Materia socio-medica最新文献

{"title":"The Frequencies of HLA-A Gene Variants in the Bosnian Population.","authors":"Hilada Nefic, Aner Mesic, Biljana Klimenta, Amira Skopljak, Fatima Hukic, Gazmend Temaj, Belma Zujo, Meliha Tahirovic-Hadziosmanovic","doi":"10.5455/msm.2025.37.323-329","DOIUrl":"10.5455/msm.2025.37.323-329","url":null,"abstract":"<p><strong>Background: </strong>HLA-A gene is one of the most polymorphic loci in human genome and its variants influence disease susceptibility and immune checkpoint inhibitor (ICI) therapy response. HLA-A*03 allele has been identified as a biomarker associated with poor ICI response.</p><p><strong>Objective: </strong>This study aimed to characterize HLA-A allele and genotype frequencies in the Bosnian population, assess sex specific differences, and evaluate the prevalence of HLA-A*03.</p><p><strong>Methods: </strong>Blood samples from 75 individuals were analyzed. Genomic DNA was isolated using the Miller method, and HLA-A typing was performed using PCR with sequence specific primers (PCR-SSP). Polymorphism parameters were calculated using PowerMarker v3.25. Differences between males and females were assessed using chi square and Fisher's exact tests.</p><p><strong>Results: </strong>Twelve HLA-A allelic groups and 28 genotypes were identified. The most frequent alleles were HLA-A*02 (33.33%), A*01 (16.67%), A*24 (11.33%), A*03 (10%), and A*11 (8%). The most common genotypes were HLA-A*01/*02 (12%), A*02/*02 (12%), and A*02/*03 (8%). Females showed significantly higher frequencies of HLA-A*02, A*03, and A*31, as well as genotypes HLA-A*02/*03, A*02/*11, and A*02/*31. The population exhibited high polymorphism (heterozygosity 0.8667; gene diversity 0.8232; PIC 0.8054). Strong similarity with European and Western groups and substantial divergence from East Asian and African populations were detected.</p><p><strong>Conclusion: </strong>The Bosnian population demonstrates high HLA-A polymorphism, with HLA-A*02 as the most common allele. Females more frequently carry the HLA-A*03 allele and several related genotypes, suggesting potential sex specific implications for ICI therapy response. These findings provide a foundation for future studies investigating the clinical relevance of HLA-A variation in Bosnian cancer patients undergoing immunotherapy.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"37 4","pages":"323-329"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12923282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fine Needle Aspiration Cytology of Lymph Nodes in Metastatic Cancer and Lymphoma: Our Single-institution Experience.","authors":"Sanela Vesnic, Anes Joguncic, Vesna Sarajlic, Mirsad Doric","doi":"10.5455/msm.2024.36.18-22","DOIUrl":"https://doi.org/10.5455/msm.2024.36.18-22","url":null,"abstract":"<p><strong>Background: </strong>Lymphadenopathy is a common finding in clinical practice. The cause of enlarged nodes on clinical examination alone is challenging and there may be multiple reasons for this enlargement. It may become enlarged due to stimulation by infectious agents or the involvement of metastasis or malignant diseases, such as lymphoma.</p><p><strong>Objective: </strong>The aim of the study was to investigate the diagnostic role of fine needle aspiration cytology of lymph nodes in metastatic cancer and lymphoma.</p><p><strong>Methods: </strong>A total of 48 FNAC lymph nodes suspicious for malignancy were sampled with follow-up biopsy in Clinical Center of University of Sarajevo from 2017 to 2023. Lymph nodes were aspirated using 20-22 G needle with minimally 2 passes, spread on slides, air-dried, stained with May-Grünwald-Giemsa or Papanikolaou and residual material sent for cytoblock.</p><p><strong>Results: </strong>Out of 48 cytological samples, 30 (62.5%) revealed metastatic epithelial cells and 12 (25%) lymphoproliferative neoplasm. Three samples were suspected for malignancies, one sample was unrepresentative, one inconclusive and one falsely negative. Histopathological confirmation had 35 patients, while others were confirmed based on clinical presentation and radiological techniques. Compared to histopathological diagnosis, cytology had a sensitivity of 89.47%, specificity of 93.33%, positive predictive value (PPV) 95.04% and negative predictive values (NPV) 86.13% for epithelial metastatic cancer. The overall diagnostic test accuracy was 91.06%. For lymphoproliferative neoplasms cytology in comparison to histopathology had sensitivity 85.71%, specificity 91.18%, PPV 76.4% and NPV 95.04%. The overall diagnostic test accuracy was 89.81%. In both ways cytology is showing significant possibility to be used as a primary tool in detecting cancers.