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[Late-onset neutropenia following ocrelizumab treatment in relapsing multiple sclerosis]. [复发性多发性硬化症ocrelizumab治疗后的晚发性中性粒细胞减少]。
Revue medicale de Liege Pub Date : 2025-03-01
Sarvnaz Shalchian Tehran, Aurélie Jaspers
{"title":"[Late-onset neutropenia following ocrelizumab treatment in relapsing multiple sclerosis].","authors":"Sarvnaz Shalchian Tehran, Aurélie Jaspers","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We are reporting two cases of late-onset severe neutropenia following treatment with ocrelizumab in patients with relapsing multiple sclerosis. These cases highlight a rare but clinically significant side effect of a widely used multiple sclerosis treatment. This article aims to raise awareness among clinicians regarding this potential hematological complication, emphasizing the importance of vigilant monitoring and early intervention. Through these cases, we discuss the underlying pathophysiological mechanisms. Additionally, we wish to emphasize the importance of a multidisciplinary approach to manage this complication, involving close collaboration between neurologists, hematologists, and other specialists.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 3","pages":"151-153"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Open necrosectomies after severe acute pancreatitis : is there still a place for it in 2024 ?] [重症急性胰腺炎后开放性坏死切除术：2024年仍有一席之地吗？]
Revue medicale de Liege Pub Date : 2025-03-01
Casimir Fleur Rahantasoa Finaritra, Nirina Nomenjanahary Rasamoelison, Warren Razanajatovo Niarison, Fanjandrainy Rasoaherinome Njanahary, Luc Hervé Samison
{"title":"[Open necrosectomies after severe acute pancreatitis : is there still a place for it in 2024 ?]","authors":"Casimir Fleur Rahantasoa Finaritra, Nirina Nomenjanahary Rasamoelison, Warren Razanajatovo Niarison, Fanjandrainy Rasoaherinome Njanahary, Luc Hervé Samison","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>the indication for pancreatic necrosectomy arises in a context of seriousness. Several factors can influence postoperative outcomes. Our objective is to identify the clinical and paraclinical factors which would influence the occurrence of complications after pancreatic necrosectomy.</p><p><strong>Patients and methods: </strong>it is a retrospective study of the postoperative outcomes of patients treated by pancreatic necrosectomy from January 1th, 2019 to December 31th, 2023.</p><p><strong>Results: </strong>fifty-nine cases were selected with sex ratio = 1.03 and mean age = 45 years [range 28;79]. The morbidity rate was 61 % (n = 36). The most frequent complication was postoperative hemorrhagic shock (n = 14) followed by septic shock (n = 12). Malnutrition, hyperleukocytosis, fasting > 5 days, bleeding > 500 ml, extensive necrosis (30 % - 50 %), a long stay in intensive care (> 5 days) were related to serious complications (p < 0.001). Antibiotic therapy, and the number of drains was not associated to the occurrence of severe morbidity.</p><p><strong>Conclusion: </strong>both the severity of the disease and the patient's condition were related to the prognosis. The right timing for surgery is recommended to avoid serious complications.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 3","pages":"175-181"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[How to optimize intraoperative frozen section examinations in pathology]. 【如何优化术中冰冻切片的病理检查】。
Revue medicale de Liege Pub Date : 2025-03-01
Stéphanie Rizzo, Marie-Sophie Kesteman, Gilles Leduc, Roland Greimers, Philippe Delvenne
{"title":"[How to optimize intraoperative frozen section examinations in pathology].","authors":"Stéphanie Rizzo, Marie-Sophie Kesteman, Gilles Leduc, Roland Greimers, Philippe Delvenne","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The intraoperative frozen section examination allows to offer to the surgeon relevant information which could change the patient intraoperative management. The sensitivity of this technique is limited by the size of the analysed sample and by cryogenisation's artefacts. The intraoperative consultations have to be performed for precise indications because some exams could be harmful. It is mandatory to be aware of different problems which could alter the intraoperative diagnosis: inadequate sampling, technical issues or insufficient communication between the surgeon and the pathologist. Nevertheless, the intraoperative frozen section examination remains a reliable procedure useful in many pathological contexts.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 3","pages":"196-200"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The story of «waves and rays» in medicine. Part 2 : The history of radiotherapy after the second world war]. 医学中的“波和射线”的故事。第2部分：第二次世界大战后放射治疗的历史。
Revue medicale de Liege Pub Date : 2025-03-01
Philippe Coucke
