Magyar onkologia最新文献

[The evolution of surgical management for early-stage breast cancer at a university breast centre in Hungary]. [匈牙利一所大学乳腺中心早期乳腺癌手术治疗的进展]。

Magyar onkologia Pub Date : 2026-09-11 Epub Date: 2026-07-22

György Lázár, Zoltán Horváth, Tibor Takács, Zsolt Simonka, Attila Paszt

引用次数: 0

[Lymphatic mapping and sentinel node biopsy in penile cancer: from the cradle of the technique to current perspectives]. [阴茎癌的淋巴定位和前哨淋巴结活检：从技术的摇篮到目前的观点]。

Magyar onkologia Pub Date : 2026-09-11 Epub Date: 2026-07-28

Sergi Vidal-Sicart, Renato A Valdés Olmos

{"title":"[Lymphatic mapping and sentinel node biopsy in penile cancer: from the cradle of the technique to current perspectives].","authors":"Sergi Vidal-Sicart, Renato A Valdés Olmos","doi":"","DOIUrl":"","url":null,"abstract":"Lymph node status is the most important prognostic factor in penile squamous cell carcinoma, yet radical inguinal lymph node dissection (ILND) carries substantial morbidity. Sentinel lymph node biopsy was pioneered in penile cancer and subsequently evolved to a concept of dynamic sentinel node biopsy (DSNB), a multidisciplinary staging procedure integrating radiotracer injection, lymphoscintigraphy, intraoperative localization, and pathological ultrastaging with high dianostic efficiency. Over time, gradual improvements including preoperative ultrasonography with fine-needle aspiration cytology (FNAC), SPECT/CT, more refined pathological assessment, and hybrid tracers have reduced false-negative rates improving reliability in experienced centers. Current EAU-ASCO guidance supports DSNB as the preferred surgical strategy to stage patients with intermediate- and high-risk clinically node-negative (cN0) penile cancer. This review summarizes the historical development of penile sentinel node surgery, the current DSNB evidence, the role of modern imaging and hybrid tracers as well as persistent limitations of the approach such as non-visualization, false-negative rate, and other important areas in which further standardization and innovation are needed.","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"70 3","pages":"191-200"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Sentinel node biopsy and lymphatic mapping from a nuclear medicine perspective: principles, methods and experiences in Szeged]. [核医学视角下前哨淋巴结活检和淋巴定位：塞格德的原则、方法和经验]。

Magyar onkologia Pub Date : 2026-09-11 Epub Date: 2026-07-15

Zsuzsanna Besenyi, Máté Lázár, László Pávics, Gábor Sipka, István Farkas

{"title":"[Sentinel node biopsy and lymphatic mapping from a nuclear medicine perspective: principles, methods and experiences in Szeged].","authors":"Zsuzsanna Besenyi, Máté Lázár, László Pávics, Gábor Sipka, István Farkas","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To summarise the principles, indications, radiopharmaceuticals, preoperative imaging and intraoperative detection methods of sentinel node biopsy (SNB) and lymphatic mapping, and to present the experience of the Department of Nuclear Medicine and Theranostics, University of Szeged.Methods: This review is based on current EANM/SNMMI guidelines, the relevant international literature and institutional data.Results: SNB has become an accepted component of oncological care in melanoma, breast cancer, gynaecological, urological and head-and-neck malignancies. Lymphoscintigraphy combined with SPECT/CT is mandatory in numerous indications. At the University of Szeged, preoperative isotope-guided sentinel node localisation combined with intraoperative gamma probe-assisted sentinel node biopsy has been performed in nearly 6,000 patients since 1999.Conclusions: SNB is a multidisciplinary procedure requiring nuclear medicine, surgery and pathology. Hybrid tracers and multimodal intraoperative detection further improve detection rates and reduce false-negative results.","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"70 3","pages":"277-285"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Changes in the surgery and histopathology of sentinel lymph nodes for breast cancer at the Bács-Kiskun County Teaching Hospital (Kecskemét) - Experiences of nearly 30 years and 4000 operations.] [Bács-Kiskun县教学医院乳腺癌前哨淋巴结手术和组织病理学的变化——近30年4000例手术的经验]

