Metabolism open最新文献

{"title":"The role of kidney biopsy in deciphering diabetic versus non-diabetic origin of kidney disease among patients with type 2 diabetes mellitus and nephrotic range proteinuria: A retrospective study","authors":"Efstratios Kardalas ,&nbsp;Aggeliki Paikopoulou ,&nbsp;Dimitra A. Vassiliadi ,&nbsp;Dimitris Kounatidis ,&nbsp;Natalia G. Vallianou ,&nbsp;Christine Vourlakou ,&nbsp;Irene Karampela ,&nbsp;Maria Dalamaga ,&nbsp;Marinella Tzanela ,&nbsp;Theodora Stratigou","doi":"10.1016/j.metop.2024.100313","DOIUrl":"10.1016/j.metop.2024.100313","url":null,"abstract":"<div><h3>Background</h3><p>Diabetes mellitus (DM) is tightly associated with the increased prevalence of diabetic kidney disease (DKD). Nonetheless, severe renal function impairment and/or nephrotic range-proteinuria could also result from non-diabetic renal disease (non-DRD) among patients with DM. The ‘Gold standard’ for the differential diagnosis between DKD and non-DRD is kidney biopsy, although no real consensus exists. Thus, this study intends to associate the clinical and biochemical profile of patients with DM and renal disease with the histopathological data of kidney biopsy.In addition, we aimed to evaluate the role of kidney biopsy, especially when other causes, other than DM, are highly suspected among patients with DM and kidney disease.</p></div><div><h3>Methods</h3><p>Thirty two patients with T2DM and nephrotic range levels of proteinuria or with co-existing factors pointing towards a non-diabetic origin of kidney disease were studied, retrospectively. All 32 patients underwent kidney biopsy and were classified according to histopathological findings into 3 groups: a) isolated diabetic kidney disease (DKD), b) non-diabetic kidney disease (NDKD) and c) mixed kidney disease (MKD).</p></div><div><h3>Results</h3><p>Fifteen out of the 32 patients had findings of an isolated DKD, while 17 out of 32 patients suffered from NDKD (13 patients) or MKD (4 patients). DKD patients were younger (p = 0.016) and had a higher HbA1c value (p = 0.069, borderline statistical significance), while the NDKD patients had significantly shorter disease duration (p = 0.04). Furthermore, the incidence of diabetic retinopathy (DR) was lower among the NDKD patients (p &lt; 0.001), who had also significantly less interstitial fibrosis (p = 0.02). Finally, the presence of DR, higher levels of interstitial fibrosis and longer T2DM duration were recognized as factors, which were positively associated with DKD.</p></div><div><h3>Conclusion</h3><p>This study advocates the usefulness of kidney biopsy in patients with T2DM and nephrotic range levels of proteinuria, especially when DR is absent and shorter disease duration is observed.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100313"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000458/pdfft?md5=940e89fbbcb6631353fc2c894d8f746d&pid=1-s2.0-S2589936824000458-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of phase angle and Triglyceride-Glucose index as biomarkers for prediction and management of diabetic foot disease","authors":"E. Soler Climent ,&nbsp;L. Lledó Rico ,&nbsp;M. García Poblet ,&nbsp;I. Sospedra ,&nbsp;I. Junquera-Godoy ,&nbsp;J.L. Martinez-De-Juan ,&nbsp;J. Gomis-Tena ,&nbsp;J. Saiz ,&nbsp;G. Prats-Boluda ,&nbsp;R. Santoyo Pérez","doi":"10.1016/j.metop.2024.100315","DOIUrl":"10.1016/j.metop.2024.100315","url":null,"abstract":"<div><h3>Introduction</h3><p>Approximately 25 % of diabetic patients develop diabetic foot ulcers (DFUs), significantly increasing morbidity, mortality, and healthcare costs. Effective control and prevention are crucial.</p></div><div><h3>Objective</h3><p>This study aims to identify easily measurable parameters for predicting DFU risk by assessing the correlation between Phase Angle (PA) and the Triglyceride-Glucose (TyG) index with DFU risk.