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Current Status of Biological Treatment in Ankylosing Spondylitis Patients and Some Related Factors. 强直性脊柱炎患者的生物治疗现状及相关因素。
Materia socio-medica Pub Date : 2023-09-01 DOI: 10.5455/msm.2023.35.222-227
Bui Hai Binh, Nguyen Ngoc Trung, Nguyen-Van Hung, Nguyen-Thi Ngoc Yen, Nguyen-Thi Nhu Hoa, Nguyen Thanh Hiep, Nguyen Minh Duc, Le-Thi Bich Phuong
{"title":"Current Status of Biological Treatment in Ankylosing Spondylitis Patients and Some Related Factors.","authors":"Bui Hai Binh,&nbsp;Nguyen Ngoc Trung,&nbsp;Nguyen-Van Hung,&nbsp;Nguyen-Thi Ngoc Yen,&nbsp;Nguyen-Thi Nhu Hoa,&nbsp;Nguyen Thanh Hiep,&nbsp;Nguyen Minh Duc,&nbsp;Le-Thi Bich Phuong","doi":"10.5455/msm.2023.35.222-227","DOIUrl":"10.5455/msm.2023.35.222-227","url":null,"abstract":"<p><strong>Background: </strong>Axial spondyloarthritis (axSpA) is a potentially disabling inflammatory arthritis of the spine, usually presenting as chronic back pain typically before the age of 45 years. It is often associated with one or more articular features, including synovitis, enthesitis, and dactylitis. It may also be associated with several non-articular features; these include uveitis, psoriasis, and inflammatory bowel diseases1.</p><p><strong>Objective: </strong>The aim of this article is to describe the status of using biological drugs and some related factors in treating ankylosing spondylitis in Vietnam.</p><p><strong>Methods: </strong>A joint prospective and retrospective cross-sectional descriptive study was conducted on 161 ankylosing spondylitis patients treated with biological drugs at the Centre for Rheumatology between January 2018 and July 2021. Data were collected at the first dose and after 3, 6, 12, 24, and 36 months, including general characteristics, clinical and para-clinical features, drug use status, and related factors.</p><p><strong>Results: </strong>Of the 161 patients, 86.3% were male, with a mean age of 31.1 ± 11.6 years and a mean disease duration of 7.6 ± 6.6 years. Most patients were started on biologics at stage II (46.6%) or III (28.6%). Moreover, 68.9% had active disease based on the Bath Ankylosing Spondylitis Disease Activity Index. The most commonly prescribed first-line therapy was anti-tumor necrosis factor (69.6%), with infliximab the most frequently prescribed drug (44.7%). The rate of biological drug treatment decreased gradually from 100% at the start to 77% after one year and 39.1% after three years. Moreover, 74% of patients changed drugs due to non-response, and 50% discontinued treatment for economic reasons. Age was associated with treatment adherence, and drug change rates were higher in female patients and patients with active disease. Age was significantly associated with drug discontinuation (p < 0.05).</p><p><strong>Conclusion: </strong>Infliximab was the most commonly prescribed first-line drug. The rate of biological therapy gradually decreased after three years. Most patients changed drugs due to non-response, and many discontinued the drugs for economic reasons. Among the individual and clinical factors, age was associated with treatment adherence.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"35 3","pages":"222-227"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/5c/MSM-35-222.PMC10545927.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41127081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping the Private Healthcare Sector in Riyadh Region: Size, Services, and Alignment with the Saudi Ministry of Health Priorities. 绘制利雅得地区私营医疗保健部门的地图:规模、服务以及与沙特卫生部优先事项的一致性。
Materia socio-medica Pub Date : 2023-09-01 DOI: 10.5455/msm.2023.35.172-177
Hassan Alshahrani, Naif Al-Matrafi, Nujud Al-Qahtani, Rajaa Taliby, Muna Hassanein, Ibtehaj Al-Rowilly
