Revista da Associacao Medica Brasileira (1992)最新文献_第2页

The use of dupilumab in children and adolescents with severe atopic dermatitis: a systematic review and meta-analysis.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.1590/1806-9282.2024D711

Maria Fernanda Mollaco Navarro da Cruz, Luca Schiliró Tristão, Clara Lucato Dos Santos, Sandra Lopes Mattos E Dinato, Wanderley Marques Bernardo

引用次数: 0

Tregs in pregnancy with type 1 diabetes mellitus: pilot study.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.1590/1806-9282.20241283

Juliana Malafaia Von, Rosiane Mattar, Erika Ono, Evelyn Traina, Karen Priscilla Tezotto Pendeloski, Patricia Medici Dualib, Edward Araujo Júnior, Silvia Daher

{"title":"Tregs in pregnancy with type 1 diabetes mellitus: pilot study.","authors":"Juliana Malafaia Von, Rosiane Mattar, Erika Ono, Evelyn Traina, Karen Priscilla Tezotto Pendeloski, Patricia Medici Dualib, Edward Araujo Júnior, Silvia Daher","doi":"10.1590/1806-9282.20241283","DOIUrl":"10.1590/1806-9282.20241283","url":null,"abstract":"Objective: Pregnancy in women with type 1 diabetes mellitus has been associated with adverse outcomes due to persistent hyperglycemia and impaired maternal-fetal interactions. Regulatory T cells seem to exert a critical role in this process. Pregnancy can change the profile of Treg cells and affect the outcome of pregnancy; therefore, our purpose was to characterize the profile of regulatory T cells in the peripheral blood of pregnant and nonpregnant (controls) women with type 1 diabetes mellitus.Methods: This prospective case-control study recruited 36 women with type 1 diabetes mellitus, 16 pregnant and 20 nonpregnant. Peripheral blood samples were collected in the three trimesters of pregnancy and only once in the control group. Flow cytometry was used to assess peripheral blood T subpopulations: CD3+, CD4+, CD8+, CD4+ Treg (CD4+CD25+CD127-FOXP3+), and CD8+ Treg (CD8+CD25+FOXP3). In addition, the expression of CD4+CD25high and CD4+CD25low was analyzed.Results: Compared to controls, the pregnant women (regardless of the trimester) presented a lower percentage of TCD4+CD25high, TCD4+CD25low, and CD8 Treg (CD8+CD25+FOXP3+). Moreover, a higher percentage of total TCD8+ lymphocytes was observed in pregnant women than in controls.Conclusion: This study reported changes in the circulating Treg cell profile that seem to be associated with pregnancy in type 1 diabetes mellitus patients and pregnancy outcomes.","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20241283"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of associations between polycystic ovary syndrome and INSR gene polymorphisms rs2059806 and rs2252673.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.1590/1806-9282.20241056

Emre Taşkin, Semra Eroğlu

{"title":"Investigation of associations between polycystic ovary syndrome and INSR gene polymorphisms rs2059806 and rs2252673.","authors":"Emre Taşkin, Semra Eroğlu","doi":"10.1590/1806-9282.20241056","DOIUrl":"10.1590/1806-9282.20241056","url":null,"abstract":"Objective: The etiology of polycystic ovary syndrome is still clearly unknown. Research results indicate that polycystic ovary syndrome may be a multifactorial disease whose inheritance pattern is potentially autosomal dominant. INSR gene polymorphisms are frequently seen among polycystic ovary syndrome patients who also have insulin resistance. The aim of this study was to investigate associations between INSR gene polymorphisms rs2059806 and rs2252673 with polycystic ovary syndrome.Methods: A total of 48 polycystic ovary syndrome and 50 control subjects were recruited in this case-control study. A real-time polymerase chain reaction method (particularly the cycle threshold method) was used for polymorphism genotyping. Genotype and allele frequencies as well as the effects of the genotypes on having polycystic ovary syndrome were evaluated by appropriate statistical methods. Also, differences between genotypes in terms of clinical characteristics were tested.Results: There was no difference in genotype and allele frequencies between the polycystic ovary syndrome and control groups when calculated under both additive and dominant models (p>0.05). The polycystic ovary syndrome group showed significantly higher mean testosterone levels (p<0.001) and significantly lower estradiol (p=0.006), follicle-stimulating hormone (p=0.021), and progesterone (p<0.001) levels compared to controls. The GG genotype (polymorphic) of the rs2252673 polymorphism in the polycystic ovary syndrome group showed significantly higher mean testosterone and progesterone levels compared to both GC and CC genotypes (p=0.004 and p=0.019, respectively).Conclusion: Being the first of its kind that investigates associations between polycystic ovary syndrome and INSR gene rs2059806 and rs2252673 polymorphisms in a population from Turkey, the present study detected no association.","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20241056"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity classification: a comparative study of machine learning models excluding weight and height data.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.1590/1806-9282.20241282

Ahmed Cihad Genc, Erkut Arıcan

引用次数: 0

Comparative study of long-term efficacy of spinal fusion surgery and non-surgical treatment for chronic radicular lumbar disease.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.1590/1806-9282.20240902

