Mymensingh medical journal : MMJ最新文献

{"title":"High-Risk Human Papilloma Virus Genotyping in Patients with Clinically Suspected Precancerous and Cancerous Lesions of Cervix.","authors":"J S Rashid, P Rahman, R R Khan, S S Afrin, N Mudi, M K Saha, F Yeasmin, S S Karim, R K Dewan, P Zaman, M Rahman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nowadays, human papilloma virus (HPV) testing has been added with cytology to aid in detection of high-grade cervical lesions, especially in women aged ≥30 years. This study aimed to evaluate the relationship between high-risk HPV (hrHPV) genotype and clinicopathological parameters among the diagnosed patients with both precancerous and cancerous cervical lesions. This cross-sectional study was carried out in the Department of Pathology of Dhaka Medical College and in the collaboration with 'DNA Solution LTD, Dhaka', Bangladesh. The study was conducted over a period of 24 months from July 2018 to June 2020. Following informed written consent, a total of 51 women (18 patients with clinically suspected malignant lesions and 33 with a positive VIA test) were included in this study, and all were subjected to colposcopic examination performed by a gynecologist. Ethical issues were ensured in accordance with the 1975 Declaration of Helsinki. SPSS version 24.0 was used during data analysis. The average age ±SD of the patients with cervical lesions was 41.86±9.84 years with a range from 25 to 60 years. Approximately half of the participants (n=25, 49.0%) were married for less than 16 years and almost one-tenth were multiparous. Among all cytological and histological findings, hrHPV-16 (n=21, 41.18%) was commonest, followed by hrHPV-18 (n=3, 5.88%) and hrHPV-68 (n=1, 1.96%). Two patients had co-infection with hrHPV (16, 18) and hrHPV (16, 51) in particular. However, the rest 24 cases remained undetected. Among the hrHPV-positive cases (n=27), hrHPV-16 was detected in 5 cases while those were negative for intraepithelial lesions. In cervical swabs, 6 cases of hrHPV-16, 2 cases of hrHPV-18 and one case of co-infection hrHPV (16, 18) were histologically diagnosed as invasive SCC G-II. Among 51 cases, the most common histological diagnosis was CIN I (n=18, 35.3%). hrHPV genotyping was found to be associated with cytological findings and histological diagnosis.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 3","pages":"816-824"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Kriya Yoga, Pranayama and Brainwave Entrainment for Stress Reduction: An HRV-Based Exploration.","authors":"V Malhotra, C Suryawanshi, F J Cidral-Filho, S Wakode, A Thomas, P K Porter","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Stress contributes to non-communicable diseases like hypertension and diabetes, with heart rate variability (HRV) reflecting autonomic nervous system (ANS) activity. This interventional study was conducted at the Department of Physiology, All India Institute of Medical Sciences (AIIMS), Bhopal, India, from 2019 to 2025. This study evaluated yogic (Kriya Yoga, Anulom Vilom, Kapalbhati, etc.) and non-yogic (exercise, brain entrainment) interventions in 30 healthy volunteers using HRV. Kriya Yoga and Anulom Vilom reduced stress indices by 71.45% and 56.01%, enhancing parasympathetic tone. Kapalbhati and exercise increased sympathetic activation (+41.66%, +85.33%). Brain entrainment lowered stress by 48.86%. Cooling pranayamas (Chandra Nadi: -69.14%) were optimal for stress management, while heating techniques may exacerbate stress. So, the efficacy of stress-reduction techniques varies based on their physiological impact.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 3","pages":"921-931"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Sensitivity Pattern of Sputum and Nasopharyngeal Swab in Children with Cystic Fibrosis: A Lesson from a Specialized Shishu (Children) Hospital in Bangladesh.","authors":"P K Sarkar, N Akand, S Tahura, M Kamruzzaman, J Akter, K A Zaman, T Farhana, S S Rima, M J Alam, M K Hassan, J Fardous, B Chowdhury","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Infection control in Cystic fibrosis (CF) patients plays a crucial role in improving the survival of patients with CF. Antimicrobial sensitivity patterns in these patient groups in our country are currently lacking. Therefore, the purpose of this observational study was to evaluate the microbiological cultures and antimicrobial susceptibility