Revista da Associacao Medica Brasileira (1992)最新文献

{"title":"Investigation of the relationship between venous thromboembolism and thrombophilic variants.","authors":"Ayca Kocaaga, Müfide Okay Özgeyik","doi":"10.1590/1806-9282.20241171","DOIUrl":"10.1590/1806-9282.20241171","url":null,"abstract":"<p><strong>Objective: </strong>Venous thromboembolism could be manifested as deep venous thrombosis or pulmonary embolism. The aim of this study was to assess the impact of genetic risk factors including prothrombin 20210, Factor V Leiden, plasminogen activator inhibitor 4G/5G, and Factor XIII V34L on the occurrence of venous thromboembolism in patients.</p><p><strong>Methods: </strong>This study was conducted on 128 patients with deep venous thrombosis and 84 patients with pulmonary embolism. The diagnosis of venous thromboembolism was based on the patient's history, clinical findings, and D-dimer and confirmed by Doppler ultrasonography or computed tomography angiography. After confirmation of venous thromboembolism diagnosis, both groups were assessed for the four abovementioned mutations.</p><p><strong>Results: </strong>The majority of deep venous thrombosis patients were much younger than pulmonary embolism patients, with a median age of 51.7 years. It was observed that plasminogen activator inhibitor 4G/5G was most commonly represented in the deep venous thrombosis (44.5%) group, followed by the pulmonary embolism (44.0%) group. The second-highest frequency of Factor XIII V34L was observed in the deep venous thrombosis (28.1%) and pulmonary embolism (32.1%) groups. Factor V Leiden heterozygosity was also common in the deep venous thrombosis (18.0%) and pulmonary embolism (27.4%) groups. We found that coagulation factor II (FII) G20210A heterozygosity was the least in the deep venous thrombosis (10.9%) and pulmonary embolism (9.5%) groups.</p><p><strong>Conclusion: </strong>To date, only a few studies have been thrombophilia parameters associated with venous thromboembolism, particularly Factor XIII V34L, in Turkish population with venous thromboembolism patients. Our findings suggest that genetic risk factors play a role in the formation of venous thromboembolism.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20241171"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and delivery outcomes in coronavirus disease 2019: a cross-sectional study from a tertiary center.","authors":"Suzan Şahin, Bülent Kaya, Emre Mat, Gazi Yıldız, Adil Barut","doi":"10.1590/1806-9282.20240842","DOIUrl":"10.1590/1806-9282.20240842","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to document the clinical and laboratory characteristics and maternal and delivery outcomes of pregnant women with coronavirus disease 2019.</p><p><strong>Methods: </strong>We retrospectively assessed pregnant women who had been admitted either with symptoms of coronavirus disease 2019 or for delivery from March 2020 to January 2023. The participants were evaluated in two cohorts: the initial cohort included all pregnant women hospitalized with coronavirus disease 2019, and the final cohort included those who delivered under the circumstances of coronavirus disease 2019.</p><p><strong>Results: </strong>The initial cohort included 295 pregnant women with symptomless (n=124, 42%), mild (n=122, 41.4%), moderate (n=18, 6.1%), and severe (n=31, 10.5%) coronavirus disease 2019. Among comorbidities, hypothyroidism (n=40, 13.6%) had the highest share. The most frequent laboratory abnormality was elevated D-dimer levels (94.6%). The final cohort included 193 women. Eight patients (4.1%) required intensive care unit (ICU) stay. Mortality occurred in five patients (2.6%). Out of 121 cesarean section (SC) deliveries, 61.2% were on an emergency basis. Rates of preterm, low birth weight, and stillbirth were 18.7%, 14.5%, and 3.1%, respectively. Moderate-severe coronavirus disease 2019 showed significant inverse correlations with delivery week, birth weight, and APGAR scores at 1 and 5 min (p<0.0001).</p><p><strong>Conclusion: </strong>A considerable proportion of pregnant women with coronavirus disease 2019 experienced maternal and delivery complications, particularly preterm and low birth weight. Hypothyroidism had a notable share among comorbidities.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20240842"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional decline in nonagenarians admitted for hip fracture.","authors":"Sonia Jiménez-Mola, María Plaza-Carmona, Francisco Javier Idoate Gil, Pilar Sáez-López, Paula Fernández García, Jesús Seco-Calvo","doi":"10.1590/1806-9282.20240796","DOIUrl":"10.1590/1806-9282.20240796","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to determine the characteristics of nonagenarian patients admitted for hip fracture and assess whether they present differences in complications and functional outcomes at discharge compared to younger patients.