Minerva gastroenterology最新文献

Association between celiac disease and risk of kidney diseases: a systematic review and meta-analysis. 乳糜泻与肾脏疾病风险之间的关系：一项系统综述和荟萃分析。

IF 1.9

Minerva gastroenterology Pub Date : 2025-05-21 DOI: 10.23736/S2724-5985.25.03733-7

Sawai S Rathore, Shifa P Shaikh, Hyder R Zaidi, George O Salako, Chiranjeevee R Saravanan, Rabiat R Kuranga, Narendra Yagateela, Sai T Bandala, Bijay M Jeswani

{"title":"Association between celiac disease and risk of kidney diseases: a systematic review and meta-analysis.","authors":"Sawai S Rathore, Shifa P Shaikh, Hyder R Zaidi, George O Salako, Chiranjeevee R Saravanan, Rabiat R Kuranga, Narendra Yagateela, Sai T Bandala, Bijay M Jeswani","doi":"10.23736/S2724-5985.25.03733-7","DOIUrl":"https://doi.org/10.23736/S2724-5985.25.03733-7","url":null,"abstract":"Introduction: Celiac disease (CD), an autoimmune disorder, has been linked to chronic kidney disease but results are inconsistent. This meta-analysis investigates the association between CD and the risk of kidney disease.Evidence acquisition: A systematic literature search was conducted using PubMed, Embase, and Google Scholar up to March 31, 2024. Studies included observational reports on CD and kidney diseases. Random-effects models estimated pooled odds ratios (ORs) and 95% confidence intervals (CIs) to report the overall effect size, with significance set at P<0.05. Study quality was assessed using the Newcastle-Ottawa Scale (NCOS). Publication bias was evaluated using Egger's regression and Begg's rank correlation tests.Evidence synthesis: Nine studies with 2022,686 patients were included. The pooled prevalence of overall kidney disease, glomerulonephritis, and end-stage renal disease (ESRD) in CD patients was 2.29% (95% CI 1.34-3.49), 1.31% (95% CI 0.52-2.47), and 1.55% (95% CI 0.11-4.59), respectively. CD was significantly associated with a higher risk of overall kidney disease (OR=1.98, 95% CI 1.48-2.65), glomerulonephritis (OR=2.68, 95% CI 1.54-4.66), and ESRD (OR=2.58, 95% CI 1.32-5.03). Most studies were of high or moderate quality according to NCOS, and no publication bias was detected.Conclusions: CD patients have an elevated risk of various kidney diseases, including glomerulonephritis and ESRD. Monitoring renal function and managing CD are crucial to mitigating potential kidney damage. Future research should investigate the mechanisms underlying this association and explore targeted interventions to prevent or delay renal complications in CD patients.","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of medical therapy on liver transplant eligibility in patients with portopulmonary hypertension: a systematic review. 药物治疗对门脉性肺动脉高压患者肝移植资格的影响：一项系统综述。

IF 1.9

Minerva gastroenterology Pub Date : 2025-05-15 DOI: 10.23736/S2724-5985.25.03915-4

Matthew T Siuba, Ahmed Abushamma, Aman Qureshi, Shelley Ivary, Adriano R Tonelli

{"title":"Impact of medical therapy on liver transplant eligibility in patients with portopulmonary hypertension: a systematic review.","authors":"Matthew T Siuba, Ahmed Abushamma, Aman Qureshi, Shelley Ivary, Adriano R Tonelli","doi":"10.23736/S2724-5985.25.03915-4","DOIUrl":"https://doi.org/10.23736/S2724-5985.25.03915-4","url":null,"abstract":"Introduction: Portopulmonary hypertension (PoPH) occurs in roughly 5% of patients evaluated for liver transplant and increases perioperative morbidity and mortality. PoPH patients often succumb to complications of the underlying liver disease, therefore liver transplantation can be a lifesaving intervention. Medical treatment of PoPH optimizes patients for transplantation, but the knowledge on the effect of PH specific therapy on transplant eligibility is limited.Evidence acquisition: We searched Medline, Embase, and Cochrane Library from inception to August 19, 2024. We aimed to include studies of adult patients with PoPH treated with pharmacologic therapies with comparison to placebo, baseline condition of the patient, or another medication. We only included studies where liver transplantation outcomes were reported.Evidence synthesis: Out of 606 studies retrieved, 17, all observational cohorts, met inclusion criteria. None of the included studies had suitable control or comparison groups to assess medication efficacy in a pooled fashion. As a result, this systematic review aimed to describe the effect of PoPH treatments on transplant eligibility across studies and medication classes. A total of 812 patients received medical treatment, with 52% receiving liver transplant. Of studies reporting transplant eligibility, 65% of treated PoPH patients became transplant eligible.Conclusions: Within the limitations of the available data, PoPH therapies improve transplant eligibility. Prospective studies, especially RCTs, are needed to better define the best treatment strategy in this population.","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gluten hepatitis: a case of an idiopathic rise in liver enzymes and their normalization on a gluten free diet. 麸质肝炎：一个特发性肝酶上升的情况下，他们的正常化无麸质饮食。