{"title":"Mapping the Private Healthcare Sector in Riyadh Region: Size, Services, and Alignment with the Saudi Ministry of Health Priorities.","authors":"Hassan Alshahrani,&nbsp;Naif Al-Matrafi,&nbsp;Nujud Al-Qahtani,&nbsp;Rajaa Taliby,&nbsp;Muna Hassanein,&nbsp;Ibtehaj Al-Rowilly","doi":"10.5455/msm.2023.35.172-177","DOIUrl":"10.5455/msm.2023.35.172-177","url":null,"abstract":"<p><strong>Background: </strong>Mapping exercises are important to inform development of interventions aiming to enhance private sector's contribution towards achieving health systems objectives.</p><p><strong>Objective: </strong>To map size, types, and distribution of private health institutions, and to identify the services they offer, and their alignment with Ministry of Health priorities.</p><p><strong>Methods: </strong>A cross-sectional study targeted licensed, for-profit private health institutions in Riyadh Region, Saudi Arabia. Secondary data were collected from Department of Private Health Institutions in Riyadh and the Ministry of Health Year Statistical Book. Descriptive statistics were employed to analyze the collected data.</p><p><strong>Results: </strong>Private hospitals increased from 40 (2017) to 46 (2021), with private sector hospital beds rising from 5,426 (2017) to 6,339 (2021). Pharmaceutical institutions comprised 55.4% of private health institutions, followed by polyclinics (23%) and supportive health services centers (17.1%). Laboratories, hospitals, and clinics represented 2%, 1%, and 0.5% of private health institutions respectively. Ambulance and radiology service centers were least available private health institutions at 0.1%. Home healthcare, remote care, telemedicine, family medicine, and long-term care were offered by 1.3%, 0.5%, 0.4%, and 0.1% of private health institutions respectively. Private hospitals accounted for 41.4% of total hospitals and private hospitals beds constituted 30.9% of Riyadh's total, with an average of 137.8 beds per hospital. Around 82% of private health institutions were in Riyadh city, with around 18% in peripheral provinces.</p><p><strong>Conclusion: </strong>Private healthcare sector has witnessed substantial growth, primarily influenced by supply rather than demand dynamics. Incentives are essential to promote investment in Ministry of Health priorities.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"35 3","pages":"172-177"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c5/5c/MSM-35-172.PMC10545926.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41169971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Medication Use Among Adolescents in Sarajevo Canton. 萨拉热窝州青少年药物使用情况评估。
Materia socio-medica Pub Date : 2023-09-01 DOI: 10.5455/msm.2023.35.178-183
Vanja Piljak, Selma Skrbo, Naida Omerovic, Anela Hadzifejzovic Trnka, Dina Lagumdzija, Nermina Ziga Smajic
{"title":"Assessment of Medication Use Among Adolescents in Sarajevo Canton.","authors":"Vanja Piljak,&nbsp;Selma Skrbo,&nbsp;Naida Omerovic,&nbsp;Anela Hadzifejzovic Trnka,&nbsp;Dina Lagumdzija,&nbsp;Nermina Ziga Smajic","doi":"10.5455/msm.2023.35.178-183","DOIUrl":"https://doi.org/10.5455/msm.2023.35.178-183","url":null,"abstract":"<p><strong>Background: </strong>Adolescents are a susceptible population in terms of medication use. They are not only inclined to abuse illegal substances but are also prone to nonmedical medication use, which exposes them to a significant risk of various adverse drug reactions (ADR).</p><p><strong>Objective: </strong>This research aims to assess medication use among adolescents in Sarajevo Canton.</p><p><strong>Methods: </strong>This paper features information about the most frequently used medications, reasons for their use, sources of their procurement, ADR and concurrent use with other medications and/or alcohol. To obtain this data, a questionnaire with open- and close-ended questions was created. The survey was conducted online and 444 participants were included.</p><p><strong>Results: </strong>Medications were used by 90.1% of adolescents. The most commonly used medications were non-opioid analgesics, antibiotics, dietary supplements, antihistamines and benzodiazepines. Mild to moderate pain was the most frequent reason for medication use. Participants were at risk of ADR, drug-drug interactions (DDI), and drug-alcohol interactions.</p><p><strong>Conclusion: </strong>It is up to healthcare workers, especially pharmacists, to educate and guide adolescent patients on rational medication use and inform them about potential dangers following the use of these medications.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"35 3","pages":"178-183"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/72/MSM-35-178.PMC10545922.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41175091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Presence of Type 1 Diabetes-Related Autoantibodies in Pediatric Population in Bosnia and Herzegovina. 波斯尼亚和黑塞哥维那儿童人群中1型糖尿病相关自身抗体的存在。
