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[The role of whole brain irradiation nowadays: more or less or different?] [如今全脑照射的作用：更多、更少还是不同？］
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2023-10-08
Ferenc Lakosi
{"title":"[The role of whole brain irradiation nowadays: more or less or different?]","authors":"Ferenc Lakosi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In patients with poor performance status (KPS<50), ineligibility for effective systemic treatment and multiple brain metastases (BM) best supportive care is the preferred treatment over whole brain radiotherapy (WBRT). WBRT should be considered for the treatment of non-limited number (>4) brain metastases, depending on the patient's life expectancy, neurological symptoms, size, number and location of brain metastases, indication, type and availability of systemic therapy. In these patients if life expectancy is >4 months without small cell histology and without hippocampal lesions, hippocampal sparing WBRT with or without memantine is recommended. Simultaneous integrated boost for the BM is a logical and supportable concept. Prophylactic cranial irradiation (PCI) is still recommended in small cell lung cancer patients with complete remission. Hippocampal sparing WBRT needs further validation in this indication.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"60-65"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Systemic treatment of adult gliomas: a narrative review]. [成人胶质瘤的系统治疗：综述]。
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2024-01-04
László Mangel
{"title":"[Systemic treatment of adult gliomas: a narrative review].","authors":"László Mangel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Gliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later, in the first years of this century temozolomide was introduced to the everyday clinical practice as the most effective \"anti-glioma\" medicine, and it is still widely used both in monotherapy and in different combinations. Nevertheless, in the last two decades, considering the recognition of different predictive molecular markers, different targeted therapies, e.g. VEGFR inhibitor agents were also introduced into the routine clinical practice, and there have been promising results published in immunotherapy trials in the recent years, as well. Besides the promising results with the novel systemic therapies, it should be emphasized that both in the primary and the salvage care of the glial tumors the most effective treatment options are the individualized combinations of local and systemic treatment modalities, with the proper interpretation of brain imaging data and patient-centered clinical management.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"67-75"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Brain tumor surgery in adults.] [成人脑肿瘤手术]
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2023-11-12
György Attila Bagó, Gergő Dávid Nagy
{"title":"[Brain tumor surgery in adults.]","authors":"György Attila Bagó, Gergő Dávid Nagy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Despite the advanced medical and radiation therapy, the role of surgical resection of brain neoplasms still remains indisputable. The maximal safe resection of benign brain tumors may result in complete recovery of the patient. Surgery of malignant tumors can resolve mass effect, improve the neurological condition of the patient providing the possibility for further complex oncotherapy based on molecular level histopathology results. The advances in technical and multidisciplinary environment of brain tumor surgery facilitate more radical and safer resection resulting in better outcomes and preservation of quality of life, even in case of tumors which were considered inoperable until recently. In this review we present the recent technical innovations used in brain tumor surgery and discuss the surgical strategy of the most common tumor types (gliomas, meningiomas, cranial nerve tumors and brain metastases). The surgical management of complex skull base tumors, pituitary tumors, as well as neuro-endoscopic surgery and pediatric brain tumors are discussed in other papers of this special issue.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"13-25"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Neurosurgical treatment of tumors of the pineal region - literature review and overview of cases at OMIII]. [松果体区肿瘤的神经外科治疗--文献综述和OMIII病例概述]。
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2023-11-23
Tamás Mezei, János Báskay, Péter Pollner, Viktória Kovács, Balázs Markia, Gábor Nagy, András Bajcsay, László Sipos
{"title":"[Neurosurgical treatment of tumors of the pineal region - literature review and overview of cases at OMIII].","authors":"Tamás Mezei, János Báskay, Péter Pollner, Viktória Kovács, Balázs Markia, Gábor Nagy, András Bajcsay, László Sipos","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pineal region tumors account for less than 1% of adult supratentorial tumors. Their treatment requires a multimodality approach. Previously, the treatment of choice was direct surgery, which is associated with high surgical risk. Advances in minimally invasive techniques and onco-radiotherapy offer a safe and multimodal personalized therapy. The aim of our study was to describe the practice of our Institute based on combined endoscopic and radiotherapy techniques. We performed a retrospective clinical study. We processed data from 23 adult patients who underwent endoscopic third ventricle fenestration and pineal tumor biopsy between 2014 and 2023. Descriptive statistics, t-test, Fisher's exact test and Kaplan-Meier analysis were performed. Clinical improvement with endoscopic intervention was achieved in 78.3% of cases. Significant increase in preoperative performance status was observed in the postoperative period (p=2.755e-5), and radiotherapy resulted in regression or stable disease. Our results suggest a safe treatment with good clinical outcome and an excellent alternative to direct surgery.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"27-35"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Local treatment of ipsilateral breast cancer recurrences: comparison of alternative therapeutic options]. [同侧乳腺癌复发的局部治疗：替代疗法的比较]。
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2024-01-30
Viktor Smanykó
{"title":"[Local treatment of ipsilateral breast cancer recurrences: comparison of alternative therapeutic options].","authors":"Viktor Smanykó","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We compared the clinical outcomes of second breast conserving therapy (2ndBCT) versus salvage mastectomy (sMT) for the treatment of ipsilateral breast tumour recurrences (IBTR). 195 patients who presented with an IBTR after previous breast conserving treatment were salvaged either with re-excision and perioperative interstitial brachytherapy (n=39) or sMT (n=156). A total dose of 5×4.4Gy was delivered to the tumour bed, on 3 consecutive days. The median follow-up time was 59 and 56 months. During follow-up 4 (10.2%) and 28 (17.9%) second local recurrences occurred after 2ndBCT and sMT, respectively. There were no significant differences between treatments in 5-year oncological outcomes (local and regional recurrence-free survival, disease- and metastasis-free survival, cancer-specific and overall survival). After 2ndBCT, the rate of good to excellent cosmesis was 70%. 2ndBCT is a safe and feasible option for the management of IBTR, resulting similar 5-year oncological outcomes and better cosmetic results compared to sMT.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"86-88"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Stereotactic radiosurgery of brain tumors]. [脑肿瘤的立体定向放射外科]。
