing Wei, Lina Miao, Ze Chang, Min Jia, Longtao Liu, Xiao Liang, Yunling Zhang","doi":"10.1142/S0192415X25500387","DOIUrl":"https://doi.org/10.1142/S0192415X25500387","url":null,"abstract":"As reperfusion therapy becomes more common, cerebral ischemia-reperfusion (I/R) injury has emerged as a notable factor affecting the outcome of ischemic stroke. The intricate pathological mechanisms involved include oxidative stress, neuroinflammation, and various forms of cell death, characterized by interactions between multiple signaling pathways. Natural products, such as traditional Chinese medicines (TCMs), offer multi-targeted intervention effects through their diverse natural active compounds and integrate pharmacological and nutritional functions into 1 entity (Food and Medicine Homology), supporting their long-term use to prevent cerebral I/R injury. It was found that TCMs, such as Gastrodia elata Blume and Lycium barbarum L., potentially exert synergistic effects on redox imbalance, inflammation, apoptosis, and autophagy by concurrently modulating various pathways, including Nrf2/ARE, NF-κB, PI3K/Akt/mTOR, Bcl-2/Bax, and PARP-1. The prophylactic administration of TCMs may represent a novel approach for mitigating cerebral I/R injury. To advance the application of TCMs from the laboratory to clinical practice, it is essential to conduct clinical research to confirm their effectiveness and safety in preventing cerebral I/R injury.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 4","pages":"999-1026"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0