{"title":"[The story of «waves and rays» in medicine. Part 2 : The history of radiotherapy after the second world war].","authors":"Philippe Coucke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We take up the historical epic of waves and rays in medicine, starting from the years around the Second World War. In this article, we focus on the benchmarks in the development of radiotherapy, making brief forays into the field of medical imaging when technical developments in this latter field strongly influence the evolution of the former. Following the scientific and technical advances due to the «Manhattan» project, the modern era is witnessing a multitude of medical innovations. The last decades of the twentieth century correspond to the widespread arrival of digitization and computerization, a real booster in diagnostic and therapeutic techniques. Today, we are facing a new revolution, based on the confluence of science and technology and the advent of artificial intelligence. The historical narrative ends arbitrarily a little before this post-modern era, because given the almost exponential speed of evolution, it becomes impossible to make it an accessible narrative for everyone.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 3","pages":"182-190"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Postpartum dyspnoea : an inaugural and atypical manifestation of preeclampsia]. [产后呼吸困难：子痫前期的初始和非典型表现]。
Revue medicale de Liege Pub Date : 2025-02-01
Valentine Dewandre, Géraldine Lambert, Pierre-Yves Dewandre, Sébastien Grandfils
{"title":"[Postpartum dyspnoea : an inaugural and atypical manifestation of preeclampsia].","authors":"Valentine Dewandre, Géraldine Lambert, Pierre-Yves Dewandre, Sébastien Grandfils","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hypertensive disorders of pregnancy and recommendations for their management are currently well defined. However, postpartum manifestations are considerably less so. Postpartum preeclampsia is a poorly studied pathological entity. It is not certain whether it is a distinct entity from antenatal preeclampsia. Diagnostic criteria include the new onset of hypertension within 48 hours to 6 weeks after delivery, associated with at least one other clinical or biological criterion. Most cases of postpartum preeclampsia occur within 7 to 10 days after delivery. Risk factors are similar to those of antenatal preeclampsia. Neurological signs such as headaches are the most common clinical manifestations. Atypical symptoms such as dyspnea should prompt consideration of different diagnoses, including postpartum cardiomyopathy and pulmonary embolism. Management of postpartum preeclampsia is essential to limit its impact on maternal morbidity and mortality. It primarily relies on antihypertensive treatment, possibly including diuretics and magnesium sulfate. Here we report a case of postpartum preeclampsia revealed by worsening dyspnoea, leading the patient to the emergency department on the 9th day postpartum.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 2","pages":"85-89"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Post-intensive care syndrome prevention and management : a key role for advanced practice nurses]. 重症监护后综合征的预防与管理：高级实习护士的关键作用。
Revue medicale de Liege Pub Date : 2025-02-01
Pauline Minguet, Camille Colson, Sarah Neis-Gilson, Bernard Lambermont, Anne-Françoise Rousseau
{"title":"[Post-intensive care syndrome prevention and management : a key role for advanced practice nurses].","authors":"Pauline Minguet, Camille Colson, Sarah Neis-Gilson, Bernard Lambermont, Anne-Françoise Rousseau","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The number of patients who survive a stay in intensive care unit (ICU) is increasing. It is our ethical responsibility to consider their quality of life after discharge. A risk factor for post-intensive care syndrome (PICS) is the perceived suffering during the ICU stay. Preventing this syndrome is a public health concern because of its secondary costs for both the patient and the society. Advanced practice registered nurses, in an environment where efficiency is required, could help in PICS prevention and management. Perspectives include individualized care during and after intensive care as well as improved coordination with primary care.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 2","pages":"90-94"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[MR Imaging of ano-perineal fistulas]. [无会阴瘘管的MR成像]。
Revue medicale de Liege Pub Date : 2025-02-01
Paul Meunier, Catherine Reenaers, Catherine Van Kemseke, Sophie Vieujean, Edouard Louis, Michel Meurisse, Carla Coïmbra, Romain Gillard
{"title":"[MR Imaging of ano-perineal fistulas].","authors":"Paul Meunier, Catherine Reenaers, Catherine Van Kemseke, Sophie Vieujean, Edouard Louis, Michel Meurisse, Carla Coïmbra, Romain Gillard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The frequency of occurrence of ano-perineal fistulas, especially in the context of inflammatory bowel diseases, makes them a subject of growing interest, mainly because of the discomfort and medico-social impact they induce in patients who carry them. Their treatment depends on their extent and potential for evolution. MRI appears as the technique of first choice for their assessment and follow-up. After a brief technical review, we'll look at the anatomy and imaging assessment of ano-perineal fistulas in terms of inflammatory activity and healing, two important characteristics that could influence both the prognosis and the therapeutic strategy.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 2","pages":"130-136"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Interbody fusion for active lumbar discopathy : long term functional outcome and comparison between the anterior and posterior approach]. [活动期腰椎间盘突出症的椎体间融合术：前路和后路的长期功能结果和比较]。
