Materia socio-medica最新文献

{"title":"Preliminary Results of the Efficacy and Safety of Cryoablation for Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation: a Study From Vietnam.","authors":"Nguyen Duy Linh, Phan Dinh Phong, Tran Song Giang, Pham Tran Linh, Bui The Dung, Do Doan Loi, Pham Minh Tuan","doi":"10.5455/msm.2025.37.54-57","DOIUrl":"10.5455/msm.2025.37.54-57","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation is the most common type of arrhythmia. The symptoms of atrial fibrillation not only significantly impacted quality of life but also associated with thrombotic events and heart failure, thereby increased risk of mortality. According to current guidelines, the initial treatment strategy for patients with atrial fibrillation is antiarrhythmic medication.</p><p><strong>Objective: </strong>This study aimed to evaluate the safety, efficacy, and procedural adaptations required for cryoablation in Vietnamese patients with paroxysmal atrial fibrillation (AF).</p><p><strong>Methods: </strong>Fifteen patients with paroxysmal AF underwent cryoablation using a standardized protocol. Patient characteristics, procedural parameters, and outcomes were recorded. Safety was assessed by monitoring acute complications, and procedural success was defined as complete pulmonary vein isolation (PVI) confirmed by bidirectional block.</p><p><strong>Results: </strong>Complete PVI was achieved in 100% of patients, with an average procedural duration of 125 ± 32 minutes and fluoroscopy time of 14 ± 8 minutes. No acute complications related to cryoablation.</p><p><strong>Conclusion: </strong>Cryoablation demonstrated safety and efficacy in achieving PVI for paroxysmal AF in a resource-limited setting. Larger studies with extended follow-up are required to further validate these outcomes and explore the long-term efficacy and sustainability of cryoablation techniques.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"54-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Non-pharmacological Herbs in Treating Cough and Respiratory Symptoms in Saudi Arabia: a Multi-center Study.","authors":"Abdullah A Yousef, Abdullah Al-Shamrani, Alzahra Y Alradhi, Fatimah M Bukhamsen, Aqilah T Alqassab, Sumayyah A Kobeisy, Saleh AlHarbi, Halima AlalKami, Ahmed M Alrashdan","doi":"10.5455/msm.2025.37.18-23","DOIUrl":"10.5455/msm.2025.37.18-23","url":null,"abstract":"<p><strong>Background: </strong>Herbal medicinal products, a subgroup of complementary and alternative therapy (CAM), are widely used for pediatric respiratory symptoms in Saudi Arabia. However, regional variations and safety concerns remain understudied.</p><p><strong>Objective: </strong>This study examines the prevalence and patterns of herbal remedy use for cough and respiratory illness among Saudi children.</p><p><strong>Methods: </strong>A multi-center cross-sectional questionnaire-based study was conducted across five Saudi regions (N=475). Data were collected via a validated questionnaire (Cronbach's α = 0.85) and analyzed using SPSS v25.</p><p><strong>Results: </strong>The mean age was 3.97 ± 3.60 years. Herbal remedy use was highest in the Western province (37.8%, p <0.001). Sesame oil (19.8%) and olive oil (18.2%) were most common. Family/friends provided 82.8% of advice. Self-rated improvement was \"excellent/good\" in 59.9%, with 96.6% reporting no adverse effects. Fathers with postgraduate degrees used fewer herbal remedies (p=0.003).</p><p><strong>Conclusion: </strong>Herbal remedy use is prevalent, emphasizing the need for healthcare providers to document usage and educate families. Further research is required to evaluate efficacy and safety.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"18-23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes of Physicians and Nurses Toward Interprofessional Collaboration: a Systematic Literature Review.","authors":"Polyxeni Lazarou Gregoriou, Andreas Charalambous, Elena Rousou, Evridiki Papastavrou, Anastasios Merkouris","doi":"10.5455/msm.2025.37.64-73","DOIUrl":"10.5455/msm.2025.37.64-73","url":null,"abstract":"<p><strong>Background: </strong>Interprofessional collaboration involves coordinated efforts by professionals from various disciplines, such as physicians and nurses, aimed at improving patient care outcomes. This teamwork enhances cooperation among healthcare professionals with diverse expertise, contributing significantly to patient safety, satisfaction, expedited recovery, cost-effectiveness, and reduced mortality rates.</p><p><strong>Objective: </strong>This paper explores the available evidence regarding the attitudes of physicians and nurses towards interprofessional collaboration and identifies factors that influence their willingness to engage in collaborative practice.