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Therapeutic success in primary biliary cholangitis and gut microbiota: a safe highway? 原发性胆汁性胆管炎的治疗成功与肠道微生物群：安全的高速公路？
IF 1.9
Minerva gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-01-19 DOI: 10.23736/S2724-5985.23.03590-8
Ludovico Abenavoli, Giuseppe Gm Scarlata, Emidio Scarpellini, Anna C Procopio, Francesca R Ponziani, Luigi Boccuto, Nenad Cetkovic, Francesco Luzza
{"title":"Therapeutic success in primary biliary cholangitis and gut microbiota: a safe highway?","authors":"Ludovico Abenavoli, Giuseppe Gm Scarlata, Emidio Scarpellini, Anna C Procopio, Francesca R Ponziani, Luigi Boccuto, Nenad Cetkovic, Francesco Luzza","doi":"10.23736/S2724-5985.23.03590-8","DOIUrl":"10.23736/S2724-5985.23.03590-8","url":null,"abstract":"<p><p>Primary biliary cholangitis (PBC) is a chronic, cholestatic, autoimmune disease, characterized by destruction of bile ducts. PBC predominantly affects women between 40 and 60 years of age. The presence of antimitochondrial antibodies (AMA) is a serological feature of PBC. These highly specific antibodies are found in about 95% of patients with the disease. The family of enzymes located in the inner membrane of the mitochondria, called the 2-oxo-acid dehydrogenase complex represents the target of the AMA. Ursodeoxycholic acid (UDCA) is a synthetic bile acid capable of protecting cholangiocytes from cholestatic damage caused by the accumulation of bile acids with a mechanism of action not yet well clarified. UDCA represents the gold standard therapy for PBC patients with recommended dose of 13-15 mg/kg/day. However, not every patient responds to therapy. On the other hand, the gut microbiota plays a key role in the onset of PBC through still unclear biochemical pathways. Less is known about its role as a potential biomarker after drug treatment. Actually, few studies analyzed the changes in gut microbiota composition before and after UDCA treatment. For this reason, this review represents an examination of the studies carried out on changes in gut microbiota composition in patients affected by PBC before and after treatment.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"430-441"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anesthesiologist-directed care for elective gastrointestinal endoscopy: results of an Italian multicentric prospective observational study. 麻醉师指导下的择期胃肠道内窥镜检查：意大利多中心前瞻性观察研究的结果。
IF 1.9
Minerva gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-06-05 DOI: 10.23736/S2724-5985.24.03656-8
Mauro Manno, Giuliano F Bonura, Paola Soriani, Roberta Pileggi, Giovanni Aragona, Vincenzo Cennamo, Antonio Colecchia, Rita Conigliaro, Marco DI Marco, Carlo Fabbri, Lorenzo Fuccio, Rosa F LA Fortezza, Alberto Merighi, Alessandro Mussetto, Giorgio Nervi, Paolo Orsi, Romano Sassatelli, Rocco M Zagari, Paolo Biancheri
{"title":"Anesthesiologist-directed care for elective gastrointestinal endoscopy: results of an Italian multicentric prospective observational study.","authors":"Mauro Manno, Giuliano F Bonura, Paola Soriani, Roberta Pileggi, Giovanni Aragona, Vincenzo Cennamo, Antonio Colecchia, Rita Conigliaro, Marco DI Marco, Carlo Fabbri, Lorenzo Fuccio, Rosa F LA Fortezza, Alberto Merighi, Alessandro Mussetto, Giorgio Nervi, Paolo Orsi, Romano Sassatelli, Rocco M Zagari, Paolo Biancheri","doi":"10.23736/S2724-5985.24.03656-8","DOIUrl":"10.23736/S2724-5985.24.03656-8","url":null,"abstract":"<p><strong>Background: </strong>Sedation, ranging from minimal, moderate and deep sedation to general anesthesia, improves patient comfort and procedure quality in gastrointestinal endoscopy (GIE). There are currently no comprehensive recommendations on sedation practice in diagnostic and therapeutic GIE. We aimed to investigate real-life sedation practice in elective GIE.</p><p><strong>Methods: </strong>We performed a multicentric observational study across 14 Endoscopy Units in Italy. We recorded consecutive data on all diagnostic procedures performed with Anesthesiologist-directed care (ADC) and all therapeutic procedures performed with ADC or non-Anesthesiologist sedation (NAS) over a three-month period.