Revista espanola de medicina nuclear e imagen molecular最新文献

{"title":"Decoding polymyalgia rheumatica, the role of Nuclear Medicine Imaging","authors":"E. Noriega-Álvarez ,&nbsp;B. Rodríguez-Alfonso ,&nbsp;C. Merino Argumánez ,&nbsp;L. Domínguez Gadea ,&nbsp;V. Peiró-Valgañón","doi":"10.1016/j.remnie.2023.12.002","DOIUrl":"10.1016/j.remnie.2023.12.002","url":null,"abstract":"<div><p><span><span>Polymyalgia rheumatica (PMR) is an inflammatory </span>joint disease<span> that presents in patients older than 50 years with prolonged morning pain and stiffness in the shoulder and hip joints and neck. The lack of specific clinical findings, laboratory signs, biomarkers and established imaging methods makes it difficult to diagnose patients with this disease. </span></span>¹⁸<span><span>F-FDG PET/CT is a functional imaging technique<span><span> that is an established tool in oncology and has also proven useful in the field of </span>inflammatory diseases. The aim of this paper is to present literature evidence on the use of </span></span>molecular imaging methods such as PET/CT for early diagnosis, assessment of disease activity and therapeutic response in PMR. At the same time, the advantages, disadvantages and contraindications of other methods are considered.</span></p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of a novel deep learning attenuation correction software for MPI using a cardio dedicated CZT camera. Experience in the clinical practice","authors":"Miguel Ochoa-Figueroa ,&nbsp;Carlos Valera-Soria ,&nbsp;Christos Pagonis ,&nbsp;Marcus Ressner ,&nbsp;Pernilla Norberg ,&nbsp;Veronica Sanchez-Rodriguez ,&nbsp;Jeronimo Frias-Rose ,&nbsp;Elin Good ,&nbsp;Anette Davidsson","doi":"10.1016/j.remnie.2023.09.004","DOIUrl":"10.1016/j.remnie.2023.09.004","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the diagnostic performance of a novel deep learning attenuation correction software (DLACS) for myocardial perfusion imaging (MPI) using a cadmium–zinc–telluride (CZT) cardio dedicated camera with invasive coronary angiography (ICA) correlation for the diagnosis of coronary artery disease (CAD) in a high-risk population.</p></div><div><h3>Methods</h3><p>Retrospective study of 300 patients (196 males [65%], mean age 68 years) from September 2014 to October 2019 undergoing MPI, followed by ICA and evaluated by means of quantitative angiography software, within six months after the MPI. The mean pre-test probability score for coronary disease according to the European Society of Cardiology criteria was 37% for the whole cohort. The MPI was performed in a dedicated CZT cardio camera (D-SPECT Spectrum Dynamics) with a two-day protocol, according to the European Association of Nuclear Medicine guidelines. MPI was retrospectively evaluated with and without the DLACS.</p></div><div><h3>Results</h3><p>The overall diagnostic accuracy of MPI without DLACS to identify patients with any obstructive CAD at ICA was 87%, sensitivity 94%, specificity 57%, Positive Predictive Value 91% and Negative Predictive Value 64%. Using DLACS the overall diagnostic accuracy was 90%, sensitivity 91%, specificity 86%, Positive Predictive Value 97% and Negative Predictive Value 66%.</p></div><div><h3>Conclusion</h3><p>Use of the novel DLACS enhances performance of the MPI using the CZT D-SPECT camera and achieves improved results, especially avoiding artefacts and reducing the number of false positive results.</p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2253808923000769/pdfft?md5=b60838677d572f9e5d35d66c9abaf97a&pid=1-s2.0-S2253808923000769-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous innovation in precision radio-guided surgery","authors":"Sergi Vidal-Sicart ,&nbsp;Elena Goñi ,&nbsp;Isaac Cebrecos ,&nbsp;Mª Eugenia Rioja ,&nbsp;Andrés Perissinotti ,&nbsp;Catalina Sampol ,&nbsp;Oscar Vidal ,&nbsp;David Saavedra-Pérez ,&nbsp;Ada Ferrer ,&nbsp;Carles Martí ,&nbsp;José Ferrer Rebolleda ,&nbsp;Mª José García Velloso ,&nbsp;Jhon Orozco-Cortés ,&nbsp;Berta Díaz-Feijóo ,&nbsp;Aida Niñerola-Baizán ,&nbsp;Renato Alfredo Valdés Olmos","doi":"10.1016/j.remnie.2023.11.001","DOIUrl":"10.1016/j.remnie.2023.11.001","url":null,"abstract":"<div><p><span>Since its origins, nuclear medicine has faced technological changes that led to modifying operating modes and adapting protocols. In the field of radioguided surgery, the incorporation of preoperative scintigraphic imaging and intraoperative detection with the gamma probe<span> provided a definitive boost to sentinel lymph node biopsy to become a standard procedure for </span></span>melanoma and breast cancer.