Revista da Associacao Medica Brasileira (1992)最新文献

{"title":"Associations with short-term and long-term use of inhaled corticosteroid in adults with asthma. A retrospective analysis.","authors":"Ariele Pedroso, Joice Mara de Oliveira, Thainá Bessa Alves, Vitória Cavalheiro Puzzi, Natielly Soares Correia, Heloisa Galdino Gumieiro Ribeiro, Marcos Ribeiro, Karina Couto Furlanetto","doi":"10.1590/1806-9282.20241240","DOIUrl":"10.1590/1806-9282.20241240","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to compare anthropometric data and pulmonary and extrapulmonary physical functional outcomes of short- and long-term use of inhaled corticosteroids in adults with asthma.</p><p><strong>Methods: </strong>This cross-sectional study with retrospective analysis included clinically stable adults with asthma. Anthropometric data, exacerbation history, pulmonary function, disease control, dyspnea in daily life, quality of life, anxiety, depression, functional exercise capacity, performance in daily activities, body composition, physical activity level, respiratory muscle strength, lower limb strength, and handgrip strength were assessed and compared. Participants were separated into two groups based on the current duration of inhaled corticosteroids use below (short-term) or above (long-term) 3 years (≤3 years [n=37] and >3 years [n=30]) for comparative analysis.</p><p><strong>Results: </strong>A total of 67 participants were analyzed (69% female, 49±14 years, body mass index 29±6 kg/m², FEV1 2.21±0.79 L). The group ≤3 years presented statistically higher spirometric values and exercise capacity compared to the group >3 years even after analysis of covariance adjustments for age, body mass index, disease control, and treatment duration (forced vital capacity 3.39 [3.09-3.70] L vs. 2.93 [2.59-3.26] L, p=0.048; FEV1 2.40 [2.17-2.63] L vs. 2.00 [1.75-2.25] L, p=0.023; 6-min walk test 567 [536-599] vs. 519 [484-554] m, respectively, p=0.048). All the other variables were similar between groups (p>0.05 for all).</p><p><strong>Conclusion: </strong>Participants who used inhaled corticosteroids for more than 3 years exhibited worse pulmonary function and exercise capacity. Despite this, exacerbation history, disease control, quality of life, anxiety, depression, and dyspnea in daily life, among other physical functional outcomes, were similar between short- and long-term use of inhaled corticosteroids in adults with asthma.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 6","pages":"e20241240"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Musculoskeletal problems and health perceptions of women who applied to the orthopedic clinic after cesarean section.","authors":"Muhsin Dursun","doi":"10.1590/1806-9282.20241804","DOIUrl":"10.1590/1806-9282.20241804","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to retrospectively investigate the musculoskeletal problems and health perceptions of women who applied to the orthopedic clinic after cesarean delivery.</p><p><strong>Methods: </strong>This study used a descriptive and cross-sectional design. It was conducted with 243 women who sought treatment in an orthopedic clinic between January 2023 and May 2024. Women who agreed to participate in the study, who had a cesarean section for the first time, who did not have any musculoskeletal problems before the cesarean section, who had musculoskeletal problems for a year or more after the cesarean section, and who sought treatment in the orthopedics and traumatology outpatient clinic were included in the study. Data were collected through the \"Personal Information Form,\" the \"Extended Nordic Musculoskeletal Questionnaire,\" and the \"Nottingham Health Profile.\"</p><p><strong>Results: </strong>The average age of the participating women was 32.61±6.89 years. Of all the women, 44.8% experienced pain mostly in the back and lower back region within the last year following cesarean delivery. Nottingham Health Profile scores were negatively affected by several variables such as age, weight gained during pregnancy, BMI, and musculoskeletal disorders (p<0.050). An analysis of the effect sizes showed that Cohen's d values for back and lower back regions according to pain experience within the last year were 1.07 and 1.07, respectively, indicating a high effect size.</p><p><strong>Conclusions: </strong>Musculoskeletal problems, particularly in the back and lower back regions, negatively affect women's overall health perception after cesarean delivery.