</p><p><strong>Results: </strong>Dedicated ADC is available five days/week in 28.6% (4/14), four days/week in 21.5% (3/14), three days/week in 35.7% (5/14), two days/week in 7.1% (1/14) and one day/week in 7.1% (1/14) of participating Centers. ADC use for elective diagnostic GIE varied from 15.4% to 75.1% of the total number of procedures performed with ADC among different Centers. ADC use for elective therapeutic GIE varied from 10.8% to 98.9% of the total number of elective therapeutic procedures performed among different Centers.</p><p><strong>Conclusions: </strong>Our study highlights the lack of standardization and consequent great variability in sedation practice for elective GIE, with ADC being potentially overused for diagnostic procedures and underused for complex therapeutic procedures. A collaborative effort involving Endoscopists, Anesthesiologist and Institutions is needed to optimize sedation practice in GIE.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"405-412"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helicobacter pylori infection does not influence the progression from gastroesophageal reflux disease to Barrett's esophagus to esophageal adenocarcinoma. 幽门螺杆菌感染不会影响从胃食管反流病到巴雷特食管再到食管腺癌的进展。
IF 1.9
Minerva gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-05-10 DOI: 10.23736/S2724-5985.24.03609-X
Ahmed Edhi, Manesh K Gangwani, Muhammad Aziz, Fouad Jaber, Zubair Khan, Sumant Inamdar, Aaron P Thrift, Tusar K Desai
{"title":"Helicobacter pylori infection does not influence the progression from gastroesophageal reflux disease to Barrett's esophagus to esophageal adenocarcinoma.","authors":"Ahmed Edhi, Manesh K Gangwani, Muhammad Aziz, Fouad Jaber, Zubair Khan, Sumant Inamdar, Aaron P Thrift, Tusar K Desai","doi":"10.23736/S2724-5985.24.03609-X","DOIUrl":"10.23736/S2724-5985.24.03609-X","url":null,"abstract":"<p><strong>Introduction: </strong>We conducted a meta-analysis evaluating the overall risk of esophageal adenocarcinoma (EAC) in individuals with Helicobacter pylori infection, and a network meta-analysis to assess the role of H. pylori infection in the progression from Barrett's esophagus (BE) to EAC.</p><p><strong>Evidence acquisition: </strong>The MEDLINE, EMBASE and Cochrane databases were searched between 1988 and June 2023 for observational studies of H. pylori infection and the risk of EAC. Summary odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using the DerSimonian-Laird method. I<sup>2</sup> statistics were calculated to examine heterogeneity.</p><p><strong>Evidence synthesis: </strong>Thirteen studies were included in the meta-analysis and 3 additional studies were included in the network meta-analysis. For comparisons with controls, individuals with H. pylori infection were 46% less likely to develop EAC than individuals without H. pylori infection (OR, 0.54; 95% CI: 0.46, 0.64), with low heterogeneity between studies (I<sup>2</sup>=4.4%). The magnitude of the inverse association was stronger in the two large cohort studies (OR=0.31) than in the 11 case-control studies (OR=0.55). When comparing to controls, the network meta-analysis of 6 studies showed that H. pylori infection was associated with a lower risk of GERD (OR=0.68) or BE (OR=0.59) or EAC (OR=0.54); however, H. pylori infection was not associated with risk of EAC in patients with BE (OR=0.91; 95% CI: 0.68, 1.21).</p><p><strong>Conclusions: </strong>This meta-analysis provides the strongest evidence yet that H. pylori infection is inversely associated with EAC. H. pylori does not appear to be associated with BE progression to EAC.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"454-462"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of artificial intelligence combined with MDT teaching model in colorectal cancer training teaching. 人工智能结合MDT教学模式在结直肠癌培训教学中的应用。
IF 1.9
Minerva gastroenterology Pub Date : 2024-11-19 DOI: 10.23736/S2724-5985.24.03784-7
Jiawen Liu, Ning Zhang, Bo Li, Shouliang Cai
{"title":"Application of artificial intelligence combined with MDT teaching model in colorectal cancer training teaching.","authors":"Jiawen Liu, Ning Zhang, Bo Li, Shouliang Cai","doi":"10.23736/S2724-5985.24.03784-7","DOIUrl":"10.23736/S2724-5985.24.03784-7","url":null,"abstract":"","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role and mechanisms of long non-coding RNA HOTAIR in regulating the Wnt/β-catenin signaling pathway in gastric cancer cells and its impact on tumor invasion and metastasis. 长非编码RNA HOTAIR在调控胃癌细胞Wnt/β-catenin信号通路中的作用和机制及其对肿瘤侵袭和转移的影响
