Revista da Associacao Medica Brasileira (1992)最新文献

{"title":"Perinatal outcomes after laser photocoagulation of anastomoses in monochorionic pregnancies.","authors":"Talita Micheletti, Gabriela Pigozzi, Marina Pereira Domingues, Mariana Ziliotto Sgnaolin, Marcelo Brandão da Silva, Mauricio Obal Colvero, Edward Araujo Júnior","doi":"10.1590/1806-9282.20250330","DOIUrl":"10.1590/1806-9282.20250330","url":null,"abstract":"<p><strong>Objective: </strong>To describe the perinatal outcomes of monochorionic pregnancies complicated with twin-to-twin transfusion syndrome, laser photocoagulation of placental anastomoses was presented as an initial experience in a reference center in South Brazil.</p><p><strong>Methods: </strong>Case series between October 2020 and March 2024, including monochorionic twin/triplet pregnancies complicated with twin-to-twin transfusion syndrome. This syndrome was classified according to Quintero's stage. The maternal and surgical characteristics, as well as the perinatal outcomes were assessed.</p><p><strong>Results: </strong>Of the 17 pregnant women diagnosed with twin-to-twin transfusion syndrome, 11 (64.7%) were treated at our center, including 9 monochorionic-diamniotic, 1 dichorionic-triamniotic, and 1 monochorionic-diamniotic triplet. Of the 9 laser ablations of placental anastomoses included in the study, 8 (88.9%) had 2 or more live births, and 1 (11.1%) had no live births. The mean gestational age at surgery was 21.9 weeks. Regarding Quintero stage at the time of surgery, 2 were stage I, 3 were stage II, and 4 were stage IV. The interval between surgery and delivery was 10.8 weeks, with a mean gestational age at delivery of 32.7 weeks. The mean birth weight of the recipient was 1,845 g, and that of the donor was 1,667.8 g.</p><p><strong>Conclusion: </strong>Our initial experience with laser ablation of placental anastomoses in monochorionic pregnancies complicated by twin-to-twin transfusion syndrome showed good perinatal outcomes with lower complication rates.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 8","pages":"e20250330"},"PeriodicalIF":1.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspartate Aminotransferase to Platelet Ratio Index (APRI), Göteborg University Cirrhosis Index (GUCI), and Fibrosis 4 Score (FIB-4) proved to be the optimal biomarkers for the assessment of liver fibrosis in patients chronically infected with hepatitis C virus in Brazil.","authors":"Bianca Peixoto Dantas, Mariana Cavalheiro Magri, Caroline Manchiero, Arielle Karen da Silva Nunes, Thamiris Vaz Gago Prata, Fátima Mitiko Tengan","doi":"10.1590/1806-9282.20250241","DOIUrl":"10.1590/1806-9282.20250241","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 8","pages":"e20250241"},"PeriodicalIF":1.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic median arcuate ligament release with an antegrade approach in adolescents and young adults: a single center experience.","authors":"Kutay Bahadir, Demet Sarıdemir Ünal, Selin Ural, Yunus Emre Sacın, Ayse Keven, Gungor Karaguzel, Ayhan Mesci","doi":"10.1590/1806-9282.20250082","DOIUrl":"10.1590/1806-9282.20250082","url":null,"abstract":"<p><strong>Objective: </strong>Median arcuate ligament syndrome is a rare pathology where the median arcuate ligament causes compression on the celiac trunk. Different techniques are utilized in the treatment of median arcuate ligament syndrome, and studies on a standard laparoscopic technique are limited. The aim of this study is to evaluate the surgical and clinical outcomes of patients who underwent laparoscopic \"antegrade\" release of median arcuate ligament in a single tertiary center.</p><p><strong>Methods: </strong>This retrospective study includes nine adolescents/young adults who underwent laparoscopy for median arcuate ligament syndrome between 2016 and 2024. All laparoscopic procedures were performed with an antegrade approach. The patients' demographic data, symptoms, radiologic imaging methods, operative technique, and postoperative outcomes were recorded.</p><p><strong>Results: </strong>There were seven female and two male patients in our series. The median age at diagnosis was 17 (range: 15-26) years. The most common symptoms were postprandial abdominal pain (n=9), nausea and vomiting (n=8), and weight loss (n=7). Doppler ultrasonography and/or computed tomography angiography (n=9, 100%) were performed in all patients as preoperative diagnostic imaging. The mean operation time was 92 (range: 60-110) min. The mean oral intake time was 1.2 (range: 1-3) days. The mean hospitalization time was 3 (range: 2-5) days. There was no conversion to laparotomy. One patient had a recurrence during follow-up and underwent a secondary intervention. The mean follow-up time was 62.6 (3-88) months.