</p></div><div><h3>Materials and methods</h3><p>A comparative case-control study was conducted at the General Hospital of Elche from March to June 2023 with 70 participants (33 with diabetes, 37 without). Cases had diabetes for over five years and a diabetic foot risk grade of 0, 1, or 2 (IWGDF 2019). Exclusion criteria included inability to walk, prior use of orthoses, and severe complications like edema or wounds. Predictive variables were PA, TyG index, body composition, and biochemical markers. Statistical analyses included Pearson/Spearman tests for correlations, Student's t-test/Mann-Whitney test for group comparisons, and ANOVA/Kruskal-Wallis tests for normally and non-normally distributed variables.</p></div><div><h3>Results</h3><p>PAand TyG index were strongly linked to diabetic foot risk, supporting their potential as biomarkers. Significant relationships with other relevant biomarkers were also confirmed.</p></div><div><h3>Conclusion</h3><p>PA and TyG index are valuable, easily measurable biomarkers for assessing diabetic foot risk, and can be monitored in primary care settings. Implementing these biomarkers in routine practice could enhance the management of diabetic complications, particularly in resource-limited settings, by enabling early detection and intervention, thus improving patient outcomes and reducing the burden of advanced complications.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100315"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000471/pdfft?md5=2b913fb16841984666aee863aecd437f&pid=1-s2.0-S2589936824000471-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142097805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet patterns, gut microbiota and metabolic disorders: Perspectives and challenges","authors":"Maria Dalamaga,&nbsp;Christina Tsigalou","doi":"10.1016/j.metop.2024.100310","DOIUrl":"10.1016/j.metop.2024.100310","url":null,"abstract":"<div><p>The worldwide surge in obesity and associated metabolic disorders is emerging as a significant public health issue for societies and healthcare systems. Available evidence has shown that alterations in the gut microbiota could be implicated in the pathogenesis of obesity and associated disorders. A healthy gut microbiome is characterized by richness and high microbial diversity. Gut microbiota affect how the host responds to diet, and conversely, the host may modify the gut microbiota through changes in dietary habits. Diet can impact and alter the composition, diversity, and species richness of the gut microbiota over time. An unhealthy diet, high in fat and sugar, may lead to decreased microbial diversity, reduced synthesis of metabolites that maintain gut permeability, damage to the mucus layer, increased bacterial translocation and lipopolyssacharide which can trigger endotoxemia, chronic subclinical inflammation and metabolic disorders. Currently, the impact of diet on gut microbial composition and its involvement in the pathogenic mechanisms underlying metabolic disorders is one of the most promising areas of research in nutrition. This special issue has gathered original research articles in topics related to diet patterns, gut microbiota, obesity and associated metabolic disorders as well as brief reports, reviews and perspectives in the wider field of translational and clinical metabolic research. In particular, the aim of this Special Issue was to present evidence connecting gut microbiota with metabolic disorders, explore the underlying mechanisms of this association, and examine how diet patterns may influence this relationship.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100310"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000422/pdfft?md5=b2f625c6ba80ea1b2b360308621c4f1f&pid=1-s2.0-S2589936824000422-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Picroside Ⅱ alleviates renal fibrosis through YY1-dependent transcriptional inhibition of TGFβ1","authors":"Xianjing Zhang ,&nbsp;Jiarong Zhang ,&nbsp;Xiaojun Xu ,&nbsp;Suzhen Chen ,&nbsp;Fei Gao","doi":"10.1016/j.metop.2024.100316","DOIUrl":"10.1016/j.metop.2024.100316","url":null,"abstract":"<div><p>Diabetic Nephropathy (DN) has become the leading cause of end-stage renal disease worldwide. Studies have indicated that Transforming Growth Factor beta1 (TGFβ1) is the most potent factor contributing to renal fibrosis, and understanding the exact pathogenic mechanism of renal fibrosis is crucial for alleviating the