</p><p><strong>Methods: </strong>A systematic review was conducted spanning from 2016 to 2023, adhering to predefined criteria and the PRISMA guidelines and checklist. Searches were performed in PubMed, Scopus, CINAHL Plus, Cochrane, and Google Scholar. The inclusion criteria comprised studies (regardless of design) addressing interprofessional collaboration, published within the last ten years, and involving both physicians and nurses. Only articles with full text access and written in English or Greek were included.</p><p><strong>Results: </strong>The review identified 13 relevant studies. The analysis revealed that nurses generally exhibit more favourable attitudes towards interprofessional collaboration compared to physicians. Moreover, thematic analysis highlighted key factors influencing the attitudes of both nurses and physicians, including education level, age and years of experience.</p><p><strong>Conclusion: </strong>This review highlights critical aspects and gaps in current literature, emphasizing the need for future research to further explore these areas. Findings also underscore the importance of incorporate these insights into hospital policies to effectively enhance interprofessional collaboration.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"64-73"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discriminatory Performance of APACHE II Score and the Prediction of Mortality within the ICU in Patients with Sepsis Admitted to the ICU.","authors":"Ahmad Habeeb Dala Ali, Sabariah Noor Harun, Noordin Othman, Baharudin Ibrahim, Omer Elhag Abdulbagi, Ibrahim Abdullah, Indang Ariati Ariffin","doi":"10.5455/msm.2025.37.153-158","DOIUrl":"10.5455/msm.2025.37.153-158","url":null,"abstract":"<p><strong>Background: </strong>Severity of illness assessment tools are utilized to triage critically-ill patients and provide a valuable inputs to the healthcare provider to decide the type and intensity of treatment or interventions.</p><p><strong>Objective: </strong>The aim of this study was to evaluate the discriminatory capabilities of Acute Physiology And Chronic Health Evaluation II (APACHE II) score in the prediction of Intensive care units (ICUs) mortality among patients with sepsis admitted to the ICU.</p><p><strong>Methods: </strong>Records of patients with sepsis admitted to ICUs were retrospectively reviewed. Discriminatory performance of APACHE II score was assessed by using the receiver operating characteristic's (ROC's) area under the curve (AUC).</p><p><strong>Results: </strong>The mean±SD of APACHE II score was 27.1±8.4. APACHE II score demonstrated a very good discriminatory performance with an accuracy rate of 75% and an AUC-ROC 0.80 (95%CI: 0.74 - 0.85) at an optimal cutoff of 26. APACHE II score was found to be correlated with ICU mortality with a correlation coefficient of (0.52). ICU mortality was significantly higher in patients with APACHE II score ≥26.</p><p><strong>Conclusion: </strong>This study revealed that the discriminatory performance of APACHE II score in predicting ICU mortality in patient with sepsis was very good. These findings can have potential clinical implications in the identification and management of patients with sepsis admitted to the ICU.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 2","pages":"153-158"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rusty Pipe Syndrome: a Rare Syndrome During Breast Feeding-Our Experience.","authors":"Georgios Iatrakis, Stefanos Zervoudis, Panagiotis Eskitzis, Vasiliki Michou, Anisa Markja, Panagiotis Peitsidis, Aristidis Tzeferakos, Panagiotis Tsikouras","doi":"10.5455/msm.2025.37.149-152","DOIUrl":"10.5455/msm.2025.37.149-152","url":null,"abstract":"<p><strong>Background: </strong>The presence of blood in breast milk gives it a rusty or brownish color, which is referred to as \"Rusty Pipe Syndrome (RPS)\".</p><p><strong>Objective: </strong>This study presents case reports to raise awareness about RPS and examine differences from existing literature.</p><p><strong>Methods: </strong>Data from six cases with confirmed RPS were collected from Rea Maternity Hospital in Athens, Greece and Alexandroupolis General University Hospital in Alexandroupolis, Greece, from March 2020 until July 2024.</p><p><strong>Results: </strong>Six women aged 25 to 36, experienced RPS during breastfeeding. The majority of them had no previous birth history (83%), were primigravida (83%) and had bilateral presence of blood in the milk (67%), with symptoms appeared on the second postpartum day (50%).</p><p><strong>Conclusion: </strong>Based on extensive studies and literature reviews, RPS is generally considered a benign condition, typically presenting bilaterally. However, unilateral cases, such as those observed in our study, are rare.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 2","pages":"149-152"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infertility - a Great Challenge of the Past, Present, and Future.","authors":"Ivana Erceg Ivkosic, Jana Mesic, Rajko Fures, Zlatko Hrgovic, Luka Bulic, Eva Brenner, Vesna Cosic, Blazenka Miskic, Dinko Kolaric","doi":"10.5455/msm.2025.37.74-79","DOIUrl":"10.5455/msm.2025.37.74-79","url":null,"abstract":"<p><strong>Background: </strong>The Infertility refers to the inability of couples to conceive after 12 months of regular, unprotected sexual intercourse. The incidence of infertility is increasing and is estimated to be 8-12%, or even up to 20%. Primarily, it involves organic causes, but the psychological aspect is not excluded.