</p><p><strong>Conclusion: </strong>FNAC is a fast, reliable, and efficient method for diagnosing malignant lymphadenopathy. The cytological diagnosis can sometimes be accepted as the definitive diagnosis without further correlation with histopathology, especially in advanced malignancies and known primary malignancies.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"36 1","pages":"18-22"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10999137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and Related Factors of Bacterial Infection Among Patients With Cirrhosis.","authors":"Nguyen-Thi Ngoc Lan, Dau Quang Lieu, Tran Ngoc Anh, Le Hoai Thuong, Tran-Thi Khanh Tuong, Mai Hong Bang","doi":"10.5455/msm.2024.36.90-96","DOIUrl":"https://doi.org/10.5455/msm.2024.36.90-96","url":null,"abstract":"<p><strong>Background: </strong>Infection causes cirrhosis to decompensate, affecting liver function and resulting in several complications, including esophageal variceal hemorrhage, hepatic encephalopathy, and hepatorenal syndrome. Objective: This study aimed to identify the prevalence, essential features, and related factors of bacterial infection among patients with cirrhosis in Vietnam.</p><p><strong>Methods: </strong>This retrospective study included 317 patients diagnosed with cirrhosis, who were divided into two groups: group 1 including 125 patients with bacterial infection and group 2 including 192 patients without bacterial infection. Infection was diagnosed on the basis of its localization.</p><p><strong>Results: </strong>Spontaneous bacterial peritonitis (SBP; 31.2%) and pneumonia (28.8%) were the most common infections identified. The procalcitonin (PCT) level had a strong diagnostic value with an area under the curve value of 0.868. The most common type of gram-negative bacteria was Escherichia coli, while the gram-positive bacteria seen were Staphylococcus, Enterococcus, and Streptococcus among the patients with infection. In the logistic regression analysis, Child-Pugh class B and C (p<0.001, OR=4.14, CI=1.90-9.03; OR=4.76, CI=2.03-11.16, respectively) and the presence of acute kidney injury (p=0.009, OR=2.57, CI=1.27-5.22) and gastrointestinal hemorrhage (p=0.035, OR=0.39, CI=0.16-0.94) significantly differed between the groups.</p><p><strong>Conclusion: </strong>The most prevalent type of bacterial infection in patients with cirrhosis is SBP, with gram-negative bacteria being the most common cause. The PCT level is useful in identifying infection in patients with cirrhosis. Decompensated cirrhosis is linked to a higher risk of infection.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"36 1","pages":"90-96"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10999149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Attitudes of Breastfeeding Mothers and Healthcare Professionals About Breastfeeding.","authors":"Tomica Kukina Zvigac, Rajko Fures, Zlatko Hrgovic, Damir Rosic, Lucije Radic, Albert Despot, Kresimir Zivkovic, Suzana Pekez","doi":"10.5455/msm.2024.36.300-304","DOIUrl":"10.5455/msm.2024.36.300-304","url":null,"abstract":"<p><strong>Background: </strong>The attitudes of breastfeeding mothers and healthcare professionals greatly influence decisions about initiation of breastfeeding, duration of breastfeeding, and repeated breastfeeding in multiparous women.</p><p><strong>Objective and methods: </strong>This research aimed to examine, through a questionnaire, the attitudes of breastfeeding mothers and healthcare professionals about breastfeeding in the area covered by the district nurses of the Zagreb-West Health Center. 76 mothers and 74 healthcare professionals participated in the study, which was conducted during 2021.</p><p><strong>Results: </strong>All healthcare professionals (100%) believe that breastfeeding in the first 6 months is important, and 97% of them believe that they are adequately educated about proper breastfeeding techniques. Furthermore, 98% of them believe that they provide mothers with all the necessary help and support regarding breastfeeding. 93% of healthcare professionals support breastfeeding in public. Most breastfeeding mothers were over 30 years old and had a higher level of education. Only 47% of women in the maternity unit had skin-to-skin contact, while 73% stayed in the room with their baby. In 89% of women, the first breastfeeding occurred within the first hour after birth. The greatest assistance during breastfeeding was provided to mothers by healthcare personnel (94%).