Magyar onkologia Pub Date : 2026-09-11 Epub Date: 2026-05-16

Gábor Cserni, Róbert Maráz, László Venczel, Gábor Boross, Péter Molnár, Mária Sinkó, Nóra Szeleczki, Éva Ambrózay, Orsolya Serfőző, Gabriella Gábor, Dóra Tigyi, Judit Kocsis, Zsolt Horváth, Rita Bori

{"title":"[Changes in the surgery and histopathology of sentinel lymph nodes for breast cancer at the Bács-Kiskun County Teaching Hospital (Kecskemét) - Experiences of nearly 30 years and 4000 operations.]","authors":"Gábor Cserni, Róbert Maráz, László Venczel, Gábor Boross, Péter Molnár, Mária Sinkó, Nóra Szeleczki, Éva Ambrózay, Orsolya Serfőző, Gabriella Gábor, Dóra Tigyi, Judit Kocsis, Zsolt Horváth, Rita Bori","doi":"","DOIUrl":"","url":null,"abstract":"We introduced sentinel lymph node biopsy for breast cancer in 1997. Axillary lymphadenectomy was performed routinely at the beginning, then limited to sentinel node positive cases, macrometastatic cases and ultimately, to >2 nodes or post-neoadjuvant metastatic cases. From vital blue dye only labelling, (combined) radiocolloid, fluorescent and radar localisation labelling all received their place in the staging procedure. Histopathology also changed: 1. from extensive analysis identifying as many small metastases as possible to identifying/excluding macrometastatic involvement, 2. from routine to restricted use of immunohistochemistry, 3. from routine imprint cytology identifying as many macrometastases as possible to its selective use. The review describes these changes and also points to the rationale behind them. Along practical considerations, surgical and pathological techniques may undergo further changes in the future.","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"70 3","pages":"227-237"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Data and clinical experience of patients undergoing sentinel lymph node biopsy between 2020 and 2025 at the National Institute of Oncology, Hungary]. [2020年至2025年在匈牙利国家肿瘤研究所接受前哨淋巴结活检患者的数据和临床经验]。

Magyar onkologia Pub Date : 2026-09-11 Epub Date: 2026-07-24

Mihály Kispál, Tamara Érseki, Anna Pataki, Emese Diós, István Kenessey, Katalin Bőcs, Eszter Papp, Gitta Pánczél, Luca Ambrus, Kata Czirbesz, Tamás Mersich, Tímea Balatoni

{"title":"[Data and clinical experience of patients undergoing sentinel lymph node biopsy between 2020 and 2025 at the National Institute of Oncology, Hungary].","authors":"Mihály Kispál, Tamara Érseki, Anna Pataki, Emese Diós, István Kenessey, Katalin Bőcs, Eszter Papp, Gitta Pánczél, Luca Ambrus, Kata Czirbesz, Tamás Mersich, Tímea Balatoni","doi":"","DOIUrl":"","url":null,"abstract":"Aim: The authors present a retrospective analysis of sentinel lymph node biopsy (SLNB) data from patients with primary cutaneous melanoma treated at the National Institute of Oncology.Methods: A total of 806 patients who underwent SLNB between 2020 and 2025 were included. Primary tumor characteristics were evaluated in relation to progression-free survival (PFS) and overall survival (OS) and, in SLNB-positive patients, the impact of adjuvant therapies was assessed.Results: Breslow thickness showed a significant negative association with both PFS and OS. Significant differences in survival outcomes were also observed between SLNB-positive and SLNB-negative patients. Among SLNB-positive patients, no significant difference in PFS was detected between those receiving adjuvant therapy and those who did not, nor among different adjuvant modalities. However, adjuvant therapy was associated with a significant improvement in OS.Conclusions: Although our findings differ from results reported in clinical trials, longer follow-up is required for proper conclusions.","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"70 3","pages":"203-211"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Anthracycline use in breast cancer based on our current knowledge]. [基于我们目前的知识，蒽环类药物在乳腺癌中的应用]。

Magyar onkologia Pub Date : 2026-09-11 Epub Date: 2026-03-22

Gábor Rubovszky, Alíz Nikolényi, Katalin Boér

引用次数: 0

Sentinel Node Navigation Surgery for Upper Gastrointestinal Malignancies: Current Status, Clinical Significance, and Future Perspectives. 前哨淋巴结导航手术治疗上消化道恶性肿瘤：现状、临床意义和未来展望。