Revue medicale de Liege Pub Date : 2025-02-01
Mejdeddine Al Barajraji, Salim El Hadwe, Damien Dresse, Jean-Michel Remacle, Vincent Bonhomme, Thibault Remacle
{"title":"[Interbody fusion for active lumbar discopathy : long term functional outcome and comparison between the anterior and posterior approach].","authors":"Mejdeddine Al Barajraji, Salim El Hadwe, Damien Dresse, Jean-Michel Remacle, Vincent Bonhomme, Thibault Remacle","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>There is limited evidence regarding the long-term functional outcomes of anterior lumbar interbody fusion (ALIF) or posterior lumbar interbody fusion (PLIF) in patients with refractory active lumbar discopathy (ALD).</p><p><strong>Methods: </strong>We retrospectively surveyed 194 patients who underwent lumbar fusion for ALD using the Roland-Morris Disability Questionnaire (RMDQ) and Modified MacNab's Criteria (MMCQ) and reviewed medical records for complications.</p><p><strong>Results: </strong>The cohort included 54 patients (median age: 53.5 years). Thirty underwent ALIF (L4L5: 4, L5S1: 20, L4S1: 6) and 24 had PLIF (L4L5: 8, L5S1: 12). Median follow-up was 83 (66-114) months. Excellent outcomes were more frequent in the ALIF group (34 % vs 21 %). RDQ scores were higher in the PLIF group (9 (3-17) vs 5 (0-11)). ALIF patients had fewer cases of proximal junctional kyphosis (7 % vs 25 %) but higher chronic analgesic use (33 % vs 17 %) and documented failed back surgery syndrome (13 % vs 0 %). No major complications were observed.</p><p><strong>Conclusions: </strong>Both ALIF and PLIF are safe for treating recalcitrant ALD. ALIF may offer better long-term function and less disability, albeit with potentially higher analgesic use.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 2","pages":"95-100"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Differential diagnosis of hepatic lesions associated to alterations of liver vascularization : regenerative nodules, adenomas or hepatocellular carcinoma ?] [肝血管化改变相关肝脏病变的鉴别诊断：再生结节、腺瘤还是肝细胞癌？]
Revue medicale de Liege Pub Date : 2025-02-01
Augustin Carton, Jean Delwaide
{"title":"[Differential diagnosis of hepatic lesions associated to alterations of liver vascularization : regenerative nodules, adenomas or hepatocellular carcinoma ?]","authors":"Augustin Carton, Jean Delwaide","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This work describes a case of hepatocellular adenoma with β-catenin mutated discovered during imaging follow-up of hyperplastic regeneration nodules in patient with cirrhosis due to a a Budd-Chiari syndrome. This case highlights the importance of using imaging protocols in the follow-up of patients with hepatic vascular diseases to identify adenomas at an early stage and differentiate them from large regenerative nodules, as well as to provide a complete immunohistochemical profile of all biopsied hepatocellular lesions. Indeed, since the early 2000s, the identification of genetic alterations associated with immuno-histochemical markers has allowed the classification of hepatocellular adenomas into six molecular subtypes. Each subtype presents different histological, clinical, radiological and evolutionary characteristics, all important for the management of the lesion. Furthermore, the risk of malignant transformation of an adenoma is not limited to the subtype β-mutated catenin, lesion size and male sex, but hepatic vascular disorders also appear to be another major risk factor.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 2","pages":"101-108"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Non-tuberculous mycobacterial infections : experience at the University Hospital of Liège and current status of associated immunodeficiencies in adults]. [非结核分枝杆菌感染：在利弗里奇大学医院的经验和成人相关免疫缺陷的现状]。
Revue medicale de Liege Pub Date : 2025-02-01
Constance Paquot, Doriane Calmes, Michel Moutschen
{"title":"[Non-tuberculous mycobacterial infections : experience at the University Hospital of Liège and current status of associated immunodeficiencies in adults].","authors":"Constance Paquot, Doriane Calmes, Michel Moutschen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Non-tuberculous mycobacterial (NTM) infections present a major challenge in both diagnosis and treatment. The management of NTM varies based on the species involved and the host's risks factors. With their prevalence continuing to rise, healthcare professionals are likely to encounter these infections more often in the years ahead. It is therefore essential to be aware of the predominant NTM species in our environment, as well as the associated risk factors. In this context, we present a study conducted at the University Hospital of Liège between 2016 and 2020, aimed at identifying the NTM species responsible for infections in the Liège area. We also explore the immune mechanisms involved in fighting these infections, focusing on primary immunodeficiencies that should be considered in adult patients with NTM infections.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 2","pages":"116-121"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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