Revista da Associacao Medica Brasileira (1992)最新文献

{"title":"Predicting treatment responses using magnetic resonance imaging-based radiomics in hepatocellular carcinoma patients undergoing transarterial radioembolization.","authors":"Sinan Sozutok, Ferhat Can Piskin, Huseyin Tugsan Balli, Sevinc Puren Yucel, Kairgeldy Aikimbaev","doi":"10.1590/1806-9282.20240721","DOIUrl":"10.1590/1806-9282.20240721","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluates the efficacy of magnetic resonance imaging-based radiomics in predicting treatment responses in hepatocellular carcinoma patients undergoing transarterial radioembolization.</p><p><strong>Methods: </strong>Pre-treatment magnetic resonance imaging scans from 65 hepatocellular carcinoma patients were analyzed. Radiomic features were extracted from axial T1-weighted and T2-weighted sequences using a standardized workflow involving image preprocessing, segmentation, and feature extraction. Multivariate logistic regression models combining radiomic and clinical features were developed to predict treatment outcomes. The performance of the models was evaluated using the area under the curve metric.</p><p><strong>Results: </strong>The study included 65 patients with a median age of 64 years; 44.6% showed a complete response, while 55.4% showed a non-complete response. The median radiomics score in the T1-weighted portal phase was -0.49 for non-complete responders and -0.07 for complete responders (p<0.001). In the T2-weighted sequence, the median radiomics score was -0.76 for non-complete responders and 1.1 for complete responders (p<0.001). Tumor size ≥5 cm was a significant predictor of non-complete response in univariate analysis (p=0.027) but not in multivariate analysis after adding radiomics scores. The area under the curve for the radiomics signature in predicting non-complete response was 0.754 for T1-weighted and 0.850 for T2-weighted sequences.</p><p><strong>Conclusion: </strong>Magnetic resonance imaging-based radiomics enhances the prediction of treatment responses in hepatocellular carcinoma patients undergoing transarterial radioembolization. Integrating radiomic features with clinical parameters significantly improves predictive accuracy.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"70 11","pages":"e20240721"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology in oncology: a mini review.","authors":"Eyyup Cavdar, Kubilay Karaboyun, Yakup Iriagac","doi":"10.1590/1806-9282.20241347","DOIUrl":"10.1590/1806-9282.20241347","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"70 12","pages":"e20241347"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in a Brazilian sample of patients with inflammatory bowel disease.","authors":"Khadija Assis Pascholatto, Laura Ribeiro Santos, Thelma Larocca Skare, Odery Ramos Júnior, Renato Nisihara","doi":"10.1590/1806-9282.20240963","DOIUrl":"10.1590/1806-9282.20240963","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory bowel diseases such as Crohn's disease and ulcerative colitis are influenced by environmental and immunological factors and may differ according to the patient's sex.</p><p><strong>Objective: </strong>The objective was to study the differences in the clinical profile of a Brazilian sample of inflammatory bowel disease patients according to sex.</p><p><strong>Methods: </strong>Retrospective study with chart review of 158 inflammatory bowel disease patients (43 with Crohn's disease and 115 with ulcerative colitis) from a single university hospital in southern Brazil.</p><p><strong>Results: </strong>The Crohn's disease sample showed a female/male ratio of 2.1, and the sample of ulcerative colitis showed a ratio of 1.5. The only significant difference found in the clinical profile was an increased constipation rate in female patients with ulcerative colitis. No other differences in epidemiological, symptom profile, or treatment could be detected.</p><p><strong>Conclusions: </strong>More females with inflammatory bowel diseases sought healthcare facilities compared to males. The only notable difference was a higher incidence of constipation symptoms among females; all other aspects were similar between the sexes.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"70 12","pages":"e20240963"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of mobilization with movement in patients operated for distal radius fracture: a single-blinded, randomized controlled study.","authors":"Levent Horoz, Basak Cigdem-Karacay, Ismail Ceylan, Halil Alkan","doi":"10.1590/1806-9282.20241190","DOIUrl":"10.1590/1806-9282.20241190","url":null,"abstract":"<p><strong>Objective: </strong>BACKGROUND: There are limited data on the use of Mulligan's mobilization with movement technique in patients who underwent surgery for distal radius fracture. AIMS: This study aimed to evaluate the effectiveness of adding Mulligan's mobilization with movement to the conventional exercise program for those who underwent open reduction and volar plate application due to distal radius fracture.