Materia socio-medica最新文献

筛选
英文 中文
Preliminary Results of the Efficacy and Safety of Cryoablation for Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation: a Study From Vietnam.
Materia socio-medica Pub Date : 2025-01-01 DOI: 10.5455/msm.2025.37.54-57
Nguyen Duy Linh, Phan Dinh Phong, Tran Song Giang, Pham Tran Linh, Bui The Dung, Do Doan Loi, Pham Minh Tuan
{"title":"Preliminary Results of the Efficacy and Safety of Cryoablation for Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation: a Study From Vietnam.","authors":"Nguyen Duy Linh, Phan Dinh Phong, Tran Song Giang, Pham Tran Linh, Bui The Dung, Do Doan Loi, Pham Minh Tuan","doi":"10.5455/msm.2025.37.54-57","DOIUrl":"10.5455/msm.2025.37.54-57","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation is the most common type of arrhythmia. The symptoms of atrial fibrillation not only significantly impacted quality of life but also associated with thrombotic events and heart failure, thereby increased risk of mortality. According to current guidelines, the initial treatment strategy for patients with atrial fibrillation is antiarrhythmic medication.</p><p><strong>Objective: </strong>This study aimed to evaluate the safety, efficacy, and procedural adaptations required for cryoablation in Vietnamese patients with paroxysmal atrial fibrillation (AF).</p><p><strong>Methods: </strong>Fifteen patients with paroxysmal AF underwent cryoablation using a standardized protocol. Patient characteristics, procedural parameters, and outcomes were recorded. Safety was assessed by monitoring acute complications, and procedural success was defined as complete pulmonary vein isolation (PVI) confirmed by bidirectional block.</p><p><strong>Results: </strong>Complete PVI was achieved in 100% of patients, with an average procedural duration of 125 ± 32 minutes and fluoroscopy time of 14 ± 8 minutes. No acute complications related to cryoablation.</p><p><strong>Conclusion: </strong>Cryoablation demonstrated safety and efficacy in achieving PVI for paroxysmal AF in a resource-limited setting. Larger studies with extended follow-up are required to further validate these outcomes and explore the long-term efficacy and sustainability of cryoablation techniques.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"54-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Use of Non-pharmacological Herbs in Treating Cough and Respiratory Symptoms in Saudi Arabia: a Multi-center Study.
Materia socio-medica Pub Date : 2025-01-01 DOI: 10.5455/msm.2025.37.18-23
Abdullah A Yousef, Abdullah Al-Shamrani, Alzahra Y Alradhi, Fatimah M Bukhamsen, Aqilah T Alqassab, Sumayyah A Kobeisy, Saleh AlHarbi, Halima AlalKami, Ahmed M Alrashdan
{"title":"The Use of Non-pharmacological Herbs in Treating Cough and Respiratory Symptoms in Saudi Arabia: a Multi-center Study.","authors":"Abdullah A Yousef, Abdullah Al-Shamrani, Alzahra Y Alradhi, Fatimah M Bukhamsen, Aqilah T Alqassab, Sumayyah A Kobeisy, Saleh AlHarbi, Halima AlalKami, Ahmed M Alrashdan","doi":"10.5455/msm.2025.37.18-23","DOIUrl":"10.5455/msm.2025.37.18-23","url":null,"abstract":"<p><strong>Background: </strong>Herbal medicinal products, a subgroup of complementary and alternative therapy (CAM), are widely used for pediatric respiratory symptoms in Saudi Arabia. However, regional variations and safety concerns remain understudied.</p><p><strong>Objective: </strong>This study examines the prevalence and patterns of herbal remedy use for cough and respiratory illness among Saudi children.</p><p><strong>Methods: </strong>A multi-center cross-sectional questionnaire-based study was conducted across five Saudi regions (N=475). Data were collected via a validated questionnaire (Cronbach's α = 0.85) and analyzed using SPSS v25.</p><p><strong>Results: </strong>The mean age was 3.97 ± 3.60 years. Herbal remedy use was highest in the Western province (37.8%, p <0.001). Sesame oil (19.8%) and olive oil (18.2%) were most common. Family/friends provided 82.8% of advice. Self-rated improvement was \"excellent/good\" in 59.9%, with 96.6% reporting no adverse effects. Fathers with postgraduate degrees used fewer herbal remedies (p=0.003).</p><p><strong>Conclusion: </strong>Herbal remedy use is prevalent, emphasizing the need for healthcare providers to document usage and educate families. Further research is required to evaluate efficacy and safety.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"18-23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attitudes of Physicians and Nurses Toward Interprofessional Collaboration: a Systematic Literature Review.