Materia socio-medica Pub Date : 2023-09-01 DOI: 10.5455/msm.2023.35.190-195
Lamija Zecevic-Pasic, Suzana Tihic-Kapidzic, Snijezana Hasanbegovic, Ermin Begovic, Refet Gojak, Nejra Dzananovic
{"title":"Presence of Type 1 Diabetes-Related Autoantibodies in Pediatric Population in Bosnia and Herzegovina.","authors":"Lamija Zecevic-Pasic,&nbsp;Suzana Tihic-Kapidzic,&nbsp;Snijezana Hasanbegovic,&nbsp;Ermin Begovic,&nbsp;Refet Gojak,&nbsp;Nejra Dzananovic","doi":"10.5455/msm.2023.35.190-195","DOIUrl":"10.5455/msm.2023.35.190-195","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus type 1 (T1D) is an autoimmune organ-specific disease with a wide range of clinical manifestations, in which the β cells of the pancreatic islets of Langerhans are destroyed by the action of autoreactive T lymphocytes and the formation of autoantibodies against β cell components. Among used serological markers of T1D, anti-glutamic acid decarboxylase antibodies (GAD65), anti-tyrosine phosphatase antibodies (IA2), islet cell antibodies (ICA), insulin autoantibodies (IAA) and anti-zinc transporter antibodies (Zn-T8) are of great significance.</p><p><strong>Objective: </strong>This study aimed to analyze presence of type 1 diabetes-related autoantibodies (GAD65, IA2, ICA, IAA and Zn-T8 and effects of age and gender on their occurrence in pediatric population.</p><p><strong>Methods: </strong>Sixty seven (N=67) T1D pediatric patients were included in the study. The levels of immunological parameters such as anti-glutamic acid decarboxylase antibodies (GAD-Ab), anti-tyrosine phosphatase antibodies (IA2-Ab), islet cell antibodies (ICA) and insulin autoantibodies (IAA) were determined by chemiluminescence immunoassay (CLIA) and anti-zinc transporter antibodies (Zn-T8-Ab) were determined by enzyme-linked immunosorbent assay (ELISA). For statistical analysis, we used SPSS statistical program.</p><p><strong>Results: </strong>Our study revealed that among 67 patients with T1D (40 male and 27 female), with an average age of 12,1±3,9 years. The average age of diabetes diagnosis was 6,15±3,29 years. 24 (35,8%) cases were positive for GAD65, 15 (22,4%) for ICA, 34 (50,7%) for IAA, 16 (23,9%) for IA2 and 36 (53,7%) for Zn-T8. The largest number of patients had single positive antibody, the most dominated among them was IAA dominated (40,9%), then Zn-T8 (31,8%). According to Spearman correlation test Zn-transporter shows a significant positive correlation with age of the participants (p=0.027) and disease duration (p=0.006). Anti IA2 shows significant negative correlation with HbA1c (p=0.043). Zn-transporter is associated with patients age and duration of T1D.</p><p><strong>Conclusion: </strong>In most cases, patients with T1D are positive for at least one of the specific autoantibodies. Zn-T8 is the most frequently detected and is an important serological marker of type 1 diabetes mellitus. Gender effects on autoantibodies seems to be insignificant, while age alongside disease duration shows important effects.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"35 3","pages":"190-195"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/db/54/MSM-35-190.PMC10545919.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41176076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Satisfaction of Patients with HIV/AIDS Infection from the Care Provided in the Special Infection Unit of University General Hospital of Alexandroupoli. 亚历山德鲁波利大学总医院特殊感染病房护理对HIV/AIDS感染者的满意度。
Materia socio-medica Pub Date : 2023-09-01 DOI: 10.5455/msm.2023.35.184-189
Petros Ouzounakis, Lambrini Kourkouta, Aikaterini Frantzana, Christos Iliadis, Areti Tsaloglidou, Konstantinos Koukourikos, Christos Sialakis, Evaggelos Alexopoulos
{"title":"Satisfaction of Patients with HIV/AIDS Infection from the Care Provided in the Special Infection Unit of University General Hospital of Alexandroupoli.","authors":"Petros Ouzounakis,&nbsp;Lambrini Kourkouta,&nbsp;Aikaterini Frantzana,&nbsp;Christos Iliadis,&nbsp;Areti Tsaloglidou,&nbsp;Konstantinos Koukourikos,&nbsp;Christos Sialakis,&nbsp;Evaggelos Alexopoulos","doi":"10.5455/msm.2023.35.184-189","DOIUrl":"https://doi.org/10.5455/msm.2023.35.184-189","url":null,"abstract":"<p><strong>Background: </strong>C HIV/AIDS infection is characterized by a very low number of T lymphocytes (CD4), which makes sufferers vulnerable to various infections, and so they seek continuous care in Special Infections Units.