</p><p><strong>Methods: </strong>This randomized controlled, single-blind study was conducted with 53 patients who had been operated on for distal radius fracture. The patients were divided into two groups, the mobilization with movement group and the control group. Patients in the mobilization with movement group were mobilized using Mulligan's mobilization with movement technique in addition to the rehabilitation program used in the control group. The degree of volar inclination and radial inclination were recorded. Radial height was measured in millimeters. Ulnar variance was recorded. Perimeter was measured using the Figure of Eight method. The range of motion of the joint was measured by goniometry. Hand grip strength was measured with Jamar® hand dynamometer, and pinch grip was measured with a pinch meter. The Patient-Rated Wrist Evaluation questionnaire was used to assess functionality.</p><p><strong>Results: </strong>There is no statistically significant difference identified between the groups (p>0.05). The intra-group changes in the data of the groups were found to be statistically significant in visual analog scale, range of motion, pinch grip, hand grip, and Patient-Rated Wrist Evaluation parameters (p<0.05). There was a statistically significant difference between the mobilization with movement group and the control group for pronation value and hand grip strength value in measurements (p<0.05).</p><p><strong>Conclusions: </strong>XThe mobilization with movement had no additive effect on parameters other than hand grip strength and pronation.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"70 11","pages":"e20241190"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male baldness and skin cancer: what are we missing in daily practice?","authors":"Hudson Dutra Rezende, Juliana Carvalho Delgado, Loanda Oliveira Fukuma, Marinna Sampaio Campos, Sandra Lopes Mattos E Dinato","doi":"10.1590/1806-9282.20241303","DOIUrl":"10.1590/1806-9282.20241303","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"70 11","pages":"e20241303"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual function in female business leaders: a cross-sectional study.","authors":"Renata Attili Maia, Gisele Vissoci Marquini, Manoel João Batista Castello Girão, Marair Gracio Ferreira Sartori, Zsuzsanna Ilona Katalin de Jarmy-Di Bella","doi":"10.1590/1806-9282.20241293","DOIUrl":"10.1590/1806-9282.20241293","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to provide a golden opportunity to access sexual function in women who act as leaders in companies through the use of an instrument validated for this purpose (the Female Sexual Function Index). The number of women in leadership positions has been gradually increasing, which shows the need for women to prepare themselves to reorganize the different aspects of life, including social, family, and personal factors as well as sexuality.</p><p><strong>Methods: </strong>This is a cross-sectional study involving female executives employed in private companies who answered the Female Sexual Function Index. A convenience sample was made up of 50 women in leadership positions who had been employed for at least 1 year and were aged between 35 and 50 years in childbearing age.</p><p><strong>Results: </strong>The mean total Female Sexual Function Index score of the evaluated sample was 22.6+7.6, characterizing sexual dysfunction, and the domain that was less negatively impacted was pain. It was also observed that all Female Sexual Function Index domains were worse in women between 41 and 50 years old (p<0.05), except desire.</p><p><strong>Conclusion: </strong>The total Female Sexual Function Index score of female company leaders was below the cutoff point for adequate sexual function. According to the results of this study and the applied methodology, professional success may not be associated with the quality of sexual life.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"70 12","pages":"e20241293"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of non-pharmacological interventions on sleep in premature infants: meta-analysis.","authors":"Fatma Şule Bilgiç, Aysu Yıldız Karaahmet, Berker Okay","doi":"10.1590/1806-9282.20241187","DOIUrl":"10.1590/1806-9282.20241187","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"70 11","pages":"e20241187"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of musical-animated toys and audiobooks on fear and pain in the tracheostomy care of children in the palliative care.","authors":"Gamze Akay, Türkan Kadiroğlu, Fatma Güdücü Tüfekci, Aysun Öncer, Döne Kiliç Bulut","doi":"10.1590/1806-9282.20241023","DOIUrl":"10.1590/1806-9282.20241023","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to evaluate the effects of musical-animated toys and audiobooks on the fear and pain in the tracheostomy care of children in the palliative care clinic.</p><p><strong>Methods: </strong>The study design was a single-center, single-arm, crossover-controlled study. The sample consisted of 16 children who were 3-6 years old. Musical-animated toys and audiobooks were used to divert the children's attention during tracheostomy care. The children whose control data were collected on the first day were shown musical-animated toys on the second day and listened to an audiobook a week later. The children were video-recorded during the interventions.</p><p><strong>Results: </strong>The children who received musical-animated toy and audiobook interventions during and after tracheostomy care expressed less pain than those in the control group, and their fear levels were less during the care.</p><p><strong>Conclusion: </strong>Audiobook and musical-animated toy interventions were effective in reducing children's procedure-related fear and pain during tracheostomy care in the pediatric palliative care clinic.