Materia socio-medica Pub Date : 2025-01-01 DOI: 10.5455/msm.2025.37.64-73
Polyxeni Lazarou Gregoriou, Andreas Charalambous, Elena Rousou, Evridiki Papastavrou, Anastasios Merkouris
{"title":"Attitudes of Physicians and Nurses Toward Interprofessional Collaboration: a Systematic Literature Review.","authors":"Polyxeni Lazarou Gregoriou, Andreas Charalambous, Elena Rousou, Evridiki Papastavrou, Anastasios Merkouris","doi":"10.5455/msm.2025.37.64-73","DOIUrl":"10.5455/msm.2025.37.64-73","url":null,"abstract":"<p><strong>Background: </strong>Interprofessional collaboration involves coordinated efforts by professionals from various disciplines, such as physicians and nurses, aimed at improving patient care outcomes. This teamwork enhances cooperation among healthcare professionals with diverse expertise, contributing significantly to patient safety, satisfaction, expedited recovery, cost-effectiveness, and reduced mortality rates.</p><p><strong>Objective: </strong>This paper explores the available evidence regarding the attitudes of physicians and nurses towards interprofessional collaboration and identifies factors that influence their willingness to engage in collaborative practice.</p><p><strong>Methods: </strong>A systematic review was conducted spanning from 2016 to 2023, adhering to predefined criteria and the PRISMA guidelines and checklist. Searches were performed in PubMed, Scopus, CINAHL Plus, Cochrane, and Google Scholar. The inclusion criteria comprised studies (regardless of design) addressing interprofessional collaboration, published within the last ten years, and involving both physicians and nurses. Only articles with full text access and written in English or Greek were included.</p><p><strong>Results: </strong>The review identified 13 relevant studies. The analysis revealed that nurses generally exhibit more favourable attitudes towards interprofessional collaboration compared to physicians. Moreover, thematic analysis highlighted key factors influencing the attitudes of both nurses and physicians, including education level, age and years of experience.</p><p><strong>Conclusion: </strong>This review highlights critical aspects and gaps in current literature, emphasizing the need for future research to further explore these areas. Findings also underscore the importance of incorporate these insights into hospital policies to effectively enhance interprofessional collaboration.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"64-73"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infertility - a Great Challenge of the Past, Present, and Future.
Materia socio-medica Pub Date : 2025-01-01 DOI: 10.5455/msm.2025.37.74-79
Ivana Erceg Ivkosic, Jana Mesic, Rajko Fures, Zlatko Hrgovic, Luka Bulic, Eva Brenner, Vesna Cosic, Blazenka Miskic, Dinko Kolaric
{"title":"Infertility - a Great Challenge of the Past, Present, and Future.","authors":"Ivana Erceg Ivkosic, Jana Mesic, Rajko Fures, Zlatko Hrgovic, Luka Bulic, Eva Brenner, Vesna Cosic, Blazenka Miskic, Dinko Kolaric","doi":"10.5455/msm.2025.37.74-79","DOIUrl":"10.5455/msm.2025.37.74-79","url":null,"abstract":"<p><strong>Background: </strong>The Infertility refers to the inability of couples to conceive after 12 months of regular, unprotected sexual intercourse. The incidence of infertility is increasing and is estimated to be 8-12%, or even up to 20%. Primarily, it involves organic causes, but the psychological aspect is not excluded.</p><p><strong>Objective: </strong>The aim of this article was to discrabe the observing of various causes of infertility.</p><p><strong>Methods: </strong>Authors used, as sources, published relevant facts in the articles deposited in important scientific indexed databases Medline, Scopus, PubMed Central, Hinari, etc. to write this review.</p><p><strong>Results and discussion: </strong>The diagnosis of female infertility involves a detailed medical history, laboratory tests, hormonal evaluation, and imaging studies such as ultrasound and eventually hysteroscopy and laparoscopy. Advances in genetic testing have deepened our understanding of infertility origins in both genders. Sperm analysis is pivotal for diagnosing male infertility. Infertility treatment includes identifying causes and applying various therapies, including conservative surgical, and assisted reproductive technology (ART).</p><p><strong>Conclusion: </strong>The currently used ART methods include ovulation tracking with planned intercourse, insemination and in vitro fertilization (IVF).</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"74-79"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Influence of Gender and Length of Therapy Use on Sleep Quality in Patients with Parkinson's Disease.
