Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia最新文献_第7页

Clinically important pharmacokinetic drug-drug interactions with antibacterial agents. 抗菌剂与临床上重要的药代动力学药物相互作用。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI: 10.37201/req/037.2024

A Torrent Rodríguez, A Font I Barceló, M Barrantes González, D Echeverria Esnal, D Soy Muner, J A Martínez, M Tuset Creus

{"title":"Clinically important pharmacokinetic drug-drug interactions with antibacterial agents.","authors":"A Torrent Rodríguez, A Font I Barceló, M Barrantes González, D Echeverria Esnal, D Soy Muner, J A Martínez, M Tuset Creus","doi":"10.37201/req/037.2024","DOIUrl":"10.37201/req/037.2024","url":null,"abstract":"Antimicrobial agents are widely used, and drug interactions are challenging due to increased risk of adverse effects or reduced efficacy. Among the interactions, the most important are those affecting metabolism, although those involving drug transporters are becoming increasingly known. To make clinical decisions, it is key to know the intensity of the interaction, as well as its duration and time-dependent recovery after discontinuation of the causative agents. It is not only important to be aware of all patient treatments, but also of supplements and natural medications that may also interact. Although they can have serious consequences, most interactions can be adequately managed with a good understanding of them. Especially in patients with polipharmacy it is compulsory to check them with an electronic clinical decision support database. This article aims to conduct a narrative review focusing on the major clinically significant pharmacokinetic drug-drug interactions that can be seen in patients receiving treatment for bacterial infections.","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":" ","pages":"299-322"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11231487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A descriptive overview of cases of congenital cytomegalovirus at a tertiary hospital between 2017 and 2023]. [2017年至2023年一家三级医院先天性巨细胞病毒病例的描述性概述]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-08-01 Epub Date: 2024-05-23 DOI: 10.37201/req/117.2023

E Medina García, A Berzosa, M Illán Ramos, V Cursach Pedrosa, C Aranda Cazón, G Herranz Carrillo, E Criado Vega, J T Ramos Amador

{"title":"[A descriptive overview of cases of congenital cytomegalovirus at a tertiary hospital between 2017 and 2023].","authors":"E Medina García, A Berzosa, M Illán Ramos, V Cursach Pedrosa, C Aranda Cazón, G Herranz Carrillo, E Criado Vega, J T Ramos Amador","doi":"10.37201/req/117.2023","DOIUrl":"10.37201/req/117.2023","url":null,"abstract":"Objective: Cytomegalovirus infection (CMV) is the most common congenital infection in developed countries. The aim of our study was to describe the features of the children that have congenital CMV infection at our hospital for the last 6 years.Methods: A retrospective descriptive study was designed that included all the children with CMV congenital infection that were diagnosed at tertiary hospital of Madrid Community between 2017 and 2023.Results: Twenty-two children were included. 54.5% have a prenatal diagnosis, 50% of them were in the third trimester, 25% at first trimester and 25% at the second. 22.7% were preterm. CMV was isolated in all the samples with CV more than 1000 copies/ml. When CMV was made in blood, 11/22 (50%) had a high CV. Only one newborn had a high CV at CRL. 44% have affectation at transfontanellar ultrasound evidenced by vasculopathy (62%), intraventricular hemorrhage (IVH) or periventricular calcifications (20%). 68% were asymptomatic, al though 20% had a retarded intrauterine growth (RIG) at birth or clinical features or analytical were objectified (neutropenia, thrombocytopenia, cholestasis). 33% got treatment with val ganciclovir and 33% had sequelae (hearing loss).Conclusions: CMV congenital infection is still a severe public health issue in developed countries. Most of the cases are mild or asymptomatic even though we should have high clinical suspicion with compatible symptoms and consistent maternal history in order to make an early diagnosis and treatment to prevent or reduce sequelae.","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":" ","pages":"351-355"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11231485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141083028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Candent issues in pneumonia. Reflections from the Fifth Annual Meeting of Spanish Experts 2023. 肺炎的隐患。来自 2023 年第五届西班牙专家年会的思考。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-06-01 Epub Date: 2024-03-04 DOI: 10.37201/req/018.2024