IF 1.9

Minerva gastroenterology Pub Date : 2025-04-23 DOI: 10.23736/S2724-5985.25.03934-8

Francesca Manza, Lisa Lungaro, Fabio Caputo, Anna Costanzini, Gianni Testino, David S Sanders, Umberto Volta, Roberto DE Giorgio, Giacomo Caio

引用次数: 0

Gastric juice analysis in clinical practice: are we ready for the prime time? 胃液分析在临床实践中的应用：准备好了吗？

IF 1.9

Minerva gastroenterology Pub Date : 2025-03-31 DOI: 10.23736/S2724-5985.25.03861-6

Emanuele Dilaghi, Gianluca Esposito, Gianluca Franchellucci, Bruno Annibale, Angelo Zullo

引用次数: 0

Disease-specific non-invasive assessment of liver fibrosis and portal hypertension in 2024. 2024年肝纤维化和门脉高压的疾病特异性非侵入性评估。

IF 1.9

Minerva gastroenterology Pub Date : 2025-03-31 DOI: 10.23736/S2724-5985.25.03845-8

Tancredi V Li Cavoli, Armando Curto, Erica N Lynch, Andrea Galli, Stefano Milani

{"title":"Disease-specific non-invasive assessment of liver fibrosis and portal hypertension in 2024.","authors":"Tancredi V Li Cavoli, Armando Curto, Erica N Lynch, Andrea Galli, Stefano Milani","doi":"10.23736/S2724-5985.25.03845-8","DOIUrl":"https://doi.org/10.23736/S2724-5985.25.03845-8","url":null,"abstract":"Advanced liver disease is a global health challenge which requires a timely and accurate diagnosis for optimal patient management. Traditionally, liver biopsy has been the gold standard for diagnosing and staging liver diseases; however, its invasiveness and associated risks, including bleeding, infection, and sampling errors, limit its utility. Non-invasive tests (NITs) have emerged as critical tools in liver disease evaluation, offering safe and effective alternatives to biopsy. This review explores the spectrum of NITs, highlighting their benefits, limitations, and clinical applications in specific liver diseases. NITs have demonstrated significant utility in monitoring chronic viral hepatitis, metabolic-associated steatotic liver disease (MASLD), and cholestatic liver diseases, reducing the need for invasive procedures. While further refinement and validation are needed, NITs represent a major advancement in liver disease management, enhancing early diagnosis, monitoring treatment response, and improving patient outcomes. This review delves into the various non-invasive tests employed in liver disease evaluation, emphasizing their benefits, limitations, and clinical applications. By examining the current landscape of NITs, we aim to elucidate how these advancements are revolutionizing the diagnosis and management of liver diseases, ultimately enhancing patient care and outcomes.","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic approaches to small bowel strictures. 内镜入路治疗小肠狭窄。

IF 1.9

Minerva gastroenterology Pub Date : 2025-03-21 DOI: 10.23736/S2724-5985.25.03868-9

Katelin Durham, Rami El Abiad, Mouen Khashab

引用次数: 0

Clinical aspects and controversies of spontaneous portosystemic shunts in cirrhotic patients. 肝硬化患者自发性门系统分流的临床特点及争议。

IF 1.9

Minerva gastroenterology Pub Date : 2025-03-19 DOI: 10.23736/S2724-5985.25.03874-4

Simona Parisse, Erika Coltorti, Flaminia Ferri, Fabio Melandro, Mario Corona, Pierleone Lucatelli, Quirino Lai, Stefano Ginanni Corradini

{"title":"Clinical aspects and controversies of spontaneous portosystemic shunts in cirrhotic patients.","authors":"Simona Parisse, Erika Coltorti, Flaminia Ferri, Fabio Melandro, Mario Corona, Pierleone Lucatelli, Quirino Lai, Stefano Ginanni Corradini","doi":"10.23736/S2724-5985.25.03874-4","DOIUrl":"https://doi.org/10.23736/S2724-5985.25.03874-4","url":null,"abstract":"Spontaneous portosystemic shunts (SPSSs) are common among patients with liver cirrhosis. These vascular structures are collateral veins that directly connect the portal vein system with the systemic circulation. The prevalence increases as cirrhosis worsens. Published studies exist investigating the possible association between presence and extension of SPSSs and clinical manifestation of liver cirrhosis, however some issues continue to be debated. Recent research on this topic has extended knowledge and brought out interesting new aspects. The aim of this review is to provide a comprehensive and updated revision of the role of SPSSs in liver cirrhosis, from pathophysiology to clinical and therapeutic considerations, specifically addressing the most controversial and emerging findings. On this purpose PubMed and Medline were used as data sources and an extensive review of the literature, including the most recent and relevant published studies, was performed. The presence of SPSSs, especially if multiple and/or large, is associated with an increased risk of developing several complications of liver cirrhosis. Patients with higher MELD have larger SPSSs with negative impact on survival. Regarding hepatocellular carcinoma, there is evidence suggesting a potential tumorigenic effect associated with SPSSs, but further investigations on humans are needed. In the context of liver transplantation, the negative effect of SPSSs on graft function and patients' survival is a matter of debate, with no consensus on their surgical management. Currently, several interventional treatments have been proposed for SPSSs that have demonstrated excellent outcomes in selected populations.","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portal hypertension-associated gastric pathology: role of endoscopic banding ligation. 门脉高压相关的胃病理：内镜绑扎的作用。