</p><p><strong>Objective: </strong>The purpose of the survey is to investigate the factors that contribute to the satisfaction derived from the health services provided to people living with the human immunodeficiency virus; and they are monitored at the Special Infections Unit of the University General Hospital of Alexandroupoli.</p><p><strong>Methods: </strong>All patients who came to the Special Infections Unit of the University General Hospital of Alexandroupoli during the period June - July 2021 were asked to complete an anonymous questionnaire on satisfaction derived from the health services provided (E - PQ - SPCSS) and satisfaction derived from their work and quality of life (Occupational Stress Questionnaire, JCQ). The statistical package SPSS 19.0 was used for the statistical analysis of the data. With the help of the ANOVA statistical test, the differences between the variables were checked. P-Value in all audits was set at 0.05. Values showing equal to or less than 0.05 were considered statistically significant.</p><p><strong>Results: </strong>They were 85 patients who participated. Amongst them, they were mainly men (75.3%), the mean age was 35-50 years (50.6%), residents of Thrace (62.3%). 37.7% of the participants said they had some difficulty accessing SIU. Quality of life was positively correlated with education (p<0.001) where the higher reported level of education was, the higher satisfaction rates were. A positive correlation (p<0.001) was also observed amongst income rates where the higher incomes reported, the higher the satisfaction rates were. Lower incomes were significantly associated (p = 0.029) with mental disorders (anxiety, depression). Quality of life was positively associated with both satisfaction with medical as well as nursing care (p <0.008). The adequacy and clarity of the information the patients receive from SIU physicians during their visit shows a significant positive correlation (p<0.001). In addition, there is a significant correlation regarding the problems patients may have experienced in the last 6 months in terms of access to treatment (p<0.021).</p><p><strong>Conclusion: </strong>Participants showed high satisfaction rates from the medical and nursing care provided at the SIU of the PGNA. The opportunity of expression given to users - patients through satisfaction studies promotes and creates a climate of trust between them and the decision-making teams of health units.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"35 3","pages":"184-189"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0a/00/MSM-35-184.PMC10545923.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Gut Microbiome in Neonates Born by Caesarean Section and Vaginal Seeding with Gut Microbiomes of Neonates Born by Caesarean Section Without Vaginal Seeding and Neonates Born by Vaginal Delivery. 剖腹产和阴道播种新生儿肠道微生物组与未经阴道播种的剖腹产和经阴道分娩新生儿肠道微生物群的比较。
Materia socio-medica Pub Date : 2023-09-01 DOI: 10.5455/msm.2023.35.234-243
Xanthi Anthoulaki, Efthimios Oikonomou, Anastasia Bothou, Stavroula Papanikolopoulou, Konstantinos Nikolettos, Christos Damaskos, Nikolaos Garbis, Dimitrios Kyriakou, Theopi Nalbanti, Georgios Iatrakis, Nikolaos Nikolettos, Panagiotis Tsikouras
{"title":"Comparison of Gut Microbiome in Neonates Born by Caesarean Section and Vaginal Seeding with Gut Microbiomes of Neonates Born by Caesarean Section Without Vaginal Seeding and Neonates Born by Vaginal Delivery.","authors":"Xanthi Anthoulaki,&nbsp;Efthimios Oikonomou,&nbsp;Anastasia Bothou,&nbsp;Stavroula Papanikolopoulou,&nbsp;Konstantinos Nikolettos,&nbsp;Christos Damaskos,&nbsp;Nikolaos Garbis,&nbsp;Dimitrios Kyriakou,&nbsp;Theopi Nalbanti,&nbsp;Georgios Iatrakis,&nbsp;Nikolaos Nikolettos,&nbsp;Panagiotis Tsikouras","doi":"10.5455/msm.2023.35.234-243","DOIUrl":"10.5455/msm.2023.35.234-243","url":null,"abstract":"<p><strong>Background: </strong>Pregnancy is an admirable biological process, resulting in significant changes in many of the body's normal systems so that they can support the development of the fetus. These changes involve hormonal changes, weight gain, immune system regulation, and others that need to be synchronized to maintain both maternal and fetal health.</p><p><strong>Objective: </strong>The purpose of this study was to compare gut microbiome in neonates born by caesarean section and vaginal seeding with gut microbiomes of neonates born by caesarean section without vaginal seeding and neonates born by vaginal delivery.