Revista da Associacao Medica Brasileira (1992)最新文献

{"title":"Sleep deprivation in third-trimester pregnancies is multi-causal and requires careful differential consideration.","authors":"Carla Alexandra Scorza, Fulvio Alexandre Scorza, Josef Finsterer","doi":"10.1590/1806-9282.20241690","DOIUrl":"10.1590/1806-9282.20241690","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 5","pages":"e20241690"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of serum agouti-related peptide levels in women with polycystic ovary syndrome.","authors":"Gülsüm Kırılmaz, İbrahim Kale","doi":"10.1590/1806-9282.20241836","DOIUrl":"10.1590/1806-9282.20241836","url":null,"abstract":"<p><strong>Objective: </strong>Agouti-related peptide, secreted by the terminals of agouti-related peptide neurons in the hypothalamus and released into the systemic circulation, has been implicated in regulating food intake, obesity, and the development of insulin resistance. Therefore, the aim of this study was to evaluate serum agouti-related peptide levels in women with polycystic ovary syndrome.</p><p><strong>Methods: </strong>This cross-sectional, case-control study included 88 women with polycystic ovary syndrome and 88 age- and body mass index-matched controls. Serum agouti-related peptide levels were quantified using commercial enzyme-linked immunosorbent assay kits. First, serum agouti-related peptide levels were compared between the control and polycystic ovary syndrome groups, followed by comparisons between the subgroups.</p><p><strong>Results: </strong>The median serum agouti-related peptide level was 331.1 ng/L in the polycystic ovary syndrome group and 362 ng/L in the control group (p=0.994). Both the polycystic ovary syndrome and control groups were further stratified by body mass index into normal weight and overweight subgroups. Serum agouti-related peptide levels were similar across all the four subgroups (p=0.717). Additionally, the polycystic ovary syndrome group was divided into five subgroups based on polycystic ovary syndrome phenotype and compared with the control group regarding serum agouti-related peptide levels. Serum agouti-related peptide levels were comparable across the five subgroups (p=0.267).</p><p><strong>Conclusions: </strong>Serum agouti-related peptide levels were comparable between the polycystic ovary syndrome and non-polycystic ovary syndrome groups and in the subgroup analyses. Although the sample size was insufficient to draw definitive conclusions, the results suggest that serum agouti-related peptide levels are unlikely to play a significant role in the pathophysiology of polycystic ovary syndrome or be directly influenced by the condition.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 5","pages":"e20241836"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotyping of the gene polymorphisms FASL 844C/T and FAS 670A/G in patients with idiopathic infertility in Iraq.","authors":"Abbas Ali Manshd, Mohammed Ali Alaboudi, Abbas Abdulameer Al-Raad","doi":"10.1590/1806-9282.20241860","DOIUrl":"10.1590/1806-9282.20241860","url":null,"abstract":"<p><strong>Objective: </strong>The failure to conceive following 12 months of unprotected intercourse is referred to as infertility. About 35% of the instances include women and 30% involve men.</p><p><strong>Aim: </strong>The aim of this study was to investigate the gene polymorphisms FASL-844C/T and FAS-670A/G in the promoter region to evaluate susceptibility to male infertility.</p><p><strong>Methods: </strong>We have investigated single-nucleotide polymorphisms of FAS-670A/G gene and FASL-844C/T gene in 100 subjects. A total of 50 male patients with infertility constituted the infertility group and another group consisting of 50 apparently healthy individuals comprised the control group.</p><p><strong>Results: </strong>The prevalence rate of FAS-670A/G gene polymorphism was statistically significant among both azoospermia and oligospermia subgroups, the homozygous mutant genotype GG (p=0.014 and p=0.043), and mutant allele G (p=0.001 and p=0.004), respectively. Also, FASL-844C/T gene polymorphism was statistically significant among both azoospermia and oligospermia subgroups, the homozygous mutant genotype TT (p=0.032 and p=0.032), and mutant allele T (p=0.007 and p=0.002), respectively.</p><p><strong>Conclusions: </strong>FAS homozygous mutant genotype (GG) and FASL homozygous mutant genotype (TT) act as etiologic factors in male infertility.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 5","pages":"e20241860"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between health literacy and healthy lifestyle behaviors of women with preeclampsia.","authors":"Merve Kolcu, Nur Bahar Kuru Aktürk, Gizem Öztürk, Mine Akkuş","doi":"10.1590/1806-9282.20241801","DOIUrl":"10.1590/1806-9282.20241801","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to explore the relationship between the levels of health literacy and healthy lifestyle behaviors in women with preeclampsia. This research was planned as a descriptive relational study.