Revista espanola de medicina nuclear e imagen molecular最新文献

{"title":"Comparison of the diagnostic performances of CT attenuation corrected and non-attenuation corrected SPECT myocardial perfusion scintigraphy in coronary artery disease","authors":"G. Kara Gedik ,&nbsp;A. Volkan Çelik ,&nbsp;M.U. Yalçın ,&nbsp;M. Koplay ,&nbsp;F. Yılmaz ,&nbsp;H. Önner","doi":"10.1016/j.remnie.2024.500085","DOIUrl":"10.1016/j.remnie.2024.500085","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Tissue attenuation reduces the specificity of the myocardial perfusion imaging single photon emission tomography (SPECT), which leads reduced diagnostic accuracy. The aim of this study is to compare performances of non-attenuation corrected (NAC), computed tomography based-attenuation corrected (AC) and prone images for qualitative and semi-quantitative analysis of myocardial perfusion SPECT in diagnosis of coronary artery disease (CAD).</div></div><div><h3>Materials and methods</h3><div>Eightysix patients in whom NAC, AC and prone images were obtained with SPECT, and whose coronary angiography/CT coronary angiography was completed within 3 months, were retrospectively studied. Myocardial perfusion scintigraphy was performed using SPECT/CT dual-headed gamma camera. Images were evaluated qualitatively and semi-quantitatively using 20-segment model. Analyzes of global myocardium and LAD, RCA, Cx vascular areas as regional analysis were performed. In qualitative evaluation, if SPECT study was abnormal, relevant coronary artery area was recorded. Quantitative Perfusion SPECT (QPS) program was used in semi-quantitative analysis; SSS (Summed Stress Score) ≥ 4 was accepted for presence of CAD in per-patient analysis. In regional analysis SSS ≥ 2 was taken into account. Coronary angiography/CT coronary angiography was used as gold standard. Threshold value was determined as ≥50% and above luminal diameter narrowing. While AC and NAC methods were compared for per-patient analysis and each vascular area; 3 imaging methods including prone acqusition, were compared for the RCA area. Diagnostic performances of the methods were evaluated by comparing the areas under the curve with ROC analysis.</div></div><div><h3>Results</h3><div>In visual evaluation, sensitivity of AC was significantly lower than NAC in analyzes of per-patient, RCA and Cx areas (global 76.92% vs 86.15%, RCA 60.87% vs 82.61%, Cx 58.97% vs 69.23%, respectively; <em>p</em> &lt; 0.05). Sensitivity of prone imaging was significantly higher than AC in analysis of the RCA area (76.09% vs 60.87%, respectively; <em>p</em> &lt; 0.05) Specificity values ​​were higher in analyzes of global, RCA and Cx areas in AC than in NAC method; this difference was significant in RCA and Cx areas (RCA 70% vs 42.50%, Cx 85.11% vs 70.21%, respectively; <em>p</em> &lt; 0.05). In semi-quantitative evaluation, AC and NAC had similar sensitivity and specificity in global and regional analyzes; in RCA area, no significant difference was detected between the 3 methods. In ROC analysis, no significant difference was detected between methods in per-patient and regional analyzes both in visual and semi-quantitative evaluation.</div></div><div><h3>Conclusions</h3><div>CT-based attenuation correction increases specificity, but reduces sensitivity in the diagnosis of CAD in regional areas of RCA and Cx. Prone imaging remains important in evaluation of RCA area.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500085"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between metabolic response determined with [18F]FDG PET/CT and pathological response after neoadjuvant treatment and surgery in patients with esophageal cancer","authors":"J.R. Infante ,&nbsp;J. Quirós ,&nbsp;R. Barco ,&nbsp;C. Bejarano ,&nbsp;E. Agudo ,&nbsp;J. Fernández ,&nbsp;A. Baena ,&nbsp;A. Utrera ,&nbsp;A. Martínez ,&nbsp;C. Durán ,&nbsp;J. Serrano","doi":"10.1016/j.remnie.2025.500088","DOIUrl":"10.1016/j.remnie.2025.500088","url":null,"abstract":"<div><h3>Aim</h3><div>To assess the correlation between the result of the PET/CT study with [¹⁸F]FDG and the histological outcome in patients with esophageal cancer undergoing chemoradiotherapy and subsequent surgery.