pattern of pediatric CF patients. A total of 50 respiratory samples were prospectively collected from the patients with CF got admitted in the Dhaka Shishu Hospital, Bangladesh from February 2021 to October 2021. Sputum and nasopharyngeal swabs were processed for culture and microbiological testing. Sample collection and evaluation were performed according to the Good Laboratory Practice guidelines (GLP). Informed written consent was ensured before participation. Statistical analysis was performed with SPSS v26.0. The median age of the children was 30 months (6-120) months, with a male predominance (66.0% vs. 34.0%). Single and two organisms were isolated in 72.0% (n=36) and 12.0% (n=6) of cases, respectively. During the study period, 36.0% of the patients harbored Pseudomonas aeruginosa, 18.0% harbored Klebsiella pneumoniae and both Staphylococcus aureus and Escherichia coli were detected in 16.0% of cases. Levofloxacin was found to be the most active antibiotic agent with 100.0% susceptibility. In contrast, nearly all isolates were resistant to amoxicillin, erythromycin and rifampicin. Levofloxacin is the most effective agent to treat CF patients. Active surveillance of the resistance pattern should always continue to be promoted.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 3","pages":"866-873"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Air Flow Limitation Severity with eGFR in Stable COPD Patients: A Cross-Sectional Study.","authors":"T Farhana, M A Qayyum, M A Hossain, S S Hossain, S Shamsuzzaman, N Hossain, M M Rahman, S S Reshma, A I Khan, B P Bonny, D Debnath, M Rahman, M A S Khan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is primarily a lung disease, but its consequences also affect other vital organs. Forced expiratory volume in one second (FEV₁), a basic spirometry finding along with others (Predicted FEV₁% and FVC), is essential for COPD diagnosis and severity analysis. Renal functional evaluation is essential, in addition to other systemic evaluations. Its evaluation is important because drugs used for the treatment of COPD are mostly excreted through the kidneys, which may cause its impairment. The estimated GFR (eGFR) by the modification of the diet in renal disease (MDRD) study group equation can approximate the actual GFR. This study aimed to elicit the association between airflow limitation severity and eGFR in stable COPD patients. This cross-sectional observational study included 95 patients with stable COPD who presented at the NIDCH between June 2018 and June 2019. The mean spirometry indices were compared with the eGFR-based groups (eGFR ≥60 mL/min/1.73 m² and eGFR <60 mL/min/1.73 m²). Correlation test was done to elicit the association of FEV₁ with eGFR. In addition, the prediction capability of eGFR along with other clinically relevant effector variables for FEV₁ was analyzed. FEV₁ was strongly correlated with eGFR (r=0.754, p<0.001). Predicted FEV₁% and FVC had moderate correlations with eGFR (r=0.646, p<0.001 and r=0.691, p<0.001, respectively), whereas FEV₁/FVC had weak correlations with eGFR (r=0.440, p<0.001). eGFR showed good prediction capability (β=-0.176, p<0.001) among other clinically relevant effector variables (age, sex, smoking, exacerbation history, mMRC grade, CAT score and BMI). All spirometry indices (FEV₁, PFEV₁%, FVC and FEV₁/FVC) were correlated with eGFR. FEV₁ was strongly correlated (positively) with eGFR and showed linear relation. Furthermore, eGFR had a good predictive capability for FEV₁. FEV₁ in stable COPD patients can be used as a predictor of renal function (eGFR), enabling early detection of renal functional impairment. Based on this, further evaluation, preventive measures or modifications in treatment strategy could be adopted accordingly.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 3","pages":"887-896"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluconazole Prophylaxis in Children with Acute Leukemia during Induction Chemotherapy in a Tertiary Care Hospital in Bangladesh.","authors":"F Islam, S D M Taimur, T Sultana, I Nigar, A T M Rahman, C Y Jamal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Patients with hematological malignancies often develop febrile neutropenia (FN) as a complication of cancer chemotherapy. Opportunistic infection, especially invasive fungal infection (IFI) is frequently encountered during the neutropenic phase. With this perspective different anti-fungal