</p><p><strong>Methods: </strong>In Democritus University of Thrace, from 2019 to 2022, gut microbiomes were compared for three groups of neonates. Group A included 110 neonates born by CS who underwent vaginal seeding, group B included 85 neonates born by CS without vaginal seeding and group C included 95 neonates born by vaginal delivery.</p><p><strong>Results: </strong>Vaginal seeding in neonates born with CS resulted in gut microbiome which was similar to the gut microbiome of neonates born by vaginal delivery (including lactobacillus species and bacteroides). On the contrary, gut microbiome of neonates born by CS without vaginal seeding was \"limited\".</p><p><strong>Conclusion: </strong>According to our findings, vaginal seeding alters the gut microbiome of the neonates born with CS. However, there is a need for further investigation to prove its efficacy and its safety for the neonate.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"35 3","pages":"234-243"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fd/90/MSM-35-234.PMC10545928.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41169970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Comparative Study of the Administration of the Combination Preparation of Isoflavones and Hyaluronic Acid in Menopausal Women for the Treatment of the Symptoms of Menopause, Urogenital Atrophy and Oteoporosis in Relation to Existing Hormone Replacement Therapies. 异黄酮和透明质酸联合制剂在更年期妇女中的应用与现有激素替代疗法治疗更年期、泌尿生殖系统萎缩和耳孔症症状的比较研究。
Materia socio-medica Pub Date : 2023-09-01 DOI: 10.5455/msm.2023.35.206-214
Anna Chalkidou, Efthimios Oikonomou, Dimitrios Lambrinos, Anastasia Bothou, Dimitrios Kyriakou, Konstantinos Nikolettos, Georgios Marinos, Georgios Iatrakis, Stefanos Zervoudis, Nikolaos Nikolettos, Panagiotis Tsikouras
{"title":"The Comparative Study of the Administration of the Combination Preparation of Isoflavones and Hyaluronic Acid in Menopausal Women for the Treatment of the Symptoms of Menopause, Urogenital Atrophy and Oteoporosis in Relation to Existing Hormone Replacement Therapies.","authors":"Anna Chalkidou,&nbsp;Efthimios Oikonomou,&nbsp;Dimitrios Lambrinos,&nbsp;Anastasia Bothou,&nbsp;Dimitrios Kyriakou,&nbsp;Konstantinos Nikolettos,&nbsp;Georgios Marinos,&nbsp;Georgios Iatrakis,&nbsp;Stefanos Zervoudis,&nbsp;Nikolaos Nikolettos,&nbsp;Panagiotis Tsikouras","doi":"10.5455/msm.2023.35.206-214","DOIUrl":"10.5455/msm.2023.35.206-214","url":null,"abstract":"<p><strong>Background: </strong>Menopause is characterized by a series of symptoms and effects from the various systems and organs, for which, the decline in estrogen production from the ovaries is considered responsible.</p><p><strong>Objective: </strong>The aim of this study was to make comparative study of the administration of the combination preparation of isoflavones and hyaluronic acid in menopausal women for the treatment of the symptoms of menopause, urogenital atrophy and osteoporosis in relation to existing hormone replacement therapies.</p><p><strong>Methods: </strong>In this five-year, double-blind, placebo-controlled clinical study, a total of 274 postmenopausal women were enrolled and classified into three groups. Participants in group A, were 96 women who did not receive Hormone Replacement Therapy (HRT), in the second group, 92 received daily treatment with tibolone (2.5 mg) as monotherapy, and in the third group, 86 received treatment with a pharmaceutical formulation of hyaluronic acid 120 mg and isoflavones. MF11RCE 80 mg.</p><p><strong>Results: </strong>In the postmenopausal women of our study, a significant reduction of postmenopausal symptoms was found in both groups B and C of participants who received hormone replacement preparations compared to group A who did not receive HRT. Furthermore, no difference in efficacy was observed between the administered preparations of isoflavones and tibolone.</p><p><strong>Conclusion: </strong>The combination of isoflavones and hyaluronic acid has the same efficacy as tibolone in menopausal symptoms.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"35 3","pages":"206-214"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/91/43/MSM-35-206.PMC10545921.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41176495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective Study of the Correlation Between Twin Pregnancies and Perinatal Outcome in Association to the Impact of Preterm Birth. 双胎妊娠和围产期结果与早产影响的相关性的回顾性研究。
