Mymensingh medical journal : MMJ最新文献

{"title":"A Cadaveric Study of Morphological Variations of the Abductor Pollicis Longus Muscle and Its Tendinous Insertions.","authors":"S S Sangma, G Mohan, S Seth, C Rukadikar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study examined the abductor pollicis longus (APL) and abductor pollicis brevis (APB) muscles, which are key muscles involved in thumb abduction and fine motor function, with anatomical variations of the APL particularly accessory tendons implicated in the pathogenesis of De Quervain's tenosynovitis by contributing to crowding within the first dorsal compartment. This cadaveric observational study was conducted at the Department of Anatomy in collaboration with the Department of Physiology, All India Institute of Medical Sciences, Gorakhpur, India, using twenty prosected upper limbs from voluntarily donated cadavers of Indian origin (10 rights and 10 lefts). Morphological parameters recorded included tendon length, width, attachment patterns, presence of accessory APL (a-APL) and APB variations, while biomechanical measurements included fascicle length, pennation angle and muscle mass, with physiological cross-sectional area (PCSA) and maximum force (Fmax) calculated using standard biomechanical formulas. All 20 specimens demonstrated a normal APL muscle belly and tendon; accessory APL tendons were identified in 70.0% of specimens, with 8 right-sided and 6 left-sided occurrences. Mean ±SD tendon length of APL was 62.8±17.41 mm on the right and 71.0±19.84 mm on the left, while mean width was 2.3±0.59 mm and 2.6±0.52 mm, respectively. A rare anatomical variation was observed in one specimen where APB originated from the accessory APL tendon. Biomechanical analysis showed APL had a PCSA of 3.27 cm² and predicted Fmax of 114.45 N, whereas APB demonstrated a PCSA of 1.42 cm² and Fmax of 49.70 N. These findings confirm that accessory APL tendons and atypical APB origins are common anatomical variants with significant clinical implications in De Quervain's tenosynovitis and that integration of morphometric and biomechanical data can enhance surgical decompression strategies, rehabilitation planning, ergonomic counseling and evidence-based nursing care.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1290-1299"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and Child Health Status among Women Attending an Antenatal Clinic in a Tertiary Care Hospital of Bangladesh.","authors":"M K Khan, S B Hossain, M J I Nabil, S H Shihab, M F S Porna, J F Promy, M N U Sakib, A Shafin, P Chakrabarti, A Biswas, S I Semonti, K M M Hoque, S Yeasmin, R Moni, M A Talha","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Maternal and child health (MCH) is one of the bases of public health, however, specific research on antenatal care, child health practices and delivery outcomes remain limited in Bangladesh. This study aimed to assess the MCH situation among women attending a tertiary care hospital. It was a cross-sectional survey conducted from September 2025 to October 2025 among 460 purposively selected women attending the Antenatal Care Clinic of Mymensingh Medical College Hospital (MMCH) for an antenatal checkup. Face to face interview with a structured questionnaire was used to collect data on sociodemographic characteristics, reproductive history, child care practices, antenatal visits and delivery outcomes and then analyzed descriptively. The mean age of respondents was 26.56±4.7 years, among whom 83.5% were aged between 17-30 years. Most women had only secondary (35.0%) and primary (33.7%) levels of education. Majority were housewives (93.0%) with having 1-2 children (82.2%). Mean monthly household income was 22,998.91±11,641.31 Bangladeshi Taka. Most (97.2%) of the women fed colostrum and 90.2% completed immunization to their babies, while 5.2% of families experienced death of children of under-five years, mainly due to pneumonia, diarrhea and unknown causes. Mean antenatal care visit was 3.48±2.08, where 4.6% had no visits. 73.3% delivered their babies in the hospitals; however, 57.2% needed lower uterine cesarean section. Deliveries were mostly conducted by doctors (73.7%). The study found that most participants accessed antenatal care and institutional delivery, with high rates of colostrum feeding and child immunization, however, gaps exist in antenatal coverage, mode of delivery and prevention of child mortality. A systematic approach with targeted interventions is essential to improve MCH outcomes in Bangladesh.