agents had been tried as prophylaxis in leukemia. Evaluation of the role of fluconazole was as antifungal prophylaxis in children with acute leukemia during induction chemotherapy. This randomized double-blind placebo controlled prospective study was carried out in the Department of Pediatric Hematology and Oncology, Bangladesh Medical University (BMU), Bangladesh from September 2016 to August 2017. Total 60 (30 were in fluconazole and 30 were in placebo group) patients of age range from 1 to 18 years were included in this study. Mean age of the patients were 7.08±3.33 years in fluconazole group 6.29±2.79 years in placebo group. Male: Female ratio was 1.14:1. Out of total 60 patients 44 were ALL and 16 AML. Mean duration of neutropenia in fluconazole and placebo group were 13.40±5.75 days and placebo 16.83±5.77 days respectively. Success rate of fluconazole prophylaxis was 25(83.3%). Failure rates of placebo were 40.0%. Duration of empirical antifungal therapy in fluconazole and placebo group differed significantly (p=0.008). Difference of neutrophil recovery achievement in two groups was also significant (p=0.015). The mean duration from AFP to EAF therapy is 17.60±1.51 days and 14.33±5.72 days in patient with fluconazole and placebo group respectively. Prophylactic fluconazole can be used to decrease the fungal infection as well as the duration of febrile neutropenia during induction chemotherapy of Acute Leukemia in children.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 3","pages":"786-790"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Outcome of Closed Lateral Internal Sphincterotomy in the Treatment of Chronic Anal Fissure Compared to Open Method.","authors":"G M Shawon, M A Rahman, M N Islam, T H Nayamoth, A S M Chowdhury, K Y Ishad, S Mohammed","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lateral internal sphincterotomy (LIS) has long been regarded as the standard treatment for chronic anal fissure (CAF). Both open and closed methods are practiced for LIS. In this study evaluated and compared the early clinical outcome in terms of patient morbidity and procedure related complications of both the methods. This was a quasi-experimental study conducted in the department of Surgery, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh (SSMCMH), Dhaka, Bangladesh from May 2018 to April 2019. Fifty (50) patients of chronic anal fissure had been chosen purposively and divided into two groups. Experimental group had 25 patients who underwent closed LIS and Control group had 25 patients who underwent open LIS. All patients were followed up at 2 weeks' and 6 weeks' after surgery. Mean duration of operation in closed method was 8.40±2.10 minutes and in open method 13.48±1.76 minutes, which was significant (p<0.001). Post-operative pain at different time interval was lower in experimental group and significantly lower at 48th hour with a p-value of 0.002. Closed LIS is a safe and time worthy method with less patient morbidity and less post-operative complications for the treatment of CAF.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 3","pages":"840-845"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Status of Body Mass Index and Blood Pressure in Low Dose Oral Contraceptive Pill Users.","authors":"A Begum, A Nessa, U H Khanom, I Mansoora, F S Joarder","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Low dose oral contraceptives are a major category of prescription drugs used by a large number of reproductive women. Since the introduction of the first combined oral contraceptives in the 1960s, great progress has been made to reduce side effects and improve tolerability without compromising efficacy. The most commonly used are combinations of drugs that contain both estrogen and progesterone. Long-term use of hormonal contraceptives by women of reproductive age can lead to increase body mass index (BMI) and blood pressure. The aim of this study was to estimate the status of body mass index and blood pressure in low dose oral contraceptive pill users in Mymensingh locality. This cross sectional analytical type of study was conducted in the Department of Physiology, Mymensingh Medical College, Bangladesh from July 2023 to June 2024. A total number of 140 reproductive women, age ranged from 18-52 years was included in this study. Among them 70 low dose oral contraceptive pill non users were taken as control group (Group I) and 70 low dose oral