Ali Abu Siyam, Suha Khayri Ababneh, Ibrahim Al-Odat, Sokiyna Ababneh, Ahed J Alkhatib
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Descriptive analysis was used to describe data including frequency and percentages to describe categorical variables such as age, and the mean and standard deviation to describe non-categorical variables such as age. The relationships between variables and gastric cancer were calculated based on Chi-Square and One Way ANOVA tests, significance was considered if p value ≤0,05.</p><p><strong>Results: </strong>The mean age was 53.2580±18.98 years. Seventy percent of participants were males. About 30% of participants had a family history of gastric cancer. About 40% of participants were smokers. About 50% of participants were alcoholic. About 75% of participants had Helicobacter pylori. 80% of participants were at high salt intake. About 50% of participants had chronic gastritis. Abnormal endoscopic image reports were reported in approximately 30% of participants. Biopsy results were negative in 90% of participants. The reports of CT scans were negative in approximately 80%. Genetic mutations were detected in Tp53 (50.1%), KRAS (20%), and CDH1 (29,9%). No significant relationships were found between gastric cancer and study variables.</p><p><strong>Conclusion: </strong>Most of the people had risk factors such as Helicobacter pylori infection, salt intake, and mutations in TP53, KRAS, and CDH1. However, statistical analyses did not find significant correlations between those and gastric cancer.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"36 4","pages":"280-287"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830230/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Role of TP53, KRAS, CDH1, Demographic and Clinical Variables in Gastric Cancer.\",\"authors\":\"Ali Abu Siyam, Suha Khayri Ababneh, Ibrahim Al-Odat, Sokiyna Ababneh, Ahed J Alkhatib\",\"doi\":\"10.5455/msm.2024.36.280-287\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Worldwide, gastric cancer remains the fifth most prevalent type of cancer and is the third leading cause of cancer-related deaths. 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The relationships between variables and gastric cancer were calculated based on Chi-Square and One Way ANOVA tests, significance was considered if p value ≤0,05.</p><p><strong>Results: </strong>The mean age was 53.2580±18.98 years. Seventy percent of participants were males. About 30% of participants had a family history of gastric cancer. About 40% of participants were smokers. About 50% of participants were alcoholic. About 75% of participants had Helicobacter pylori. 80% of participants were at high salt intake. About 50% of participants had chronic gastritis. Abnormal endoscopic image reports were reported in approximately 30% of participants. Biopsy results were negative in 90% of participants. The reports of CT scans were negative in approximately 80%. Genetic mutations were detected in Tp53 (50.1%), KRAS (20%), and CDH1 (29,9%). No significant relationships were found between gastric cancer and study variables.</p><p><strong>Conclusion: </strong>Most of the people had risk factors such as Helicobacter pylori infection, salt intake, and mutations in TP53, KRAS, and CDH1. 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引用次数: 0
摘要
背景：在世界范围内，胃癌仍然是第五大最常见的癌症类型，也是癌症相关死亡的第三大原因。胃癌约占全球癌症发病率的7%，每年癌症相关死亡率约占9%。目的：本研究的目的是分析发布在Kaggle (https://www.kaggle.com/datasets/datasetengineer/gastric-cancer-gc-dataset).Methods)上的胃癌数据集：该数据集包括212354名参与者，其中10%患有胃癌。对该数据集进行分析，提取有关胃癌的信息。数据分析采用SPSS version 25。使用描述性分析来描述数据，包括频率和百分比来描述分类变量，如年龄；使用平均值和标准差来描述非分类变量，如年龄。各变量与胃癌的关系采用卡方检验和单因素方差分析（One - Way ANOVA）， p值≤0.05认为有显著性。结果：患者平均年龄53.2580±18.98岁。70%的参与者是男性。约30%的参与者有胃癌家族史。大约40%的参与者是吸烟者。大约50%的参与者是酗酒者。大约75%的参与者患有幽门螺杆菌。80%的参与者盐摄入量高。大约50%的参与者患有慢性胃炎。大约30%的参与者报告了异常的内窥镜图像。90%的参与者活检结果为阴性。约80%的CT扫描报告为阴性。在Tp53（50.1%）、KRAS（20%）和CDH1（29.9%）中检测到基因突变。没有发现胃癌与研究变量之间的显著关系。结论：大多数人存在幽门螺杆菌感染、盐摄入、TP53、KRAS、CDH1基因突变等危险因素。然而，统计分析并没有发现这些与胃癌之间的显著相关性。
The Role of TP53, KRAS, CDH1, Demographic and Clinical Variables in Gastric Cancer.
Background: Worldwide, gastric cancer remains the fifth most prevalent type of cancer and is the third leading cause of cancer-related deaths. Gastric cancer is responsible for around 7% of global cancer occurrence and approximately 9% of annual cancer-related mortalities.
Objective: The aim of the study was to analyze gastric cancer dataset posted on Kaggle (https://www.kaggle.com/datasets/datasetengineer/gastric-cancer-gc-dataset).
Methods: This dataset comprises 212354 participants, of whom 10% had gastric cancer. This dataset was analyzed to extract the information regarding gastric cancer. The analysis of data was performed SPSS version 25. Descriptive analysis was used to describe data including frequency and percentages to describe categorical variables such as age, and the mean and standard deviation to describe non-categorical variables such as age. The relationships between variables and gastric cancer were calculated based on Chi-Square and One Way ANOVA tests, significance was considered if p value ≤0,05.
Results: The mean age was 53.2580±18.98 years. Seventy percent of participants were males. About 30% of participants had a family history of gastric cancer. About 40% of participants were smokers. About 50% of participants were alcoholic. About 75% of participants had Helicobacter pylori. 80% of participants were at high salt intake. About 50% of participants had chronic gastritis. Abnormal endoscopic image reports were reported in approximately 30% of participants. Biopsy results were negative in 90% of participants. The reports of CT scans were negative in approximately 80%. Genetic mutations were detected in Tp53 (50.1%), KRAS (20%), and CDH1 (29,9%). No significant relationships were found between gastric cancer and study variables.
Conclusion: Most of the people had risk factors such as Helicobacter pylori infection, salt intake, and mutations in TP53, KRAS, and CDH1. However, statistical analyses did not find significant correlations between those and gastric cancer.
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