Laboratory medicine最新文献_第8页

Association between triglyceride to HDL cholesterol ratio and a risk of diabetes mellitus: a systematic review and meta-analysis. 甘油三酯与高密度脂蛋白胆固醇比率与糖尿病风险之间的关系：系统回顾和荟萃分析。

Laboratory medicine Pub Date : 2025-01-06 DOI: 10.1093/labmed/lmae052

Hongjing Zhong, Laiming Luo, Xiaomei Wang, Yao Xiao

{"title":"Association between triglyceride to HDL cholesterol ratio and a risk of diabetes mellitus: a systematic review and meta-analysis.","authors":"Hongjing Zhong, Laiming Luo, Xiaomei Wang, Yao Xiao","doi":"10.1093/labmed/lmae052","DOIUrl":"10.1093/labmed/lmae052","url":null,"abstract":"Objective: The aim of this study was to investigate the link between the triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C) and the occurrence of type 2 diabetes mellitus (T2DM).Methods: PubMed, Embase, and Scopus databases were searched for cohort and case-control studies that reported on the link between TG/HDL-C and a risk of T2DM, with no restrictions on criteria used for the definition and categorization of low and high TG/HDL-C ratios.Results: A total of 20 studies were included. There was considerable variability in terms of categorization of low or normal and higher TG/HDL-C ratio among the studies. Patients with high TG/HDL-C ratio had markedly higher risk of developing T2DM compared with patients with low or normal TG/HDL-C. Each unit increase in the ratio correlated with the increased risk of diabetes. Subgroup analysis based on sex showed an increased risk of T2DM in males and females with a high ratio compared with the group with a low/normal ratio.Conclusion: Higher TG/HDL-C ratio correlates with increased risk of T2DM. Despite limitations, the study demonstrates a possible value of using TG/HDL-C ratio as a biomarker for diabetes risk.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jerk (d(acceleration)/dt) as an operative variable in pneumatic tube transport (PTT). 作为气动管道输送（PTT）操作变量的抖动（d（加速度）/dt）。

Laboratory medicine Pub Date : 2025-01-06 DOI: 10.1093/labmed/lmae055

Christopher J Mattiello, Douglas F Stickle

{"title":"Jerk (d(acceleration)/dt) as an operative variable in pneumatic tube transport (PTT).","authors":"Christopher J Mattiello, Douglas F Stickle","doi":"10.1093/labmed/lmae055","DOIUrl":"10.1093/labmed/lmae055","url":null,"abstract":"Background: Jerk, the rate of change of acceleration (d(acceleration)/dt), is a known operative variable in public transportation safety, but this term has never appeared in the literature regarding pneumatic tube transport (PTT) and specimen integrity. We investigated profiles of acceleration and jerk for 2 PTT routes within our hospital system.Methods: Acceleration data were collected for PTT for 2 routes (A, B) using an accelerometer. Acceleration vectors (a) were analyzed in terms of distributions of jerk (da/dt), and distributions of θ, the angle between successive acceleration vectors.Results: Routes A and B had transit times of approximately 300 s. Acceleration vectors (a) ranged in magnitude from 0 to 8 g. For B, a > 1.2 g comprised 29.0% of results, compared to 13.5% of results for A (ratio = 2.1). Jerk ranged from 0 to 94 g/s. For B, jerk > 0.5 g/s comprised 71.9% of results, compared to 32.5% of results for A (ratio = 2.2). θ ranged from 0 to 180 degrees. For B, θ > 5 degrees comprised 59.3% of results, compared to 26.6% of results for A (ratio = 2.2).Conclusion: Differences in distribution in acceleration, jerk, and θ ran in parallel as variables for comparison between 2 PTT routes. Jerk and θ are likely to be operative variables in effects of PTT.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prothrombin deficiency with recurrent subretinal hemorrhage. 凝血酶原缺乏症伴复发性视网膜下出血。

Laboratory medicine Pub Date : 2025-01-06 DOI: 10.1093/labmed/lmae057

Eros Qama, Kritika Krishnamurthy, Joseph J Mulvey, Kenneth G Liu, David L Fernandes, Yanan Fang

