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Available markers of excessive alcohol use. 过量饮酒的可用标记。
IF 1.9
Minerva gastroenterology Pub Date : 2025-07-25 DOI: 10.23736/S2724-5985.25.03884-7
Fabio Caputo, Alberto Casabianca, Lisa Lungaro, Anna Costanzini, Gianni Testino, Matteo Guarino, Giacomo Caio, Roberto DE Giorgio
{"title":"Available markers of excessive alcohol use.","authors":"Fabio Caputo, Alberto Casabianca, Lisa Lungaro, Anna Costanzini, Gianni Testino, Matteo Guarino, Giacomo Caio, Roberto DE Giorgio","doi":"10.23736/S2724-5985.25.03884-7","DOIUrl":"https://doi.org/10.23736/S2724-5985.25.03884-7","url":null,"abstract":"<p><p>The need for objective diagnostic tools in people with alcohol intake abuse is one of the major needs in daily clinical practice. Determination of blood alcohol concentration is commonly used in cases of suspected acute alcohol intoxication, especially in the emergency room. A dose-dependent correlation between alcohol consumption and mean corpuscular volume (MCV) is a known index of excessive alcohol intake. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels are frequently elevated (2-4 times above normal) in patients with alcohol use disorder and an AST/ALT ratio >2 is indicative of alcohol-related liver disease. Several studies highlighted a positive correlation between alcohol consumption and serum gamma-glutamyl transferase (γGT) levels, with increased values in about 75% of patients drinking >60 g/day of ethanol for at least 5 weeks. Also, 60-80 g of alcohol per day for a minimum of 2 weeks can result in increased carbohydrate-deficient transferrin (CDT) levels (normally less than 2% of total transferrin). Complete abstinence from alcohol leads to a normalization of CDT values in approximately 2-3 weeks. Ethyl glucuronide (EtG) is detectable in urine from a minimum of 6 hours up to a maximum of 100 hours after alcohol intake. In-vitro studies showed that the levels of phosphatidylethanol (PEth) in human red blood cells were proportional to ethanol concentration and exposure time, suggesting an important role in differentiating abstinence from unhealthy drinking. γGT and CDT are the most useful markers for monitoring chronic alcohol abstinence, whereas blood alcohol concentration and urinary EtG are the most valuable indexes of acute alcohol consumption. In conclusion, no specific laboratory marker alone is reliable to identify patients with alcohol abuse, thus the best diagnostic strategy includes combined index use in addition to other screening tools (i.e., clinical history/context and questionnaires).</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controversies in management of Helicobacter pylori infection from a U.S. perspective: population screening and treatment. 从美国的角度看幽门螺杆菌感染管理的争议：人群筛查和治疗。
IF 1.9
Minerva gastroenterology Pub Date : 2025-07-25 DOI: 10.23736/S2724-5985.25.03827-6
Min J Kim, Mimi C Tan
{"title":"Controversies in management of Helicobacter pylori infection from a U.S. perspective: population screening and treatment.","authors":"Min J Kim, Mimi C Tan","doi":"10.23736/S2724-5985.25.03827-6","DOIUrl":"https://doi.org/10.23736/S2724-5985.25.03827-6","url":null,"abstract":"<p><p>Helicobacter pylori is responsible for several gastrointestinal disorders, of which gastric cancer is the most concerning. Given the racial and ethnic disparities seen with H. pylori infection and gastric cancer in the U.S., certain populations (immigrants, non-white racial groups) remain at high-risk. While several guidelines recommend screening for H. pylori in these high-risk groups, specific guidance on how to implement population screening and the cost-effectiveness of this approach is lacking. Here we discuss several controversies including the cost-effectiveness and implementation of a population-based H. pylori screening program, empiric vs. tailored therapy based on antibiotic susceptibility, and the role of potassium-competitive acid blockers (PCABs) in H. pylori treatment. With the rapidly changing landscape of H. pylori management, here we review the latest studies and guidelines for practical clinical application.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementing research, improving practice: synergizing the clinical research nurse and the nurse researcher. 实施研究，改进实践：临床研究型护士与护理研究者协同工作。