</p><p><strong>Methods: </strong>Prospective longitudinal study in patients over 75 years of age admitted for hip fracture over a 1-year period. A total of 542 patients were included, of which 165 patients were aged over 90 years (30.9%). Demographic variables, pre-fracture functional status, medical history, type of fracture, functional evolution, discharge destination, and mortality were collected. Differences between the two population groups were analyzed.</p><p><strong>Results: </strong>Of the 542 patients over 75 years admitted for hip fracture, 165 were aged over 90 years (30.9%), 74.5% were women, 62% were independently ambulatory prior to the fracture, and 70% had a Barthel Index score >60. Cognitive impairment was absent in 49% of cases. Surgical treatment was performed in 91.5% of cases. There were no differences in the baseline status when compared to younger patients (aged 75-89 years) except for a higher likelihood of residing in a nursing home (OR 1.74; CI 1.18-2.55). Nonagenarian patients were at higher risk of not being able to walk at discharge (OR 2.00; CI 1.29-3.10). Discharge to a nursing home or functional recovery unit was more likely (OR 1.85; CI 1.22-2.81).</p><p><strong>Conclusion: </strong>Patients over 90 years of age are more susceptible to worsening their function during admission and have a higher risk of not being able to walk at discharge. Efforts should be made to reverse this decline in order to reduce the associated mortality.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20240796"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Being a parent of children with attention-deficit hyperactivity disorder.","authors":"Derya Evgin, Nuray Caner, Elif Bilge Alimoğlu, Yağmur Sezer Efe","doi":"10.1590/1806-9282.20241335","DOIUrl":"10.1590/1806-9282.20241335","url":null,"abstract":"<p><strong>Objective: </strong>This study was conducted to determine the relationship between stress and anxiety levels of parents of children with attention-deficit hyperactivity disorder and parent-child behaviors.</p><p><strong>Methods: </strong>The study was conducted with parents (n=181) of children with attention-deficit hyperactivity disorder who were followed up in the Child Psychiatry Outpatient Clinic of a tertiary hospital in Turkey. Ethics committee approval and institutional permissions were obtained, and data were collected using the Questionnaire Form, Conner's Parent Rating Scale, Alabama Parenting Questionnaire, and State Anxiety Inventory. Descriptive statistics, correlation, and linear regression analyses were used for data analysis.</p><p><strong>Results: </strong>Of the parents who participated in the study, 86.2% were mothers of children diagnosed with attention-deficit hyperactivity disorder. The mean scores of the Conner's Parent Rating Scale, Alabama positive and negative parental attitudes, and the State Anxiety Inventory were 42.44±17.12, 69.92±7.27, ±37.22±9.23, and 38.29±8.33, respectively. There was a significant positive relationship at a moderate level between the mean scores of the parents' State Anxiety Inventory, a significant positive relationship at a weak level between the mean scores of the parents' negative parenting behaviors and Conner's Parent Rating Scale, and a significant negative relationship at a weak level with the mean scores of the parents' positive parenting behaviors (p<0.05).</p><p><strong>Conclusion: </strong>In this study, it was found that anxiety of parents of children diagnosed with attention-deficit hyperactivity disorder was associated with perceived stress, negative parenting behaviors, and behavioral problems of children.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20241335"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collision tumor in the thyroid gland, \"even with\" Hashimoto's thyroiditis: a double-edged sword in thyroidology?","authors":"Ilkay Cinar, Ilker Sengul","doi":"10.1590/1806-9282.20240146","DOIUrl":"10.1590/1806-9282.20240146","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20240146"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between hope and religious beliefs in Turkish women experiencing pregnancy loss.","authors":"Nurdan Kaya Yılmaz, Nazlı Baltacı, Emel Odabaşoğlu","doi":"10.1590/1806-9282.20240792","DOIUrl":"10.1590/1806-9282.20240792","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to determine the level of hope and religious attitudes and the relationship between them in women experiencing pregnancy losses.