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2023-11-02
Imre Fedorcsák, András Bajcsay, Levente Jánváry
{"title":"[Stereotactic radiosurgery of brain tumors].","authors":"Imre Fedorcsák, András Bajcsay, Levente Jánváry","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Stereotactic radiosurgery is today a well-established treatment modality for various intracranial pathologies. The principle of high dose focused intracranial radiation guided by stereotactic technique (\"Gamma Knife\") was introduced by the Swedish neurosurgeon Prof. Lars Leksell in 1968. After the advent of CT and later MR imaging, stereotactic radiosurgery evolved rapidly regarding indications, and new technical solutions made it possible for linear accelerator systems to perform radiosurgery. A huge number of patients are treated yearly worldwide with this technology. In this article we overview the major indications, advantages and possible complications of stereotactic radiosurgery.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"53-59"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[External radiation therapy of primary central nervous system tumors - current trends and practice]. [原发性中枢神经系统肿瘤的体外放射治疗--当前趋势与实践]。
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2023-10-22
Árpád Kovács
{"title":"[External radiation therapy of primary central nervous system tumors - current trends and practice].","authors":"Árpád Kovács","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The family of primary central nervous system (CNS) tumors is a highly heterogeneous group of diseases. In the complex care of CNS tumors, in addition to surgical and systemic treatments, modern external beam radiation therapy (EBRT) plays a prominent role. This summary article provides an overview of the current indications related to EBRT, diagnostic procedures, contouring, planning, and radiation therapy techniques and applications that can be used in daily routine for adults' most common primary CNS tumors.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"37-50"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Intra- and perioperative imaging options in neurosurgery]. [神经外科术中和围术期成像方案]。
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2024-01-12
Loránd Erőss, László Halász, Gabriella Miklós
{"title":"[Intra- and perioperative imaging options in neurosurgery].","authors":"Loránd Erőss, László Halász, Gabriella Miklós","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The treatment of central nervous system tumors is still a major challenge for the oncological and neurosurgical teams. Due to the heterogeneous histological and topological characteristics of these neoplasms, every case requires individual evaluation. In addition to histology and stage, survival is largely determined by the extent of resection, which can be severely limited by the proximity of eloquent brain regions. A key component of current modern neuro-oncological care is the planning and execution of surgical intervention to ensure the longest possible progression-free survival with adequate quality of life. The simultaneous development of several pre- and intra-operative imaging modalities is making optimal therapy more and more accessible and safe. Structural, diffusion and functional MRI offers the possibility to visualize the tumor and the surrounding areas both before and during surgery. For the surgeon, the optimal intra-operative environment, orientation and visual acuity are provided by increasingly sophisticated microscopes, navigation devices, intra-operative imaging equipment, endo- and exoscopes.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"5-12"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The importance and areas of modern supportive and early integrated palliative care in the treatment of brain tumor patients]. [现代支持性和早期综合姑息治疗在脑肿瘤患者治疗中的重要性和领域]。
Magyar onkologia Pub Date : 2024-03-14 Epub Date: 2023-10-22
Orsolya Horváth, Péter Kovács
{"title":"[The importance and areas of modern supportive and early integrated palliative care in the treatment of brain tumor patients].","authors":"Orsolya Horváth, Péter Kovács","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>During the care of brain tumor patients, supportive care and palliation are carried out in an individualized manner, accompanied by adequate communication, in a multidisciplinary professional environment. In the case of brain tumor patients, the burden of symptoms resulting from the progression of the disease and the complications of treatments occur in a particularly high proportion. The supportive care of patients in a modern approach covers the targeted treatment of physical and psychosocial problems and also includes integrated palliation. Palliative care is a form of care that can be used in addition to curative therapies, and it is advisable and necessary to introduce it as early as possible among brain tumor patients due to the significant deterioration of the quality of life. Dealing with seriously ill patients on a daily basis is also an emotional burden for the professional staff, and carries the risk of burnout. The support of the staff and family members, as well as the issues of adequate communication, are also part of the scope of the supportive care approach.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 1","pages":"77-85"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Surgical treatment of paediatric brain tumours]. [小儿脑肿瘤的外科治疗]。
Magyar onkologia Pub Date : 2023-12-18 Epub Date: 2023-11-23
Balázs Markia, Renáta Kiss-Miki, Gabriella Déri
{"title":"[Surgical treatment of paediatric brain tumours].","authors":"Balázs Markia, Renáta Kiss-Miki, Gabriella Déri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Central nervous system (CNS) tumours are the second most common neoplasm types in children. In most cases the aetiology is unknown, but some genetic syndromes can be related to CNS tumours. The symptoms are not specified, that is why in case of younger ages the tumour can reach extreme sizes. In case of infants the surgical technique is determined by the amount of circulating blood. Precise haemostasis is of utmost importance. In the last years, because of the development of imaging, surgical and anaesthetic techniques, the overall survival rate increased among paediatric brain cancer patients, and with this, the quality of life as well has improved significantly. Between 1975 and 2010 there was a 50% improvement in 5-year survival.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"67 4","pages":"333-339"},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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