condition. Previous research has identified Yin Yang 1 (YY1) as an effective inhibitor of TGF-β1. Our study, through dual-luciferase reporter gene assays and Western blot experiments, screened and obtained the small molecule compound PdⅡ. Subsequently, validation in a high-glucose-induced renal mesangial cell injury model showed that PdⅡ treatment significantly increased the expression of YY1 protein and mRNA, while correspondingly reducing the expression of TGFβ1 protein and mRNA. Dual-luciferase reporter gene assay results revealed that, compared to the control group, the luciferase transcription activity of YY1 molecules increased in the PdⅡ treatment group, and the luciferase transcription activity of TGFβ1 decreased. By further designing mutations in the binding sites between TGFβ1 and YY1 on the promoter, transfecting fluorescent enzyme reporter gene plasmids with TGFβ1 mutant promoter into mesangial cells damaged by high glucose, and then treating the cells with PdⅡ, it was observed that the luciferase transcription activity of TGFβ1 did not decrease. Therefore, these results suggest that PdⅡ may inhibit TGFβ1 transcriptional activity by activating YY1, thereby slowing down the progression of diabetic nephropathy.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100316"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000483/pdfft?md5=db8615e10ae15f93785f3707a5a60833&pid=1-s2.0-S2589936824000483-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute liver steatosis signals the chromatin for regeneration via MIER1","authors":"","doi":"10.1016/j.metop.2023.100258","DOIUrl":"10.1016/j.metop.2023.100258","url":null,"abstract":"<div><p>During liver regeneration, especially after a hepatectomy, hepatocytes experience significant lipid accumulation. These transiently accumulated lipids are generally believed to provide substrates for energy supply or membrane biomaterials for newly generated hepatocytes. Remarkably, a recent study found that acute lipid accumulation during regeneration can act as a signal for chromatin remodeling to regulate regeneration. Chen, Y.H., et al. identified MIER1 (mesoderm induction early response protein 1) as a crucial inhibitor of liver regeneration through <em>in vivo</em> CRISPR screening. MIER1 binds to and restrains cell cycle genes’ expression. During liver regeneration, acute lipid accumulation suppresses MIER1 translation via the EIF2S pathway, resulting in transient down-regulation of MIER1 protein, which promotes cell cycle gene expression and liver regeneration. Interestingly, the researchers also found that the dynamic regulation of MIER1 was impaired in fatty and aging livers with chronic steatosis, while of knockout of MIER1 in these animals improved their regenerative capacity. In conclusion, this study provides valuable insights into the complex mechanisms underlying liver regeneration and highlights the potential therapeutic applications of targeting MIER1 for improving liver regeneration in disease states associated with impaired lipid homeostasis.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100258"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936823000300/pdfft?md5=ee89c2960dce48e481cfe703d7871b2c&pid=1-s2.0-S2589936823000300-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135429721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperuricemia and associated factors among hypertensive patients attending an academic hospital of Ethiopia: A cross-sectional study","authors":"Oman Philmon Daka ,&nbsp;Tesfahun Bekele Jember ,&nbsp;Kibur Hunie Tesfa","doi":"10.1016/j.metop.2024.100312","DOIUrl":"10.1016/j.metop.2024.100312","url":null,"abstract":"<div><h3>Background</h3><p>Hypertension is a major public health problem in developing countries. Globally, nearly 1.13 billion adults had hypertension in 2015 and this is estimated to increase to 1.56 billion by 2025. Hyperuricemia is an important predictor of the progression of hypertension and is common in hypertensive patients. Hypertensive patients with hyperuricemia are at higher risk of cardiovascular disease.