</p><p><strong>Conclusion: </strong>Continuous education of healthcare professionals and raising public awareness about the importance of breastfeeding must be a priority for every society.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"36 4","pages":"300-304"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Law Enforcement Mechanisms in the Care of Occupational Health and Safety in the Workplace of Health Professionals in Kosovo.","authors":"Albina Xhemajli, Naser Rugova, Doncho Donev","doi":"10.5455/msm.2024.36.187-191","DOIUrl":"https://doi.org/10.5455/msm.2024.36.187-191","url":null,"abstract":"<p><strong>Background: </strong>Workplace health and safety are critical concerns for healthcare professionals, who are often exposed to various occupational hazards.</p><p><strong>Objective: </strong>The aim of the study was to analyze the effectiveness and impact of law enforcement mechanisms in ensuring occupational health and safety for healthcare professionals in Kosovo.</p><p><strong>Methods: </strong>Consist in conduct research on the role of law enforcement mechanisms in ensuring the occupational health and safety of healthcare professionals in Kosovo, using a qualitative methodology with questionnaires targeting the Health Inspectorate and Labor Inspectorate.</p><p><strong>Results: </strong>The study found that while laws and regulations for workplace safety in healthcare exist in Kosovo, their enforcement is inconsistent and often inadequate.</p><p><strong>Conclusion: </strong>The study concludes that the enforcement of workplace health and safety laws in Kosovo's healthcare sector is inadequate, leading to unsafe working conditions for healthcare professionals.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"36 3","pages":"187-191"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges of Occupational Health and Safety Management in Healthcare Institutions in Kosovo.","authors":"Albina Xhemaili Kelmendi, Naser Rugova, Doncho Donev","doi":"10.5455/msm.2024.36.149-154","DOIUrl":"10.5455/msm.2024.36.149-154","url":null,"abstract":"<p><strong>Background: </strong>Occupational health and safety (OHS) in healthcare institutions are crucial for the well-being of healthcare workers who are exposed to numerous risks in their working environment. In Kosovo, where healthcare institutions operate under resource constraints, understanding the challenges of OHS management challenges is vital for developing effective strategies.</p><p><strong>Objective: </strong>This study aims to explore the challenges of OHS management in Kosovo's healthcare system, focusing on three levels of healthcare provision in both the public and private sectors. The study aims to identify gaps in policies, practices, and infrastructure that affect the safety of healthcare workers and propose actionable recommendations.</p><p><strong>Methods: </strong>A qualitative research design was used, involving 191 healthcare professionals from primary, secondary, and tertiary levels of healthcare. Participants were randomly selected from public and private institutions. Data collection methods included semi-structured interviews and focus group discussions, ensuring a comprehensive understanding of OHS practices, perceptions, and barriers. Thematic analysis was used to identify key patterns and findings.</p><p><strong>Results: </strong>The findings revealed significant challenges in OHS management, including inadequate infrastructure, lack of personal protective equipment, insufficient training, and weak enforcement of regulations. Healthcare professionals reported high exposure to biological, chemical, and physical hazards, compounded by limited institutional support. Private sector facilities demonstrated slightly better resource availability but faced similar regulatory gaps.</p><p><strong>Conclusion: </strong>The study highlights critical deficiencies in OHS management in Kosovo's health system, posing risks to health professionals and the overall service quality. Addressing these challenges requires a multifaceted approach, including policy reforms, enhanced enforcement mechanisms, capacity-building initiatives, and improved resource allocation. Strengthening OHS management is essential for safeguarding the health workforce and ensuring sustainable healthcare delivery in Kosovo.