IF 1.9
Minerva gastroenterology Pub Date : 2025-07-03 DOI: 10.23736/S2724-5985.25.03976-2
Daniele Napolitano, Alessio Lo Cascio, Mattia Bozzetti, Monica Guberti
{"title":"Implementing research, improving practice: synergizing the clinical research nurse and the nurse researcher.","authors":"Daniele Napolitano, Alessio Lo Cascio, Mattia Bozzetti, Monica Guberti","doi":"10.23736/S2724-5985.25.03976-2","DOIUrl":"https://doi.org/10.23736/S2724-5985.25.03976-2","url":null,"abstract":"","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastric juice analysis in clinical practice: are we ready for the prime time? 胃液分析在临床实践中的应用：准备好了吗？
IF 1.9
Minerva gastroenterology Pub Date : 2025-06-01 Epub Date: 2025-03-31 DOI: 10.23736/S2724-5985.25.03861-6
Emanuele Dilaghi, Gianluca Esposito, Gianluca Franchellucci, Bruno Annibale, Angelo Zullo
{"title":"Gastric juice analysis in clinical practice: are we ready for the prime time?","authors":"Emanuele Dilaghi, Gianluca Esposito, Gianluca Franchellucci, Bruno Annibale, Angelo Zullo","doi":"10.23736/S2724-5985.25.03861-6","DOIUrl":"10.23736/S2724-5985.25.03861-6","url":null,"abstract":"<p><p>Helicobacter pylori (H. pylori) infection is the main cause of the most frequent gastroduodenal diseases and gastric atrophy, with or without intestinal metaplasia, which predisposes to gastric cancer development. Gastric juice analysis may be useful in diagnosing these conditions, revealing the H. pylori infection and hypochlorhydria status by measuring ammonium concentrations and pH levels. EndoFaster<sup>®</sup> is a device introduced to perform these analyses on gastric juice in real-time. The available data showed very high negative predictive values in ruling out the infection and corpus atrophic gastritis, thereby potentially reducing the need for gastric biopsies when test results are negative. This review aims to assess the potential role of EndoFaster<sup>®</sup> in supporting the diagnosis of H. pylori infection, detecting gastric precancerous lesions, and other specific clinical applications, potentially reducing unnecessary gastric biopsies.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"132-139"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between celiac disease and risk of kidney diseases: a systematic review and meta-analysis. 乳糜泻与肾脏疾病风险之间的关系：一项系统综述和荟萃分析。
IF 1.9
Minerva gastroenterology Pub Date : 2025-06-01 Epub Date: 2025-05-21 DOI: 10.23736/S2724-5985.25.03733-7
Sawai S Rathore, Shifa P Shaikh, Hyder R Zaidi, George O Salako, Chiranjeevee R Saravanan, Rabiat R Kuranga, Narendra Yagateela, Sai T Bandala, Bijay M Jeswani
{"title":"Association between celiac disease and risk of kidney diseases: a systematic review and meta-analysis.","authors":"Sawai S Rathore, Shifa P Shaikh, Hyder R Zaidi, George O Salako, Chiranjeevee R Saravanan, Rabiat R Kuranga, Narendra Yagateela, Sai T Bandala, Bijay M Jeswani","doi":"10.23736/S2724-5985.25.03733-7","DOIUrl":"10.23736/S2724-5985.25.03733-7","url":null,"abstract":"<p><strong>Introduction: </strong>Celiac disease (CD), an autoimmune disorder, has been linked to chronic kidney disease but results are inconsistent. This meta-analysis investigates the association between CD and the risk of kidney disease.</p><p><strong>Evidence acquisition: </strong>A systematic literature search was conducted using PubMed, Embase, and Google Scholar up to March 31, 2024. Studies included observational reports on CD and kidney diseases. Random-effects models estimated pooled odds ratios (ORs) and 95% confidence intervals (CIs) to report the overall effect size, with significance set at P<0.05. Study quality was assessed using the Newcastle-Ottawa Scale (NCOS). Publication bias was evaluated using Egger's regression and Begg's rank correlation tests.