</p></div><div><h3>Objective</h3><p>To assess the prevalence of hyperuricemia and its associated factors among hypertensive patients attending the University of Gondar Comprehensive Specialized Hospital (UGCSH).</p></div><div><h3>Method</h3><p>An institutional-based cross-sectional study was conducted on 248 hypertensive patients attending the University of Gondar Comprehensive Specialized Hospital from January 2020 to February 2021. A convenient sampling technique was employed to select study participants. Socio-demographic and clinical characteristics were collected using a structured questionnaire via face-to-face interviews and reviewing medical records respectively. The biochemical parameters were measured by using a Mindray BS-200E chemistry analyzer. Data was entered using EpiData version 4.6.0.0 and analyzed using STATA vs. 14.0. Bivariable and multivariable binary logistic regression were fitted to identify factors associated with hyperuricemia. The odds ratio and 95 % CI were calculated to assess the strength of the association and a P-value &lt;0.05 in the multivariable was considered statistically significant.</p></div><div><h3>Results</h3><p>A total of 248 patients were enrolled; 140 (56.5 %) were female. The mean age of patients was 57.9 ± 10.5 years. The overall prevalence of hyperuricemia was 42.3 %; males had a prevalence of 36.1 % and females of 47.1 %. High waist circumference, high body mass index, dyslipidemia, low estimated Glomerular Filtration Rate, elevated fasting blood glucose, elevated total cholesterol, elevated triglycerides, elevated Low-Density Lipoprotein cholesterol, and Low High-Density Lipoprotein cholesterol were found to be significantly associated with hyperuricemia.</p></div><div><h3>Conclusion</h3><p>This study demonstrated the predominant existence of hyperuricemia in hypertensive patients. Therefore, early diagnosis and monitoring of hyperuricemia are required before further complications occur.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100312"},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000446/pdfft?md5=4d13548924e32361cb97cad6406548e1&pid=1-s2.0-S2589936824000446-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142077493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal medicine use and its impact on glycemic control among diabetes patients at governmental hospitals in Debre Berhan, Ethiopia: A cross-sectional study","authors":"Girma Deshimo Lema ,&nbsp;Enguday Demeke Gebeyaw ,&nbsp;Zena Admasu Yferu ,&nbsp;Seife Feleke Mulatu ,&nbsp;Asrat Berihun Dagnaw ,&nbsp;Getachew Bizuneh Aydagnuhm ,&nbsp;Esubalew Amanu Ayicheh","doi":"10.1016/j.metop.2024.100311","DOIUrl":"10.1016/j.metop.2024.100311","url":null,"abstract":"<div><h3>Background</h3><p>Diabetes mellitus (DM) is a major health concern worldwide. Diabetes patients are increasingly using herbal medicine (HM) without seeking advice from their healthcare providers. However, its impact on glycemic control is not documented in Ethiopia. Thus, this study aimed to assess herbal medicine use and its effect on glycemic control among diabetes patients at governmental hospitals in Debre Berhan town, Ethiopia.</p></div><div><h3>Methods</h3><p>A cross-sectional study involving 430 diabetic patients was conducted at two different hospitals in Debre Berhan town from January 1 to March 30, 2024. Data were gathered using a guided self-administered questionnaire to collect data including glycemic control assessed via hemoglobin A1c (HbA1c) levels. Data was analyzed using SPSS version 25. Logistic regression model was used to assess the predictors of herbal medicine usage, while an independent samples <em>t</em>-test was conducted to compare the mean HbA1c levels between herbal medicine users and non-users among diabetes patients.</p></div><div><h3>Results</h3><p>Of the 430 participants, 72.6 % were diagnosed with type 2 diabetes. The study revealed 48.1 % (95 % CI: 43.3–53) participants used herbal medicine. <em>Moringa stenopetala</em> (33.5 %), <em>Trigonella foenumgraecum</em> (27.4 %), and <em>Thymus schimperi</em> (17.9 %) were the predominant herbs utilized by diabetic patients. The use of herbal medicine was associated with the patients’ diabetic knowledge (AOR: 1.59; 95 % CI: 1.01–2.49), occupation (AOR: 3.7; 95 % CI: 1.36–10.23), income (AOR: 3.58; 95 % CI: 1.22–10.55), and family history of diabetes (AOR: 1.9; 95 % CI: 1.19–3.18). Glycemic status was not controlled for 86 % of herbal users compared to 66.8 % of non-users. Participants who used herbal medicine had significantly higher mean HbA1c by a mean difference of 0.41 (95%CI: 0.04–0.78).