Yuanmei Li, Huijuan Song, Hongzhen Zhou, Jungui Zhou, Zhou Zhou

{"title":"Comparative study of long-term efficacy of spinal fusion surgery and non-surgical treatment for chronic radicular lumbar disease.","authors":"Yuanmei Li, Huijuan Song, Hongzhen Zhou, Jungui Zhou, Zhou Zhou","doi":"10.1590/1806-9282.20240902","DOIUrl":"10.1590/1806-9282.20240902","url":null,"abstract":"Objective: The objective of this study was to compare the long-term efficacy of spinal fusion surgery versus non-surgical treatment for chronic radicular lumbar spondylopathy.Methods: A total of 93 patients with chronic radicular lumbar spondylopathy admitted to our hospital from February 2020 to February 2021 were randomly divided into a non-surgical group (n=46, conservative treatment) and a surgical group (n=47, spinal fusion surgery). Efficacy, recurrence rate, pain index, lumbar function recovery, and quality of life were evaluated and compared between the groups.Results: The surgical group had a higher total effective rate (97.87 vs. 86.96%, p<0.05) and a lower recurrence rate after 1 year (4.26 vs. 21.74%, p<0.05) compared to the non-surgical group. There was no significant difference in visual analog scale scores for lower back pain and lower limb pain between the groups before treatment and for the first 3 days (p>0.05). However, at 1 month, 3 months, and 1 year after treatment, the visual analog scale scores were significantly lower in the surgical group (p<0.05). The Japanese Orthopedic Association score showed no significant difference before treatment (p>0.05) but increased significantly in the surgical group after 1 month, 3 months, and 1 year (p<0.05). Similarly, there was no significant difference in the Short Form 36-Item Health Survey score before treatment (p>0.05), but the surgical group had significantly higher scores after 1 year (p<0.05).Conclusion: Spinal fusion surgery offers better long-term efficacy than non-surgical treatment for chronic radicular lumbar spondylopathy. It effectively alleviates lower back and limb pain, promotes lumbar function recovery, and improves quality of life, making it a recommended treatment option.","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20240902"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superstitions and practices of women in the perinatal period in Turkey: a cross-sectional study.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.1590/1806-9282.20241206

Fatma Şule Bilgiç, Aysu Yildiz Karaahmet

{"title":"Superstitions and practices of women in the perinatal period in Turkey: a cross-sectional study.","authors":"Fatma Şule Bilgiç, Aysu Yildiz Karaahmet","doi":"10.1590/1806-9282.20241206","DOIUrl":"10.1590/1806-9282.20241206","url":null,"abstract":"Objective: In this study, it was aimed to examine the superstitions and practices of women about pregnancy, birth, puerperium, and baby care.Methods: The cross-sectional study was conducted on the online platform in May-June 2023 with 612 women across Turkey. The data were obtained through the \"Data Collection Form\" and the \"Non-Functional Belief and Practices Scale.\"Results: The study was completed with 612 women. Notably, 77.7% of the women participating in the study are single and 73.3% live in the city. Notably, 39.1% believed in traditional methods and 70.8% did not use a traditional practice. It was found that there was a significant difference between the total score of the scale and all its subdimensions, the place of living, and belief in traditional practices. The mean age of the women was 24.79±7.54 years, the NFBPS-P related to Pregnancy subdimension was 88.72±13.40, the NFBPS-CB related to Childbirth subdimension was 30.90±5.38, the NFBPS-P subdimension of Postpartum was 35.70±5.74, the NFBPS-IC related to Infant Care subdimension was 71.35±8.79, and the mean total score of the Non-Functional Belief and Practices Scale was 226.68±27.08. There was a positive correlation between the total score of the women and all subdimensions of the Non-Functional Belief and Practices Scale (p<0.05).Conclusion: It was found that women's nonfunctional beliefs and practices related to pregnancy, childbirth, puerperium, and baby care were high. It was determined that women living in the city and believing in traditional practices had higher beliefs and practices in nonfunctional practices.","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20241206"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The reliability of the mini mental state examination and Montreal Cognitive Assessment for assessing cognitive impairment also depends on the type of cognitive deficits.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.1590/1806-9282.20241310

Josef Finsterer

引用次数: 0

Aging anxiety levels of women in menopause and associated factors.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.1590/1806-9282.20240573