</p><p><strong>Objective: </strong>The aim of this article was to discrabe the observing of various causes of infertility.</p><p><strong>Methods: </strong>Authors used, as sources, published relevant facts in the articles deposited in important scientific indexed databases Medline, Scopus, PubMed Central, Hinari, etc. to write this review.</p><p><strong>Results and discussion: </strong>The diagnosis of female infertility involves a detailed medical history, laboratory tests, hormonal evaluation, and imaging studies such as ultrasound and eventually hysteroscopy and laparoscopy. Advances in genetic testing have deepened our understanding of infertility origins in both genders. Sperm analysis is pivotal for diagnosing male infertility. Infertility treatment includes identifying causes and applying various therapies, including conservative surgical, and assisted reproductive technology (ART).</p><p><strong>Conclusion: </strong>The currently used ART methods include ovulation tracking with planned intercourse, insemination and in vitro fertilization (IVF).</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"74-79"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Gender and Length of Therapy Use on Sleep Quality in Patients with Parkinson's Disease.","authors":"Zikrija Dostovic, Nermin Mesic, Nerimana Suljkanovic, Denisa Salihovic","doi":"10.5455/msm.2025.37.58-63","DOIUrl":"10.5455/msm.2025.37.58-63","url":null,"abstract":"<p><strong>Background: </strong>Normal sleep duration is crucial for maintaining brain homeostasis. Sleep disorders in Parkinson's disease are numerous, multifactorial, and result in significant morbidity.</p><p><strong>Objective: </strong>The aim of the study was to investigate the association between gender and the duration of therapy on sleep quality in patients with Parkinson's disease.</p><p><strong>Methods: </strong>The study is prospective, and includes 40 consecutively hospitalized patients with verified Parkinson's disease. The study included subjects of both genders and all age groups. To analyze the data on the subjects, we used: medical histories, nursing documentation of patients, a questionnaire with sociodemographic data, and the Parkinson's Disease Sleep Assessment Scale. We divided all subjects into two groups: subjects who have been using therapy for up to 5 years and those who have been using therapy for more than 5 years.</p><p><strong>Results: </strong>Among subjects who have been taking medication for less than 5 years, 33.3% were female and 66.6% were male. Of the total number of respondents who have been taking therapy for more than 5 years, 36.3% are female and 63.6% are male. The duration of the therapy has a statistically significant effect on the quality of sleep in patients with Parkinson's disease (p < 0.05). The subject's gender does not have a significant independent influence on the quality of sleep in patients with Parkinson's disease (p > 0.05). The interaction of gender and length of therapy use has no significant separate effect on the quality of sleep in Parkinson's disease patients (p > 0.05). The quality of sleep is better in male and female subjects who take the therapy until the age of 5.</p><p><strong>Conclusion: </strong>The duration of therapy use has a significant impact on the quality of sleep in Parkinson's disease patients. The gender of the subject has no significant independent influence on the quality of sleep in patients with Parkinson's disease.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"58-63"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction of Serum Interleukin-17 and Interleukin-23 Levels Following Narrow Band Ultraviolet B Treatment in Patients with Moderate-to-severe Psoriasis Vulgaris.","authors":"Pham Thi Minh Phuong, Tran Thi Huyen, Quach Thi Ha Giang, Trinh Minh Trang, Hoang Thi Phuong, Le Thi Hai Yen, Nguyen Van Thuong, Le Huu Doanh","doi":"10.5455/msm.2025.37.125-130","DOIUrl":"10.5455/msm.2025.37.125-130","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis, a common skin disorder, involves immune cells and cytokines in its pathogenesis. Narrow band ultraviolet B (NB-UVB) treatment has demonstrated efficacy and safety in managing this condition.</p><p><strong>Objective: </strong>This study aimed to assess changes in serum interleukin (IL)-17, IL-23, and tumor necrosis factor-alpha (TNF-α) levels during NB-UVB treatment for psoriasis vulgaris.