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1032-1039"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Functional Outcome of Thoraco-Lumbar Burst Fractures Stabilization By Pedical Screw and Rod.","authors":"K M R Islam, S Chowdhury","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thoraco-lumbar burst fractures are a type of spinal injury that typically result from high-energy trauma. These fractures involve compression of the vertebral body with posterior displacement of bone fragments into the spinal canal. Treatment typically involves surgical stabilization with pedicle screw and rod instrumentation. The aim of the study was to evaluate the results of thoracolumbar burst fractures with incomplete neurological lesion stabilized by pedicle screw and rod. This was a prospective experimental study carried out at Bangladesh Medical University, Dhaka, Bangladesh from January 2019 to December 2019. A total of 15 patients with Thoraco-Lumbar Burst fracture aged over 15 years were included in the study. A detailed history of the selected patient was taken with mode of injury, time of injury, other history, then thorough general, local, neurological examination for proper assessment. Among the 15 cases, 12 cases (80.0%) were male and 3 cases (20.0%) were female. The age range of patient was from 17 55 years. Most commonly affected people were laborers 5(33.33%). Fall from height was the commonest cause of injury 11(73.30%). Most commonly level of injury was L1 07 (46.70%). Pedicle screw and rod used in all cases for long segment reconstruction above and below the involved level. According to Frankel grade preoperatively most common grade was C 10 and next common was B 5. Post operatively most was D 9 and next was E 4 and C-2. According to Denis et al pain scale most commonly 8 (53.34%) cases complain no pain and work scale most commonly 2(13.33%) cases were completely well and can perform normal work up to latest follow-up. Mean hospital stay was (13.27±3.54) days (10 20) days. Satisfactory results (excellent and good) were in 13(86.66%), fair 1(6.67%) and 1(6.67%) unsatisfactory (poor) results. The results of the study demonstrates that functional outcome of Thoraco-Lumbar burst fractures stabilization by pedicle screw and rod is an effective procedure.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1123-1131"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of Gram-Positive Cocci and Their Antimicrobial Susceptibility in Delayed Surgical Site Infections in Mymensingh, Bangladesh.","authors":"M R Nahar, M A Hoque, S A Nasreen, N Haque, F A Sathi, J Khanam, S A Tasnim","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Surgical site infection is one of the most frequent post-operative consequences are infections caused by invasive surgical procedures that occur within 30 days if the patient does not have a prosthetic in place or within a year if a prosthetic is implanted in the patient. Many Gram-positive and Gram-negative bacteria are causing surgical site infections. The objective of this study was to isolate and identify the Gram-Positive Cocci and their antibiotic susceptibility patterns from patients with delayed surgical site infections in Mymensingh Medical College Hospital of Bangladesh. This cross-sectional study involved 155 patients suffering from postsurgical wound infection more than three weeks as respondents. The study was conducted in the Department of Microbiology, Mymensingh Medical College, Bangladesh from March 2024 to February 2025. The bacterial pathogens were isolated from pus/ wound swab samples obtained from those patients. The Gram-Positive Cocci were identified through several standard biochemical tests and finally, the culture sensitivity tests of those bacterial isolates were performed by disk diffusion method. Data was documented using standard questionnaires. The mean age of the patients in the study was 33.97 years. Most of the patients 96(61.9%) were female. Out of a total 155 samples, 143(92.30%) were positive by culture. Among them Gram positive were 16(11.2%); Staphylococcus aureus was 11(68.75%), coagulase negative Staphylococcus (CONS) was 4(25.0%) and Enterococcus spp. was 1(6.25%). Among the isolated Staphylococcus aureus, 6(54.54%) were found MRSA. The Staphylococcus aureus showed 100.0% sensitivity to meropenem and linezolid and 100.0% resistant to Ceftriaxone. The Coagulase negative Staphylococcus isolates were 100.0% sensitive to cefoxitin and showed resistant to most the drugs. The Enterococcus spp. was sensitive to amoxiclav, linezolid and Pipercillin-Tazobactum. Meropenem and linezolid have shown better activity on to S. aureus. CoNS exhibited higher resistance to many antibiotics compared to S. aureus.