{"title":"[The path leading to robotic surgery].","authors":"Attila Szijártó, Klára Lévay, Damján Pekli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Robotic surgery, as a type of minimally invasive surgery, is applied in the medical care, and offers numerous benefits for patients. In this article, the development and changes in robotics, and the aim of robot manufacturing will be reviewed. Furthermore, by summarizing the history of the surgical field, we are going to describe the main paradigm shifts, which show the human acceptance and usage of novel ideas in Europe and in the USA. As a summary, the complex structure, place in surgery and the advantages of the surgical robots and some state-of-the-art research projects will be described, to let us forecast the surgical field of the future.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 3","pages":"201-205"},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Szilvia Gazdag-Hegyesi, Ádám Gáldi, Tamás Pócza, Tibor Major, Zoltán Takácsi Nagy, Csilla Pesznyák
{"title":"[Photon field junction for external beam radiotherapy of breast cancer involving axillary and supraclavicular lymph nodes].","authors":"Szilvia Gazdag-Hegyesi, Ádám Gáldi, Tamás Pócza, Tibor Major, Zoltán Takácsi Nagy, Csilla Pesznyák","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We present evaluation of junction of coplanar external beam photon fields and its portal dosimetric analysis for breast cancer with positive lymph nodes. In our work, we compared twelve patients affected by breast cancer with axillary and supraclavicular lymph nodes, using conformal external beam plans from a dosimetric point of view. 3-3 plans were prepared per patient. Three methods were used for the conformal technique to investigate the potential of lymph nodes treatment field's collimations. During the evaluation of the portal dosimetry images, it was concluded that the junction plane at isocenter appeared as a discrete coldline, when fitted the regional field with or without collimation manually and by the software. However, the coverage of the isocenter plane is strongly influenced by the linear accelerator and the fitted field edges. Based on our results, in order to avoid uncertainties arising from field junctions and the overdosed areas of the target volume, it is more appropriate to choose another advanced irradiation technique such as intensity-modulated radiation therapy.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 2","pages":"163-168"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Szilárd Veres, Fruzsina Martinovszky, Márk Di Giovanni, Bettina Budai, Beatrix Beszedics, István Szabó, Henriett Butz, Attila Patócs, Bálint Török, Mátyás Ujlaki, László Dávid Tárnoki, Domonkos Ádám Tárnoki
{"title":"[Examination of breast density in breast cancer discordant twin pairs].","authors":"Szilárd Veres, Fruzsina Martinovszky, Márk Di Giovanni, Bettina Budai, Beatrix Beszedics, István Szabó, Henriett Butz, Attila Patócs, Bálint Török, Mátyás Ujlaki, László Dávid Tárnoki, Domonkos Ádám Tárnoki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Previous twin studies show that genetic factors are responsible for 63% of the variability in breast density. We analyzed the mammographic images of 9 discordant twin pairs for breast cancer from the population-based Hungarian Twin Registry. We measured breast density using 3D Slicer software. Genetic variants predisposing to breast cancer were also examined. One of the examined twin pairs had a BRCA2 mutation in both members. There was no significant difference between the mean values of breast density in the tumor and non-tumor groups (p=0.323). In terms of parity and the presence of menopause, we found mostly no significant difference between the members of the twin pair. In our cohort of identical twins discordant for breast cancer, the average breast density showed no significant difference, which can be explained by the common genetic basis of breast cancer and breast density.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 2","pages":"171-176"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zsombor Melegh, Erzsébet Csernák, Andrea Kohánka, Mónika Rubovszkyné Gallai, Eszter Bencze, Melinda Szőke, Luca Pap, Andrea Simon, Zsófia Küronya, Krisztina Biró, Lajos Géczi, Erika Tóth
{"title":"[Mutation frequency of homologous recombination repair genes in prostate adenocarcinomas].","authors":"Zsombor Melegh, Erzsébet Csernák, Andrea Kohánka, Mónika Rubovszkyné Gallai, Eszter Bencze, Melinda Szőke, Luca Pap, Andrea Simon, Zsófia Küronya, Krisztina Biró, Lajos Géczi, Erika Tóth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The best predictive marker for the expected efficacy of PARP inhibitor therapy is mutations in BRCA1/2 or other homologous recombination repair genes. These tests are part of routine molecular pathology diagnostics. Among 281 patients with prostate adenocarcinoma, somatic pathogenic mutations in one of these genes were identified in 21.4% of patients. In 28.5% of the patients, the test was unsuccessful; the main limitation of successful testing was the age of the paraffin blocks and low DNA concentration. In the case of BRCA1/2 testing, the success rate was significantly reduced for samples older than 5 years, while in tests involving a broader set of homologous recombination repair genes, the success rate was significantly reduced for samples older than 2 years. Therefore, it is very important to test high-risk prostate cancers at the time of primary diagnosis, and probably also liquid biopsy testing of circulating tumor DNA will play an important role in safe diagnosis in the near future.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 2","pages":"137-141"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tibor Major, Júlia Vizkeleti, Péter Ágoston, Zoltán Takácsi-Nagy, Csaba Polgár
