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[Environmental exposome and interstitial lung diseases]. [环境暴露与间质性肺病]。
Revue medicale de Liege Pub Date : 2026-05-01
Julien Guiot, Fanny Gester, Anne-Noëlle Frix, Anna Denis, Jean-Louis Corhay, Renaud Louis
{"title":"[Environmental exposome and interstitial lung diseases].","authors":"Julien Guiot, Fanny Gester, Anne-Noëlle Frix, Anna Denis, Jean-Louis Corhay, Renaud Louis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Interstitial lung diseases (ILDs) encompass a heterogeneous group of pulmonary disorders whose prevalence is increasing, partly driven by the environmental exposome. Fine particulate matter (PM2.5), air pollutants, bioaerosols, and occupational exposures (such as silica, asbestos, and organic dust) play a major role in the initiation, progression, and exacerbations of ILDs. These agents induce oxidative stress, inflammation, and fibrotic activation. Conditions such as asbestosis, anthracosilicosis, idiopathic pulmonary fibrosis, sarcoidosis, and hypersensitivity pneumonitis illustrate the interaction between individual susceptibility and environmental factors. Infections and the lung microbiome also contribute to pathophysiology and may act as disease triggers in at-risk populations. The exposome concept provides an integrative framework to understand these complex interactions. Despite recent advances, uncertainties remain, particularly regarding the long-term effects of inhaled ultrafine particles.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 5-6","pages":"327-333"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Eco-health: shared perspectives on primary care practice]. [生态卫生：关于初级保健实践的共同观点]。
Revue medicale de Liege Pub Date : 2026-05-01
Laeticia Buret, Stéphanie Vanhaeren, Nolwenn Lechien, Charlotte Bréda
{"title":"[Eco-health: shared perspectives on primary care practice].","authors":"Laeticia Buret, Stéphanie Vanhaeren, Nolwenn Lechien, Charlotte Bréda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Eco-health is an integrative approach aimed at improving human health while preserving ecosystems, in the context of environmental and climate change with major health consequences. Part of the «One Health» framework, it's based on a systemic view of the interactions between human, animal, environmental, and social health, and promotes actions that have co-benefits for both health and the environment. Primary care plays a strategic role in the implementation of eco-health. It's an essential lever for the transition to a sustainable health system due to its long-term proximity to the population. The eco-health approach in primary care is based mainly on three areas: prevention and health promotion, the relevance of care, and the eco-design of clinical and organizational practices. These actions, based on the principle of co-benefits, simultaneously reduce the environmental footprint of care and improve its quality. Eco-health thus appears to be an operational and ethical way to strengthen the sustainability of the healthcare system in the face of contemporary public health and environmental challenges.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 5-6","pages":"395-400"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Climate change and skin]. [气候变化与皮肤]。
Revue medicale de Liege Pub Date : 2026-05-01
Thibaut Delahaye, Gilles Absil, Thomas Damsin, Florence Libon, Arjen Nikkels
{"title":"[Climate change and skin].","authors":"Thibaut Delahaye, Gilles Absil, Thomas Damsin, Florence Libon, Arjen Nikkels","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Climate change, pollution, extreme weather events, and ecosystem disruption cause a wide range of consequences for the skin and dermatologic diseases, affecting epidemiology, disease behaviour, and therapeutic response. Some inflammatory dermatoses are worsened by ultraviolet radiation, such as cutaneous lupus and Darier disease. In addition, UV radiation is responsible for most skin cancers. Humidity favours skin infections, particularly fungal infections. Pollution exacerbates atopic dermatitis. Rising temperatures increase sweating, an aggravating factor for fungal infections, Darier disease, and hidradenitis suppurativa. Even some drug-related cutaneous adverse effects are modulated by weather conditions. Several aspects of the dermatological activity contribute to pollution and climate changes, by, for instance, packaging, metabolites and conservatives, UV filters and waste generated by dermatological surgery.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 5-6","pages":"373-379"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Microplastics and thrombo-inflammation in acute ischemic stroke : adding fuel to the fire]. [微塑料和急性缺血性中风的血栓炎症：火上浇油]。
Revue medicale de Liege Pub Date : 2026-05-01
Colas Gardier, Zoé Grondal, Julien Ly, Géraldine Dasnoy-Sumell, Lindsay Vogel, François Delvoye