</p><p><strong>Methods: </strong>The data were collected from 251 pregnant women with preeclampsia who were admitted to a training and research hospital between February and July 2024. The Patient Information Form, Health Literacy Scale, and Healthy Lifestyle Behaviours in Pregnancy Scale were used for data collection.</p><p><strong>Results: </strong>The mean Health Literacy Scale total score of the women was 76.25±14.48, and the mean Healthy Lifestyle Behaviours in Pregnancy Scale total score was 110.17±17.57. A moderate positive correlation was found between the mean total scores of the scales (r=0.365, p<0.05).</p><p><strong>Conclusion: </strong>As health literacy levels increased among women diagnosed with preeclampsia, the level of healthy lifestyle behaviors also increased. It would be beneficial to integrate the topic of health literacy into prenatal care and pregnancy preparation classes.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 5","pages":"e20241801"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How can we predict mortality in acute stroke?","authors":"Egidio Bezerra da Silva Neto, Williames Matheus Malaquias da Silva, Wendel Aguiar Carlini, Luana Karoline Castro Silva, Guilherme Dias Miranda Salgado Ribeiro, Julio Martinez Santos, Johnnatas Mikael Lopes","doi":"10.1590/1806-9282.20250057","DOIUrl":"10.1590/1806-9282.20250057","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 5","pages":"e20250057"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic value of serum C-reactive protein/albumin and homocysteine/high-density lipoprotein-cholesterol in coronary microvascular angina pectoris.","authors":"Wenxin Zhao, Xianfeng Zhao, Zhongyan Li","doi":"10.1590/1806-9282.20241772","DOIUrl":"10.1590/1806-9282.20241772","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate the correlation between the serum C-reactive protein/albumin ratio and homocysteine/high-density lipoprotein-cholesterol ratio with microvascular angina and assess their predictive value.</p><p><strong>Methods: </strong>A total of 70 patients diagnosed with microvascular angina comprised the observation group, while 68 patients with normal or minimal (<50%) coronary stenosis and normal coronary blood flow formed the control group. Serum C-reactive protein, albumin, homocysteine, high-density lipoprotein-cholesterol, and other indexes were measured, and C-reactive protein/albumin and homocysteine/high-density lipoprotein-cholesterol ratios were calculated. Logistic regression, Pearson's correlation, and receiver operating characteristic analyses were conducted to identify independent risk factors for microvascular angina.</p><p><strong>Results: </strong>Significant differences in C-reactive protein, C-reactive protein/albumin, homocysteine, and homocysteine/high-density lipoprotein-cholesterol levels were found between the microvascular angina and control groups (p<0.05). Multivariate logistic regression analysis showed that C-reactive protein, C-reactive protein/albumin, homocysteine, and homocysteine/high-density lipoprotein-cholesterol were independent risk factors for microvascular angina, with the risk increasing alongside elevated C-reactive protein/albumin and homocysteine/high-density lipoprotein-cholesterol levels. The receiver operating characteristic analysis demonstrated that C-reactive protein/albumin, homocysteine/high-density lipoprotein-cholesterol, and their combined use were predictive of microvascular angina, with the combined area under the curve value exceeding that of individual markers.</p><p><strong>Conclusions: </strong>Elevated C-reactive protein/albumin and homocysteine/high-density lipoprotein-cholesterol offer predictive value for microvascular angina diagnosis, with the combination providing superior diagnostic accuracy over individual indicators, supporting early microvascular angina identification.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 5","pages":"e20241772"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do surgeries have a number needed to treat of 1.0?","authors":"José Nunes de Alencar, Ana Camila de Castro Gandolfi","doi":"10.1590/1806-9282.20250347","DOIUrl":"10.1590/1806-9282.20250347","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 5","pages":"e20250347"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of nursing students' health literacy level on their knowledge and attitude toward epilepsy.","authors":"Kezban Koraş Sözen, Neziha Karabulut","doi":"10.1590/1806-9282.20241808","DOIUrl":"10.1590/1806-9282.20241808","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate the effect of nursing students' health literacy level on their epilepsy knowledge and attitude.</p><p><strong>Methods: </strong>Descriptive and cross-sectional study data were collected using a descriptive characteristics form, Epilepsy Knowledge Scale, Epilepsy Attitude Scale, and European Health Literacy Scale-Turkish adaptation.</p><p><strong>Results: </strong>The mean Epilepsy Knowledge Scale and Epilepsy Attitude Scale scores were moderate, and the mean European Health Literacy Scale-Turkish adaptation score was adequate. The health literacy level significantly explained participants' epilepsy knowledge.