C M Rodríguez-Leal, C González-Corralejo, F J Candel, M Salavert

{"title":"Candent issues in pneumonia. Reflections from the Fifth Annual Meeting of Spanish Experts 2023.","authors":"C M Rodríguez-Leal, C González-Corralejo, F J Candel, M Salavert","doi":"10.37201/req/018.2024","DOIUrl":"10.37201/req/018.2024","url":null,"abstract":"Pneumonia is a multifaceted illness with a wide range of clinical manifestations, degree of severity and multiple potential causing microorganisms. Despite the intensive research of recent decades, community-acquired pneumonia remains the third-highest cause of mortality in developed countries and the first due to infections; and hospital-acquired pneumonia is the main cause of death from nosocomial infection in critically ill patients. Guidelines for management of this disease are available world wide, but there are questions which generate controversy, and the latest advances make it difficult to stay them up to date. A multidisciplinary approach can overcome these limitations and can also aid to improve clinical results. Spanish medical societies involved in diagnosis and treatment of pneumonia have made a collaborative effort to actualize and integrate last expertise about this infection. The aim of this paper is to reflect this knowledge, communicated in Fifth Pneumonia Day in Spain. It reviews the most important questions about this disorder, such as microbiological diagnosis, advances in antibiotic and sequential therapy, management of beta-lactam allergic patient, preventive measures, management of unusual or multi-resistant microorganisms and adjuvant or advanced therapies in Intensive Care Unit.","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":" ","pages":"221-251"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140023851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical study types and guidance for their correct post-pandemic interpretation. 临床研究类型及其大流行后的正确解释指南。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-06-01 Epub Date: 2024-02-26 DOI: 10.37201/req/003.2024

M Martínez-Sellés, L Prieto-Valiente

{"title":"Clinical study types and guidance for their correct post-pandemic interpretation.","authors":"M Martínez-Sellés, L Prieto-Valiente","doi":"10.37201/req/003.2024","DOIUrl":"10.37201/req/003.2024","url":null,"abstract":"Randomized clinical trials (RCTs) are key to the advancement of medicine and microbiology, but they are not the only option. Observational studies provide information on long-term efficacy and safety, are less expensive, allow the study of rare events, and obtain information more quickly than RCTs. On the other hand, they are more vulnerable to confounding factors. Prospective exploratory pilot studies share many aspects with RCTs but are not subject to supervision by external commissions or mandatory registration. Multitesting can pervert the balance of publications in favor of the desired effect. Bonferroni's reasoning shows that if 10 studies are performed with an ineffective antibiotic, the probability that at least one will show P <0.05 might be 40%. Scenarios in which there is intensive pressure to perform research, such as the recent pandemic, might result in many research teams trying to study the effect of an antimicrobial. Even if the drug has no efficacy, if 100 research teams conduct a study to assess its usefulness, it might be virtually certain that at least one will get a P value <0.05. If the other studies (with P >0.05) are not published, the scientific commu nity would consider that there is strong evidence in favor of its usefulness. In conclusion, RCTs are a very good source of clinical information, but are not the only one. The systematic registration of all research can and should be applied to all types of clinical studies.","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":" ","pages":"203-208"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dalbavancin as long-term treatment in Corynebacterium striatum Infections: a literature review. 达尔巴万星作为纹状体杆菌感染的长期治疗方法：文献综述。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI: 10.37201/req/149.2023

M Camara-Rodriguez, F Jover-Diaz, E Delgado-Sánchez, A Infante-Urríos, J Peris-García

引用次数: 0

[Rapid diagnosis of a case of post-surgical meningitis with BioFire® Joint Infection Panel]. [使用 BioFire® 关节感染面板快速诊断一例手术后脑膜炎病例]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI: 10.37201/req/009.2024

B Cuadrado García, A Madueño Alonso, A Martín Bermúdez, L Romero-Acevedo, P Pérez Orán, M Lecuona Fernández

引用次数: 0

Microbiological and epidemiological features of respiratory syncytial virus. 呼吸道合胞病毒的微生物学和流行病学特征。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-06-01 Epub Date: 2024-03-21 DOI: 10.37201/req/006.2024