{"title":"[Microplastics and thrombo-inflammation in acute ischemic stroke : adding fuel to the fire].","authors":"Colas Gardier, Zoé Grondal, Julien Ly, Géraldine Dasnoy-Sumell, Lindsay Vogel, François Delvoye","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The widespread use of petroleum-derived plastics has led to massive environmental exposure to micro- and nanoplastics (MNPs), generated by the degradation of plastic polymers. Ubiquitous, these contaminants enter the body mainly through the gastrointestinal tract, but also via inhalation or iatrogenic sources, reach the systemic circulation, and accumulate in the brain. Recent data show increasing cerebral concentrations of MNPs, paralleling their environmental rise, as well as their presence in human thrombi and atherosclerotic plaques. Acute ischemic stroke, a leading cause of mortality and disability worldwide, is driven by thrombo-inflammatory mechanisms involving coordinated activation of the endothelium, platelets, and leukocytes. Converging preclinical and clinical evidence suggests that MNPs amplify these processes. They promote intestinal permeability and induce systemic and local inflammation through activation of all cellular components involved in thrombo-inflammation. In addition, MNPs may contribute to the development and destabilization of atherosclerotic plaques and, indirectly, to atrial fibrillation via activation of the thrombo-inflammatory processes. Despite methodological limitations, these findings indicate that MNPs represent an emerging environmental factor that may worsen both the risk and prognosis of acute ischemic stroke. Preventive, detection, and exposure-control strategies are therefore urgently needed to address this major public health challenge.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 5-6","pages":"342-347"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[How can we address carcinogenic environmental and behavioural factors ?] [我们如何处理致癌的环境和行为因素？］
Revue medicale de Liege Pub Date : 2026-05-01
Sarah Saglime, Pierre Frères, Brieuc Sautois, Sylvie Streel, Charles Pottier
{"title":"[How can we address carcinogenic environmental and behavioural factors ?]","authors":"Sarah Saglime, Pierre Frères, Brieuc Sautois, Sylvie Streel, Charles Pottier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nearly half of all tumours are attributable to potentially modifiable behavioural, environmental, and occupational risk factors. Strengthening preventive strategies is therefore essential to reduce the morbidity and mortality associated with these cancers. This article summarizes the risk factors on which we can act preventively, both individually and collectively. It then addresses the topics of screening and interception, other cornerstones of cancer care.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 5-6","pages":"310-314"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Food and Health : rethinking prevention in medicine in the era of transforming food systems]. [食品与健康：在食品体系转型时代重新思考医学预防]。
Revue medicale de Liege Pub Date : 2026-05-01
Axelle Hoge, Céline Crützen, Elsa Mescoli
{"title":"[Food and Health : rethinking prevention in medicine in the era of transforming food systems].","authors":"Axelle Hoge, Céline Crützen, Elsa Mescoli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Diet is a major determinant of health and an essential lever for preventing non communicable diseases. However, it cannot be understood independently from the food systems that shape food supply, prices, accessibility, and attractiveness, and that simultaneously contribute to environmental pressures. Recent research highlights a growing convergence between public health objectives and ecological sustainability, prompting an expanded analysis of the role of food environments in structuring individual choices. In this context, nutritional guidelines are evolving and now promote a predominantly plant based, minimally processed diet that is compatible with sustainable production methods. Nevertheless, the social sciences remind us that eating practices remain shaped by cultural, economic, and social determinants, and that inequalities in access to healthy and sustainable food persist. For medical practice, these perspectives call for embedding nutritional support within the material and cultural realities of patients and for recognizing food environments as full fledged determinants of health. Understanding these interdependencies strengthens the coherence, effectiveness, and equity of nutritional prevention strategies.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 5-6","pages":"294-298"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[From Silent Spring to neuronal silence : pesticides and neurodegenerative diseases]. [从寂静的春天到神经元的沉默：杀虫剂和神经退行性疾病]。
Revue medicale de Liege Pub Date : 2026-05-01
Zayd Jedidi, Pauline Smeets, Justine Laverdeur, Haroun Jedidi, Frédérique Depierreux