Materia socio-medica Pub Date : 2025-01-01 DOI: 10.5455/msm.2025.37.58-63
Zikrija Dostovic, Nermin Mesic, Nerimana Suljkanovic, Denisa Salihovic
{"title":"The Influence of Gender and Length of Therapy Use on Sleep Quality in Patients with Parkinson's Disease.","authors":"Zikrija Dostovic, Nermin Mesic, Nerimana Suljkanovic, Denisa Salihovic","doi":"10.5455/msm.2025.37.58-63","DOIUrl":"10.5455/msm.2025.37.58-63","url":null,"abstract":"<p><strong>Background: </strong>Normal sleep duration is crucial for maintaining brain homeostasis. Sleep disorders in Parkinson's disease are numerous, multifactorial, and result in significant morbidity.</p><p><strong>Objective: </strong>The aim of the study was to investigate the association between gender and the duration of therapy on sleep quality in patients with Parkinson's disease.</p><p><strong>Methods: </strong>The study is prospective, and includes 40 consecutively hospitalized patients with verified Parkinson's disease. The study included subjects of both genders and all age groups. To analyze the data on the subjects, we used: medical histories, nursing documentation of patients, a questionnaire with sociodemographic data, and the Parkinson's Disease Sleep Assessment Scale. We divided all subjects into two groups: subjects who have been using therapy for up to 5 years and those who have been using therapy for more than 5 years.</p><p><strong>Results: </strong>Among subjects who have been taking medication for less than 5 years, 33.3% were female and 66.6% were male. Of the total number of respondents who have been taking therapy for more than 5 years, 36.3% are female and 63.6% are male. The duration of the therapy has a statistically significant effect on the quality of sleep in patients with Parkinson's disease (p < 0.05). The subject's gender does not have a significant independent influence on the quality of sleep in patients with Parkinson's disease (p > 0.05). The interaction of gender and length of therapy use has no significant separate effect on the quality of sleep in Parkinson's disease patients (p > 0.05). The quality of sleep is better in male and female subjects who take the therapy until the age of 5.</p><p><strong>Conclusion: </strong>The duration of therapy use has a significant impact on the quality of sleep in Parkinson's disease patients. The gender of the subject has no significant independent influence on the quality of sleep in patients with Parkinson's disease.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"58-63"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Manifestation of Necrotic Palatal Ulceration in COVID-19 Infection: a Case Report.
Materia socio-medica Pub Date : 2025-01-01 DOI: 10.5455/msm.2025.37.80-82
Mimoza Canga, Alketa Qafmolla, Edit Xhajanka, Irene Malagnino
{"title":"Manifestation of Necrotic Palatal Ulceration in COVID-19 Infection: a Case Report.","authors":"Mimoza Canga, Alketa Qafmolla, Edit Xhajanka, Irene Malagnino","doi":"10.5455/msm.2025.37.80-82","DOIUrl":"10.5455/msm.2025.37.80-82","url":null,"abstract":"<p><strong>Background: </strong>The global pandemic caused by the COVID-19 virus is a serious disease that has significantly affected the lives of millions of people.</p><p><strong>Objective: </strong>The objective of this case study is to describe the development of a necrotic ulcer on the palate in a COVID-19 patient.</p><p><strong>Case presentation: </strong>This is the clinical case of a 35-year-old male patient with a 20-year history of two pack-a-day smoking who contracted COVID-19. He was admitted to the Department of Oral and Maxillofacial Surgery at the \"Mother Teresa\" University Hospital Center in Tirana, Albania, presenting with oral pain, facial swelling, and necrosis in the palatal region and the lower lip.</p><p><strong>Conclusion: </strong>This case report from Albania is significant as it presents an ulcer with necrotic tissue located in the hard palate region of a patient infected with SARS-CoV-2.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"80-82"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Public Awareness of Corticosteroid Use and Side Effects: a Cross-Sectional Study from Jordan.
