Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia最新文献_第8页

Candent issues in pneumonia. Reflections from the Fifth Annual Meeting of Spanish Experts 2023. 肺炎的隐患。来自 2023 年第五届西班牙专家年会的思考。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-06-01 Epub Date: 2024-03-04 DOI: 10.37201/req/018.2024

C M Rodríguez-Leal, C González-Corralejo, F J Candel, M Salavert

{"title":"Candent issues in pneumonia. Reflections from the Fifth Annual Meeting of Spanish Experts 2023.","authors":"C M Rodríguez-Leal, C González-Corralejo, F J Candel, M Salavert","doi":"10.37201/req/018.2024","DOIUrl":"10.37201/req/018.2024","url":null,"abstract":"Pneumonia is a multifaceted illness with a wide range of clinical manifestations, degree of severity and multiple potential causing microorganisms. Despite the intensive research of recent decades, community-acquired pneumonia remains the third-highest cause of mortality in developed countries and the first due to infections; and hospital-acquired pneumonia is the main cause of death from nosocomial infection in critically ill patients. Guidelines for management of this disease are available world wide, but there are questions which generate controversy, and the latest advances make it difficult to stay them up to date. A multidisciplinary approach can overcome these limitations and can also aid to improve clinical results. Spanish medical societies involved in diagnosis and treatment of pneumonia have made a collaborative effort to actualize and integrate last expertise about this infection. The aim of this paper is to reflect this knowledge, communicated in Fifth Pneumonia Day in Spain. It reviews the most important questions about this disorder, such as microbiological diagnosis, advances in antibiotic and sequential therapy, management of beta-lactam allergic patient, preventive measures, management of unusual or multi-resistant microorganisms and adjuvant or advanced therapies in Intensive Care Unit.","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":" ","pages":"221-251"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140023851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical study types and guidance for their correct post-pandemic interpretation. 临床研究类型及其大流行后的正确解释指南。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-06-01 Epub Date: 2024-02-26 DOI: 10.37201/req/003.2024

M Martínez-Sellés, L Prieto-Valiente

{"title":"Clinical study types and guidance for their correct post-pandemic interpretation.","authors":"M Martínez-Sellés, L Prieto-Valiente","doi":"10.37201/req/003.2024","DOIUrl":"10.37201/req/003.2024","url":null,"abstract":"Randomized clinical trials (RCTs) are key to the advancement of medicine and microbiology, but they are not the only option. Observational studies provide information on long-term efficacy and safety, are less expensive, allow the study of rare events, and obtain information more quickly than RCTs. On the other hand, they are more vulnerable to confounding factors. Prospective exploratory pilot studies share many aspects with RCTs but are not subject to supervision by external commissions or mandatory registration. Multitesting can pervert the balance of publications in favor of the desired effect. Bonferroni's reasoning shows that if 10 studies are performed with an ineffective antibiotic, the probability that at least one will show P <0.05 might be 40%. Scenarios in which there is intensive pressure to perform research, such as the recent pandemic, might result in many research teams trying to study the effect of an antimicrobial. Even if the drug has no efficacy, if 100 research teams conduct a study to assess its usefulness, it might be virtually certain that at least one will get a P value <0.05. If the other studies (with P >0.05) are not published, the scientific commu nity would consider that there is strong evidence in favor of its usefulness. In conclusion, RCTs are a very good source of clinical information, but are not the only one. The systematic registration of all research can and should be applied to all types of clinical studies.","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":" ","pages":"203-208"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dalbavancin as long-term treatment in Corynebacterium striatum Infections: a literature review. 达尔巴万星作为纹状体杆菌感染的长期治疗方法：文献综述。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI: 10.37201/req/149.2023

M Camara-Rodriguez, F Jover-Diaz, E Delgado-Sánchez, A Infante-Urríos, J Peris-García

引用次数: 0

[Rapid diagnosis of a case of post-surgical meningitis with BioFire® Joint Infection Panel]. [使用 BioFire® 关节感染面板快速诊断一例手术后脑膜炎病例]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI: 10.37201/req/009.2024

B Cuadrado García, A Madueño Alonso, A Martín Bermúdez, L Romero-Acevedo, P Pérez Orán, M Lecuona Fernández

引用次数: 0

Microbiological and epidemiological features of respiratory syncytial virus. 呼吸道合胞病毒的微生物学和流行病学特征。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-06-01 Epub Date: 2024-03-21 DOI: 10.37201/req/006.2024

I Sanz-Muñoz, L Sánchez-de Prada, J Castrodeza-Sanz, J M Eiros

{"title":"Microbiological and epidemiological features of respiratory syncytial virus.","authors":"I Sanz-Muñoz, L Sánchez-de Prada, J Castrodeza-Sanz, J M Eiros","doi":"10.37201/req/006.2024","DOIUrl":"10.37201/req/006.2024","url":null,"abstract":"The properties of the main surface proteins and the viral cycle of the respiratory syncytial virus (RSV) make it an attractive pathogen from the perspective of microbiology. The virus gets its name from the manner it infects cells, which enables it to produce syncytia, which allow the virus' genetic material to move across cells without having to release viral offspring to the cellular exterior, reducing immune system identification. This causes a disease with a high impact in both children and adults over 60, which has sparked the development of several preventive interventions based on vaccines and monoclonal antibodies for both age groups. The epidemiological characteristics of this virus, which circulates in epidemics throughout the coldest months of the year and exhibits a marked genetic and antigenic drift due to its high mutation capability, must be taken into consideration while using these preventive methods. The most important microbiological and epidemiological elements of RSV are covered in this study, along with how they have affected the creation of preventive medications and their use in the future.","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":" ","pages":"209-220"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Usefulness of the MPB-INFURG-SEMES model to predict bacteremia in the patient with solid tumor in the Emergency Department]. [MPB-INFURG-SEMES模型在预测急诊科实体瘤患者菌血症方面的实用性]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-06-01 Epub Date: 2024-03-23 DOI: 10.37201/req/004.2024