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1026-1031"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Upper Gastrointestinal Endoscopy in Pediatric Gastrointestinal Disorders in Bangladesh: A Retrospective Study.","authors":"N Musabbir, F Begum, M W Mazumder, M Rukunuzzaman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Over the last few years upper gastrointestinal (GI) endoscopy has been proven to be an effective diagnostic and therapeutic tool for various gastrointestinal diseases in children. This retrospective study was done in a tertiary care center of Bangladesh for one year to assess the indications of upper GI endoscopy including the diagnostic and therapeutic yields for various gastrointestinal disorders in children. During this period, 211 patients, aged ≤16 years, referred either from outpatient clinics or admitted inpatient wards were enrolled in study and their demographic data, endoscopic details (indications, findings and any complications) were collected and normal and abnormal endoscopic findings were compared. Mean age was found 9.5±3.5 years. The most common indication of upper GI endoscopy was recurrent abdominal pain (24.1%) followed by upper gastrointestinal bleeding (20.4%). Normal upper GI endoscopy was found in 74.51% of patients who had recurrent abdominal pain and oesophageal varices were found in 51.16% of patients with upper gastrointestinal bleeding. Upper gastrointestinal bleeding, endoscopic surveillance of oesophageal varices, foreign body ingestion and screening for oesophageal varix in chronic liver disease patient were significantly associated with abnormal upper GI endoscopy findings with p value 0.005, 0.001, 0.019 and 0.001 respectively. This study showed that recurrent abdominal pain was associated with normal upper GI endoscopy result in majority cases, so it should be reserved as second line investigation in patients with recurrent abdominal pain. However, every child with upper gastrointestinal bleeding should be evaluated by upper GI endoscopy. Upper GI endoscopy should be chosen in a justifiable way in paediatric population considering the signs and symptoms of disease.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1249-1255"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conversion of Laparoscopic Cholecystectomy to Open Cholecystectomy: An Experience at Mymensingh Medical College Hospital.","authors":"A K M Islam, M Khatun, M M Hossain, A H M Sufian, A K Das, S M A Islam, M M H Rahman, K Hassan, I S Ziniya, A B M Habibullah, A Y M Hasan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Laparoscopic cholecystectomy is the standard procedure for symptomatic gallstone disease; however, conversion to open cholecystectomy remains necessary in selected cases to ensure patient safety. This study assessed the frequency, intraoperative causes and selected operative factors related to conversion from laparoscopic to open cholecystectomy at Mymensingh Medical College Hospital, Bangladesh. This descriptive observational study was conducted from April to September 2018 among 73 patients aged more than 20 years undergoing laparoscopic cholecystectomy for symptomatic gallstone disease. Data were collected prospectively using a pretested structured questionnaire from patients, hospital records, direct intraoperative observation and operative notes. Associations between selected variables and conversion were assessed using Fisher's exact test, with p<0.05 considered statistically significant. The mean age of the patients was 43.6±12.9 years and 61 patients, 83.56%, were female. Conversion to open cholecystectomy was required in 7 patients, 9.59%. Dense adhesions and hemorrhage were the leading causes of conversion, each occurring in 2 patients, 2.74% of the total study population. Severe hemorrhage, 28.6% vs. 0.0%, p<0.05 and dense adhesions, 28.6% vs. 0.0%, p<0.05, were significantly associated with conversion. Bile duct injury, gallbladder mass and empyema of the gallbladder were less frequent causes of conversion and did not show statistically significant association. Conversion from laparoscopic to open cholecystectomy was required in approximately one in ten patients. Dense adhesions and significant hemorrhage were the principal conversion-related intraoperative factors in this local tertiary hospital setting. These findings provide baseline institutional data for future larger studies on difficult laparoscopic cholecystectomy, conversion risk assessment and operative preparedness.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"988-995"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Spine to Limbs: Imaging Insights and Clinical Correlation in Caudal Regression Syndrome.","authors":"N Munir, K Begum, A B Jahan, F Jahan, M Begum, R A Ferdousi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Caudal regression syndrome (CRS) refers to a spectrum of congenital structural defects of the caudal region. We present a case of caudal regression syndrome with the objective of correlating the symptoms of caudal regression syndrome with the detailed imaging findings. A 05-year-old boy who was admitted to Mymensingh Medical College Hospital in August 2025 , presented with a post-urethroplasty state of hypospadias, complaining of urinary incontinence through the normal meatus and a urethrocutaneous fistula. He had