Materia socio-medica Pub Date : 2025-01-01 DOI: 10.5455/msm.2025.37.24-31
Sufian M Rifaei, Shahd Etoom, Suzan Adel Hanandeh, Sara Haj Ali, Aroob Mohammad Alzboon, Mohammad Dakhil Al-Jaraideh, Shatha Aktham, Kamal Khaled Moh'd Hamad, Mohamad Alharoun, Ahed J Alkhatib
{"title":"Public Awareness of Corticosteroid Use and Side Effects: a Cross-Sectional Study from Jordan.","authors":"Sufian M Rifaei, Shahd Etoom, Suzan Adel Hanandeh, Sara Haj Ali, Aroob Mohammad Alzboon, Mohammad Dakhil Al-Jaraideh, Shatha Aktham, Kamal Khaled Moh'd Hamad, Mohamad Alharoun, Ahed J Alkhatib","doi":"10.5455/msm.2025.37.24-31","DOIUrl":"10.5455/msm.2025.37.24-31","url":null,"abstract":"<p><strong>Background: </strong>Corticosteroid usage is very widespread these days. However, the way corticosteroids are administered, the side effects of the drug and the risks associated with its usage are not widely known.</p><p><strong>Objective: </strong>The authors evaluated the responses of a diverse group who were aware of the methods of corticosteroid administration, side effects and information provided by the health care provider. To assess the awareness level and identify the gaps in knowledge descriptive statistics were used.</p><p><strong>Methods: </strong>The study was a cross sectional online survey conducted during July and December of 2024 using non-probability convenience sampling. A collection of queries were used to test knowledge of steroids as well as its effects. The sample included Jordanians aged 18 and above. The data was analyzed using logistic regression and chi-square with the SPSS (version 27).</p><p><strong>Results: </strong>From the participants, it was seen that 39.8% used corticosteroids. The most recognized were the oral (81%) and intravenous (60.9%). Most commonly noticed side effects were weight gain (81%) and mood swings (45.9%), rare ones being anemia (7%) and epilepsy (4.3%) were less known. There was high awareness about corticosteroid use in respiratory illnesses like asthma (71%) and autoimmune conditions like rheumatoid disease (64%), but awareness about their use in metabolic and oncological diseases was limited. Only 40.9% of participants said that side effects info was provided to them.</p><p><strong>Conclusion: </strong>There were significant gaps in community awareness which might compromise the therapeutic utility of corticosteroids.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"24-31"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and Paraclinical Characteristics and Predictive Factors of Chronic Obstructive Pulmonary Exacerbation.
Materia socio-medica Pub Date : 2025-01-01 DOI: 10.5455/msm.2025.37.32-36
Hoang Thuy, Nguyen Dinh Tien, Nguyen Thi Huong Giang, Nguyen Thi Nguyet, Nguyen Ngoc Nghia, Tran Thi Ly
{"title":"Clinical and Paraclinical Characteristics and Predictive Factors of Chronic Obstructive Pulmonary Exacerbation.","authors":"Hoang Thuy, Nguyen Dinh Tien, Nguyen Thi Huong Giang, Nguyen Thi Nguyet, Nguyen Ngoc Nghia, Tran Thi Ly","doi":"10.5455/msm.2025.37.32-36","DOIUrl":"10.5455/msm.2025.37.32-36","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a common global condition, yet real-world data on exacerbations in Vietnamese patients remains limited. This highlights the need for further exploration of clinical complexities in this population.</p><p><strong>Objective: </strong>The aim of this study was to characterize the clinical and paraclinical features of COPD and identify predictors of exacerbation.</p><p><strong>Methods: </strong>A cross-sectional, prospective study was conducted on 180 inpatients at Vietnam National Lung Hospital from January 2016 to June 2021. Clinical and paraclinical data were collected.</p><p><strong>Results: </strong>The mean patient age was 69.38 ± 9.40 years, with 92.8% male. Common symptoms included dyspnea (97.8%), cough (85.6%), and expectoration (80.0%). GOLD stage distribution was: GOLD III (53.7%), GOLD IV (29.3%), and GOLD II (17.0%). Significant predictors of exacerbation included smoking (OR=2.79), comorbidities (OR=3.95), increased dyspnea (OR=14.83), increased sputum (OR=3.13), decreased alveolar murmur (OR=4.11), wheezing (OR=2.70), white blood cell count ≥10 G/L (OR=4.79), GOLD group D (OR=9.75), and FEV1 <30% (GOLD IV) (OR=7.51) (p < 0.05).</p><p><strong>Conclusion: </strong>Clinical and paraclinical predictors can aid in forecasting and mitigating COPD exacerbations.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"32-36"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic Effects of Hypoxia-Preconditioned Mesenchymal Stem Cells Secretome and Alkaline Water in Alleviating Oxidative Stress and Inflammation in Type 2 Diabetic Rats.