</p></div><div><h3>Conclusions</h3><p>Herbal medicine use was common among diabetes patients in this study. Poor knowledge about diabetes, a family history of diabetes, lower income, and a farming occupation were identified as strong predictors of HM use. Patients who used herbal medicine had significantly higher mean HbA1c levels compared to non-users. Healthcare providers should engage patients in discussions about herbal medicine use, emphasizing the potential risks to glycemic management. Future research should explore specific herbs used, their mechanisms of action, and strategies to integrate herbal medicine safely into diabetes management protocols.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100311"},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000434/pdfft?md5=76acc8ed39a63f1bdce94bd18658cc41&pid=1-s2.0-S2589936824000434-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coffee pulp improves glucose and lipid metabolism disorder in high-fat diet-induced diabetic mice","authors":"Shuaishuai Zhu ,&nbsp;Chenying Wang ,&nbsp;Zhuo-Xian Meng","doi":"10.1016/j.metop.2024.100303","DOIUrl":"10.1016/j.metop.2024.100303","url":null,"abstract":"<div><h3>Background</h3><p>Coffee berry extracts are anti-lipogenic and lipolytic. This study aims to investigate the effect and mechanism of coffee pulp on high-fat diet (HFD)-induced glucose and lipid metabolism disorder in mice.</p></div><div><h3>Methods</h3><p>The type 2 diabetes (T2D) mouse model was established by feeding the C57BL/6 J mice with HFD. Mice were administered with coffee pulp diluted in drinking water before or after the establishment of the T2D mouse model. After treatment, the body weight and fasting blood glucose (FBG) of mice were monitored; the intraperitoneal glucose tolerance test (IPGTT) of mice was performed; plasma insulin was determined by ELISA; serum total cholesterol (TC), triglyceride (TG) and liver TG were determined by biochemical analysis; hematoxylin-eosin (H&amp;E) staining was used to evaluate organ histomorphology. Gene expression of key genes in de novo lipogenesis (DNL) in the liver was examined by quantitative reverse transcription PCR (RT-qPCR).</p></div><div><h3>Results</h3><p>Mice that consumed coffee pulp after modeling showed reduced FBG and liver TG, improved IPGTT, and alleviated fatty liver. Consuming coffee pulp before modeling prevented HFD-induced blood glucose and plasma TG increases. Mice consuming coffee pulp also had lower body fat and liver TG compared to the model group. qPCR results showed that the expression of transcription factors (Srebp1, PPARγ) and genes (Fasn, CideA, Plin3, Plin4, Plin5) related to DNL and lipid droplets (LD) formation in the liver of mice consuming coffee pulp were significantly lower than those of the control group.</p></div><div><h3>Conclusions</h3><p>Our study demonstrated that coffee pulp can attenuate HFD-induced disorders of glucose and lipid metabolism, and this effect may be related to the key pathways of lipid synthesis DNL and LD formation pathways in the liver.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100303"},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000355/pdfft?md5=88538692c3cf7f4a23b2f59581b86211&pid=1-s2.0-S2589936824000355-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental detection of hereditary bisalbuminemia in a patient with positive DAT coombs: A case-based review","authors":"Elena Avgoustou ,&nbsp;Dimitris Kounatidis ,&nbsp;Natalia G. Vallianou ,&nbsp;Irene Karampela ,&nbsp;Theodora Stratigou ,&nbsp;Maria Dalamaga","doi":"10.1016/j.metop.2024.100307","DOIUrl":"10.1016/j.metop.2024.100307","url":null,"abstract":"<div><p>Bisalbuminemia is a rare, typically benign condition marked by the presence of a