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 6","pages":"e20241804"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for benign prostatic hyperplasia: a comprehensive review.","authors":"Mário Henrique Bitar Siqueira","doi":"10.1590/1806-9282.20250343","DOIUrl":"10.1590/1806-9282.20250343","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 6","pages":"e20250343"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Postoperative evaluation of interleukin-8 and C1q/TNF-related protein-12 in patients undergoing coronary artery bypass grafting surgery\".","authors":"Ömer Faruk Rahman, Fevzi Ayyıldız","doi":"10.1590/1806-9282.20250435","DOIUrl":"10.1590/1806-9282.20250435","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 6","pages":"e20250435"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis of the Brazilian contribution to anesthesiology and pain management publications.","authors":"Italo Carvalho Martins, Luís Phelipe Gama de Moraes, Bianca Sousa Belfort Ferreira, Ian Gabriel Lucchese de Sá Cruz, Vinicius Freire Pereira, Isabela Pinheiro Souza, Ed Carlos Rey Moura, Caio Márcio Barros de Oliveira, Plínio da Cunha Leal","doi":"10.1590/1806-9282.20250021","DOIUrl":"10.1590/1806-9282.20250021","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 6","pages":"e20250021"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum heat shock protein 90 alpha levels in mild and severe preeclampsia.","authors":"Kübra Hamzaoğlu Canbolat, Abdullah Serdar Açıkgöz, Koray Gök, Abdullah Tüten, Barış Kaya, Tuğba Kolomuç Gayretli, Mustafa Doğan Özçil, Eduard Malik, Onur Güralp","doi":"10.1590/1806-9282.20241990","DOIUrl":"10.1590/1806-9282.20241990","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to assess serum heat shock protein 90 alpha levels as a marker in preeclampsia.</p><p><strong>Methods: </strong>This cross-sectional study was carried out in 2015 at Istanbul Cerrahpasa University, University Hospital for Obstetrics and Gynecology. The mild (n=60) and severe (n=60) preeclampsia groups were compared with healhty, uncomplicated pregnancies, matched for gestational age within ±1 week (n=120). The main inclusion criteria were women between 18 and 40 years old who had a singleton pregnancy. Pregnant women with any known medical diseases (chronic hypertension, renal diseases, inflammatory diseases, or infections), regular contractions with cervical changes, and premature rupture of membranes were excluded from the study.</p><p><strong>Results: </strong>Median serum heat shock protein 90 alpha was significantly elevated in mild preeclamptic women compared to women in the gestational age-matched control group [3.41 vs. 2.62 ng/mL, p<0.001]. The mean serum heat shock protein 90 alpha levels were significantly elevated in the severe preeclampsia group compared to their gestational age-matched control group [3.94 vs. 2.55 ng/mL, p<0.001]. Mean serum heat shock protein 90 alpha levels were comparable between the mild and severe preeclampsia groups (3.41 vs. 3.94 ng/mL, p=0.407) and mild early-onset and severe early-onset groups (p=0.104). Serum heat shock protein 90 alpha showed a weak positive correlation with both systolic and diastolic arterial blood pressure.</p><p><strong>Conclusion: </strong>Heat shock protein 90 alpha level was elevated in preeclamptic patients. The level of heat shock protein 90 alpha in serum may be suitable for evaluating endothelial dysfunction.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 6","pages":"e20241990"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effectiveness of three different conservative methods in myogenous temporomandibular disorders.","authors":"Nazım Tolgahan Yıldız, Zafer Erden, Gürsoy Coşkun, Filiz Can, Hakan Hıfzı Tüz","doi":"10.1590/1806-9282.20242102","DOIUrl":"10.1590/1806-9282.20242102","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to compare the effectiveness of exercise, transcutaneous electrical nerve stimulation, and manual therapy on pain intensity, maximum mouth opening, and masticatory muscle activity-during chewing of the masseter and temporalis anterior in myogenous temporomandibular disorders.</p><p><strong>Methods: </strong>A total of 51 myogenous temporomandibular disorders patients were randomly assigned to three groups: exercise group, transcutaneous electrical nerve stimulation group, and manual therapy group. For 6 weeks, exercise group received exercise only, transcutaneous electrical nerve stimulation group received exercise+transcutaneous electrical nerve stimulation, and manual therapy group received exercise+manual therapy. At baseline and after 6-week treatment, pain intensity was assessed using a visual analog scale, maximum mouth opening using a millimeter ruler, and masticatory muscle activity-during chewing of the masseter and temporalis anterior using surface electromyography.</p><p><strong>Results: </strong>After treatment, significant improvements in pain intensity, maximum mouth opening, and masticatory muscle activity-during chewing values were found in all the three groups. The greatest improvements were seen in manual therapy group. The decreases in pain intensity and increases in masticatory muscle activity-during chewing values were statistically significantly higher in transcutaneous electrical nerve stimulation group than in exercise group (p<0.05). The increases in maximum mouth opening were similar in transcutaneous electrical nerve stimulation group and exercise group.</p><p><strong>Conclusion: </strong>Exercise is an effective method for improving pain intensity, maximum mouth opening, and masticatory muscle activity-during chewing in myogenous temporomandibular disorders. Combining exercise with manual therapy may provide the highest therapeutic effect on these parameters. Combining exercise with transcutaneous electrical nerve stimulation may also lead to further improvements in pain intensity and masticatory muscle activity-during chewing.