{"title":"[Application of new imaging modalities for brachytherapy of cancer patients].","authors":"Tibor Major, Júlia Vizkeleti, Péter Ágoston, Zoltán Takácsi-Nagy, Csaba Polgár","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the Radiotherapy Centre of the National Institute of Oncology, Budapest, a 0.55 T MR scanner (MAGNETOM Free. Max) and a ring-like X-ray machine (ImagingRing) have been in operation since 2022. The MR scanner has a tunnel diameter of 80 cm, the X-ray machine has a ring diameter of 121 cm. The latter can also be used for cone-beam CT (CBCT) imaging. The MR scanner is mainly used for planning gynaecological brachytherapy (BT) treatments. Image distortions in MR imaging were investigated with a special grid phantom. After head and neck and breast implant, image quality of ImagingRing CBCT and planning CT was compared. The position of the radiation source was verified by radiographs taken during treatment. Despite the lower field strength, the image quality of the MR scanner was found to be adequate for treatment planning of gynaecological BT. Image distortions were found to be clinically negligible. On CBCT images obtained with ImagingRing, catheters could always be well identified, and anatomical organs were adequately visualized for head and neck treatments, but not for breast implants. The MR scanner is suitable for treatment planning for gynaecological BT due to its good image quality and low image distortion. The image quality of the ImagingRing is suitable for treatment planning for small body sizes, but not for larger sizes. The device can be used to in vivo check of the radiation source position during treatment.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 2","pages":"155-162"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
András Wéber, István Szatmári, Mária Dobozi, Zsuzsanna Kéki, Lászlóné Hilbert, Gabriella Géczy Branyiczkiné, Péter Nagy, Csaba Polgár, István Kenessey
{"title":"[County differences in incidence and mortality of malignant neoplasms in Hungary between 2005 and 2019].","authors":"András Wéber, István Szatmári, Mária Dobozi, Zsuzsanna Kéki, Lászlóné Hilbert, Gabriella Géczy Branyiczkiné, Péter Nagy, Csaba Polgár, István Kenessey","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The objective of our study was to map county differences in incidence and mortality by cancers and examine their changes over time. Based on the database of National Cancer Registry and Central Statistical Office, age-standardized incidence and mortality rates per 100,000 person-years were calculated for each county for 15 cancer types and 3 time periods. East-West divide was apparent in incidence and mortality of lung cancer, with larger weight in East (Borsod-Abaúj-Zemplén, Heves, Jász-Nagykun-Szolnok, Békés counties). Concentration of lip and oral cavity malignancies was identified in the northeastern periphery (Borsod-Abaúj-Zemplén, Szabolcs-Szatmár-Bereg counties). Breast cancer incidence was the highest in Budapest. As a conclusion, changes in cancer incidence and mortality over time were similar to developed countries; however, values were higher. Differences in spatial distribution follow territorial pattern of social deprivation, which correspond to higher prevalence of health risk factors. Our study contributes to planning of public health programs by pinpointing regional inequalities in different cancer types.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 2","pages":"95-112"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Petra Parrag, Mária Dobozi, István Szatmári, András Wéber, Péter Nagy, Csaba Polgár, István Kenessey
{"title":"[The pitfalls of lung cancer coding practices based on the evaluation of the National Cancer Registry].","authors":"Petra Parrag, Mária Dobozi, István Szatmári, András Wéber, Péter Nagy, Csaba Polgár, István Kenessey","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The quality of input data determines the reliability of epidemiological assessments. Thus, the verification of cases reported to the National Cancer Registry is required. The objective of our study was evaluating the reliability of cases diagnosed by lung cancer, exploring the patterns of erroneous reports. The validation of the 11,750 lung cancer cases reported to the Cancer Registry in 2018 was performed with the involvement of the recording hospitals, analyzing the characteristics of reports by gender, age and attributes of the reporting institutions. 81.3 percent of the reported cases was confirmed, in 40.4 percent of the false reports, malignancy was not present at all. Among the erroneous cases women and the elderly age group were overrepresented. The highest deleted rate occurred in Borsod- Abaúj-Zemplén county. As a conclusion, there is a strong need for the improvement of the efficiency in encoding lung cancer. The most common errors: confusion of malignant-benign, cancerous-non-cancerous and primary-metastatic lesions. The reliability is not affected by the role of individual institutions in the hierarchy of health care. The availability of reliable epidemiological data is crucial in the fight against cancer, which requires broad professional cooperation.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 2","pages":"115-123"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bernadett Lévay, Ilona Péter, Georgina Fröhlich, Pál Koltai, Gabriella Ivády, Balázs Járay, Péter Pogány, János Szőke, Erika Tóth, Nóra Udvarhelyi, Ferenc Oberna