dribbling of urine through hypospadias and deformed feet since birth. He also developed progressive lower limb weakness and walking difficulty at the age of 3 years. On clinical examination bilateral calf and hypothenar muscle wasting, reduced muscle power and tone, absent ankle and diminished knee jerks, diminished bulbocavernosus reflex, intact perianal sensation and anal tone were observed. Right-sided planovalgus (flat foot), left-sided cavus foot deformity, a smaller pelvic girdle with flat buttocks and hard swelling over the lower lumbar region were found. On x-ray lumbosacral spine both view, low-positioned L5 vertebra fused with a rudimentary S1 vertebra on the right with the absence of the rest of the sacral pieces and coccyx, broad spinous process of L5 were seen. Vertical talus, absent navicular bones and adducted forefeet and supinated great toes were seen on x-ray foot both view. RGU and MCU confirmed urethrocutaneous fistula. MRI of whole spine with contrast showed spinal cord and subarachnoid space termination at a slightly upper level with multifocal syrinx and anterior epidural lipoma. MR myelogram revealed short and thickened filum terminale. MR neurography demonstrated altered course of both sided lumbo-sacral plexus. Multifocal syrinx at cervical and dorso-lumbar vertebral levels resulted in lower motor type neuropathy and bladder incontinence. Though the patient had autonomic dysfunction of bladder due to the external urethral sphincter dysfunction, dribbling continued through the normal meatus and the weakest fistula tract evidenced by nil post voidal residue. This patient had no bowel incontinence due to intact inferior rectal nerve, a branch of pudendal nerve supplying the rectum.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1307-1311"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of Unilateral Transverse Cordotomy or Kashima Operation for Bilateral Vocal Cord Immobility.","authors":"M Y Ali, S Zaman, M M Billah, M S Uddin, R K Sarkar, M N Hasan, S H Rahman, M A Siddika","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Endoscopic laser cordotomy, also known as Kashima operation, is used for the treatment of bilateral vocal cord palsy where the glottis chink is made posteriorly, sufficient enough for patient to breathe comfortably without any stridor. The objective of the study was to assess outcome of unilateral transverse cordotomy (Kashima operation) for bilateral vocal cord immobility. This prospective observational study was conducted in the Department of Otolaryngology-Head & Neck Surgery, Bangladesh Medical University, Dhaka, Bangladesh from January 2020 to June 2021 with 12 patients having bilateral vocal cord immobility with shortness of breath (SOB) or tracheostomized for SOB due to bilateral vocal cord immobility. The diagnosis was confirmed by fiberoptic laryngoscopy. Endoscopic assessment of subglottis and trachea was also done for assessment of any co-incidental pathology which may affect the outcome. Outcome of the surgery was evaluated by Flow volume loop Spirogram, Medical Research Council Dyspnoea Scale (MRCDS) 2007 and Voice Handicap Index (VHI) scores. All the information were recorded in a pretested questionnaire. The mean ±SD preoperative MRCDS was 4.33±0.49 and mean postoperative MRCDS was 1.75±1.06, 1.50±0.80 and 1.33±0.6 at 1st, 2nd and 3rd months of follow-up respectively. Mean ±SD preoperative total VHI score was 24.50±2.11 and postoperative score was 75.50±25.57, 44.17±31.50 and 37.33±22.86 at 1st, 2nd and 3rd months of follow-up respectively. MRCDS was significantly improved after Kashima operation (p<0.001). But no significant difference was observed in pre and at 3 months postoperative VHI score (p>0.05). In this study, preoperative mean of FVC, PEFR, PIFR, FEF50% and FIF50% were found 1.7±0.09 L, 2.5±0.12 L/S, 1.75±0.11 L/S, 0.84±0.06 and 2.08±0.38 respectively. Postoperative means of FVC, PEFR, PIFR, FEF 50% and FIF 50% were found 2.5±0.12 L, 4.5±0.12 L/S, 3.54±0.54 L/S, 1.84±0.40 and 3.54±0.69 at follow-up period of 2 months respectively. Statistically significant differences were observed in between pre and postoperative all the parameters of spirometry (p<0.001). In this study, only 2(16.67%) cases were developed complications after surgery. Vocal cord oedema in 1(8.33%) case and Fibrosis with granuloma in 1(8.33%) case. Kashima procedure is an effective surgery to reduce the severity of dyspnoea in bilateral vocal cord immobility without significant change of voice.