I Sanz-Muñoz, L Sánchez-de Prada, J Castrodeza-Sanz, J M Eiros

{"title":"Microbiological and epidemiological features of respiratory syncytial virus.","authors":"I Sanz-Muñoz, L Sánchez-de Prada, J Castrodeza-Sanz, J M Eiros","doi":"10.37201/req/006.2024","DOIUrl":"10.37201/req/006.2024","url":null,"abstract":"The properties of the main surface proteins and the viral cycle of the respiratory syncytial virus (RSV) make it an attractive pathogen from the perspective of microbiology. The virus gets its name from the manner it infects cells, which enables it to produce syncytia, which allow the virus' genetic material to move across cells without having to release viral offspring to the cellular exterior, reducing immune system identification. This causes a disease with a high impact in both children and adults over 60, which has sparked the development of several preventive interventions based on vaccines and monoclonal antibodies for both age groups. The epidemiological characteristics of this virus, which circulates in epidemics throughout the coldest months of the year and exhibits a marked genetic and antigenic drift due to its high mutation capability, must be taken into consideration while using these preventive methods. The most important microbiological and epidemiological elements of RSV are covered in this study, along with how they have affected the creation of preventive medications and their use in the future.","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":" ","pages":"209-220"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Usefulness of the MPB-INFURG-SEMES model to predict bacteremia in the patient with solid tumor in the Emergency Department]. [MPB-INFURG-SEMES模型在预测急诊科实体瘤患者菌血症方面的实用性]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-06-01 Epub Date: 2024-03-23 DOI: 10.37201/req/004.2024

M Muelas González, E Torner Marchesi, G Peláez Díaz, M Ramos Aranguez, J Cabañas Morafraile, W López Forero, R Rubio Díaz, J González Del Castillo, F J Candel, A Julián-Jiménez

{"title":"[Usefulness of the MPB-INFURG-SEMES model to predict bacteremia in the patient with solid tumor in the Emergency Department].","authors":"M Muelas González, E Torner Marchesi, G Peláez Díaz, M Ramos Aranguez, J Cabañas Morafraile, W López Forero, R Rubio Díaz, J González Del Castillo, F J Candel, A Julián-Jiménez","doi":"10.37201/req/004.2024","DOIUrl":"10.37201/req/004.2024","url":null,"abstract":"Objective: To analyse a new risk score to predict bacteremia (MPB-INFURG-SEMES) in the patients with solid tumor attender for infection in the emergency departments (ED).Methods: Prospective, multicenter observational cohort study of blood cultures (BC) obtained from adult patients with solid neoplasia treated in 63 EDs for infection from November 1, 2019, to March 31, 2020. The predictive ability of the model was analyzed with the area under the Receiver Operating Characteristic curve (AUC-ROC). The prognostic performance for true bacteremia was calculated with the chosen cut-off for getting the sensitivity, specificity, positive predictive value and negative predictive value.Results: A total of 857 blood samples wered cultured. True cases of bacteremia were confirmed in 196 (22.9%). The remaining 661 cultures (77.1%) wered negative. And, 42 (4.9%) were judged to be contaminated. The model's area under the receiver operating characteristic curve was 0.923 (95% CI,0.896-0.950). The prognostic performance with a model's cut-off value of ≥ 5 points achieved 95.74% (95% CI, 94,92-96.56) sensitivity, 76.06% (95% CI, 75.24-76.88) specificity, 53.42%(95% CI, 52.60-54.24) positive predictive value and 98.48% (95% CI, 97.66- 99.30) negative predictive value.Conclusions: The MPB-INFURG-SEMES score is useful for predicting bacteremia in the adults patients with solid tumor seen in the ED.","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":" ","pages":"257-265"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Bacteremia caused by Enterocloster aldenensis in an oncological patient]. [一名肿瘤患者由阿登氏肠球菌引起的菌血症]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-05-17 DOI: 10.37201/req/025.2024

Fernando Cobo, V. Pérez-Carrasco, Leticia Castellano-Sánchez, J. A. Garcia-Salcedo, José María Navarro-Marí

引用次数: 0

[Glecaprevir/pibrentasvir in combination with ribavirin as salvage therapy in chronic hepatitis C]. [Glecaprevir/pibrentasvir联合利巴韦林作为慢性丙型肝炎的挽救疗法]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-04-19 DOI: 10.37201/req/020.2024

M. Sánchez Suárez, A. Martín Roldán, María Rosa Cantudo Cuenca

引用次数: 0