contraceptive pill users were taken as study group (Group II). The results were calculated and analyzed by using SPSS (Statistical Product and Service Solutions), version 26.0. Data were expressed in Mean ±SD and statistical significance of difference among the groups was calculated by unpaired Student's 't' test. Correlation among body mass index, systolic blood pressure and diastolic blood pressure were done by Pearson's correlation coefficient test. The mean±SD of body mass index (BMI) of control group and study group were 23.24±2.19 in kg/m2 and 26.60±1.94 in kg/m2 respectively. In study group, body mass index was increased in comparison with control group. The mean ±SD of systolic blood pressure of control group and study group were 122.93±10.88 mm of Hg and 141.66±5.47 mm of Hg respectively. In study group, systolic blood pressure was increased in comparison with control group. The mean ±SD of diastolic blood pressure of control group and study group were 81.21±5.92 mm of Hg and 91.87±6.13 mm of Hg respectively. In study group, diastolic blood pressure was increased in comparison with control group. In this study, body mass index and blood pressure was statistically highly significant (p<0.001) in study group in comparison to control group. Therefore, by this study we recommended that OCP users should follow up for early detection and prevention of complication leading to a healthy life.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 3","pages":"619-624"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Risk Factors Associated with Stillbirth in a Tertiary Level Hospital.","authors":"M S Khatun, T T Mirza, M S Alam, M Siddika, S A Tithy, H Akhter, S Choudhoury","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A Stillbirth is the birth of a newborn after 28th completed week (weighing 1000 gm or more) when the baby does not breathe or show any signs of life after delivery. It has an enormous impact on mothers, families, health care professionals and the community. Bangladesh has high stillbirth rate due to lack of access to antenatal care, home trial, high parity, social norms and customs etc. Multiple maternal and fetal risk factors have been identified that are associated with stillbirth. This study is intended to provide information for proper antepartum surveillance and also build up awareness in the community to prevent perinatal mortality. Objective of this study was evaluation of risk factors associated with stillbirth. This was cross-sectional observational study conducted from 10th February 2019 to 10th August 2019. Consecutive 100 pregnant women admitted in Obstetrics and Gynaecology department of MMCH and had delivered stillbirth baby were included in the study. Data was collected through a pre-designed questionnaire and analyzed by SPSS Version 26.0. In this study, 76.0% women were found between 20 to 30 years of age. Most of the women studied were gravida second and third (72.0%). Most stillbirth baby were preterm with gestational age between 35 to 36 weeks (60.0%). Maternal hypertensive disorder was the commonest medical disorder associated with stillbirth (34.0%), followed by DM (6.0%). Obstetric complications associated with stillbirth were PROM (12.0%), prolonged labour (8.0%), obstructed labour (5.0%), abruptio placentae (6.0%), placenta praevia (2.0%) and cord accident (6.0%). Fetal factor accounted for 8.0% of stillbirth of which majority was due to multiple congenital anomalies (6.0%). Apparently no identifiable risk factors were found in 8.0% cases. It was observed that maternal hypertensive disorders were the predominant risk factors of stillbirth. Majority of women had emergency admission and did not receive adequate antenatal care at all. Significant proportion of stillbirth was preventable by proper and regular antenatal checkup, timely referral and hospital delivery.