</div></div><div><h3>Material and methods</h3><div>41 patients (35 men) diagnosed with esophageal cancer during a 10-year interval were retrospectively evaluated. PERCIST criteria and SULpeak (ΔSULpeak) variation between pre- and post-treatment PET/CT studies were used. After neoadjuvant treatment and subsequent surgery, histological response and patient survival were determined, correlating the findings with the result of the metabolic study. Different parameters related to patient and tumors lesion characteristics were compared with respect to histologic response. ROC curves and the Kaplan-Meier method were applied for the analysis of prognostic factors and survival curves.</div></div><div><h3>Results</h3><div>The mean follow-up was 34.9 months, with 21 relapses-progressions and 25 deaths. Significant differences were demonstrated between histologic responses regarding PERCIST criteria and ΔSULpeak. Both showed adequate sensitivity and moderate specificity in relation to their histological correlation. No significant differences were found with respect to other parameters studied. Survival analysis showed significantly different progression-free survival curves for the ΔSULpeak and histologic outcome.</div></div><div><h3>Conclusion</h3><div>PERCIST criteria and ΔSULpeak differentiated between patients with and without histological response. ΔSULpeak and histological results proved to be prognostic factors. The results could help to personalize treatment and, together with other determinations, allow an active surveillance approach could be contemplated.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500088"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical muscle metastatic dissemination detected by [18F]FDG PET/CT in high-grade retroperitoneal leiomyosarcoma","authors":"R. Valverde-Jorge ,&nbsp;M. Díez-García ,&nbsp;I. Vinagre-Pérez ,&nbsp;L. Mosteiro-González ,&nbsp;I. Ratón-Zulueta ,&nbsp;I. Fernández-Tercero","doi":"10.1016/j.remnie.2025.500094","DOIUrl":"10.1016/j.remnie.2025.500094","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500094"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between [18F]-FDG PET/CT findings and pathological subtypes of lung adenocarcinoma presenting as ground-glass opacity","authors":"H. Ji ,&nbsp;S. Jiang ,&nbsp;C. Sun ,&nbsp;T. Liu ,&nbsp;G. Yang ,&nbsp;L. Zhang ,&nbsp;J. Sun ,&nbsp;J. Wu","doi":"10.1016/j.remnie.2024.500087","DOIUrl":"10.1016/j.remnie.2024.500087","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to analyze the correlation between [18F]-FDG PET/CT (positron emission tomography/computed tomography) findings and pathological subtypes of lung adenocarcinoma with ground-glass opacity (GGO).</div></div><div><h3>Materials and methods</h3><div>88 patients were included in this study, which underwent [18F]-FDG PET/CT and were finally diagnosed with lung adenocarcinoma. A total of 90 GGO lesions were analyzed. The size and SUV_max of all lesions were measured, the proportion of solid components of GGO in lesions was calculated, and quantitative classification was performed. The above GGO lesions were divided into three groups based on the 2011 IASLC/ATS/ERS lung adenocarcinoma pathological classification, namely good prognosis group, relatively good prognosis group and poor prognosis group. Chi-square test, independent sample t test, and analysis of variance were used for statistical analysis.