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Leveraging untargeted metabolomics in combination with machine learning to uncover novel insights into bladder cancer. 利用非靶向代谢组学与机器学习相结合，揭示膀胱癌的新见解。
IF 5.3 3区 医学
Cancer & Metabolism Pub Date : 2026-04-01 DOI: 10.1186/s40170-026-00427-4
Abu Hena Mostafa Kamal, Vasanta Putluri, Tanmay Gandhi, Chandra Shekar R Ambati, Chandra Sekhar Amara, Karthik Reddy Kami Reddy, Meredith Lauren Spradlin, Amrit Koirala, Sachin B Jorvekar, Sandra L Grimm, Dexue Fu, Krishna Parsawar, Felice de Jong, Chris Beecher, Subrata Sen, Seth P Lerner, M Minhaj Siddiqui, Yair Lotan, Livia S Eberlin, Arun Sreekumar, Cristian Coarfa, Nagireddy Putluri
{"title":"Leveraging untargeted metabolomics in combination with machine learning to uncover novel insights into bladder cancer.","authors":"Abu Hena Mostafa Kamal, Vasanta Putluri, Tanmay Gandhi, Chandra Shekar R Ambati, Chandra Sekhar Amara, Karthik Reddy Kami Reddy, Meredith Lauren Spradlin, Amrit Koirala, Sachin B Jorvekar, Sandra L Grimm, Dexue Fu, Krishna Parsawar, Felice de Jong, Chris Beecher, Subrata Sen, Seth P Lerner, M Minhaj Siddiqui, Yair Lotan, Livia S Eberlin, Arun Sreekumar, Cristian Coarfa, Nagireddy Putluri","doi":"10.1186/s40170-026-00427-4","DOIUrl":"10.1186/s40170-026-00427-4","url":null,"abstract":"","PeriodicalId":9418,"journal":{"name":"Cancer & Metabolism","volume":"14 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcriptome-driven constraint-based modelling reveals metabolic targets for ovarian cancer. 转录组驱动的基于约束的模型揭示了卵巢癌的代谢靶点。
IF 5.3 3区 医学
Cancer & Metabolism Pub Date : 2026-03-19 DOI: 10.1186/s40170-026-00425-6
Kate E Meeson, Joanne C McGrail, Jean-Marc Schwartz, Stephen S Taylor
{"title":"Transcriptome-driven constraint-based modelling reveals metabolic targets for ovarian cancer.","authors":"Kate E Meeson, Joanne C McGrail, Jean-Marc Schwartz, Stephen S Taylor","doi":"10.1186/s40170-026-00425-6","DOIUrl":"10.1186/s40170-026-00425-6","url":null,"abstract":"","PeriodicalId":9418,"journal":{"name":"Cancer & Metabolism","volume":"14 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor-intrinsic metabolic pathways essential for tumorigenesis and resistance to anti-PD1 in oncogenic Kras-driven lung adenocarcinoma. 肿瘤内在代谢途径对肿瘤发生和抗pd1耐药性至关重要的致癌kras驱动的肺腺癌。
IF 5.3 3区 医学
Cancer & Metabolism Pub Date : 2026-03-16 DOI: 10.1186/s40170-026-00426-5
Karthik Vasan, Zachary R Chalmers, Hyewon Kong, Navdeep S Chandel
{"title":"Tumor-intrinsic metabolic pathways essential for tumorigenesis and resistance to anti-PD1 in oncogenic Kras-driven lung adenocarcinoma.","authors":"Karthik Vasan, Zachary R Chalmers, Hyewon Kong, Navdeep S Chandel","doi":"10.1186/s40170-026-00426-5","DOIUrl":"10.1186/s40170-026-00426-5","url":null,"abstract":"","PeriodicalId":9418,"journal":{"name":"Cancer & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13104462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A shift in the cellular redox state redirects aspartate for export under glucose deprivation. 细胞氧化还原状态的改变使天冬氨酸在葡萄糖剥夺下重新输出。
IF 5.3 3区 医学
Cancer & Metabolism Pub Date : 2026-03-03 DOI: 10.1186/s40170-026-00420-x
Barbara Konrad, Gabriele Bluemel, Theresa Haitzmann, Tobias Frech, Anke Vandekeere, Mélanie Planque, Visnja Bubalo, Katharina Schindlmaier, Vanessa Jäger, Michael A Dengler, Sarah Stryeck, Luka Brcic, Jörg Lindenmann, Philipp Stiegler, Doruntina Bresilla, Corina T Madreiter-Sokolowski, Tobias Madl, Thomas O Eichmann, Nikolaus Kneidinger, Sarah-Maria Fendt, Katharina Leithner