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 3","pages":"700-706"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of Exteriorization of the Anastomotic Site in Case of Emergency Bowel Surgery.","authors":"N Islam, M A K Azad, M A Baten, K R Hoque, K S Rahman, T Jahan, M S Islam, S M Imteaz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Anastomotic leakage followed by septic peritonitis is the most serious complication following intestinal surgery. It has an impact on overall postoperative morbidity and mortality. To prevent the complications of intraperitoneal anastomotic leakage, exteriorization of the anastomosis provides a good alternative. The exteriorized anastomosis can be safely dropped back to the peritoneal cavity after healing in the same hospital admission. If anastomotic leakage occurs, then this exteriorized anastomosis can be converted into an ordinary stoma. The main goal of the present study is to assess the feasibility and to see the outcomes of an exteriorized intestinal anastomosis in emergency bowel surgery. This prospective observational study was carried out in the Department of Surgery, Mymensingh Medical College Hospital, Bangladesh from November 2018 to May 2019. Twenty (20) patients who underwent emergency laparotomy with bowel anastomosis were included in this study. The anastomosis was then exteriorized followed by a drop back to the peritoneal cavity if there was no leak from the anastomosis. Immediate complications were noted and managed accordingly as leaked anastomosis was fashioned as a stoma. The exteriorized anastomosis was successfully dropped back into the peritoneal cavity in 75.0% of cases and was possible between the 6th to 10th postoperative days. Anastomotic leak in the exteriorized segment was seen in 25.0% of patients. No added morbidity or mortality was found in leaked exteriorized anastomosis rather than they were fashioned as an ordinary stoma. One patient underwent re-operation for a pelvic abscess which was usually not related to anastomotic leakage and there was no leak after drop back. The mean hospital stay was up to 11.07th postoperative day (POD), ranging from 8th to 30th postoperative day (POD) after successful drop back of exteriorized anastomosis. But after leaked anastomosis, it was the 18th POD which was more due to prolonged management of wound infection with co-morbidities but not due to leakage-related complications. During the study process 2(10.0%) patients died, one due to ARDS and the other due to severe sepsis with complications of a burst abdomen which was also not related to anastomotic leakage. The procedure of exteriorized gut anastomosis has the advantage of shorter hospital stays and can avoid stoma formation, one-stage surgery and single hospital admission. It does not add any morbidity to the patient but also can early detect anastomotic leakage by direct visualization of the anastomotic site and can be converted to an ordinary stoma. So, exteriorized gut anastomosis can be an alternative to the formation of stoma as well as prevent complications of intra-peritoneal anastomotic leak.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 3","pages":"666-673"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis C Seropositivity among Hospitalized Patients with Decompensated Chronic Liver Disease: An Observational Study in a Tertiary Care Hospital of Bangladesh.","authors":"N Chowdhury, M I Patwary, M A I Chowdhury, S Das, G Karmaker, M M Alam, J Banik, M N Islam, J Fardous, S Islam","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Viral hepatitis due to hepatitis B virus and C virus (HCV) is a major contributor to the huge burden of chronic liver disease in Bangladesh. This study aimed to investigate the sero-prevalence of HCV among decompensated Chronic Liver Disease (CLD) patients admitted to Sylhet MAG Osmani Medical College Hospital (SOMCH), Bangladesh. This cross-sectional study was conducted among 58 admitted patients with SOMCH aged ≥18 years with a diagnosis of decompensated CLD. Detailed clinical data were extracted from the hospital records and physical examination. Here the immunochromatographic direct binding method was used for the detection of Anti-HCV antibody. The mean age ±SD of the patients was 45.7±13.3 years and 86.0% of them were male. Seropositivity of anti-HCV antibody was 17.2%, with a predominance of genotype-3. Around 58.0% patients had CLD class C in the Child-Pugh scoring system. Edema (91.0%), testicular atrophy (81.0%), leukonychia (72.0%), jaundice (58.0%), clubbing (58.0%), palmar erythema (50.0%), flapping tremor (43.0%) and ascites (40.0%) were the most common presentations of the patients. HCV infection contributed to almost one-fifth of decompensated CLD in hospital-admitted patients. Mass screening and adequate preventive measures are recommended to mitigate the burden of HCV-induced CLD.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 3","pages":"714-719"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}