Sabriye Uçan Yamaç, Nazife Bakir

{"title":"Aging anxiety levels of women in menopause and associated factors.","authors":"Sabriye Uçan Yamaç, Nazife Bakir","doi":"10.1590/1806-9282.20240573","DOIUrl":"10.1590/1806-9282.20240573","url":null,"abstract":"Objective: The aim of this study was to find out the aging anxiety levels of menopausal women applying to primary healthcare facilities and identify the associated factors.Methods: This research was conducted on a face-to-face basis with 527 menopausal women applying to family health centers in the district of Serik in Antalya province of Turkey from March 1, 2022, to July 1, 2022, and agreeing to participate in the study. After participant women's sociodemographic and menopausal data were recorded, the Aging Anxiety Scale for Menopausal Women was administered to all participant women.Results: Of 527 participant women, 41.7% were aged 50-57 years, 71.7% were elementary school graduates, 76.5% were married, 63.0% were housewives, 54.6% were from nuclear families, 49.3% spent a large part (two-thirds) of their lives in the district, 52.8% had incomes equaling their expenses, 69.3% were living with their spouses and children, and 35.7% had their last period 4 years ago or earlier. The mean scores obtained by women from the Aging Anxiety Scale for Menopausal Women and its Fear of Old People, Fear of Loss, Physical Appearance, and Psychological Concerns sub-scales were successively 30.78 (8.00), 10.55 (5.75), 6.75 (3.56), 5.81 (3.42), and 7.63 (2.96).Conclusion: In the identification and management of areas of top priority for the delivery of health services, a significant role falls on midwives and nurses, who are supposed to approach an individual with a biopsychosocial perspective.","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20240573"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of kangaroo mother care restrictions during the COVID-19 pandemic on feeding and physiological parameters in preterm neonates: a cohort study.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.1590/1806-9282.20240864

Zühal Çamur, Deniz Akyildiz

{"title":"Effects of kangaroo mother care restrictions during the COVID-19 pandemic on feeding and physiological parameters in preterm neonates: a cohort study.","authors":"Zühal Çamur, Deniz Akyildiz","doi":"10.1590/1806-9282.20240864","DOIUrl":"10.1590/1806-9282.20240864","url":null,"abstract":"Objective: This research investigates the impact of kangaroo mother care restrictions on feeding and physiological parameters in preterm newborns during the COVID-19 pandemic.Methods: A retrospective cohort design was used, including 169 preterm neonates born at 30-34 weeks of gestation, recruited from a Neonatal Intensive Care Unit in Denizli, Turkiye. The study compared a kangaroo mother care group (n=78) and a kangaroo mother care-restricted group (n=91). Data analysis was conducted using the chi-square test, Fisher's exact test, and t-test.Results: The average duration until the initiation of full oral feeding was shorter in the kangaroo mother care group (mean difference=4.58, 95%CI 0.61-8.43, p=0.020). Newborns in the kangaroo mother care-restricted group had a higher likelihood of reverting to gavage feeding (OR 6.59, 95%CI 2.98-14.58, p=0.000), and higher withdrawal rates (OR 3.36, 95%CI 1.59-7.09, p=0.001). Newborns in the kangaroo mother care group experienced significantly lower rates of apnea attacks (OR 3.29, 95%CI 1.52-7.09, p=0.002), tachycardia (OR 4.43, 95%CI 1.54-12.76, p=0.004), and desaturation (OR 3.43, 95%CI 1.70-6.93, p=0.000).Conclusion: This study highlights the positive effects of kangaroo mother care on preterm newborns' feeding and physiological parameters. It is recommended that kangaroo mother care be consistently provided to all newborns, even during exceptional circumstances such as pandemics.","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20240864"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of homocysteine, folate, vitamin B12, and vitamin D levels in pregnant women with recurrent vaginitis.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.1590/1806-9282.20241284

Gürkan Çıkım, Kemal Hansu

{"title":"Evaluation of homocysteine, folate, vitamin B12, and vitamin D levels in pregnant women with recurrent vaginitis.","authors":"Gürkan Çıkım, Kemal Hansu","doi":"10.1590/1806-9282.20241284","DOIUrl":"10.1590/1806-9282.20241284","url":null,"abstract":"Objective: The aim of this study was to evaluate the levels of homocysteine, vitamin B12, folic acid, and vitamin D in pregnant women with recurrent vaginitis and determine whether these parameters contribute to the etiology of the disease.Methods: The study included 30 pregnant women diagnosed with recurrent vaginitis in their first trimester (group I), who presented at least twice between 1.5.2019 and 1.5.2022 at the obstetrics and gynecology clinic, and 30 healthy pregnant women in their first trimester without any complaints (group II). The vagititis group was compared with the control group for serum levels of vitamin B12, homocysteine, folic acid, and vitamin D.Results: A comparison of the results between the groups revealed the following: homocysteine levels (μmol/L) were 10.75 (6.38-24.90) in group I (vaginitis positive) and 9.32 (4.26-17.10) in group II (control); vitamin B12 levels (ng/L) were 149.00 (63.00-328.00) in group I and 261.00 (126.00-544.00) in group II; folate levels (μg/L) were 10.56 (3.93-23.33) in group I and 9.48 (3.53-24.10) in group II; vitamin D levels (ng/mL) were 36.54 (23.65-75.68) in group I and 52.45 (26.57-105.00) in group II. Statistically significant elevation in homocysteine levels was observed in the vaginitis group (group I) (p<0.05). Vitamin B12 and D levels were significantly lower in the vaginitis group (group I) (p<0.05).Conclusion: In pregnant women with recurrent vaginitis, the levels of homocysteine, vitamin B12, and vitamin D may play a role in the etiology of the condition, and vitamins B12 and D may be considered for use in treatment.","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"71 1","pages":"e20241284"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0