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"70 12","pages":"e20241023"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor necrosis factor-alpha inhibitors may increase the need for fine-needle aspiration cytology in axial spondyloarthritis patients.","authors":"Zeynel Abidin Sayiner, Hayriye Sultan Munis, İpek Köroğlu, Elif Melis Baloğlu Akyol, Orhan Zengin, Ersin Akarsu","doi":"10.1590/1806-9282.20240871","DOIUrl":"10.1590/1806-9282.20240871","url":null,"abstract":"<p><strong>Objective: </strong>Tumor necrosis factor alpha inhibitors are frequently used in the treatment of axial spondyloarthritis. While tumor necrosis factor alpha is associated with some malignancies, studies on its effects on thyroid functions and thyroid nodules are limited. This study aimed to assess the effect of tumor necrosis factor alpha inhibitors treatments on the evaluation of thyroid nodules and thyroid function tests in axial spondyloarthritis patients.</p><p><strong>Methods: </strong>A total of 106 patients with axial spondyloarthritis, 48 receiving nonsteroidal antiinflammatory drugs and 58 receiving tumor necrosis factor alpha inhibitors, were included in the study. All cases were screened by ultrasound for the presence of nodules, European Thyroid Association - Thyroid Imaging Reporting and Data System classification category, thyroid volume, and thyroid function tests.</p><p><strong>Results: </strong>The prevalence of patients with multiple nodules in the tumor necrosis factor alpha inhibitors treatment group was significantly higher compared to the nonsteroidal antiinflammatory drug group (68.2 vs. 38.1%, p=0.033). Furthermore, the prevalence of nodules measuring ≥1 cm in the tumor necrosis factor alpha inhibitors treatment group was higher compared to the only nonsteroidal antiinflammatory drug treatment group (56 vs. 19.05%, p=0.011). In the tumor necrosis factor alpha inhibitors treatment group, the proportion of patients with nodules requiring fine-needle aspiration cytology was higher compared to the nonsteroidal antiinflammatory drug group (34.5 vs. 16.7%, p=0.038). No significant difference was found between thyroid-stimulating hormone and free thyroxine values before and during treatment in both groups (p>0.005).</p><p><strong>Conclusion: </strong>The number of nodules requiring fine-needle aspiration cytology according to the European Thyroid Association - Thyroid Imaging Reporting and Data System classification seems higher in nonsteroidal antiinflammatory drugs users than Tumor necrosis factor-alpha inhibitor users. Therefore, it may be rational to examine the thyroid gland while administering Tumor necrosis factor-alpha inhibitor treatment in axial spondyloarthritis patients.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"70 12","pages":"e20240871"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring the effect of antiviral treatment on the development of cirrhosis and hepatocellular carcinoma in chronic hepatitis B patients.","authors":"Kamil Mert, Bengu Tatar, Yasemin Nadir, Suheyla Serin Senger","doi":"10.1590/1806-9282.20240803","DOIUrl":"10.1590/1806-9282.20240803","url":null,"abstract":"<p><strong>Objective: </strong>Despite the availability of treatment and vaccines for chronic hepatitis B infection, it remains a public health problem. The use of nucleos(t)ide antiviral agents is effective in preventing complications such as cirrhosis and hepatocellular carcinoma, but despite the reduction, the risk persists. The objective of this study was to assess alterations in aspartate aminotransferase to platelet ratio index and Fibrosis-4 scores and examine the effectiveness of risk estimates for HCC in chronic hepatitis B scores in predicting the risk of hepatocellular carcinoma among chronic hepatitis B patients undergoing prolonged antiviral treatment.</p><p><strong>Methods: </strong>This is a retrospective 10-year follow-up study that included chronic hepatitis B patients who received antiviral treatment. The alterations in aspartate aminotransferase to platelet ratio index and Fibrosis-4 scores were examined for the first, fifth, and tenth years. In addition, the expected long-term risk of hepatocellular carcinoma, if antiviral treatment was not initiated, was calculated using the risk estimates for HCC in chronic hepatitis B scores before treatment, and the incidence of hepatocellular carcinoma despite long-term antiviral treatment was compared with these values.</p><p><strong>Results: </strong>The study included a total of 218 chronic hepatitis B patients. A noteworthy decline in aspartate aminotransferase to platelet ratio index and Fibrosis-4 scores was noted across all fibrosis groups, irrespective of the initial degree of fibrosis, during the first year of antiviral treatment. Following the calculation using risk estimates for HCC in chronic hepatitis B scores, one case was observed compared to the expected 15.04 cases of hepatocellular carcinoma.</p><p><strong>Conclusion: </strong>We showed that both aspartate aminotransferase to platelet ratio index and Fibrosis-4 scores significantly decreased until the fifth year of antiviral treatment, with a prominent decline occurring in the first year. This study demonstrates that the impact of antiviral treatment on fibrosis can be monitored using noninvasive fibrosis scores.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"70 12","pages":"e20240803"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}