</p><p><strong>Methods: </strong>This descriptive and cross-sectional study was conducted on 249 women hospitalized in perinatology clinics. Data from the participants were collected using the \"Pregnancy Diagnosis Form,\" \"Dispositional Hope Scale,\" and \"Religious Attitude Scale.\"</p><p><strong>Results: </strong>The mean total Religious Attitude Scale and Dispositional Hope Scale scores of the women were 34.02±5.26 and 49.92±8.30, respectively. A significant, albeit weak, positive correlation was observed between the mean total Religious Attitude Scale and Dispositional Hope Scale scores (p<0.01).</p><p><strong>Conclusion: </strong>The Religious Attitude Scale and Dispositional Hope Scale scores of women who experienced a PL were relatively high and above the intermediate level, respectively. Therefore, in women who experienced pregnancy losses, an increase in religious attitudes was associated with an increase in hope for the future.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20240792"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between lipoprotein(a) and coronary heart disease risk in type 2 diabetes mellitus and evaluation of statin treatment effects.","authors":"Li Li, Liwu Xu","doi":"10.1590/1806-9282.20240870","DOIUrl":"10.1590/1806-9282.20240870","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate the association between lipoprotein(a) and coronary heart disease risk in type 2 diabetes mellitus patients and evaluate the effectiveness of statin therapy.</p><p><strong>Methods: </strong>This retrospective analysis included 120 patients diagnosed with type 2 diabetes mellitus. Of these, 90 patients diagnosed with coronary heart disease via coronary angiography received rosuvastatin treatment for over 6 months. The remaining 30 patients exhibited no coronary heart disease or other diabetic macrovascular complications and had not received any lipid-lowering treatment. Patients with type 2 diabetes mellitus and coronary heart disease were categorized into two groups based on the severity of coronary lesions. Baseline characteristics and blood lipid data were compared among groups. Logistic regression analysis was employed to investigate the association between lipoprotein(a) and coronary heart disease risk in type 2 diabetes mellitus patients. Receiver operating characteristic curves were utilized to evaluate the diagnostic value of lipoprotein(a) for coronary heart disease.</p><p><strong>Results: </strong>Compared with the control group, lipoprotein(a) levers were higher in both the mild and severe groups. Logistic regression analysis demonstrated that lipoprotein(a) is independently associated with the risk of coronary heart disease in type 2 diabetes mellitus patients. The area under the receiver operating characteristic curve for lipoprotein(a) was 0.729. When lipoprotein(a) was 97.5 mg/L, the diagnosis of coronary heart disease had high sensitivity and specificity. After statin therapy, high-density lipoprotein cholesterol and apolipoprotein A levels increased, while other lipid parameters decreased. However, the lipoprotein(a) level decrease was not statistically significant.</p><p><strong>Conclusion: </strong>Lipoprotein(a) is an independent risk factor for coronary heart disease in type 2 diabetes mellitus patients. Lipid-lowering therapy with statins alone cannot reduce lipoprotein(a) levels.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20240870"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is magnesium sulfate useful for tracheal intubation? A systematic review of randomized controlled trials.","authors":"Fabiano Timbó Barbosa, Hermann Silva Brito Lima Buarque de Gusmão, Laura Queiroz Teixeira de Albuquerque, Natália de Oliveira Lima, Célio Fernando de Sousa-Rodrigues, Raul Ribeiro de Andrade","doi":"10.1590/1806-9282.20241237","DOIUrl":"10.1590/1806-9282.20241237","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20241237"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issues that cannot be ignored: the decline in adropin over the aging process.","authors":"Yanting Zhang, Penghao Yang","doi":"10.1590/1806-9282.20241186","DOIUrl":"10.1590/1806-9282.20241186","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20241186"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of auditory interventions on pain in premature infants: a systematic review and meta-analysis.","authors":"Elif Doğan, Gülçin Bozkurt, Rukiye Duman","doi":"10.1590/1806-9282.20241000","DOIUrl":"10.1590/1806-9282.20241000","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20241000"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}