</p><p><strong>Conclusion: </strong>Laparoscopic median arcuate ligament release with an antegrade approach is safe and feasible to perform and adequate in terms of symptom relief and celiac artery compression release in both adolescent and young adult groups.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 8","pages":"e20250082"},"PeriodicalIF":1.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The silent epidemic: domestic violence and its devastating impact on women's health.","authors":"José Maria Soares Júnior, Débora Krakauer, Edmund Chada Baracat","doi":"10.1590/1806-9282.2025718EDIT","DOIUrl":"10.1590/1806-9282.2025718EDIT","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 8","pages":"e2025718EDIT"},"PeriodicalIF":1.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopy without uterine manipulator vs. laparotomy in endometrial cancer: a retrospective study.","authors":"Selçuk Erkılınç, Sena Özcan, Ayşe Betül Öztürk, Serhan Can İşcan, Ufuk Atlıhan, Can Ata, Hüseyin Aytuğ Avşar, Tevfik Berk Bildacı, İlker Çakır","doi":"10.1590/1806-9282.20250434","DOIUrl":"10.1590/1806-9282.20250434","url":null,"abstract":"<p><strong>Objective: </strong>The objective of the study was to evaluate perioperative and oncologic outcomes of laparoscopy without the use of uterine manipulators and laparotomy in high-grade and serous endometrial cancer.</p><p><strong>Methods: </strong>Patients with grade III endometrioid adenocarcinoma and serous carcinoma between 2018 and 2022 were included in the study. Preoperative staging with positron emission tomography/computed tomography or thoracoabdominal computed tomography and pelvic magnetic resonance imaging was performed. All patients underwent staging surgery including hysterectomy, bilateral salpingo-oophorectomy, peritoneal washing, omentectomy, and pelvic and paraaortic lymphadenectomy up to the renal vein. No uterine manipulator was used for laparoscopic hysterectomy. Age, CA 125 level, body mass index, accompanying diseases, pathologic data including stage, lymphovascular invasion, number of pelvic and paraaortic lymph nodes, and surgical data including surgical time, surgical complications, and adjuvant therapies were collected from the hospital database retrospectively.</p><p><strong>Results: </strong>Notably, 89 patients were included in the study: 34 underwent laparotomy and 55 underwent laparoscopy. Surgical times were similar between the groups. The mean pelvic lymph node count in the laparotomy and laparoscopy groups was 33 and 34, respectively. The mean paraaortic lymph node counts in the laparotomy and laparoscopy groups were 23 and 22, respectively. Red blood cell transfusion, hemorrhage, urinary tract infection, postoperative fever, bladder atony, bladder injury, and chylous leakage showed no significant differences between the groups. However, ileus, intestinal injury, and evisceration were significantly higher in the laparotomy group. Hospital stay was significantly longer in the laparotomy group compared with the laparoscopy group. Overall and recurrence-free survival were similar between the groups.</p><p><strong>Conclusion: </strong>Laparoscopic surgery, performed without manipulators, provides comparable oncologic outcomes to open surgery in the treatment of high-grade endometrial cancer, while also offering improved perioperative results.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 8","pages":"e20250434"},"PeriodicalIF":1.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine levels in juvenile idiopathic arthritis and its types.","authors":"Seyda Dogantan, Burcu Bozkaya Yücel, Sevde Hasanoğlu Sayin, Sema Nur Taskin, Yasemin Oyaci, Sacide Pehlivan","doi":"10.1590/1806-9282.20250181","DOIUrl":"10.1590/1806-9282.20250181","url":null,"abstract":"<p><strong>Objective: </strong>Juvenile idiopathic arthritis is the most common chronic rheumatic disease of autoimmune origin in childhood. While altered DNA methylation has been associated with adult autoimmune rheumatic diseases, studies on juvenile idiopathic arthritis remain limited. This study evaluated levels of 5-methylcytosine and 5-hydroxymethylcytosine, important epigenetic biomarkers, in juvenile idiopathic arthritis and its subtypes.</p><p><strong>Methods: </strong>This single-center cross-sectional study included patients diagnosed with juvenile idiopathic arthritis aged 1 month to 18 years. Children with systemic or autoimmune diseases and comorbidities were excluded. The study comprised 58 juvenile idiopathic arthritis patients and 35 age-gender-matched healthy controls presenting with non-rheumatological complaints. Demographic and clinical characteristics, including juvenile idiopathic arthritis subtypes, were recorded. The 5-methylcytosine and 5-hydroxymethylcytosine levels were assessed quantitatively using an enzyme-linked immunosorbent assay kit. The relationships between 5-methylcytosine and 5-hydroxymethylcytosine and juvenile idiopathic arthritis and its subtypes were evaluated statistically.