</p><p><strong>Evidence synthesis: </strong>Nine studies with 2022,686 patients were included. The pooled prevalence of overall kidney disease, glomerulonephritis, and end-stage renal disease (ESRD) in CD patients was 2.29% (95% CI 1.34-3.49), 1.31% (95% CI 0.52-2.47), and 1.55% (95% CI 0.11-4.59), respectively. CD was significantly associated with a higher risk of overall kidney disease (OR=1.98, 95% CI 1.48-2.65), glomerulonephritis (OR=2.68, 95% CI 1.54-4.66), and ESRD (OR=2.58, 95% CI 1.32-5.03). Most studies were of high or moderate quality according to NCOS, and no publication bias was detected.</p><p><strong>Conclusions: </strong>CD patients have an elevated risk of various kidney diseases, including glomerulonephritis and ESRD. Monitoring renal function and managing CD are crucial to mitigating potential kidney damage. Future research should investigate the mechanisms underlying this association and explore targeted interventions to prevent or delay renal complications in CD patients.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"96-102"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of artificial intelligence combined with MDT teaching model in colorectal cancer training teaching. 人工智能结合MDT教学模式在结直肠癌培训教学中的应用。
IF 1.9
Minerva gastroenterology Pub Date : 2025-06-01 Epub Date: 2024-11-19 DOI: 10.23736/S2724-5985.24.03784-7
Jiawen Liu, Ning Zhang, Bo Li, Shouliang Cai
{"title":"Application of artificial intelligence combined with MDT teaching model in colorectal cancer training teaching.","authors":"Jiawen Liu, Ning Zhang, Bo Li, Shouliang Cai","doi":"10.23736/S2724-5985.24.03784-7","DOIUrl":"10.23736/S2724-5985.24.03784-7","url":null,"abstract":"","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"170-172"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced approaches in the comprehensive management of gastroparesis: from etiology to emerging therapies. 胃轻瘫综合治疗的先进方法：从病因学到新兴疗法。
IF 1.9
Minerva gastroenterology Pub Date : 2025-06-01 Epub Date: 2025-02-27 DOI: 10.23736/S2724-5985.24.03804-X
Vishali Moond, Sahib Singh, Umar Hayat, Parth Patel, Archit Garg, Hassam Ali, Douglas G Adler
{"title":"Advanced approaches in the comprehensive management of gastroparesis: from etiology to emerging therapies.","authors":"Vishali Moond, Sahib Singh, Umar Hayat, Parth Patel, Archit Garg, Hassam Ali, Douglas G Adler","doi":"10.23736/S2724-5985.24.03804-X","DOIUrl":"10.23736/S2724-5985.24.03804-X","url":null,"abstract":"<p><p>Gastroparesis is a chronic gastrointestinal disorder characterized by delayed gastric emptying without mechanical obstruction, leading to symptoms such as nausea, vomiting, and abdominal pain. Despite its significant impact on patient quality of life, effective management remains challenging. Current treatments, such as prokinetic agents and antiemetics, offer symptomatic relief but have limitations, necessitating the exploration of new approaches. We reviewed the most recent literature using PubMed and Medline, focusing on studies that address the etiology, pathophysiology, and management of gastroparesis, including novel pharmacological agents, endoscopic techniques, and lifestyle modifications. Emerging therapies, including gastric peroral endoscopic myotomy and ghrelin agonists, show promise in improving patient outcomes. In this review, we examine these therapeutic advancements and discuss their potential role in the future management of gastroparesis.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"116-131"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gluten hepatitis: a case of an idiopathic rise in liver enzymes and their normalization on a gluten free diet. 麸质肝炎：一个特发性肝酶上升的情况下，他们的正常化无麸质饮食。
IF 1.9
Minerva gastroenterology Pub Date : 2025-06-01 Epub Date: 2025-04-23 DOI: 10.23736/S2724-5985.25.03934-8
Francesca Manza, Lisa Lungaro, Fabio Caputo, Anna Costanzini, Gianni Testino, David S Sanders, Umberto Volta, Roberto DE Giorgio, Giacomo Caio