Materia socio-medica Pub Date : 2023-09-01 DOI: 10.5455/msm.2023.35.215-221
Spyridon Michalopoulos, Panagiotis Tsikouras, Vassiliki Varlami, Dimitrios Lambrinos, Anastasia Bothou, Konstantinos Nikolettos, Stavroula Papanikolopoulou, Georgios Marinos, Georgios Iatrakis, Nikolaos Nikolettos
{"title":"Retrospective Study of the Correlation Between Twin Pregnancies and Perinatal Outcome in Association to the Impact of Preterm Birth.","authors":"Spyridon Michalopoulos,&nbsp;Panagiotis Tsikouras,&nbsp;Vassiliki Varlami,&nbsp;Dimitrios Lambrinos,&nbsp;Anastasia Bothou,&nbsp;Konstantinos Nikolettos,&nbsp;Stavroula Papanikolopoulou,&nbsp;Georgios Marinos,&nbsp;Georgios Iatrakis,&nbsp;Nikolaos Nikolettos","doi":"10.5455/msm.2023.35.215-221","DOIUrl":"10.5455/msm.2023.35.215-221","url":null,"abstract":"<p><strong>Background: </strong>Twin pregnancies make up 2% to 4% of all births. Incidence of spontaneous twin pregnancies varies around the world, with percentages ranging from 8/1000 to >17/1000 births. The variation in twin pregnancy rates is thought to be due to dizygotic pregnancies, since monozygotic pregnancies have a consistent incidence of 3.5/1000 to 4/1000 births. The incidence of twin pregnancies after the widespread use of assisted reproduction has increased significantly.</p><p><strong>Objective: </strong>The purpose of the present study is to investigate factors , who contribute to improve the perinatal outcome in twin pregnancies. Support will be provided by the results of twin pregnancies by the Department of Obstetrics and Gynaecology of Demokrition University of Thrace (Alexandroupolis, Greece) in the last fifteen years.</p><p><strong>Methods: </strong>From the above Department, data were collected on the number of twin pregnancies, maternal age, gestational age, mode of delivery (spontaneous delivery or caesarean section), birth weight and rate of twin pregnancies with assisted reproduction.</p><p><strong>Results: </strong>The results showed the increasing trend of twin pregnancies and births. A total of 304 twin pregnancies were identified (rate 2.75%). The rate of assisted reproduction was 34.83% in our sample, while the rate of cesarean deliveries was 95.5%, showing a large increase in recent years. In ten cases, normal delivery was successfully performed. The gestational age in twin pregnancies that ended with normal delivery was 37.37 + 3 weeks and the fetuses were both cephalic presentations. The main reason for admission of newborns to the NICU Department was prematurity.</p><p><strong>Conclusion: </strong>The constantly improving education of perinatalists and understanding of the pathophysiology may lead to individualization of their treatment, and improvement of their prognosis based on recent scientific data from other international centers.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"35 3","pages":"215-221"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/1b/MSM-35-215.PMC10545924.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41166714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge and Attitudes in First Aid Practices for Thermal Burns: a Cross-sectional Study Among Adults in Northern Greece. 热烧伤急救实践中的知识和态度:希腊北部成年人的横断面研究。
Materia socio-medica Pub Date : 2023-09-01 DOI: 10.5455/msm.2023.35.228-233
Vasiliki Papachristodoulou, Gregory Tripsianis, Theodoros C Constantinidis, Despoina D Kakagia
{"title":"Knowledge and Attitudes in First Aid Practices for Thermal Burns: a Cross-sectional Study Among Adults in Northern Greece.","authors":"Vasiliki Papachristodoulou,&nbsp;Gregory Tripsianis,&nbsp;Theodoros C Constantinidis,&nbsp;Despoina D Kakagia","doi":"10.5455/msm.2023.35.228-233","DOIUrl":"10.5455/msm.2023.35.228-233","url":null,"abstract":"<p><strong>Background: </strong>Burns are a major cause of morbidity, including prolonged hospitalization, disfigurement, disability, and emotional trauma. Long-term absence from work and high healthcare costs for burn treatment have a significant socio-economic impact.</p><p><strong>Objective: </strong>his study aims to evaluate the level of knowledge for burn management in the adult population of Thrace in Northern Greece and to determine factors associated with a better level of knowledge.