Magyar onkologia Pub Date : 2026-09-11 Epub Date: 2026-07-27

Yoshihiro Hiramatsu, Eisuke Booka, Hirotoshi Kikuchi, Hiroya Takeuchi

{"title":"Sentinel Node Navigation Surgery for Upper Gastrointestinal Malignancies: Current Status, Clinical Significance, and Future Perspectives.","authors":"Yoshihiro Hiramatsu, Eisuke Booka, Hirotoshi Kikuchi, Hiroya Takeuchi","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To review the current evidence, technical considerations, clinical significance, and future perspectives of sentinel node navigation surgery (SNNS) for upper gastrointestinal malignancies, focusing on gastric and esophageal cancers.Methods: This narrative review summarizes evidence on sentinel node (SN) mapping, biopsy, and SNNS in gastric and esophageal cancers, focusing on feasibility, diagnostic accuracy, indications, and limitations.Results: In early gastric cancer, accumulating evidence supports the feasibility and diagnostic accuracy of SN mapping and biopsy, supporting SNNS as a promising platform for function-preserving gastric surgery. In esophageal cancer, clinical application remains challenging because of multidirectional lymphatic drainage and aggressive tumor biology; however, radioisotope-guided SN mapping has shown encouraging results in selected patients with early-stage disease.Conclusions: SNNS may reduce surgical invasiveness while preserving oncologic safety and postoperative function in selected patients with upper gastrointestinal malignancies. However, further validation and standardization are required before broader clinical implementation.","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"70 3","pages":"259-268"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Oncologist's perspective from sentinel node biopsy of melanoma - three decades of experience]. [肿瘤学家从黑色素瘤前哨淋巴结活检的观点-三十年的经验]。

Magyar onkologia Pub Date : 2026-09-11 Epub Date: 2026-07-15

Judit Oláh, Gabriella Erika Kis, Noémi Mezőlaki, Ádám Kocsis, György Péter Lázár, Irma Korom, Erika Varga, Balázs István Németh, Henriette Ócsai, Eszter Baltás, Rolland Gyulai

引用次数: 0

Sentinel: a brief history of nodal surgery in breast cancer. 前哨：乳腺癌淋巴结手术的简史。

Magyar onkologia Pub Date : 2026-09-11 Epub Date: 2026-04-26

Anselm Tamminen, Tuomo Meretoja

引用次数: 0

[The role of sentinel lymph node biopsy in the management of gynecologic cancers: current evidence and institutional experience]. [前哨淋巴结活检在妇科癌症治疗中的作用：现有证据和机构经验]。

Magyar onkologia Pub Date : 2026-09-11 Epub Date: 2026-08-08

Kiarash Bahrehmand, Tamás Fábián, Judit Kerepesi, Zoltán Novák

{"title":"[The role of sentinel lymph node biopsy in the management of gynecologic cancers: current evidence and institutional experience].","authors":"Kiarash Bahrehmand, Tamás Fábián, Judit Kerepesi, Zoltán Novák","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To critically review the current role of sentinel lymph node (SLN) biopsy in endometrial, cervical, vulvar and ovarian cancer, and to compare international evidence with a single institution's surgical experience.Methods: Targeted appraisal of randomized trials, prospective cohorts, systematic reviews and meta-analyses, complemented by retrospective, descriptive institutional data on 141 patients (indocyanine green mapping; robotic and laparoscopic platforms).Results: In endometrial cancer, available prospective and meta-analytic data indicate that SLN biopsy is not associated with worse oncologic outcomes than systematic lymphadenectomy. In early cervical cancer, a recent randomized trial showed that SLN biopsy alone is non-inferior to lymphadenectomy while reducing surgical morbidity. In appropriately selected vulvar cancer, groin de-escalation provides the clearest morbidity benefit. In ovarian cancer, the technique remains investigational. The institutional bilateral detection rate (78.7%) was consistent with contemporary international data.Conclusions: SLN biopsy is a key surgical de-escalation strategy in gynecologic oncology which, with adequate pathological ultrastaging, also improves oncologic staging accuracy; its success depends on patient selection and centre experience.","PeriodicalId":94127,"journal":{"name":"Magyar onkologia","volume":"70 3","pages":"269-276"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0