</div></div><div><h3>Results</h3><div>There was a negative correlation between the SUV_max and quantitative classification value (<em>r</em> = −0.638, <em>P</em> &lt; 0.001). Atypical adenomatous hyperplasia (AAH), acinar predominant adenocarcinoma (APA), lepidic predominant adenocarcinoma (LPA), papillary predominant adenocarcinoma (PPA), and solid predominant adenocarcinoma (SPA) had significant differences in GGO lesion size, SUV_max, and quantitative classification value (<em>F</em> = 3.849, <em>P</em> = 0.019; <em>F</em> = 27.420, <em>P</em> &lt; 0.001; <em>F</em> = 4.353, <em>P</em> = 0.002). There were significant differences in GGO lesion size, SUV_max, and quantitative classification value among the good prognosis group, relatively good prognosis group, and poor prognosis group (<em>F</em> = 5.626, <em>P</em> = 0.011; <em>F</em> = 37.587, <em>P</em> &lt; 0.001; <em>F</em> = 5.119, <em>P</em> = 0.008).</div></div><div><h3>Conclusion</h3><div>GGO lesion size, SUV_max, and quantitative classification value are correlated with different pathological subtypes and can be used toevaluate the prognosis of lung adenocarcinoma with GGO.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500087"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single metastasis of cutaneous malignant melanoma in the gallbladder detected with 18F-FDG PET/CT","authors":"A. Bota-Bota,&nbsp;M. Pombo-López,&nbsp;I. Martínez-Rodríguez,&nbsp;F. Gómez-de la Fuente,&nbsp;J. Jiménez-Bonilla,&nbsp;R. Quirce","doi":"10.1016/j.remnie.2025.500120","DOIUrl":"10.1016/j.remnie.2025.500120","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500120"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal and pulmonary malakoplakia with mediastinal involvement simulating a synchronous neoplasm in PET/CT study with [18F]FDG","authors":"J.R. Garcia,&nbsp;A. Compte,&nbsp;S. Romero,&nbsp;L. Mont,&nbsp;L. Pinilla,&nbsp;E. Riera","doi":"10.1016/j.remnie.2025.500124","DOIUrl":"10.1016/j.remnie.2025.500124","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500124"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of [18F]FDG PET/CT in the management of primary bone lymphoma","authors":"M.M. Losada ,&nbsp;I.G. Megías ,&nbsp;R.M. Losada ,&nbsp;L.G.R. Robles ,&nbsp;X.B. Chollet ,&nbsp;R.R. Lasanta","doi":"10.1016/j.remnie.2025.500126","DOIUrl":"10.1016/j.remnie.2025.500126","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500126"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18F-choline PET/CT in the study of primary hyperparathyroidism: Evaluation of the technique, visual and semi-quantitative analysis and correlation with other imaging techniques","authors":"E. Campaña Díaz ,&nbsp;F. Gómez-Caminero López ,&nbsp;J. Manuel Álvarez Pérez ,&nbsp;C. Montes Fuentes ,&nbsp;S. Rama Alonso ,&nbsp;J. Ángel Badell Martínez ,&nbsp;P. García-Talavera San Miguel","doi":"10.1016/j.remnie.2025.500129","DOIUrl":"10.1016/j.remnie.2025.500129","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the usefulness of performing a dual-time-point protocol in the acquisition of ¹⁸F-choline (¹⁸<span><span><span><span>F-FCH) PET/CT in the pre-surgical localization of PHPT, and to demonstrate the impact of this </span>imaging technique<span> on the management and outcome-based surgical decision making, compared to other imaging techniques. To evaluate the diagnostic performance of the test to discriminate between pathological </span></span>parathyroid gland and </span>cervical lymph node, as well as to establish its correlation with other imaging techniques (scintigraphy, ultrasound, CT and MRI).</span></div></div><div><h3>Patients and methods</h3><div>We included 39 patients who underwent surgery for PHPT, in whom dual-time-point ¹⁸<span>F-FCH PET/CT was performed. Metabolic index of parathyroid<span> (P-SUVmax; P-SUVpeak), lymph node (N-SUVpeak), thyroid (T-SUVpeak) and mediastinum (M-SUVpeak) uptake were analyzed visually and semiquantitatively in both images. PET/CT results were correlated with </span></span>^99m<span>Tc-MIBI scintigraphy, ultrasound, MRI and CT.