</p><p><strong>Results: </strong>The 5-hydroxymethylcytosine level was significantly higher, whereas the 5-methylcytosine and 5-methylcytosine/5-hydroxymethylcytosine ratios were significantly lower in the patient group than in the control group. No significant differences between different juvenile idiopathic arthritis subtypes and disease activity status were found in 5-hydroxymethylcytosine and 5-methylcytosine levels or 5-methylcytosine/5-hydroxymethylcytosine ratios (p>0.05). The 5-methylcytosine/5-hydroxymethylcytosine ratio, with an optimal cut-off value of ≤28.05, demonstrated a sensitivity of 70.69% and a specificity of 77.14% in distinguishing juvenile idiopathic arthritis patients from controls (p<0.001).</p><p><strong>Conclusion: </strong>5-Hydroxymethylcytosine and 5-methylcytosine can be potential biomarkers for juvenile idiopathic arthritis and its subtypes, indicating their roles in juvenile idiopathic arthritis development regarding molecular mechanisms and novel therapeutic approaches.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 8","pages":"e20250181"},"PeriodicalIF":1.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in remnant cholesterol levels after coronary angiography: inflammation and cardiovascular risk assessment.","authors":"Reşat Dikme, Mahmut Padak, Yusuf Güler, Ayşegül Sarpkaya, Ömer Göç, Ömer Faruk Çiçek","doi":"10.1590/1806-9282.20250423","DOIUrl":"10.1590/1806-9282.20250423","url":null,"abstract":"<p><strong>Objective: </strong>Remnant cholesterol is an important component of triglyceride-rich lipoproteins and has emerged as an important potential biomarker for the assessment of cardiovascular risk. The aim of the study is to examine acute changes in remnant cholesterol levels pre- and post-angiography and evaluate their relationship with inflammatory markers.</p><p><strong>Methods: </strong>A total of 183 patients who underwent coronary angiography were included in this retrospective study. Remnant cholesterol, low-density lipoprotein, high-density lipoprotein, creatine kinase-myocardial band, Troponin-T, C-reactive protein, and white blood cell levels were analyzed pre- and post-angiography. Correlation and regression analyses were used to evaluate the relationships between the data.</p><p><strong>Results: </strong>Remnant cholesterol levels increased significantly post-angiography (p<0.05), while low-density lipoprotein showed no significant change (p=0.0588). C-reactive protein levels were significantly higher post-angiography than pre-angiography (p<0.05), which was considered as an indicator of procedure-related inflammatory response. Correlation analysis found a significant inverse relationship between baseline remnant cholesterol and post-angiography C-reactive protein (p<0.05). However, in a multivariable regression, C-reactive protein did not have a significant independent effect on remnant cholesterol levels (p>0.05). Baseline remnant cholesterol (pre-angiography) levels showed an inverse association with post-procedure troponin T (β=-0.014, p<0.05), whereas post-angiography remnant cholesterol demonstrated no significant correlation with troponin T (p>0.05).</p><p><strong>Conclusion: </strong>This study reveals significant post-angiography increases in remnant cholesterol, indicating acute metabolic and inflammatory changes. While these findings enhance understanding of remnant cholesterol dynamics during vascular interventions, the lack of long-term outcomes necessitates cautious interpretation. Future research should validate its prognostic value and therapeutic implications. Remnant cholesterol shows potential as a biomarker but requires further investigation before clinical implementation.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 8","pages":"e20250423"},"PeriodicalIF":1.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychospiritual effects of visitation on hospitalized children.","authors":"Hüseyin Çaksen","doi":"10.1590/1806-9282.20250542","DOIUrl":"10.1590/1806-9282.20250542","url":null,"abstract":"","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 8","pages":"e20250542"},"PeriodicalIF":1.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the use of vaginal progesterone a factor in pregnant women diagnosed with gestational diabetes mellitus?","authors":"Ayşe Rabia Kanbak, Deniz Can Öztekin","doi":"10.1590/1806-9282.20250444","DOIUrl":"10.1590/1806-9282.20250444","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate the effect of vaginal progesterone used to prevent spontaneous preterm birth in the development of gestational diabetes mellitus.