</p><p>The various technological innovations and consequent adaptation of protocols come together in the coexistence of the disruptive and the gradual. As obvious examples we have the introduction of SPECT/CT in the preoperative field and Drop-in probes in the intraoperative field. Other innovative aspects with possible application in radio-guided surgery are based on the application of artificial intelligence, navigation and telecare.</p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107593177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The contribution of PET/CT to the differentiation of benign and malignant pleural effusion in patients with ovarian carcinoma","authors":"Adnan Budak ,&nbsp;Ahmet Yanarateş ,&nbsp;Emine Budak","doi":"10.1016/j.remnie.2023.05.001","DOIUrl":"10.1016/j.remnie.2023.05.001","url":null,"abstract":"<div><h3>Objective</h3><p><span><span>The present study investigates the ability of non-invasive contribution of positron emission tomography (PET)/computed tomography (CT) to distinguish between benign pleural effusions (BPE) and </span>malignant pleural effusions<span> (MPE) in patients diagnosed with </span></span>ovarian carcinoma (OC).</p></div><div><h3>Material and methods</h3><p><span><span>Included in the study were 32 OC patients with a PE diagnosis. The cases with BPE and MPE were compared in terms of the PE maximum standardized uptake value (SUVmax), PE SUVmax/mean standardized uptake (SUVmean) value of the mediastinal blood pool (TBRp), the presence of </span>pleural thickening, the presence of supradiaphragmatic lymph node, unilateral or bilateral PE, pleural effusion diameter, patient age and </span>CA125 value.</p></div><div><h3>Results</h3><p>The mean age of the 32 patients was 57<!--> <!-->±<!--> <!-->2.8 years. TBRp<!--> <!-->&gt;<!--> <!-->1.1, pleural thickening and supradiaphragmatic lymph node were observed significantly more frequently in the MPE than the BPE cases. While no pleural nodules were detected in patients with BPE, they were present in 7 of the patients with MPE. The rates of distinction between the MPE and BPE cases were as follows: the sensitivity of the TBRp value was 95.2% and specificity was 72.7%; the sensitivity of pleural thickness was 80.9% and specificity was 81.8%; the sensitivity of supradiaphragmatic lymph node was 38% and specificity was 90.9%; and the sensitivity of the pleural nodule was 33.3% and specificity was 100%. There were no significant differences between two groups in any other factors.</p></div><div><h3>Conclusions</h3><p>Pleural thickening and TBRp values ascertained through PET/CT may aid the distinction between MPE-BPE, especially in patients with advanced stage OC with a poor general condition, or those who cannot undergo surgery.</p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9845403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A different perspective on 18F-FDG PET radiomics in colorectal cancer patients: The relationship between intra & peritumoral analysis and pathological findings","authors":"Özge Vural Topuz ,&nbsp;Ayşegül Aksu ,&nbsp;Müveddet Banu Yılmaz Özgüven","doi":"10.1016/j.remnie.2023.04.005","DOIUrl":"https://doi.org/10.1016/j.remnie.2023.04.005","url":null,"abstract":"<div><h3>Objective</h3><p>We aimed to determine the value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) based primary tumoral and peritumoral radiomics in the prediction of tumor deposits (TDs), tumor budding (TB) and extramural venous invasion (EMVI) of colorectal cancer (CRC).