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 6","pages":"e20242102"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Predictive efficacy of immature granulocytes in acute complicated appendicitis\".","authors":"Enes Ağırman, Rıfat Peksöz, Sabri Selçuk Atamanalp","doi":"10.1590/1806-9282.20250286","DOIUrl":"10.1590/1806-9282.20250286","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 6","pages":"e20250286"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of asymmetric dimethylarginine, arginine, galectin-3, and echocardiographic data with bipolar disorder and schizophrenia.","authors":"Gökçe Kavak Sinanoğlu, Memduha Aydın, Kürşat Altınbaş, Sedat Abuşoğlu, Kenan Erdem","doi":"10.1590/1806-9282.20241948","DOIUrl":"10.1590/1806-9282.20241948","url":null,"abstract":"<p><strong>Objective: </strong>Cardiovascular mortality in schizophrenia and bipolar disorder patients is more than double that of the general population. There appears to be a dual effect between cardiovascular diseases and schizophrenia and bipolar disorder. Inflammation and increased oxidative stress cause cardiac remodeling and increase the severity of psychiatric illness.</p><p><strong>Methods: </strong>Echocardiographic imaging was performed simultaneously with serum samples obtained for asymmetric dimethylarginine, symmetric dimethylarginine, monomethyl-L-arginine, arginine and its metabolites, and galectin 3 levels in 80 patients with bipolar disorder who were euthymic for at least 8 weeks and 69 patients with schizophrenia undergoing treatment.</p><p><strong>Results: </strong>Monomethyl-L-arginine and arginine levels were significantly higher in bipolar disorder patients compared to schizophrenia patients. Galectin 3 level was significantly higher in bipolar disorder patients with psychotic symptoms compared to schizophrenia patients. There was no significant difference between the groups in terms of other parameters. Statistically significant differences were found between bipolar disorder and schizophrenia patients in terms of diastolic diameter (mm), systolic diameter (mm), interventricular septum (mm), left atrium (mm), and posterior wall (mm) values.</p><p><strong>Conclusion: </strong>Arginine and its metabolites, asymmetric dimethylarginine, symmetric dimethylarginine, and galectin 3, may be important biomarkers of cardiovascular diseases risk. In this study, changes in biochemical parameters and cardiac structure could not be explained by disease severity.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 6","pages":"e20241948"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of intermittently absent end-diastolic flow of the fetal umbilical artery on perinatal and neonatal outcomes.","authors":"Zeynep Kayaoglu Yildirim, Alperen Ince, Isil Turan Bakirci, Gokhan Bayanmelek, Gokhan Bolluk","doi":"10.1590/1806-9282.20242005","DOIUrl":"10.1590/1806-9282.20242005","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to compare the perinatal outcomes of pregnancies with intermittently absent end-diastolic umbilical artery Doppler flow and persistently absent flow, focusing on their implications for clinical management.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted at Basaksehir Cam and Sakura City Hospital between 2020 and 2023, and included 137 pregnancies diagnosed with either intermittently absent end-diastolic umbilical artery Doppler flow (n=38) or persistently absent flow (n=99). Demographic data, pregnancy complications, delivery details, and neonatal outcomes were analyzed.</p><p><strong>Results: </strong>The mean latency from diagnosis to delivery was statistically significantly longer in the intermittently absent end-diastolic umbilical artery Doppler flow group (15.6 days) than in the persistently absent flow group (7.88 days; p<0.0001). The intermittently absent end-diastolic umbilical artery Doppler flow group demonstrated better outcomes, with a higher gestational age at delivery and improved Apgar scores. Notably, although the difference was not statistically significant, all stillbirths (n=4) occurred in the persistently absent flow group. No intergroup differences were found in terms of intensive care unit admission or neonatal intubation.</p><p><strong>Conclusion: </strong>This study highlights an important prognostic distinction between intermittently absent end-diastolic umbilical artery Doppler flow and persistently absent flow, with intermittently absent end-diastolic umbilical artery Doppler flow representing a less severe form of placental insufficiency. These findings provide valuable insights for optimizing antenatal surveillance strategies, suggesting that intermittently absent end-diastolic umbilical artery Doppler flow cases may be candidates for outpatient management, whereas persistently absent flow cases require more intensive monitoring.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 6","pages":"e20242005"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}