</p><p><strong>Methods: </strong>A questionnaire-based cross-sectional study was conducted οn a random sample of the adult population of Thrace. Data were collected using a structured pre-coded questionnaire, which included subjects' socio-demographic characteristics and the first aid practices for burns. Multivariate logistic regression analysis was used to determine the effect of subjects' characteristics on their knowledge of burn first aid practices.</p><p><strong>Results: </strong>A total of 711 subjects (49.6% males; mean age, 41.89±16.48 years) were included in the study. The incidence of a previous burn was 55.4%. Only 10.5% of the subjects would apply the optimal practice, consisting of rinsing the burn wound with cool running water for at least 10 minutes, applying only non-adhesive dressing on it and leaving the blisters intact. The optimal practice was independently associated with female gender (aOR=1.86, p=0.016), high education level (aOR=2.00, p=0.023), the presence of >3 children (aOR=2.27, p=0.009) and previous training in first aid (aOR=2.36, p=0.001). A large number of participants reported the application of toothpaste (38%), moisturizer (35.4%), aloe (31.8%) or yogurt (27.7%) to the burn surface.</p><p><strong>Conclusion: </strong>Only a small proportion of the participants were aware of the optimal burn first aid practices, most of them female, of high socioeconomic status. We recommend a more targeted approach in the design of health campaigns in the future, in order to reach vulnerable parts of the population.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"35 3","pages":"228-233"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bb/c0/MSM-35-228.PMC10545918.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Sleeping Disorders on the Growth Parameters of Lebanese Children. 睡眠障碍对黎巴嫩儿童生长参数的影响。
Materia socio-medica Pub Date : 2023-09-01 DOI: 10.5455/msm.2023.35.201-205
Micheline Katramiz, Antoine Saadé, Mode Al Ojaimi, Mona Nahas Gholmieh
{"title":"Effect of Sleeping Disorders on the Growth Parameters of Lebanese Children.","authors":"Micheline Katramiz, Antoine Saadé, Mode Al Ojaimi, Mona Nahas Gholmieh","doi":"10.5455/msm.2023.35.201-205","DOIUrl":"10.5455/msm.2023.35.201-205","url":null,"abstract":"<p><strong>Background: </strong>Sleep is a vital physiological function for the maintenance of health and quality of life by ensuring body rest and restoring its energy levels. Remarkably, some children have sleep disordered breathing (SDB) that can disturb their normal sleep and affect the quality of their lives.</p><p><strong>Objective: </strong>The aim of this study was to assess the correlation between SDB and growth impairments and wether the growth parameters vary among genders.</p><p><strong>Methods: </strong>This study was conducted in two steps: 1500 questionnaires were distributed to children aged 3 to 12 years. The questionnaire covered personal information, medical history, and the Pediatric Sleep Questionnaire. The latter was used to evaluate the incidence of sleep-disordered breathing and was completed by parents of the involved children. Growth assessment was then determined for the population to find the correlation between sleep disorders and growth impairments.</p><p><strong>Results: </strong>A total of 931 completed questionnaires were returned (70.7% response rate). Among the respondents, 56.3% were females whereas 43.3% were males. The mean age was 8 years. The result showed that 16.11% of children were at high risk of sleep-disordered breathing. A significant effect of SDB syndrome on growth parameters (weight-for-age parameter z-score and BMI for age z-score) was observed among males. Concerning the weight for age z-score, a significant difference was found between the means of control and SDB individuals (P = 0.0302). In male groups, the difference was significant (P=0.043), while non-significant difference was found in female groups (P = 0.69).</p><p><strong>Conclusion: </strong>This study highlights a significant effect of SDB on growth parameters among males aged between 3 and 12 years.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"35 3","pages":"201-205"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/d6/MSM-35-201.PMC10545929.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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