Francesco DI Pierro, Alexander Bertuccioli, Massimiliano Cazzaniga, Mariarosaria Matera, Ilaria Cavecchia, Viviana Gerardi, Stefania Piccirelli, Daniele Salvi, Cecilia L Pugliano, Paola Cesaro, Cristiano Spada, Nicola Zerbinati
{"title":"How to navigate the many direct-to-consumer microbiota analyses and why to use them.","authors":"Francesco DI Pierro, Alexander Bertuccioli, Massimiliano Cazzaniga, Mariarosaria Matera, Ilaria Cavecchia, Viviana Gerardi, Stefania Piccirelli, Daniele Salvi, Cecilia L Pugliano, Paola Cesaro, Cristiano Spada, Nicola Zerbinati","doi":"10.23736/S2724-5985.24.03799-9","DOIUrl":"https://doi.org/10.23736/S2724-5985.24.03799-9","url":null,"abstract":"<p><p>Gut microbiota analysis, until a few years ago an exclusive research tool, has recently begun to spread among doctors and nutritionists around the world as a means aimed at better understanding patient disorders. As often happens, the commercial push has literally exploded and today there are numerous companies that offer microbiota analysis of dubious quality and/or as a business appliance aimed at selling supplements and the like. For non-experts it can therefore be difficult to find one's way among the numerous proposals. In this article we try not only to list those characteristics that could perhaps help choose one test rather than another, but we also try to discuss what the purpose of a microbiota analysis should be and what meaning to give to the concepts of dysbiosis and eubiosis. A small clinical experience is also cited to support the hypotheses made.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elisabetta Radice, Olexii Potapov, Elisa Martello, Giorgia Meineri, Paolo Risso, Francesco DI Pierro, Francesco Olandese, Galyna Shabat
{"title":"Innovative strategies for the rapid restoration of intestinal function in patients undergoing abdominal surgery: use of probiotics. Pilot study of 15 patients.","authors":"Elisabetta Radice, Olexii Potapov, Elisa Martello, Giorgia Meineri, Paolo Risso, Francesco DI Pierro, Francesco Olandese, Galyna Shabat","doi":"10.23736/S2724-5985.24.03701-X","DOIUrl":"https://doi.org/10.23736/S2724-5985.24.03701-X","url":null,"abstract":"<p><strong>Background: </strong>The clinical value of probiotics in patients undergoing abdominal surgery, particularly colorectal surgery, remains uncertain despite their well-documented health benefits. This pilot randomized controlled trial aimed to assess the effects of perioperative and postoperative oral administration of two probiotics, Clostridium butyricum CBM588<sup>®</sup> and Bifidobacterium longum ES1, on immune function, systemic inflammatory response, postoperative infections, and recovery after colorectal surgery.</p><p><strong>Methods: </strong>Fifteen adult patients underwent colorectal resection, with two groups receiving probiotics and one acting as a control. Blood and fecal samples were collected, and clinical parameters were assessed.</p><p><strong>Results: </strong>Results showed the safety of probiotics, resistance to antibiotics and gastric acid, and potential benefits in reducing postoperative infections and intestinal inflammation.</p><p><strong>Conclusions: </strong>Future trials should provide more conclusive evidence on the efficacy and safety of perioperative probiotic administration in colorectal surgery, aiming for improved patient outcomes and reduced healthcare costs.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria R Cesarone, Gianni Belcaro, David Cox, Giuseppe Gizzi, Luciano Pellegrini, Claudia Scipione, Valeria Scipione, Francesca Coppazuccari, Mark Dugall, Shu Hu, Luciano Orsini, Marcello Corsi, Beatrice Feragalli, Roberto Cotellese
{"title":"Robuvit® supplementation reduces progression of non-alcoholic fatty liver disease in elderly subjects.","authors":"Maria R Cesarone, Gianni Belcaro, David Cox, Giuseppe Gizzi, Luciano Pellegrini, Claudia Scipione, Valeria Scipione, Francesca Coppazuccari, Mark Dugall, Shu Hu, Luciano Orsini, Marcello Corsi, Beatrice Feragalli, Roberto Cotellese","doi":"10.23736/S2724-5985.24.03787-2","DOIUrl":"https://doi.org/10.23736/S2724-5985.24.03787-2","url":null,"abstract":"","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva gastroenterologyPub Date : 2024-12-01Epub Date: 2024-01-29DOI: 10.23736/S2724-5985.23.03621-5