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"36 2","pages":"149-154"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart Failure After Acute Coronary Syndrome: A Comprehensive Analysis from Bosnia and Herzegovina.","authors":"Armin Sljivo, Amel Dzanic, Lana Lekic, Aladin Altic, Arian Abdulkhaliq","doi":"10.5455/msm.2024.36.110-114","DOIUrl":"10.5455/msm.2024.36.110-114","url":null,"abstract":"<p><strong>Background: </strong>The incidence of HF following ACS remains unacceptably high at discharge and several identified risk factors contribute to the development of HF in this context.</p><p><strong>Objective: </strong>This study investigated the prevalence and clinical significance of HF in patients admitted to the Clinic for Heart, Blood Vessels, and Rheumatic Diseases at the Clinical Center of the University of Sarajevo following ACS.</p><p><strong>Methods: </strong>This retrospective observational study was conducted at the Clinic for Heart, Blood Vessels, and Rheumatic Diseases of the Clinical Center of the University of Sarajevo between February 1^st and April 1^st, 2023, involving patients who were admitted because of ACS.</p><p><strong>Results: </strong>Patients with HFrEF were significantly (p=0.034) older (70.0 (62.0;76.0) vs 67.0 (57.5;75.0)), had (p=0.046) higher median score of LDH (321.5 (222.3; 501.5) vs. 256.0 (200.0; 420.0)), fibrinogen (p=0.047) (4.5 (3.2; 5.1) vs 3.6 (2.8; 5.0)), and NT-proBNP (p<0.001) (3705.0 (2500.0; 12559.5) vs. 500.0 (275.0; 333.0)), had enlarged left atrium diameter (3.9 (3.4; 4.4) vs 3.6 (3.1; 4.1)), enlarged left ventricular diameter both in diastole (5.1 (4.5; 5.8) vs 4.6 (4.1; 5.1)) and systole (3.7 (3.2; 4.1) vs 3.5 (3.1; 3.7)), thinner interventricular septum diameter both in diastole (1.1 (1.0; 1.2) vs 1.2 (1.1; 1.3)) and systole (1.3 (1.2; 1.5) vs. 1.4 (1.3; 1.5)) and elevated right ventricular systolic pressure (37.0 (30.0; 47.5) vs. 35.0 (28.0; 40.0 )) compared to patients without HFrEF. Severe mitral regurgitation was more observed in group of patients with HFrEF (p<0.001).</p><p><strong>Conclusion: </strong>HFrEF patients showed a 40% incidence of post-ACS, had elevated LDH, fibrinogen, and NT-proBNP levels, along with distinct echocardiographic differences, including enlarged heart chambers and higher mitral regurgitation rates following ACS. Early HF risk factor management is crucial for optimizing outcomes in ACS patients.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"36 2","pages":"110-114"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of SARS-COV-2 Antibodies Associated with the Use of Personal Protective Equipment in Healthcare Workers.","authors":"Amela Dubinovic-Rekic, Nurka Pranjic","doi":"10.5455/msm.2024.36.222-228","DOIUrl":"10.5455/msm.2024.36.222-228","url":null,"abstract":"<p><strong>Background: </strong>Hypothetically, PPE played an estimated influential role in preventing SARS-CoV-2 transmission among HCWs before immune-prophylaxis by vaccination in BH. Objective: This research aims to determine the relationship between PPE use and the serological response to SARS-COV-2 among HCWs.</p><p><strong>Methods: </strong>The sample contained 127 COVID-19 outpatients with an average age of 43.5 ± 10.8, 66% women, and 80 (63%) health workers as the study group (37% non-medical workers as a control subjects). The created questionnaire collected sociodemographic data on comorbidity or not, application of PPE, and severity of the clinical picture of COVID-19 infection.</p><p><strong>Results: </strong>All subjects were monitored for the dynamics of antibodies, separately for IgM- and Ig-G three times, repeated every 3 months (only three before immuno-prophylaxis by vaccinations). A serological investigation of subjects' blood was collected by trained medical staff in vacutainers with a clotting activator to obtain the subjects' serum centrifuged, separated, and tested on the AFIAS 6 COVID-19 apparatus. Healthcare workers who did not wear goggles had significantly higher IgM antibody levels than HCWs who use them [F=9.359 (1, 102), p=.003, partial η2=.084]. Also, HCWs who did not use a visor had significantly higher IgM nucleocapsid antibody titer than those who used it daily or occasionally [F=4.790 (1, 102), p=.031, partial η2=.045]. Increase SARAS-COV-2 IgM titer three, six, or nine months after past COVID-19 infection and before vaccination.</p><p><strong>Conclusion: </strong>It presents a new acute or recent asymptomatic infection in our HCWs and unrecognized COVID-19. This implies considerable source and unrecognized risk of transmission of the SARS-COV-2 virus, and among HCWs, COVID-19 is an infectious disease with a high prevalence rate.