IF 1.9

Minerva gastroenterology Pub Date : 2025-03-06 DOI: 10.23736/S2724-5985.25.03759-3

Maria L Gambardella, Carmelo Luigiano, Giuseppe LA Torre, Giuseppe G M Scarlata, Francesco Luzza, Ludovico Abenavoli

{"title":"Portal hypertension-associated gastric pathology: role of endoscopic banding ligation.","authors":"Maria L Gambardella, Carmelo Luigiano, Giuseppe LA Torre, Giuseppe G M Scarlata, Francesco Luzza, Ludovico Abenavoli","doi":"10.23736/S2724-5985.25.03759-3","DOIUrl":"https://doi.org/10.23736/S2724-5985.25.03759-3","url":null,"abstract":"Liver cirrhosis, marked by fibrosis and nodular regeneration, triggers a cascade of events resulting in portal hypertension (PH) and, subsequently, hepatic decompensation in its final stages. PH, arising from increased intrahepatic vascular resistance, serves as a harbinger of complications such as ascites, variceal bleeding, and hepatic encephalopathy, underscoring its clinical significance. Timely diagnosis of clinically significant portal hypertension (CSPH) is of pivotal importance, prompting the exploration of noninvasive diagnostic tools such as liver stiffness and spleen stiffness measurement. β-blockers, particularly Carvedilol, emerge as stalwart therapeutic agents in managing CSPH by inducing splanchnic vasoconstriction and reducing cardiac output. However, choosing between β-blockers and endoscopic banding ligation (EBL) for variceal bleeding prophylaxis requires careful consideration, especially in decompensated cirrhosis cases. EBL, while effective in preventing variceal bleeding, has several drawbacks, ranging from its inability to effectively treat PH to its association with upper digestive tract complications such as portal hypertensive gastropathy (PHG) and portal hypertensive polyps (PHPs). This narrative review aims to underline the appropriate diagnostic and therapeutic strategies for PH and to elucidate the relationship between PH, PHG, PHPs, and the use of EBL. This investigation emphasizes the urgency for further research aimed at devising optimal management strategies for PHG and PHPs, particularly in decompensated cirrhosis. Indeed, PH in cirrhotic patients requires a multifaceted approach encompassing early diagnosis, tailored therapeutic interventions, and ongoing research efforts aimed at refining treatment strategies and improving patient outcomes.","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative strategies for the rapid restoration of intestinal function in patients undergoing abdominal surgery: use of probiotics. Pilot study of 15 patients. 快速恢复腹部手术患者肠道功能的创新策略：使用益生菌。15例患者的初步研究。

IF 1.9

Minerva gastroenterology Pub Date : 2025-03-01 Epub Date: 2024-12-06 DOI: 10.23736/S2724-5985.24.03701-X

Elisabetta Radice, Olexii Potapov, Galyna Shabat, Elisa Martello, Giorgia Meineri, Paolo Risso, Francesco DI Pierro, Francesco Olandese

{"title":"Innovative strategies for the rapid restoration of intestinal function in patients undergoing abdominal surgery: use of probiotics. Pilot study of 15 patients.","authors":"Elisabetta Radice, Olexii Potapov, Galyna Shabat, Elisa Martello, Giorgia Meineri, Paolo Risso, Francesco DI Pierro, Francesco Olandese","doi":"10.23736/S2724-5985.24.03701-X","DOIUrl":"10.23736/S2724-5985.24.03701-X","url":null,"abstract":"Background: The clinical value of probiotics in patients undergoing abdominal surgery, particularly colorectal surgery, remains uncertain despite their well-documented health benefits. This pilot randomized controlled trial aimed to assess the effects of perioperative and postoperative oral administration of two probiotics, Clostridium butyricum CBM588® and Bifidobacterium longum ES1, on immune function, systemic inflammatory response, postoperative infections, and recovery after colorectal surgery.Methods: Fifteen adult patients underwent colorectal resection, with two groups receiving probiotics and one acting as a control. Blood and fecal samples were collected, and clinical parameters were assessed.Results: Results showed the safety of probiotics, resistance to antibiotics and gastric acid, and potential benefits in reducing postoperative infections and intestinal inflammation.Conclusions: Future trials should provide more conclusive evidence on the efficacy and safety of perioperative probiotic administration in colorectal surgery, aiming for improved patient outcomes and reduced healthcare costs.","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"7-14"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary sclerosing cholangitis and inflammatory bowel disease: a complicated yet unique relationship. 原发性硬化性胆管炎和炎症性肠病：一种复杂而独特的关系。

IF 1.9

Minerva gastroenterology Pub Date : 2025-03-01 Epub Date: 2024-02-07 DOI: 10.23736/S2724-5985.23.03605-7

Matteo Peviani, Nora Cazzagon, Martina Gambato, Luisa Bertin, Fabiana Zingone, Edoardo V Savarino, Brigida Barberio

引用次数: 0