{"title":"Gluten hepatitis: a case of an idiopathic rise in liver enzymes and their normalization on a gluten free diet.","authors":"Francesca Manza, Lisa Lungaro, Fabio Caputo, Anna Costanzini, Gianni Testino, David S Sanders, Umberto Volta, Roberto DE Giorgio, Giacomo Caio","doi":"10.23736/S2724-5985.25.03934-8","DOIUrl":"10.23736/S2724-5985.25.03934-8","url":null,"abstract":"","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"172-174"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic approaches to small bowel strictures. 内镜入路治疗小肠狭窄。
IF 1.9
Minerva gastroenterology Pub Date : 2025-06-01 Epub Date: 2025-03-21 DOI: 10.23736/S2724-5985.25.03868-9
Katelin Durham, Rami El Abiad, Mouen Khashab
{"title":"Endoscopic approaches to small bowel strictures.","authors":"Katelin Durham, Rami El Abiad, Mouen Khashab","doi":"10.23736/S2724-5985.25.03868-9","DOIUrl":"10.23736/S2724-5985.25.03868-9","url":null,"abstract":"<p><p>Small bowel strictures secondary to either benign or malignant causes are associated with significant morbidity and impaired quality of life. Symptoms and their severity are dependent on the location and the degree of stenosis which, in addition to the etiology, dictate the approach to treatment. Endoscopic management of small bowel strictures include endoscopic balloon dilation, enteral stenting, endoscopic ultrasound-guided gastroenterostomy (EUS-GE), and stricturotomy. The introduction of the cautery-enhanced lumen-apposing metal stent has streamlined EUS-GE and has brought it to the forefront especially for select patients with malignant gastric outlet obstruction (GOO) with acceptable survival. This review will summarize the literature regarding the aforementioned interventions and will focus on EUS-GE and how it compares with traditional use of enteral stents and surgical gastrojejunostomy in the management of malignant GOO.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"149-159"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to navigate the many direct-to-consumer microbiota analyses and why to use them. 如何浏览众多直接面向消费者的微生物群分析，以及为什么要使用它们。
IF 1.9
Minerva gastroenterology Pub Date : 2025-06-01 Epub Date: 2024-12-17 DOI: 10.23736/S2724-5985.24.03799-9
Francesco DI Pierro, Alexander Bertuccioli, Massimiliano Cazzaniga, Mariarosaria Matera, Ilaria Cavecchia, Viviana Gerardi, Stefania Piccirelli, Daniele Salvi, Cecilia L Pugliano, Paola Cesaro, Cristiano Spada, Nicola Zerbinati
{"title":"How to navigate the many direct-to-consumer microbiota analyses and why to use them.","authors":"Francesco DI Pierro, Alexander Bertuccioli, Massimiliano Cazzaniga, Mariarosaria Matera, Ilaria Cavecchia, Viviana Gerardi, Stefania Piccirelli, Daniele Salvi, Cecilia L Pugliano, Paola Cesaro, Cristiano Spada, Nicola Zerbinati","doi":"10.23736/S2724-5985.24.03799-9","DOIUrl":"10.23736/S2724-5985.24.03799-9","url":null,"abstract":"<p><p>Gut microbiota analysis, until a few years ago an exclusive research tool, has recently begun to spread among doctors and nutritionists around the world as a means aimed at better understanding patient disorders. As often happens, the commercial push has literally exploded and today there are numerous companies that offer microbiota analysis of dubious quality and/or as a business appliance aimed at selling supplements and the like. For non-experts it can therefore be difficult to find one's way among the numerous proposals. In this article we try not only to list those characteristics that could perhaps help choose one test rather than another, but we also try to discuss what the purpose of a microbiota analysis should be and what meaning to give to the concepts of dysbiosis and eubiosis. A small clinical experience is also cited to support the hypotheses made.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"160-169"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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