{"title":"[Incidentally discovered ectopic tissue in the central neck region (level VI) of the neck - A case series, retrospective analysis and literature review].","authors":"Bernadett Lévay, Ilona Péter, Georgina Fröhlich, Pál Koltai, Gabriella Ivády, Balázs Járay, Péter Pogány, János Szőke, Erika Tóth, Nóra Udvarhelyi, Ferenc Oberna","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The thymus derives from the third branchial pouch, which migrates to the mediastinum through the central region of the neck. During the migration, particles split off and develop separately. The prevalence of ectopic thymus is 20-40%. The purpose of this retrospective case series study was to investigate the prevalence of embryological tissue remnants in the central region, in patients treated for thyroid lesions. Between January 1 2018 and September 1 2020, 84 patients who underwent central neck dissection were selected. Clinicopathological data as age, gender, histopathological result and TNM stage were analyzed. Ectopic tissue in the central neck region was discovered in 28 cases. The prevalence of ectopic lesions showed increase in Stage I thyroid carcinomas. There was no significant correlation with patients' age, gender, or with the stage. We emphasize the clinicopathological role of ectopic tissues, which can occur in the central region of the neck.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 2","pages":"177-190"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zsombor Melegh, Kamilla Németh, Eszter Székely, Katalin Borka, Rita Bori, Dávid Semjén, Boglárka Pósfai, Farkas Sükösd, Ferenc Salamon, László Bidiga, Levente Kuthi
{"title":"[The pathological processing of prostate biopsy and resection specimens].","authors":"Zsombor Melegh, Kamilla Németh, Eszter Székely, Katalin Borka, Rita Bori, Dávid Semjén, Boglárka Pósfai, Farkas Sükösd, Ferenc Salamon, László Bidiga, Levente Kuthi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Prostate cancer stands as the most prevalent malignant tumor among men; with its incidence increasing with advancing age. The spectrum of patient care options for this disease is broad, encompassing approaches such as \"active surveillance,\" definitive radiation therapy, robot-assisted surgery, among others. These diverse modalities afford opportunities for cure or successful management in the majority of cases. It is paramount to underscore that optimal treatment hinges upon a multidisciplinary framework, wherein the coordinated efforts of allied healthcare professionals yield the highest standard of patient care. Hence, it is imperative for pathologists to keep abreast of contemporary processing and specimen collection protocols, as well as the potential necessity of supplementary investigations and their clinical significance. The latest Hungarian guideline on prostate cancer care features a dedicated chapter delineating the pivotal role and responsibilities of pathologists. Through this discourse, we aim to consolidate and disseminate pertinent insights, thereby fostering the continuing enhancement of pathologists' knowledge and elucidating the intricacies of histological processing to our clinical counterparts.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 2","pages":"143-153"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Svajda, Mihály Cserepes, Barbara Hegyi, Theodora Niczky, József Tóvári
{"title":"[Immunomodulation in the tumor microenvironment: Therapeutic potential of combined inhibition of tumor hypoxia and PD-1/ PD-L1].","authors":"Laura Svajda, Mihály Cserepes, Barbara Hegyi, Theodora Niczky, József Tóvári","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tumor hypoxia plays an important role in controlling tumor progression through signaling pathways related to the transcription factor HIF-1. In addition to enhancing migration, promoting angiogenesis and regulating metabolism, the hypoxic environment also affects immune function. In this hypoxic microenvironment an immunosuppressive milieu is established, where HIF-1 upregulates the expression of PD-L1, a key regulator of the immune response. We have found that elevated expression of PD-L1 correlates with increased HIF-1 levels in cancer cell lines and clinical samples. Thus, the co-inhibition of HIF-1 and PD-1/PD-L1 offers promising therapeutic possibilities. In this review we have examined the limitations of HIF-1 and PD-1/PD-L1 inhibition as monotherapy, explored their combined benefits and evaluated the feasibility of targeting PD-L1 with HIF-1 inhibitors.</p>","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"68 2","pages":"126-135"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}