</span></div></div><div><h3>Results</h3><div><span>In 36 patients (92%), PET/CT was positive, localizing 38 pathological glands. The sensitivity (S) of PET/CT was 97% and positive predictive value (PPV) 94%. In the visual analysis, dual-time-point protocol was necessary in 61% of the cases. Correlation between PET/CT with MRI was 80%, with 4D-CT 50%, and with the other techniques &lt;50%. P-SUVmax shows correlation with adenoma weight and size, and with presurgical </span>PTH. The best cutoff point for SUVpeak to differentiate parathyroid vs. lymph node was 2.6 in early images (S = 70%; specificity = 75%; p = 0.007) and 0.86 for SUVpeak/T-SUVpeak index (S = 73%; specificity = 69%; p = 0.001).</div></div><div><h3>Conclusion</h3><div>¹⁸<span>F-FCH PET/CT is an excellent preoperative localization technique in patients with HPTP with negative, doubtful or inconclusive imaging techniques, being of vital importance in guiding minimally invasive surgery. The dual-time-point protocol was necessary in more than half of the cases (61%). The SUVpeak cut-off points to discriminate between parathyroid gland and lymph nodes were statistically significant.</span></div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 5","pages":"Article 500129"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycotic aortitis caused by intravesical BCG and concomitant lung cancer identified via FDG PET/CT","authors":"K. Oksuzoglu,&nbsp;N. Zumbul","doi":"10.1016/j.remnie.2025.500130","DOIUrl":"10.1016/j.remnie.2025.500130","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 5","pages":"Article 500130"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of fever on 18F-FDG PET/CT in vivo: Utilizing a quantitative parameter SUL","authors":"S. Huang ,&nbsp;M.S. Fang ,&nbsp;M. Zhao ,&nbsp;F. Li","doi":"10.1016/j.remnie.2025.500127","DOIUrl":"10.1016/j.remnie.2025.500127","url":null,"abstract":"<div><h3>Introduction</h3><div>Fever can affect the identification and efficacy evaluation of tumors on the ¹⁸<span>F-FDG PET/CT, and this effect can be reduced by referring to normal tissue metabolism.</span></div><div>The aim of the study was to analyze the influence of fever on glucose metabolism<span><span> in the mediastinal blood pool, liver, spleen, and bone marrow utilizing PET/CT quantitative parameter SUV normalized by </span>lean body mass (SUL).</span></div></div><div><h3>Materials and methods</h3><div><span>30 patients with fever of unknown origin and 24 patients for tumor screening with normal body temperature within 3 weeks, who underwent </span>¹⁸F-FDG PET/CT in our department, were analyzed retrospectively. The SUL_max and SUL_mean<span> of the mediastinal blood pool, liver, spleen, and bone marrow were respectively measured in the two groups, and the differences between the two groups were compared by independent sample t test or Wilcoxon–Mann–Whitney test.</span></div></div><div><h3>Results</h3><div>The SUL_max and SUL_mean of the liver in the fever group were lower than those in the control group (p = 0.001, 0.013). The SUL_max and SUL_mean of spleen and bone marrow in the fever group were higher than in the control group (all p &lt; 0.05). The SUL_max of the mediastinal blood pool in the fever group was lower than that in the control group (p = 0.007), but there was no significant difference in SUL_mean of the mediastinal between the fever group and the control group (t = 1.181, p = 0.221).</div></div><div><h3>Conclusion</h3><div><span>The fever can affect the glucose metabolism in internal organs. But there was no significant difference in the SUL</span>_mean of mediastinal blood pool. Perhaps the SUL_mean of the blood pool can be invoked as a calibration parameter in the evaluation of efficacy in tumor patients with fever.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 5","pages":"Article 500127"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}