</p><p><strong>Conclusions: </strong>Epilepsy knowledge levels among nurses are intermediate, which reveals the fact that the nursing education curriculum should be revised. It is suggested that courses on health literacy impacting the level of knowledge and attitude toward epilepsy be added to the nursing education curriculum.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 5","pages":"e20241808"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methyltransferase gene-mediated antiproliferative effect of 1,25(OH)2D3 on neuroblastoma cells.","authors":"Okan Sancer","doi":"10.1590/1806-9282.20241269","DOIUrl":"10.1590/1806-9282.20241269","url":null,"abstract":"<p><strong>Objective: </strong>1,25-Dihydroxyvitamin D3 is the body's active form of vitamin D and is also known as calcitriol. It has an effect on the body's immune system and is involved in the regulation of cell growth, differentiation, and apoptosis.</p><p><strong>Methods: </strong>The effect of 1,25-Dihydroxyvitamin D3 on the viability of human neuroblastoma human neuroblastoma cell line cells was investigated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide assay, the effect on migration was investigated by wound healing assay, and methyltransferase genes (DNA methyltransferase 3 alpha and DNA methyltransferase 3 beta) and phosphatase and tensin homolog gene expression levels were investigated by real time polymerase chain reaction method.</p><p><strong>Results: </strong>As a result of the 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide assay, 1,25-Dihydroxyvitamin D3 IC50:265.6 nM was found. It was observed that 100 and 265.6 nM applied to human neuroblastoma cell line cells had an antiproliferative effect. In addition, DNA methyltransferase 3 alpha and DNA methyltransferase 3 beta genes, which are effective as methyltransferases, caused a change in expression levels (p<0.05), while phosphatase and tensin homolog expression levels did not change (p>0.05).</p><p><strong>Conclusion: </strong>1,25-Dihydroxyvitamin D3 showed antiproliferative, antimigratory activity on neuroblastoma human neuroblastoma cell line cells and decreased the expression levels of genes involved in methylation, which may be evidence of its anticancer effect.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 5","pages":"e20241269"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of testicular parenchyma in COVID-19 patients: a case-control study using ultrasound histogram analysis.","authors":"Mehmet Demir, Hatem Kazımoğlu","doi":"10.1590/1806-9282.20250074","DOIUrl":"10.1590/1806-9282.20250074","url":null,"abstract":"<p><strong>Objective: </strong>Uncontrolled activation of immune cells, such as lymphocytes and macrophages, can result in heightened inflammatory cytokine production, leading to oxidative stress and cell death in various organs, including the brain and testes. The systemic effects of COVID-19 are not limited to the respiratory system and can also affect other organs. The aim of this study was to focus on the possible effects of COVID-19 infection on the testicles in male patients.</p><p><strong>Methods: </strong>Ultrasound images of 50 patients who were shown to have COVID-19 infection by polymerase chain reaction method and 50 healthy volunteers who did not have any complaints and were polymerase chain reaction negative were evaluated retrospectively. While forming the patient and control groups, people who smoked or had diseases such as varicocele, which caused testicular parenchyma to be affected, were excluded from the study. Tissue histogram analysis was performed on the images obtained, including the entire testicular parenchyma, and radiomics were obtained. The Mann-Whitney U test and independent samples t-test were used to compare parametric and non-parametric results in independent groups.</p><p><strong>Results: </strong>The average age of the patient group and control group was 32.13±7.3 years and 31.23±7.9 years, respectively, and no statistically significant difference was detected (p>0.05). When testicular volumes in the patient and control groups were compared, no statistically significant difference was detected (p=0.58). Statistically significant differences were found between the two groups in the radiomics examined using skewness of histogram, zone-size non-uniformity of gray-level size-zone matrix, information measure of correlation of gray-level co-occurrence matrix, run percentage of gray-level run-length matrix, high gray-level run emphasis of gray-level run-length matrix, and kurtosis of histogram (p<0.05). There was no significant difference in other parameters.</p><p><strong>Conclusion: </strong>Ultrasound histogram analysis may be useful in showing heterogeneity, which is an indicator of the impact on the testicular parenchyma in people with COVID-19 infection. Thus, in addition to other clinical findings and laboratory parameters, ultrasound histogram analysis may be helpful in demonstrating testicular parenchymal involvement in the follow-up of patients after COVID-19.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 5","pages":"e20250074"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}