bifid albumin band on serum protein electrophoresis. It can either be inherited due to a point mutation or acquired in association with various medical conditions, most commonly diabetes mellitus. Bisalbuminuria, the presence of bifid albumin in urine, may or may not accompany bisalbuminemia. Both conditions are often discovered incidentally during screening for monoclonal gammopathy. Bisalbuminemia and related variants provide insights into albumin's genetic diversity and functional roles, influencing clinical diagnostics and research in human genetics. Understanding these variants aids in distinguishing benign conditions from potential disease states, guiding appropriate clinical management. In this case-based review, we present a case of hereditary bisalbuminemia identified unexpectedly during an investigation of a positive Direct Antiglobulin Test Coombs in an adult female patient. This review aims to highlight the key features of bisalbuminemia, a rare condition that should be recognized by clinicians.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100307"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000392/pdfft?md5=e24796c078da6c2030430d6420b5530b&pid=1-s2.0-S2589936824000392-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low muscle mass is associated with low insulin sensitivity, impaired pancreatic β cell function, and high glucose excursion in nondiabetic nonobese Japanese women","authors":"Satomi Minato-Inokawa ,&nbsp;Ayaka Tsuboi-Kaji ,&nbsp;Mari Honda ,&nbsp;Mika Takeuchi ,&nbsp;Kaori Kitaoka ,&nbsp;Miki Kurata ,&nbsp;Bin Wu ,&nbsp;Tsutomu Kazumi ,&nbsp;Keisuke Fukuo","doi":"10.1016/j.metop.2024.100306","DOIUrl":"10.1016/j.metop.2024.100306","url":null,"abstract":"<div><h3>Aim</h3><p>We tested whether skeletal muscle mass is associated with insulin sensitivity, pancreatic β-cell function, and postglucose glycemia.</p></div><div><h3>Methods</h3><p>Appendicular skeletal muscle mass (ASM) (relative to body size, %ASM) by DXA, surrogate measures of insulin sensitivity, insulin secretion and the disposition index (insulin sensitivity adjusted insulin secretion: a product of the insulinogenic index and Matsuda insulin sensitivity index) inferred from serum insulin kinetics during a 75 g oral glucose tolerance test (OGTT) were evaluated in 168 young and 65 middle-aged women, whose BMI averaged &lt;23.0 kg/m² and HbA1c ≦ 5.5 %.</p></div><div><h3>Results</h3><p>In two groups of women, %ASM was associated negatively with homeostasis model assessment insulin resistance (HOMA-IR) and 2-h insulin (both p &lt; 0.01 or less). In middle-aged women not in young women, %ASM was associated inversely with the Matsuda index (p &lt; 0.001). In middle-aged women only, it also showed a positive association with the disposition index (p = 0.02) and inverse associations with 1-h and 2-h glucose (both p &lt; 0.01) and area under the glucose concentration curve during OGTT (p = 0.006). On multivariate linear regression analyses, 2-h insulin emerged as a determinant of %ASM independently of HOMA-IR in young women (standardized β: 0.287, p &lt; 0.001, R² = 0.077). In middle-aged women, the Matsuda index emerged as a determinant of %ASM (standardized β: 0.476, p &lt; 0.001) independently of HOMA-IR, log ODI and AUCg and explained 21.3 % of %ASM variability. Post-glucose glycemia and AUCg were higher and log ODI was lower in middle-aged women with low compared with high %ASM.</p></div><div><h3>Conclusion</h3><p>Low skeletal muscle mass (relative to body size) was associated with low insulin sensitivity in young and middle-aged Japanese women who were neither obese nor diabetic. Middle-aged women with low muscle mass had low disposition index, an early marker of inadequate pancreatic β-cell compensation, and hence high glucose excursion. Low skeletal muscle mass may be associated with the development of type 2 diabetes at a much lower BMI in Japanese people.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100306"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000380/pdfft?md5=ffdc0afef1e7d6169159eca5d76375bf&pid=1-s2.0-S2589936824000380-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}