{"title":"Prothrombin deficiency with recurrent subretinal hemorrhage.","authors":"Eros Qama, Kritika Krishnamurthy, Joseph J Mulvey, Kenneth G Liu, David L Fernandes, Yanan Fang","doi":"10.1093/labmed/lmae057","DOIUrl":"10.1093/labmed/lmae057","url":null,"abstract":"Ocular hemorrhage has been recorded in congenital factor deficiencies like hemophilia A, but it has never been documented in prothrombin deficiency. Here, we describe an unusual case of sudden vision loss in the right eye caused by subretinal hemorrhage following a coughing episode in a 67-year-old woman. Notably, the patient underwent left eye enucleation 12 years previously under similar circumstances due to subretinal hemorrhage. During the interview, it was discovered that the patient had a history of prothrombin deficiency, which was subsequently confirmed through laboratory testing. Aside from recurrent ocular bleeding and 1 instance of bleeding following dental extraction in childhood, there is no other history of bleeding. Subsequent molecular studies revealed a homozygous missense mutation at G1499A (Arg500Gln), a variant previously identified as R457Q. Although the likelihood of prothrombin deficiency initiating subretinal hemorrhage is low, it is likely to worsen retinal hemorrhage and contribute to difficulty in controlling bleeding. A comprehensive coagulation workup is essential in patients with ocular hemorrhage. Determining factor II activity should be included in individuals exhibiting variably prolonged prothrombin time and activated partial thromboplastin time with correction in mixing studies. Additional investigations, such as genetic sequencing and family studies, are advised for those with isolated low prothrombin levels.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":"89-92"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extra cut-off value of aldosterone-to-renin ratio for screening primary aldosteronism in hypertensive patients with diabetes mellitus. 用于筛查糖尿病高血压患者原发性醛固酮增多症的醛固酮-肾素比值的额外临界值。

Laboratory medicine Pub Date : 2025-01-06 DOI: 10.1093/labmed/lmae065

Dubo Chen, Yuzhe Li, Jiayin Wu, Wenbin Lin, Liangying Zhong, Pinning Feng, Wenjia Gan

{"title":"Extra cut-off value of aldosterone-to-renin ratio for screening primary aldosteronism in hypertensive patients with diabetes mellitus.","authors":"Dubo Chen, Yuzhe Li, Jiayin Wu, Wenbin Lin, Liangying Zhong, Pinning Feng, Wenjia Gan","doi":"10.1093/labmed/lmae065","DOIUrl":"10.1093/labmed/lmae065","url":null,"abstract":"Primary aldosteronism (PA) and diabetes mellitus (DM) may coexist. We previously found that DM and impaired glucose tolerance (IGT) may decrease the efficiency of the aldosterone-to-renin ratio (ARR) for screening PA. Thus, we wanted to determine appropriate ARR cut-off values for screening PA in patients with hypertension with DM and IGT. Data from 736 patients with hypertension were collected. They were divided into PA (77 cases), PA with DM (27 cases), PA with IGT (44 cases), hypertension without PA (353 cases), hypertension with DM (without PA, 127 cases), and hypertension with IGT (without PA, 108 cases). Receiver operating characteristic (ROC) curves were used to identify the appropriate ARR cut-off values in different conditions. Screening efficiencies of these cut-off values were evaluated across different groups. ARR cut-off values for screening PA in hypertensive patients without DM and IGT, with DM, and with IGT were 29.65, 23.15, and 26.9, respectively. All cut-off values demonstrated high sensitivity and specificity: 92.2% and 88.7%, 92.6% and 79.5%, and 88.6% and 85.2%, respectively, and areas under the ROC curves were 0.941, 0.904, and 0.909, respectively. Our results suggest that extra ARR cut-off values may be necessary for effective screening PA in hypertensive patients with DM and IGT, particularly in those with DM.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dihydropyrimidinase enzyme deficiency and congenital isolated adrenocorticotrophin deficiency: dual genetic diagnosis in a Sri Lankan boy. 二氢嘧啶酶酶缺乏症和先天性孤立肾上腺皮质激素缺乏症：一名斯里兰卡男孩的双重基因诊断。

Laboratory medicine Pub Date : 2025-01-06 DOI: 10.1093/labmed/lmae058

Shifaniya Banu Mohideen, Pitipanage Mihika Samindi Fernando, Christian Beetz, Sabine Schroder, Catarina Pereira, Senaka Gunatilleke, Pyara Rathnayake, Eresha Jasinge