Min Su, Wanchen Yu, Ying Su
{"title":"The influence of acupoint scraping combined with traditional Chinese medicine fumigation on gastrointestinal dysfunction and defecation after minimally invasive abdominal surgery.","authors":"Min Su, Wanchen Yu, Ying Su","doi":"10.23736/S2724-5985.23.03621-5","DOIUrl":"10.23736/S2724-5985.23.03621-5","url":null,"abstract":"","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"463-465"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139576996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva gastroenterologyPub Date : 2024-12-01Epub Date: 2024-01-19DOI: 10.23736/S2724-5985.23.03563-5
Lorenzo Bertani, Linda Balestrini, Lucia Chico, Giulia Della Scala, Francesca Geri, Alessandro Tornar, Claudio Belcari
{"title":"Specific probiotics and prebiotics to improve the quality of life of patients with chronic irritable bowel syndrome.","authors":"Lorenzo Bertani, Linda Balestrini, Lucia Chico, Giulia Della Scala, Francesca Geri, Alessandro Tornar, Claudio Belcari","doi":"10.23736/S2724-5985.23.03563-5","DOIUrl":"10.23736/S2724-5985.23.03563-5","url":null,"abstract":"<p><strong>Background: </strong>Irritable bowel syndrome (IBS) is a chronic disorder with an important impact on patients' quality of life. Although several data indicate that psychological symptoms are frequently reported by patients with IBS, few therapies have been evaluated regarding these issues.</p><p><strong>Methods: </strong>A retrospective observational study was conducted to evaluate the effectiveness of a probiotic-based dietary supplement (Colicron<sup>®</sup>) in a group of patients with diarrhea-predominant IBS (IBS-D). We included patients treated with Colicron<sup>®</sup> (1 cps/day for 8 weeks). Primary endpoint was the gastrointestinal symptoms' remission evaluated by Visual Analogue Scale (VAS); secondary endpoint was the impact of the treatment on physical and mental health evaluated by Hospital Anxiety and Depression Score (HADS) and Short Form Health Survey 36 (SF-36). VAS was assessed at week 4 (T4), week 8 (T8) and week 12 (T12), whereas HADS and SF-36 were performed even at the start of the Colicron<sup>®</sup> treatment (T0).</p><p><strong>Results: </strong>An improvement of VAS Score was observed at T8 (P<0.001) and T12 (P<0.05) compared to T4. Lower HADS-A (anxiety subdomain) score was obtained at each time point versus T0 (P<0.01), and higher scores of all SF-36 domains were observed during the treatment (0.05<P<0.001) compared to baseline. Moreover, HADS-D (depression subdomain) score, correlated positively, at T0 (P<0.05) and T4 (P<0.05) with the age, as well as a positive correlation was detected between disease duration (P<0.05) and age of patients (P<0.001).</p><p><strong>Conclusions: </strong>Colicron<sup>®</sup> could be useful in improving both gastrointestinal and psychological symptoms in IBS-D patients. Further prospective clinical trials are needed to confirm these preliminary data.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"413-421"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva gastroenterologyPub Date : 2024-12-01Epub Date: 2024-06-26DOI: 10.23736/S2724-5985.24.03702-1
Andrew Canakis, Kourosh Kalachi, Jay Bapaye, Nevin Varghese, Benjamin Twery, Jerrold S Canakis
{"title":"The diagnostic capability of i-scan for early gastric cancer detection: a systematic review and meta-analysis.","authors":"Andrew Canakis, Kourosh Kalachi, Jay Bapaye, Nevin Varghese, Benjamin Twery, Jerrold S Canakis","doi":"10.23736/S2724-5985.24.03702-1","DOIUrl":"10.23736/S2724-5985.24.03702-1","url":null,"abstract":"<p><strong>Background: </strong>I-scan is an image enhancing technology that utilizes contrast, surface, and tone enhancement to examine the microvascular and microsurface structures of mucosa. Its ability to diagnosis GC is of growing interest due to its ability to make an optical diagnosis; however, only a handful of studies have explored its role in this setting. We aimed to investigate the diagnostic capability of i-scan for GC detection.</p><p><strong>Methods: </strong>Multiple databases were searched for studies utilizing i-scan for GC detection until February 2024. Primary outcomes included the pooled sensitivity, specificity, and accuracy.