</p><p><strong>Methods: </strong>An interventional, pre-post comparative study was conducted on patients with moderate to severe psoriasis vulgaris undergoing NB-UVB treatment. Patients were randomly allocated to Group 1 (n=39) receiving NB-UVB based on minimal erythema dose (MED) and Group 2 (n=32) based on Fitzpatrick skin type classification. Serum IL-17, IL-23, and TNF-α levels were measured before treatment and upon achieving PASI75.</p><p><strong>Results: </strong>There were no significant differences in serum IL-17, IL-23, and TNF-α levels between Group 1 and Group 2 at either time point. In Group 1, IL-17 levels decreased from median 2.6 pg/ml before treatment to 2.5 pg/ml at PASI75 (P=0.0107). In Group 2, IL-23 levels decreased from median 9.6 pg/ml pre-treatment to 1.3 pg/ml at PASI75 (P<0.0190). Across all patients, pre-treatment IL-17 and IL-23 levels (median 2.6 pg/ml and 7.1 pg/ml, respectively) were significantly higher compared to levels at PASI75 (P=0.0349 and P=0.0023, respectively).</p><p><strong>Conclusion: </strong>NB-UVB effectively treats moderate to severe psoriasis vulgaris, leading to reduced serum IL-17 and IL-23 levels irrespective of MED-based or skin type-based dosing strategies.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 2","pages":"125-130"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manifestation of Necrotic Palatal Ulceration in COVID-19 Infection: a Case Report.","authors":"Mimoza Canga, Alketa Qafmolla, Edit Xhajanka, Irene Malagnino","doi":"10.5455/msm.2025.37.80-82","DOIUrl":"10.5455/msm.2025.37.80-82","url":null,"abstract":"<p><strong>Background: </strong>The global pandemic caused by the COVID-19 virus is a serious disease that has significantly affected the lives of millions of people.</p><p><strong>Objective: </strong>The objective of this case study is to describe the development of a necrotic ulcer on the palate in a COVID-19 patient.</p><p><strong>Case presentation: </strong>This is the clinical case of a 35-year-old male patient with a 20-year history of two pack-a-day smoking who contracted COVID-19. He was admitted to the Department of Oral and Maxillofacial Surgery at the \"Mother Teresa\" University Hospital Center in Tirana, Albania, presenting with oral pain, facial swelling, and necrosis in the palatal region and the lower lip.</p><p><strong>Conclusion: </strong>This case report from Albania is significant as it presents an ulcer with necrotic tissue located in the hard palate region of a patient infected with SARS-CoV-2.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 1","pages":"80-82"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnostic Significance of the Tumor Marker CYFRA 21-1 in Patients with Laryngeal Carcinoma.","authors":"Lejla Tokic, Sefik Hasukic, Fuad Brkic, Sekib Umihanic, Fatima Hukic, Selveta Mustafic","doi":"10.5455/msm.2025.37.131-135","DOIUrl":"10.5455/msm.2025.37.131-135","url":null,"abstract":"<p><strong>Background: </strong>Laryngeal squamous cell carcinoma (LSC) is the leading malignant tumour of the head and neck. Establishing new biomarkers is extremely important because they can be important for early diagnosis and prognosis of LSC.</p><p><strong>Objective: </strong>The aim of this study was to establish the significance of cytokeratin fragment antigen 21-1 (CYFRA 21-1) in the early diagnosis and prognosis of LSC.</p><p><strong>Methods: </strong>This was prospective research involving 35 patients of both sexes with pathohistologically confirmed LSC, who were treated in the period from 2022 to 2024. The control group consisted of 30 patients who underwent surgery for other non-malignant diseases and who had a normal indirect laryngoscopy findings. The levels of CYFRA 21-1 were determined for three time periods: preoperative, four weeks after surgery, and three months after radiotherapy or concomitant chemoradiotherapy. For the statistical analysis of data we used descriptive statistics methods, the Student T-test and the χ2 test to calculate the significance of the tested differences, where differences on the level of p<0.05 were considered to be statistically significant.</p><p><strong>Results: </strong>Statistically significantly higher mean serum levels of CYFRA 21-1 were found preoperatively in the experimental group in comparison with the control group (p<0.001). Statistically significant lower levels of CYFRA 21-1 were found four weeks after surgery in the experimental group in comparison with preoperative levels (p=0.004). A statistically significant decrease in serum levels of CYFRA 21-1 was also found three months after radiotherapy or concomitant chemoradiotherapy in comparison with the preoperative levels (p=0.001). The serum levels of CYFRA 21-1 were statistically significantly higher preoperatively in patients with stage III/IV of the disease in comparison with stage I/II (p<0.001).</p><p><strong>Conclusion: </strong>Increased levels of CYFRA 21-1 are a significant indication of the presence of LSC, especially in patients with advanced stages of the disease.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 2","pages":"131-135"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}