Materia socio-medica Pub Date : 2025-01-01 DOI: 10.5455/msm.2024.37.4-10
Irni Nasution, Agung Putra, Eko Setiawan
{"title":"Synergistic Effects of Hypoxia-Preconditioned Mesenchymal Stem Cells Secretome and Alkaline Water in Alleviating Oxidative Stress and Inflammation in Type 2 Diabetic Rats.","authors":"Irni Nasution, Agung Putra, Eko Setiawan","doi":"10.5455/msm.2024.37.4-10","DOIUrl":"10.5455/msm.2024.37.4-10","url":null,"abstract":"<p><strong>Background: </strong>Chronic inflammation and oxidative stress are central to the pathophysiology of Type 2 Diabetes Mellitus (T2DM), contributing to the progression of metabolic dysfunction and related complications.</p><p><strong>Objective: </strong>The aim of this study was to explore the therapeutic potential of combining hypoxia-preconditioned mesenchymal stem cell SH-MSC with alkaline water in a T2DM rat model.</p><p><strong>Methods: </strong>T2DM was induced in Wistar rats through a high-fat diet (HFD) followed by streptozotocin (STZ) administration. A total of 30 healthy male Wistar rats were randomly assigned to five groups: healthy control, T2DM, T2DM + Metformin, T2DM + SH-MSC, and T2DM + SH-MSC + alkaline water.</p><p><strong>Results: </strong>The combination of SH-MSC and alkaline water significantly reduced malondialdehyde (MDA) levels, a key indicator of lipid peroxidation, and suppressed the expression of p65 mRNA, a crucial component of the NF-κB signaling pathway. Notably, the most pronounced reduction in p65 mRNA expression was observed in the group receiving both SH-MSC and alkaline water, suggesting a synergistic effect in mitigating oxidative stress and inflammation.</p><p><strong>Conclusion: </strong>These findings highlight the potential of SH-MSC and alkaline water as a novel therapeutic strategy for alleviating T2DM.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"4-10"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Depth Perception and Intraocular Differences in Visual Acuities Among Older Spectacle Wearers.
Materia socio-medica Pub Date : 2025-01-01 DOI: 10.5455/msm.2025.37.37-42
Ivana Mravicic, Selma Lukacevic, Ante Barisic, Sudi Patel, Alma Biscevic, Melisa Ahmedbegovic-Pjano, Nikica Gabric
{"title":"Depth Perception and Intraocular Differences in Visual Acuities Among Older Spectacle Wearers.","authors":"Ivana Mravicic, Selma Lukacevic, Ante Barisic, Sudi Patel, Alma Biscevic, Melisa Ahmedbegovic-Pjano, Nikica Gabric","doi":"10.5455/msm.2025.37.37-42","DOIUrl":"10.5455/msm.2025.37.37-42","url":null,"abstract":"<p><strong>Background: </strong>Falls impose a heavy financial burden on society, and the incidence is age-related. The correction of refractive errors has been mooted as a valuable procedure to prevent falls. However, depth perception, estimated by stereo acuity tests, is reduced in the older population and has been cited as contributing to the higher incidence of falls in the elderly.</p><p><strong>Objective: </strong>To explore the clinical relationship between age, interocular differences in the corrected distance and near logMAR visual acuities, refractive errors, axial (eyeball) lengths, pupil sizes, and higher-order ocular aberrations (HOAs) on clinical measures of stereoacuity and aniseikonia in asymptomatic presbyopic habitual spectacle wearers.</p><p><strong>Methods: </strong>Total amount of 91 subjects underwent clinical assessment of i) subjective refractive error, ii) stereoacuity at 6m and 40cm (Randot Stereotests), iii) aniseikonia at 6m (Awaya test along vertical and horizontal meridian) iv) higher order aberrations (Hartman-Shack aberrometer) v) eyeball length and pupil size (IOL master 700). The Pythagorean theorem was applied to each pair of aniseikonia values to calculate the resultant aniseikonia (AR).</p><p><strong>Results: </strong>Mean (±sd,95%CI) age of the subjects was 56.2years (±8.10,54.6-57.9). Root mean square (RMS) interocular differences (±sd,95%CI) in spherical refractive errors, axial lengths and pupil sizes were 0.66D(±0.93,0.47-0.85), 0.24mm (±0.33,0.17-0.31), 0.15mm (±0.11,0.12-0.17). The median (mode, interquartile range) values for AR were 2.8(1.0,1.3-4.0). Significant correlations (p<.01) were revealed between: a) log distance stereoacuity (y1), age (x1) and RMS difference in the corrected distance logMAR visual acuity (x2). b) log near stereoacuity (y2), RMS differences in the corrected distance (x2) and near visual acuities (x3). These key associations are best described by: y1=0.011x1+1.101x2+1.553 (r² =0.169, n=91); y2=1.715x2+1.883x3+1.725 (r² = 0.239, n=91).</p><p><strong>Conclusion: </strong>Stereoacuity is age-related, influenced by interocular differences in the corrected visual acuities but not related to interocular differences in pupil sizes, HOAs or clinical measures of aniseikonia in older habitual spectacle wearers. Assessment of stereoacuity and aniseikonia, in older persons is useful when advising to prevent accidental mis-location and falls.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信