</p></div><div><h3>Methods</h3><p>Our retrospective study included 77 CRC patients who had preoperative ¹⁸<span>F-FDG PET/CT between June 2020 and February 2022. A total of 131 radiomic features were extracted from primary tumors and peritumoral areas on PET/CT fusion images. The relationship between TDs, TB, EMVI and T stage in the postoperative pathology of the tumors and radiomic features was investigated. Features with a correlation coefficient (CC) less than 0.8 were analyzed by logistic regression. The area under curve (AUC) obtained from the receiver operating characteristic analysis was used to measure the model performance.</span></p></div><div><h3>Results</h3><p>A model was developed from primary tumoral and peritumoral radiomics data to predict T stage (AUC 0.931), and also a predictive model was constructed from primary tumor derived radiomics to predict EMVI (AUC 0.739). Radiomic data derived from the primary tumor was obtained as a predictive prognostic factor in predicting TDs and a peritumoral feature was found to be a prognostic factor in predicting TB.</p></div><div><h3>Conclusions</h3><p>Intratumoral and peritumoral radiomics derived from ¹⁸F-FDG PET/CT are useful for non-invasive early prediction of pathological features that have important implications in the management of CRC.</p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71732623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The variation of quantitative parameters and Deauville scores with different reconstruction algorithms in FDG PET/CT imaging of lymphoma patients","authors":"Mustafa Genc ,&nbsp;Nilufer Yildirim ,&nbsp;Nazim Coskun ,&nbsp;Elif Ozdemir ,&nbsp;Seyda Turkolmez","doi":"10.1016/j.remnie.2023.07.006","DOIUrl":"10.1016/j.remnie.2023.07.006","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>18F-FDG PET with the Deauville score (DS) is a unique semiquantitative method for lymphoma. However, type of standard uptake values (max, mean, and peak) reconstruction algorithms could affect DS. We compared the Bayesian Penalized Likelihood reconstruction algorithm (BPL) with Ordered Subsets Expectation Maximization (OSEM) on quantitative parameters and DS in lymphoma. We investigated the effect of the size of the lymph node on quantitative variation.</p></div><div><h3>Patients and methods</h3><p>Raw PET data of 255 lymphoma patients were reconstructed separately with Q.Clear (GE Healthcare), a BPL, and SharpIR (GE Healthcare), an OSEM algorithm. In both images, each patient's liver, mediastinal blood pool, and SUVs (SUVmax, SUVmean, and SUVpeak) of a total of 487 lesions selected from the patients were performed. DSmax, DSmean, and DSpeak were compared.</p></div><div><h3>Results</h3><p>In our study, DS increased significantly with BPL (p &lt; 0.001), and the DS increased to 4–5 in thirty patients evaluated as 1−2–3 with OSEM. It was found that the quantitative values of the lymph nodes increased statistically with BPL (p &lt; 0.001), and the liver from the reference regions were significantly decreased (p &lt; 0.001). In addition, difference in lymph node was independently associated with size of lesion and was significantly more pronounced in small lesions (p &lt; 0.001). The effects of BPL algorithm were more pronounced in SUVmax than in SUVmean and SUVpeak. DS-mean and DS-peak scores were less changed by BPL than DS-max.</p></div><div><h3>Conclusion</h3><p>Different reconstruction algorithms in FDG PET/CT affect the quantitative evaluation. That variation may affect the change in DS in lymphoma patients, thus affecting patient management.</p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9938651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multidisciplinary challenge: Therapy with phosphorus-32 for locally advanced pancreatic cancer","authors":"V. Peiró-Valgañón ,&nbsp;A. Guardiola-Arévalo ,&nbsp;A. López Fernández ,&nbsp;E. Llorente Herrero ,&nbsp;M.T. Martín Fernández-Gallardo","doi":"10.1016/j.remnie.2023.09.006","DOIUrl":"10.1016/j.remnie.2023.09.006","url":null,"abstract":"<div><p>Pancreatic cancer is a disease with a poor prognosis, and overall survival has improved the least in the last 40 years of all cancers.