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1196-1203"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Hepatitis C Virus and Different Manifestations of Lichen Planus in a Tertiary Care Hospital.","authors":"M A K Azzad, S F Noor, M S R Bhuiyan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lichen planus (LP) is a persistent mucocutaneous disorder with an unclear cause. Recent findings indicate that LP may be an extrahepatic manifestation of Hepatitis C infection. The aim of this study was to assess the prevalence of hepatitis C among our lichen planus patients. This cross-sectional study was done in the Dermatology and Venereology Department of Bangladesh Medical University, Dhaka, Bangladesh from January 2023 to December 2023. A total of 125 individual were diagnosed with lichen planus who satisfied the inclusion criteria were enrolled in this study. Diagnoses were based on standard clinical indicators and when required, distinctive histopathological features. All patients underwent screening for anti-HCV antibodies by using ELISA. Statistical analyses were conducted using SPSS-22.0 window-based software for statistical analysis. The study included 125 patients, maintaining the same male to female ratio 1:2.1. Among these, 44(35.2%) tested positive for HCV. Out of which 15(34.1%) patients had erosive/ulcerative forms, 27(61.4%) exhibited mucocutaneous manifestations and 2(4.5%) had purely cutaneous lichen planus. The study found that over one-third of the subjects tested positive for HCV. Interestingly, specific variants of cutaneous lichen planus, including hypertrophic, segmental, flexural, actinic and annular types, which were rare in our group, had not been linked to HCV before. This implies that HCV might play a causative role in the occurrence of lichen planus in our specific geographic area.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1204-1210"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Moringa Oleifera Leaf Extract on Paracetamol Induced Liver Damage in Wistar Albino Male Rats.","authors":"R Chowdhury, M Begum, R Chowdhury, F Akther, S Anwar","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Liver disease is a leading cause of global morbidity and mortality, for which virus, toxin and drugs are common risk factors. Paracetamol is a common analgesics and antipyretic drug but at overdose can cause severe hepatotoxicity. Moringa oleifera is a highly nutritious vegetable tree with variety of potential uses which may have hepatoprotective effect. The objective of the study was to observe the effect of Moringa oleifera (Sajna) leaf extract on paracetamol induced liver damage in Wistar albino male rats. This experimental study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka, Bangladesh from 1st July 2021 to 30th June 2022. A total number of twenty-four (24) apparently healthy Wistar albino male rats, 90-120 days old, weighing between 200-250gm were taken for this study. After acclimatization for 14 days, they were divided into three groups: Negative control group (Group A), Positive control group (Group B) and Experimental group (Group C). Each of this group was consisted of eight rats. All the rats received basal diet for 28 days. In addition to basal diet Group B and Group C received paracetamol orally (2g/kg/day) for last 3 days (26th to 28th days) of the study period. Again, Group C also received aqueous extract of Moringa oleifera leaf orally (200 mg/kg/day) for 28 days. Then all the rats were sacrificed on 29th day. After sacrifice blood and liver samples were collected. Blood sample was collected from heart. Serum levels of total bilirubin, ALT, AST, ALP, GGT and hepatic contents of malondialdehyde (MDA) were measured by using standard laboratory method. Histopathology of liver was also done by using standard laboratory procedure in the Department of Pathology of SSMC. Statistical analysis was done by using Statistical Package of Social Science (SPSS) for windows version 28.0. Data were presented as mean ±SD. One way ANOVA and post hoc-Bonferroni test, Paired \"t\" test and Fisher's Exact test were done as applicable. p value ≤0.05 was considered as level of significance. The mean±SD serum total bilirubin level was 0.08±0.03, 2.01±0.34 and 0.16±0.02 mg/dL, mean serum ALT level was 32.88±4.02, 114.50±29.17 and 50.50±6.21 U/L, mean serum AST level was 46.38±8.33, 220.50±17.55 and 106.75±4.36 U/L, mean serum ALP level was 79.25±19.47, 114.50±23.40 and 103.50±5.97 U/L, mean serum GGT level was 6.95±2.08, 14.78±4.02 and 9.61±2.31 U/L, in Group A, Group B and Group C respectively. The mean serum total bilirubin, ALT, AST, ALP and GGT levels were significantly higher in Group B (p&lt;0.001) in comparison to those of Group A whereas, mean±SD serum total bilirubin, ALT, AST and GGT levels were significantly (p&lt;0.001) lower in Group C than that of Group B. The mean±SD MDA level was 3.83±1.21, 12.16±3.14 and 6.89±1.61 nmol/mg protein in Group A, Group B and Group C respectively. The mean±SD MDA level was significantly higher in Group B and Group C (p&lt;0.001 and p&lt;0.05 respectively) in comparison to ","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1149-1160"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}