{"title":"[From Silent Spring to neuronal silence : pesticides and neurodegenerative diseases].","authors":"Zayd Jedidi, Pauline Smeets, Justine Laverdeur, Haroun Jedidi, Frédérique Depierreux","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Over sixty years ago, Silent Spring, the groundbreaking book by biologist Rachel Carson, raised global awareness of the dangers of uncontrolled pesticide use and contributed to the ban on the use of dichlorodiphenyltrichloroethane (DDT) in the USA. Many years later, it is clear that most of the issues raised in this book remain highly relevant. Today, almost our entire environment is contaminated, sometimes permanently, by pesticides. Yet the chronic toxicity of these substances is still poorly understood. In recent years, a growing body of data seems to link environmental exposure to pesticides with the risk of developing chronic neurological disorders, particularly neurodegenerative diseases. This article will attempt to present a clear and concise review of the literature on the subject, focusing on the most studied conditions, namely Parkinson's disease and Alzheimer's disease.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 5-6","pages":"365-372"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Nature prescriptions and health promotion : sharing experience from primary care]. 【自然处方与健康促进：初级保健经验分享】。
Revue medicale de Liege Pub Date : 2026-05-01
Nolwenn Lechien, Laeticia Buret, Charlotte Bréda
{"title":"[Nature prescriptions and health promotion : sharing experience from primary care].","authors":"Nolwenn Lechien, Laeticia Buret, Charlotte Bréda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article examines the prescription of nature as a tool for promoting health in primary care, based on a pilot project conducted in a health center in the Liège region. Although not yet officially recognized by the social security in Belgium, this approach involves healthcare professionals prescribing time spent in nature in order to influence health determinants. The experiment, involving 89 patients, shows that these prescriptions mainly concern mental health and social isolation issues, with significant support from healthcare professionals and patients. It highlights the strategic role of primary care as an interface between healthcare, local areas, and community resources, while revealing the challenges associated with collaboration between the health and environmental sectors. Nature prescriptions thus appear to be an innovative approach, allowing us to question the reorientation of practices towards a more holistic conception of health while opening prospects for co-benefits for human and environmental health.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 5-6","pages":"401-407"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Environmental impact of medicines and approaches for more eco responsible use]. [药物对环境的影响和更环保的使用方法]。
Revue medicale de Liege Pub Date : 2026-05-01
Estelle Wéry, Aurore Gaspar, France Louis, Cindy Chaballe, Éric Ziemons, Geneviève Philippe
{"title":"[Environmental impact of medicines and approaches for more eco responsible use].","authors":"Estelle Wéry, Aurore Gaspar, France Louis, Cindy Chaballe, Éric Ziemons, Geneviève Philippe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The environmental impact of pharmaceuticals mainly stems from their carbon footprint across the life cycle and their ecotoxicity once released into ecosystems. Technological advances in the pharmaceutical industry are gradually lowering greenhouse gas emissions. Drug residues found in water, soil, and air arise mainly from industrial discharges, improper disposal of expired or unused medicines and the excretion of active compounds or metabolites, as wastewater treatment remains incomplete. The actual impact of pharmaceutical residues in the environment is still partly unknown. To mitigate ecotoxicity, the development of greener active pharmaceutical ingredients and improved wastewater treatment are being explored. Prescribers and users can also adopt more environmentally responsible practices. This article aims to raise awareness of these environmental concerns and outline pathways toward more sustainable medication use.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 5-6","pages":"380-387"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Impact of climate warming and global pollution on the obesity and diabetes epidemic]. [气候变暖和全球污染对肥胖和糖尿病流行的影响]。
Revue medicale de Liege Pub Date : 2026-05-01
André Scheen
{"title":"[Impact of climate warming and global pollution on the obesity and diabetes epidemic].","authors":"André Scheen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article discusses the potential roles of global warming and various environmental pollutants in the increasing prevalence of obesity and type 2 diabetes. Global warming may exert detrimental effects through both biological pathways (reduced thermogenesis, adipocyte dysfunction) and behavioural mechanisms (decreased physical activity, sleep disturbances). Pollutants - whether present in ambient air (fine particulate matter), water, or food (broadly defined pesticides, industrial and domestic chemicals) - can alter metabolic processes, particularly within adipocytes, a key site where they tend to accumulate. They can induce \"adiposopathy,\" low grade inflammation, oxidative stress, and insulin resistance. Pancreatic β cell dysfunction has also been reported. Thus, climate change and its environmental consequences should be taken into account when interpreting the global epidemic of obesity and type 2 diabetes that societies worldwide are currently facing.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 5-6","pages":"348-352"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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