</p><p><span>Locally advanced pancreatic adenocarcinoma, without </span>distant metastasis<span> but with limiting vascular involvement, constitutes almost one third of these patients. This group is the focus of most research efforts to introduce treatments to increase surgical salvage rates and/or survival, with two main objectives: local control and prevention of systemic progression.</span></p><p>Intratumoural treatment with phosphorus-32 microparticles<span>, guided by echoendoscopy and combined with standard chemotherapy may have significant and clinically relevant benefits in these patients, and therefore a valuable treatment option in a disease where there is an urgent need to develop new therapies to help improve outcomes.</span></p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41168429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediastinal epithelioid angiosarcoma: Characteristic findings on [18F]FDG PET/CT in an uncommon case in a young male","authors":"A. Rodríguez Pajuelo,&nbsp;P. Fernández-Rodríguez,&nbsp;J.M. Jiménez-Hoyuela García","doi":"10.1016/j.remnie.2023.07.002","DOIUrl":"https://doi.org/10.1016/j.remnie.2023.07.002","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71711230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"99mTc-HMPAO labeled autologous leukocytes scintigraphy in tumor liver disease","authors":"S. Guzmán Ortiz,&nbsp;S. de la Torre Fernández,&nbsp;A.E. Seva Delgado,&nbsp;C.M. Hernández Heredia","doi":"10.1016/j.remnie.2023.09.005","DOIUrl":"https://doi.org/10.1016/j.remnie.2023.09.005","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71711231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of ventricular remodeling, synchrony and filling rate parameters to improve the assessment of left ventricular systolic function","authors":"G. Romero-Farina ,&nbsp;S. Aguadé-Bruix ,&nbsp;E.V. Garcia ,&nbsp;J. Castell-Conesa","doi":"10.1016/j.remnie.2023.09.003","DOIUrl":"10.1016/j.remnie.2023.09.003","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>The aim of this study is to assess the relationship between structural, remodeling, synchrony, and systolic left ventricular (LV) function parameters using gated-SPECT myocardial-perfusion-images (gSPECT-MPI). In addition, obtaining the cut-off values for end-diastolic LV-shape-index (EDLVsi), end-systolic LV-shape-index (ESLVsi), ECC (eccentricity-index) and PER, and developing a new index to evaluate different patterns of the LV systolic function.</p></div><div><h3>Methods</h3><p>The study was approved by the Hospital’s Ethical-Committee (PR[AG]168.2010), and all patients gave their informed consent. We analyzed prospectively 238 patients (age 63.4 ± 13 years) who underwent stress-rest gSPECT-MPI (control-group, n = 148; patients with previous myocardial infarction [MI], n = 90).</p></div><div><h3>Results</h3><p>In the control group, with regard to remodeling parameters: the end-diastolic-volume-index (EDV) and the ECC were the parameters that influenced the EDLVsi (<em>r</em>²: 0.52, <em>p</em> &lt; 0.001). EDV, PER, men, and the ECC were the parameters (<em>r</em>²: 0.44; <em>p</em> &lt; 0.001) which influenced the ESLVsi. EDLVsi, ESLVsi, LVEF and the stroke-volume were the parameters (<em>r</em>²: 0.62; <em>p</em> &lt; 0.001) which influenced the ECC. With regards to PER: LVEF, heart-rate, bandwidth, and the standard-deviation were the influencing parameters (<em>r</em>²: 0.76; <em>p</em> &lt; 0.001). The cut-off values for EDLVsi, ESLVsi, ECC, and PER were 0.59, 0.42, 0.87, and 3.3, respectively. The PER, the ESLVsi and the bandwidth were the parameters related to patients with previous MI (AUC: 0.89); and they allow the assessment of different patterns of systolic function (PERRS-index: peak-emptying-rate, left ventricular-remodeling and synchrony).</p></div><div><h3>Conclusions</h3><p>The remodeling, synchrony and the systolic function parameters of the LV should be interpreted together (PERRS-index). In this way, we obtain different patterns of LV systolic function.</p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}