</p><p><strong>Methods: </strong>This is a cross-sectional study that investigated pregnant women aged 18-39 years. The study participants underwent a 2-h, 75-g oral glucose tolerance test at 24 and 28 weeks of gestation. A total of 3,066 patients met the inclusion criteria, and 418 were diagnosed with gestational diabetes mellitus based on at least one abnormal plasma glucose value during screening. The remaining 2,648 patients, who had normal plasma glucose levels, were classified as the control group. The two groups were compared based on various factors, including age, parity, pre-pregnancy body mass index, smoking status, gestational age, and use of vaginal progesterone.</p><p><strong>Results: </strong>The use of vaginal progesterone was statistically significant at a higher rate in the gestational diabetes mellitus group compared to the control group (22.0 vs. 16.0%; p=0.002). The mean duration of vaginal progesterone use was 53.4±14.6 days (ranging from 28 to 90 days), and this duration was statistically significantly longer in the gestational diabetes mellitus group (59.9±14.8 vs. 52.0±14.2; p<0.001).</p><p><strong>Conclusion: </strong>The findings suggest that the use of vaginal progesterone may increase the risk of gestational diabetes mellitus, and the risk appears to rise with the duration of progesterone use. It is important to consider that patients on prolonged vaginal progesterone, particularly those started early in pregnancy, may be at increased risk of diabetes. Therefore, it may be advisable to repeat the oral glucose tolerance test performed at 24-28 weeks in the following weeks.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 8","pages":"e20250444"},"PeriodicalIF":1.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of high-grade human papillomavirus-induced cervical lesions between human immunodeficiency virus-positive and human immunodeficiency virus-negative women.","authors":"Flávia Werner da Rocha Jesuino, Edward Araujo Júnior, Levon Badiglian-Filho","doi":"10.1590/1806-9282.20250214","DOIUrl":"10.1590/1806-9282.20250214","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to compare the evolution of high-grade human papillomavirus-induced cervical lesions between human immunodeficiency virus-positive and human immunodeficiency virus-negative women.</p><p><strong>Methods: </strong>Human immunodeficiency virus-positive and human immunodeficiency virus-negative women were enrolled in a retrospective cohort study after undergoing large-loop excision of the transformation zone between January 2008 and December 2017 as participants in the high-grade cervical lesion screening program. The evolution of human papillomavirus lesions induced in human immunodeficiency virus-infected women was evaluated in comparison with the general population. The following potentially confounding variables were examined: age at treatment and at the end of follow-up, histologic grade of treated intraepithelial disease, compromised margins, adequacy of colposcopy during follow-up, and recurrence of histopathologic diagnosis of high-grade squamous intraepithelial lesion.</p><p><strong>Results: </strong>Of the 195 women, 51 were human immunodeficiency virus-positive (26.2%) and 144 were human immunodeficiency virus-negative (73.8%). Age of menarche (11.8±1.5) and sexarche (14.5±2.2) were earlier in human immunodeficiency virus-positive women (p=0.021 and 0.006, respectively). Parity (2.35±109) and number of pregnancies (2.86±1.47) were higher in human immunodeficiency virus-positive women (p=0.027 and 0.018, respectively). The prevalence of incomplete schooling was lower in human immunodeficiency virus-positive women (47.1 vs. 19.8%, p=0.002). Smoking was more common in human immunodeficiency virus-positive women (58.8 vs. 31.9%, p=0.001). Compromised surgical margins were found in 33.3% of human immunodeficiency virus-positive and 16.7% of human immunodeficiency virus-negative women (p<0.001). The risk of recurrence was 37.3% in human immunodeficiency virus-positive and 13.9% in human immunodeficiency virus-negative women (p<0.001). Cumulative survival over months was shortened in human immunodeficiency virus-positive women (p<0.001).</p><p><strong>Conclusion: </strong>human immunodeficiency virus-positive women in this cohort had a significantly higher risk of recurrence than human immunodeficiency virus-negative women in addition to shorter overall survival.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 8","pages":"e20250214"},"PeriodicalIF":1.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}