</p><p><strong>Results: </strong>Seven studies were included (371 patients, 220 GC lesions). The pooled sensitivity was 84% (four studies, 95% CI: 0.65; 0.93), specificity was 83% (three studies, 95% CI: 0.68; 0.92) and accuracy was 84% studies (N.=3, 95% CI: 0.69; 0.93).</p><p><strong>Conclusions: </strong>I-scan appears to be an effective diagnostic tool for GC. However, the functional capabilities related to brightness detection may limits use. Further prospective, comparative studies are needed to determine its role in clinical practice compared to white light endoscopy, narrow band imaging and chromoendoscopy.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"399-404"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva gastroenterologyPub Date : 2024-12-01Epub Date: 2023-12-21DOI: 10.23736/S2724-5985.23.03594-5
Adil S Mir
{"title":"Upadacitinib in Crohn's disease: real-world experience.","authors":"Adil S Mir","doi":"10.23736/S2724-5985.23.03594-5","DOIUrl":"10.23736/S2724-5985.23.03594-5","url":null,"abstract":"<p><p>Small molecule therapy in inflammatory bowel disease has recently gained momentum. One such agent that was recently approved for use in Crohn's disease is upadacitinib. Even though clinical trials support the use of this agent and efficacy is impressive, real-world data remains limited and scattered in the current literature. This article aims to summarize the real-world data published so far about using upadacitinib in Crohn's disease.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"442-445"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva gastroenterologyPub Date : 2024-12-01Epub Date: 2024-03-21DOI: 10.23736/S2724-5985.24.03660-X
Jiaxing Luo, Haiguang Liu, Ouchen Wang
{"title":"Clinical experience and treatment of bilateral breast metastasis induced by signet ring cell carcinoma of stomach.","authors":"Jiaxing Luo, Haiguang Liu, Ouchen Wang","doi":"10.23736/S2724-5985.24.03660-X","DOIUrl":"10.23736/S2724-5985.24.03660-X","url":null,"abstract":"","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"468-470"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva gastroenterologyPub Date : 2024-12-01Epub Date: 2024-01-19DOI: 10.23736/S2724-5985.23.03590-8
Ludovico Abenavoli, Giuseppe Gm Scarlata, Emidio Scarpellini, Anna C Procopio, Francesca R Ponziani, Luigi Boccuto, Nenad Cetkovic, Francesco Luzza
{"title":"Therapeutic success in primary biliary cholangitis and gut microbiota: a safe highway?","authors":"Ludovico Abenavoli, Giuseppe Gm Scarlata, Emidio Scarpellini, Anna C Procopio, Francesca R Ponziani, Luigi Boccuto, Nenad Cetkovic, Francesco Luzza","doi":"10.23736/S2724-5985.23.03590-8","DOIUrl":"10.23736/S2724-5985.23.03590-8","url":null,"abstract":"<p><p>Primary biliary cholangitis (PBC) is a chronic, cholestatic, autoimmune disease, characterized by destruction of bile ducts. PBC predominantly affects women between 40 and 60 years of age. The presence of antimitochondrial antibodies (AMA) is a serological feature of PBC. These highly specific antibodies are found in about 95% of patients with the disease. The family of enzymes located in the inner membrane of the mitochondria, called the 2-oxo-acid dehydrogenase complex represents the target of the AMA. Ursodeoxycholic acid (UDCA) is a synthetic bile acid capable of protecting cholangiocytes from cholestatic damage caused by the accumulation of bile acids with a mechanism of action not yet well clarified. UDCA represents the gold standard therapy for PBC patients with recommended dose of 13-15 mg/kg/day. However, not every patient responds to therapy. On the other hand, the gut microbiota plays a key role in the onset of PBC through still unclear biochemical pathways. Less is known about its role as a potential biomarker after drug treatment. Actually, few studies analyzed the changes in gut microbiota composition before and after UDCA treatment. For this reason, this review represents an examination of the studies carried out on changes in gut microbiota composition in patients affected by PBC before and after treatment.</p>","PeriodicalId":94142,"journal":{"name":"Minerva gastroenterology","volume":" ","pages":"430-441"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}