M Muelas González, E Torner Marchesi, G Peláez Díaz, M Ramos Aranguez, J Cabañas Morafraile, W López Forero, R Rubio Díaz, J González Del Castillo, F J Candel, A Julián-Jiménez

{"title":"[Usefulness of the MPB-INFURG-SEMES model to predict bacteremia in the patient with solid tumor in the Emergency Department].","authors":"M Muelas González, E Torner Marchesi, G Peláez Díaz, M Ramos Aranguez, J Cabañas Morafraile, W López Forero, R Rubio Díaz, J González Del Castillo, F J Candel, A Julián-Jiménez","doi":"10.37201/req/004.2024","DOIUrl":"10.37201/req/004.2024","url":null,"abstract":"Objective: To analyse a new risk score to predict bacteremia (MPB-INFURG-SEMES) in the patients with solid tumor attender for infection in the emergency departments (ED).Methods: Prospective, multicenter observational cohort study of blood cultures (BC) obtained from adult patients with solid neoplasia treated in 63 EDs for infection from November 1, 2019, to March 31, 2020. The predictive ability of the model was analyzed with the area under the Receiver Operating Characteristic curve (AUC-ROC). The prognostic performance for true bacteremia was calculated with the chosen cut-off for getting the sensitivity, specificity, positive predictive value and negative predictive value.Results: A total of 857 blood samples wered cultured. True cases of bacteremia were confirmed in 196 (22.9%). The remaining 661 cultures (77.1%) wered negative. And, 42 (4.9%) were judged to be contaminated. The model's area under the receiver operating characteristic curve was 0.923 (95% CI,0.896-0.950). The prognostic performance with a model's cut-off value of ≥ 5 points achieved 95.74% (95% CI, 94,92-96.56) sensitivity, 76.06% (95% CI, 75.24-76.88) specificity, 53.42%(95% CI, 52.60-54.24) positive predictive value and 98.48% (95% CI, 97.66- 99.30) negative predictive value.Conclusions: The MPB-INFURG-SEMES score is useful for predicting bacteremia in the adults patients with solid tumor seen in the ED.","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":" ","pages":"257-265"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Bacteremia caused by Enterocloster aldenensis in an oncological patient]. [一名肿瘤患者由阿登氏肠球菌引起的菌血症]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-05-17 DOI: 10.37201/req/025.2024

Fernando Cobo, V. Pérez-Carrasco, Leticia Castellano-Sánchez, J. A. Garcia-Salcedo, José María Navarro-Marí

引用次数: 0

[Glecaprevir/pibrentasvir in combination with ribavirin as salvage therapy in chronic hepatitis C]. [Glecaprevir/pibrentasvir联合利巴韦林作为慢性丙型肝炎的挽救疗法]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-04-19 DOI: 10.37201/req/020.2024

M. Sánchez Suárez, A. Martín Roldán, María Rosa Cantudo Cuenca

引用次数: 0

[Septic arthritis due to Pasteurella multocida]. [多杀性巴氏杆菌引起的化脓性关节炎]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-04-17 DOI: 10.37201/req/019.2024

Carmen Piña Delgado, M. N. Carmona Tello, M. Bolaños Rivero, María del Carmen Lavilla Salgado, Isabel de Miguel Martínez

引用次数: 0

The role of viral diagnostic tests in respiratory tract infections: moving forward. 病毒诊断测试在呼吸道感染中的作用：向前迈进。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2024-04-12 DOI: 10.37201/req/150.2023

Raúl Ortíz de Lejarazu, J. Eiros, F. López‐Medrano, Milagros Montes, Alfredo Tagarro, María Tomás

{"title":"The role of viral diagnostic tests in respiratory tract infections: moving forward.","authors":"Raúl Ortíz de Lejarazu, J. Eiros, F. López‐Medrano, Milagros Montes, Alfredo Tagarro, María Tomás","doi":"10.37201/req/150.2023","DOIUrl":"https://doi.org/10.37201/req/150.2023","url":null,"abstract":"The increased knowledge on virology and the increased potential of their diagnostic has risen several relevant question about the role of an early viral diagnosis and potential early treatment on the management of respiratory tract infections (RTI). In order to further understand the role of viral diagnostic tests in the management of RTI, a panel of experts was convened to discuss about their potential role, beyond what had been agreed in Influenza. The objective of this panel was to define the plausible role of aetiologic viral diagnostic into clinical management; make recommendations on the potential expanded use of such tests in the future and define some gaps in the management of RTI. Molecular Infection Viral Diagnostic (mIVD) tests should be used in all adult patients admitted to Hospital with RTI, and in paediatric patients requiring admission or who would be referred to another hospital for more specialised care. The increased use of mIVD will not only reduce the inappropriate use of antibiotics so reducing the antibiotic microbe resistance, but also will improve the outcome of the patient if an aetiologic viral therapy can be warranted, saving resource requirements and improving patient flows. Implementing IVD testing in RTI has various organizational benefits as well, but expanding its use into clinical settings would need a cost-effectiveness strategy and budget impact assessment.","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":"21 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140711581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0