IF 1.9
Minerva gastroenterology Pub Date : 2024-10-29 DOI: 10.23736/S2724-5985.24.03760-4
Shunping Mao
{"title":"The role and mechanisms of long non-coding RNA HOTAIR in regulating the Wnt/β-catenin signaling pathway in gastric cancer cells and its impact on tumor invasion and metastasis.","authors":"Shunping Mao","doi":"10.23736/S2724-5985.24.03760-4","DOIUrl":"https://doi.org/10.23736/S2724-5985.24.03760-4","url":null,"abstract":"","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the effect of moxibustion therapy combined with press needle stimulation of bilateral Zusanli (ST36) and Neiguan (PC6) points on gastric motility recovery in patients with gastroparesis after pancreatoduodenectomy. 灸疗联合按针刺激双侧足三里（ST36）和内关（PC6）穴对胰十二指肠切除术后胃瘫患者胃动力恢复的影响评估
IF 1.9
Minerva gastroenterology Pub Date : 2024-10-29 DOI: 10.23736/S2724-5985.24.03774-4
Yueying Huang, Bo Huang, Lingling Liu
{"title":"Evaluation of the effect of moxibustion therapy combined with press needle stimulation of bilateral Zusanli (ST36) and Neiguan (PC6) points on gastric motility recovery in patients with gastroparesis after pancreatoduodenectomy.","authors":"Yueying Huang, Bo Huang, Lingling Liu","doi":"10.23736/S2724-5985.24.03774-4","DOIUrl":"https://doi.org/10.23736/S2724-5985.24.03774-4","url":null,"abstract":"","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
E. coli 5C: a probiotic effective for preventing post-colonoscopy gastrointestinal discomfort? 大肠杆菌 5C：一种能有效预防结肠镜检查后胃肠道不适的益生菌？
IF 1.9
Minerva gastroenterology Pub Date : 2024-10-11 DOI: 10.23736/S2724-5985.24.03772-0
Francesco DI Pierro, Massimiliano Cazzaniga, Alexander Bertuccioli, Chiara M Palazzi, Ilaria Cavecchia, Mariarosaria Matera, Nicola Zerbinati
{"title":"E. coli 5C: a probiotic effective for preventing post-colonoscopy gastrointestinal discomfort?","authors":"Francesco DI Pierro, Massimiliano Cazzaniga, Alexander Bertuccioli, Chiara M Palazzi, Ilaria Cavecchia, Mariarosaria Matera, Nicola Zerbinati","doi":"10.23736/S2724-5985.24.03772-0","DOIUrl":"https://doi.org/10.23736/S2724-5985.24.03772-0","url":null,"abstract":"","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful endoscopic decompression of an intramural duodenal hematoma secondary to pancreatitis causing duodenal and common bile duct obstruction. 成功为继发于胰腺炎导致十二指肠和胆总管梗阻的十二指肠内血肿进行内镜减压。
IF 1.9
Minerva gastroenterology Pub Date : 2024-09-26 DOI: 10.23736/S2724-5985.24.03724-0
Connor Ryan, Robert S O'Neill, David Williams
{"title":"Successful endoscopic decompression of an intramural duodenal hematoma secondary to pancreatitis causing duodenal and common bile duct obstruction.","authors":"Connor Ryan, Robert S O'Neill, David Williams","doi":"10.23736/S2724-5985.24.03724-0","DOIUrl":"https://doi.org/10.23736/S2724-5985.24.03724-0","url":null,"abstract":"","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of early enteral nutrition support on immune function in patients undergoing radical rectal cancer surgery. 早期肠内营养支持对直肠癌根治术患者免疫功能的影响。
IF 1.9
Minerva gastroenterology Pub Date : 2024-09-26 DOI: 10.23736/S2724-5985.24.03754-9
Juan Li, Xiangrong Zhu, Tingting Shao, Lisong Teng
{"title":"Impact of early enteral nutrition support on immune function in patients undergoing radical rectal cancer surgery.","authors":"Juan Li, Xiangrong Zhu, Tingting Shao, Lisong Teng","doi":"10.23736/S2724-5985.24.03754-9","DOIUrl":"https://doi.org/10.23736/S2724-5985.24.03754-9","url":null,"abstract":"","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric gastroenteritis: an integrated analysis of epidemiology, clinical manifestations, diagnostic methods, and multi-level therapeutic interventions. 小儿肠胃炎：流行病学、临床表现、诊断方法和多层次治疗干预的综合分析。
IF 1.9
Minerva gastroenterology Pub Date : 2024-09-18 DOI: 10.23736/S2724-5985.24.03739-2
Xuejing Geng, Xiansheng Cao, Wei Zhou, Jixiang Jiang, Xue Zhou, Hong Liu
{"title":"Pediatric gastroenteritis: an integrated analysis of epidemiology, clinical manifestations, diagnostic methods, and multi-level therapeutic interventions.","authors":"Xuejing Geng, Xiansheng Cao, Wei Zhou, Jixiang Jiang, Xue Zhou, Hong Liu","doi":"10.23736/S2724-5985.24.03739-2","DOIUrl":"https://doi.org/10.23736/S2724-5985.24.03739-2","url":null,"abstract":"","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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