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"36 3","pages":"222-228"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood-Stream Infections: Causative Agents, Antibiotic Resistance and Associated Factors in Older Patients.","authors":"Hoang-Van Quang, Le-Thi Kim Nhung, Pham-Thi Thanh Thuy, Phan Chau Quyen, Le Bao Huy, Ho Si Dung","doi":"10.5455/msm.2024.36.82-89","DOIUrl":"https://doi.org/10.5455/msm.2024.36.82-89","url":null,"abstract":"<p><strong>Background: </strong>The rate of multi-drug antibiotic resistance in nosocomial bloodstream infections in elderly patients is increasing. This study examined the data for bloodstream infections to gain a better understanding of bacterial antibiotic resistance.</p><p><strong>Methods: </strong>This was a retrospective study of 817 patients with the first positive blood culture between January 1, 2016 and December 31, 2019.</p><p><strong>Results: </strong>Moyen's age was 77.4 ± 9.8 years, male (52.4%) and SOFA 5.0 ± 4. ESBL(+) rate was 78/817 (9.5%). ESBL(+) rate for Escherichia coli and Klebsiella pneumoniae was 69/141 (48.9%) and 9/52 (17.3%), respectively. The most common isolates were Escherichia coli (17.3%), Stenotrophomonas maltophilia (13.7%), and Staphylococcus species (23.1%). The rate of septic shock and mortality accounted for 22.3% and 28.9%, respectively. Escherichia coli is highly sensitive to carbapenem, and resistant (>50%) with quinolone and aminoside. Klebsiella pneumoniae and Pseudomonas aeruginosa were highly sensitive to carbapenem. Acinetobacter baumannii was resistant to meropenem (75%). Stenotrophomonas maltophilia was sensitive to quinolone (13.8 %), and highly resistant to remaining antibiotics. Methicillin-resistant Staphylococcus aureus had a low resistance rate for vancomycin, teicoplanin, and linezolid. Multivariate analysis showed that the significant factors associated with mortality were age >75; SOFA >7; respiratory infection; intensive care unit treatment and presentation with septic shock.</p><p><strong>Conclusion: </strong>The mortality rate was still high, especially for antibiotic-resistant agents.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"36 1","pages":"82-89"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10999148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Anti-Ro/SSA and Anti-La/SSB Autoantibodies With Pregnancy Outcome in the General Population.","authors":"Georgios Dragoutsos, Christina Tsiggalou, Efthymios Oikonomou, Anastasia Bothou, Grigorios Trypsiannis, Konstantinos Nikolettos, Christos Damaskos, Nikolaos Garmpis, Dimitrios Kyriakou, Theopi Nalbanti, Georgios Iatrakis, Nikolaos Nikolettos, Panagiotis Tsikouras","doi":"10.5455/msm.2024.36.47-53","DOIUrl":"https://doi.org/10.5455/msm.2024.36.47-53","url":null,"abstract":"<p><strong>Background: </strong>Autoimmune diseases encompass a diverse array of disorders that disturb the optimal functioning of the immune system, which is to eliminate the 'foreign or/and dangerous' to mistakenly target the body's own tissues.</p><p><strong>Objective: </strong>The aim of this research is to evaluate the most effective approach to managing autoimmune diseases within the framework of pregnancy.</p><p><strong>Methods: </strong>The exact causes and etiologies of these diseases are multifactorial and mostly still unclear. Ro/SSA autoantibodies and La/SSB, could be found in Sjögren's disease (SJ), systemic lupus (SLE) and other autoimmune disorders. Smoking, stress, UV exposure, vitamin D deficiency, and other genetic and environmental factors have been identified as risk factors for rheumatic diseases.</p><p><strong>Results: </strong>Over the years, an ever-increasing incidence of these diseases has been observed in the general population, with the female sex being at increased risk for their occurrence. This fact raises the question of what should be the management of these pathological entities during pregnancy. Taking into account the very significant impact on the quality of paitients'daily life and the seemingly augmented prevalence of autoimmune diseases, as well as their preference in the female population, the reasonable question arises as to what should be the optimal management of these diseases in the context of pregnancy.</p><p><strong>Conclusion: </strong>Given the limited data of the global medical community regarding the etiological factors and mechanisms that trigger the onset of rheumatic diseases, the management of pregnant women is a complex conundrum that health professionals are challenged to face and solve.</p>","PeriodicalId":94128,"journal":{"name":"Materia socio-medica","volume":"36 1","pages":"47-53"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10999136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}