{"title":"A shift in the cellular redox state redirects aspartate for export under glucose deprivation.","authors":"Barbara Konrad, Gabriele Bluemel, Theresa Haitzmann, Tobias Frech, Anke Vandekeere, Mélanie Planque, Visnja Bubalo, Katharina Schindlmaier, Vanessa Jäger, Michael A Dengler, Sarah Stryeck, Luka Brcic, Jörg Lindenmann, Philipp Stiegler, Doruntina Bresilla, Corina T Madreiter-Sokolowski, Tobias Madl, Thomas O Eichmann, Nikolaus Kneidinger, Sarah-Maria Fendt, Katharina Leithner","doi":"10.1186/s40170-026-00420-x","DOIUrl":"10.1186/s40170-026-00420-x","url":null,"abstract":"","PeriodicalId":9418,"journal":{"name":"Cancer & Metabolism","volume":"14 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12955209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting FANCD2 to overcome enzalutamide resistance in prostate cancer. 靶向FANCD2克服前列腺癌对恩杂鲁胺的耐药。
IF 5.3 3区 医学
Cancer & Metabolism Pub Date : 2026-02-12 DOI: 10.1186/s40170-026-00419-4
Wenzhen Shi, Juliang Yang, Yue Xu, Huijie Yang, Junquan Hu, Shang Huang
{"title":"Targeting FANCD2 to overcome enzalutamide resistance in prostate cancer.","authors":"Wenzhen Shi, Juliang Yang, Yue Xu, Huijie Yang, Junquan Hu, Shang Huang","doi":"10.1186/s40170-026-00419-4","DOIUrl":"10.1186/s40170-026-00419-4","url":null,"abstract":"","PeriodicalId":9418,"journal":{"name":"Cancer & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting HIF-2α in colorectal cancer reveals a cholesterol biosynthesis-dependent ferroptotic vulnerability. 在结直肠癌中靶向HIF-2α揭示了胆固醇生物合成依赖的铁致凋亡易感性。
IF 5.3 3区 医学
Cancer & Metabolism Pub Date : 2026-02-12 DOI: 10.1186/s40170-026-00421-w
Prarthana J Dalal, Rashi Singhal, Boyan Hu, Drew Stark, Nicholas J Rossiter, Chesta Jain, Peter Sajjakulnukit, Costas A Lyssiotis, Yatrik M Shah
{"title":"Targeting HIF-2α in colorectal cancer reveals a cholesterol biosynthesis-dependent ferroptotic vulnerability.","authors":"Prarthana J Dalal, Rashi Singhal, Boyan Hu, Drew Stark, Nicholas J Rossiter, Chesta Jain, Peter Sajjakulnukit, Costas A Lyssiotis, Yatrik M Shah","doi":"10.1186/s40170-026-00421-w","DOIUrl":"10.1186/s40170-026-00421-w","url":null,"abstract":"","PeriodicalId":9418,"journal":{"name":"Cancer & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caspase-1/11 deficiency and cold exposure enhance the anti-tumor activity of brown adipose tissue secretome against breast cancer cells. Caspase-1/11缺乏和寒冷暴露可增强褐色脂肪组织分泌组对乳腺癌细胞的抗肿瘤活性。
IF 5.3 3区 医学
Cancer & Metabolism Pub Date : 2026-02-11 DOI: 10.1186/s40170-026-00422-9
Luís Henrique Corrêa, Heloisa Antoniella Braz-de-Melo, Igor de Oliveira Santos, Sarah Pinho Bezerra, Julia Perin Manchine, Nathalia Cristina Silva Lago, Clarissa Maria Alves Portacio-Santos, Raquel das Neves Almeida, Dalila Juliana Silva Ribeiro, Tiago Medeiros-Furquim, Lívia Pimentel Sant'ana, Matheus Garcia de Fragas, Felipe Teixeira Lopes, Rhanoica Oliveira Guerra, Niels Olsen Saraiva Câmara, Mariana S Castro, Wagner Fontes, Dario Simões Zamboni, Kelly Grace Magalhães
{"title":"Caspase-1/11 deficiency and cold exposure enhance the anti-tumor activity of brown adipose tissue secretome against breast cancer cells.","authors":"Luís Henrique Corrêa, Heloisa Antoniella Braz-de-Melo, Igor de Oliveira Santos, Sarah Pinho Bezerra, Julia Perin Manchine, Nathalia Cristina Silva Lago, Clarissa Maria Alves Portacio-Santos, Raquel das Neves Almeida, Dalila Juliana Silva Ribeiro, Tiago Medeiros-Furquim, Lívia Pimentel Sant'ana, Matheus Garcia de Fragas, Felipe Teixeira Lopes, Rhanoica Oliveira Guerra, Niels Olsen Saraiva Câmara, Mariana S Castro, Wagner Fontes, Dario Simões Zamboni, Kelly Grace Magalhães","doi":"10.1186/s40170-026-00422-9","DOIUrl":"10.1186/s40170-026-00422-9","url":null,"abstract":"","PeriodicalId":9418,"journal":{"name":"Cancer & Metabolism","volume":" ","pages":"3"},"PeriodicalIF":5.3,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12918741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fos-induced osteosarcoma growth causes a cachexia-like phenotype in mice and correlates with high Fgf21 serum levels. fos诱导的骨肉瘤生长在小鼠中引起恶病质样表型，并与高Fgf21血清水平相关。
IF 5.3 3区 医学
Cancer & Metabolism Pub Date : 2026-02-03 DOI: 10.1186/s40170-025-00417-y
Julia Luther, Armelle Carreau, Christina Baldauf, Mona Neven, Till Koehne, Michael Amling, Thorsten Schinke
{"title":"Fos-induced osteosarcoma growth causes a cachexia-like phenotype in mice and correlates with high Fgf21 serum levels.","authors":"Julia Luther, Armelle Carreau, Christina Baldauf, Mona Neven, Till Koehne, Michael Amling, Thorsten Schinke","doi":"10.1186/s40170-025-00417-y","DOIUrl":"https://doi.org/10.1186/s40170-025-00417-y","url":null,"abstract":"","PeriodicalId":9418,"journal":{"name":"Cancer & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The FGL1-LAG-3 axis attenuates melanoma-induced cachexia in mice. FGL1-LAG-3轴减弱小鼠黑素瘤诱导的恶病质。
IF 5.3 3区 医学
Cancer & Metabolism Pub Date : 2026-01-07 DOI: 10.1186/s40170-025-00418-x
Weitao Liu, Lining Wang, Shumei Jin, Tongbin Liu, Yingchen Qian, Peng Lin
{"title":"The FGL1-LAG-3 axis attenuates melanoma-induced cachexia in mice.","authors":"Weitao Liu, Lining Wang, Shumei Jin, Tongbin Liu, Yingchen Qian, Peng Lin","doi":"10.1186/s40170-025-00418-x","DOIUrl":"10.1186/s40170-025-00418-x","url":null,"abstract":"","PeriodicalId":9418,"journal":{"name":"Cancer & Metabolism","volume":" ","pages":"2"},"PeriodicalIF":5.3,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12869940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of deoxycholic acid in macrophage polarization and remodeling of the tumor microenvironment during colorectal adenoma-carcinoma transition. 去氧胆酸在结直肠腺瘤-癌转化过程中巨噬细胞极化和肿瘤微环境重塑中的作用。
IF 5.3 3区 医学
Cancer & Metabolism Pub Date : 2025-12-16 DOI: 10.1186/s40170-025-00416-z
Yujing Liu, Jie Yin, Lu Lu, Jiashu Pan, Gaoxuan Shao, Yangxian Xu, Guang Ji, Hanchen Xu
{"title":"The role of deoxycholic acid in macrophage polarization and remodeling of the tumor microenvironment during colorectal adenoma-carcinoma transition.","authors":"Yujing Liu, Jie Yin, Lu Lu, Jiashu Pan, Gaoxuan Shao, Yangxian Xu, Guang Ji, Hanchen Xu","doi":"10.1186/s40170-025-00416-z","DOIUrl":"10.1186/s40170-025-00416-z","url":null,"abstract":"","PeriodicalId":9418,"journal":{"name":"Cancer & Metabolism","volume":"13 1","pages":"47"},"PeriodicalIF":5.3,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12709865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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