{"title":"Dihydropyrimidinase enzyme deficiency and congenital isolated adrenocorticotrophin deficiency: dual genetic diagnosis in a Sri Lankan boy.","authors":"Shifaniya Banu Mohideen, Pitipanage Mihika Samindi Fernando, Christian Beetz, Sabine Schroder, Catarina Pereira, Senaka Gunatilleke, Pyara Rathnayake, Eresha Jasinge","doi":"10.1093/labmed/lmae058","DOIUrl":"10.1093/labmed/lmae058","url":null,"abstract":"We report on a male patient who was investigated for frequent apneic episodes, feeding problems, hypotonia, and left-sided middle cerebral artery infarction in the magnetic resonance imaging at 2 weeks of age. Primary diagnosis of dihydropyrimidinase (DPYS) deficiency was suspected following the analysis of urine for organic acid; DPYS deficiency was strongly suggested by the presence of dihydrouracil, thymine, and uracil. Subsequent genetic evaluation by whole exome sequencing revealed 2 separate mutations, homozygous pathogenic variant c.1010T>C p.Leu337Pro of the DPYS gene, resulting in DPYS deficiency, and homozygous pathogenic variant c.535C>T p.Arg179* of TBX19 gene, which is associated with autosomal recessive congenital isolated adrenocorticotrophic hormone deficiency. Currently, the patient is 2 years old, and he has gross motor retardation and seizure disorder. We suggest that the clinical phenotype of the proband can be a result of mixed expression of both mutations.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":"93-96"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of a prediction model for gastric cancer: a single-center prospective study. 胃癌预测模型的开发与验证：一项单中心前瞻性研究。

Laboratory medicine Pub Date : 2025-01-06 DOI: 10.1093/labmed/lmae060

Suyu Sun, Feifei Huang, Xueqin Xu, Ke Xu, Tingting Peng, Wenjing Bai, Chunwei Huang, Xingzhong Hu, Yong Pan

{"title":"Development and validation of a prediction model for gastric cancer: a single-center prospective study.","authors":"Suyu Sun, Feifei Huang, Xueqin Xu, Ke Xu, Tingting Peng, Wenjing Bai, Chunwei Huang, Xingzhong Hu, Yong Pan","doi":"10.1093/labmed/lmae060","DOIUrl":"10.1093/labmed/lmae060","url":null,"abstract":"Objective: This study aimed to develop and validate a novel nomogram for diagnosing gastric cancer (GC).Methods: In this prospective analysis, 146 patients of Wenzhou Central Hospital were recruited for a GC group and a benign lesion group and were divided into a training set and an internal validation set in a ratio of 7:3. Clinical and analytical characteristics were collected and analyzed by logistic regression analysis. The performance of the predictive model was evaluated using the receiver operating characteristic curve, calibration curve, and decision curve analysis.Results: There were 5 variables, namely albumin, carcinoembryonic antigen, carbohydrate antigen 125, creatinine, and small proline-rich protein 2A, that were identified as the final parameters for the developed model. In the training and internal validation sets, the area under the curve of the model was 0.968 and 0.979, respectively, showing good diagnostic performance.Conclusion: This study developed and validated a new nomogram based on 5 parameters. This model shows good diagnostic performance in distinguishing GC from benign lesion groups and has certain significance in clinical application.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":"31-36"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the conundrum of co-existing autoantibodies and alloantibodies in a case of Evans syndrome. 解决埃文斯综合征病例中同时存在的自身抗体和同种抗体的难题。

Laboratory medicine Pub Date : 2025-01-06 DOI: 10.1093/labmed/lmae051

Pallabi Dash, Nilasish Pani, Jayant Kumar Panda, Smita Mahapatra, Binay Bhusan Sahoo, Tusharkantee Behera

引用次数: 0

Common RBC antigens in O type Tunisian blood donors and their importance in alloimmunization. O 型突尼斯献血者中常见的红细胞抗原及其在同种免疫中的重要性。

Laboratory medicine Pub Date : 2025-01-06 DOI: 10.1093/labmed/lmae062

Mohamed Hichem Sellami, Wafa Aïssa, Hamida Ferchichi, Eya Ghazouani, Manel Châabane, Houda Kâabi, Slama Hmida

{"title":"Common RBC antigens in O type Tunisian blood donors and their importance in alloimmunization.","authors":"Mohamed Hichem Sellami, Wafa Aïssa, Hamida Ferchichi, Eya Ghazouani, Manel Châabane, Houda Kâabi, Slama Hmida","doi":"10.1093/labmed/lmae062","DOIUrl":"10.1093/labmed/lmae062","url":null,"abstract":"Background: The presence of some red blood cell (RBC) antigens may affect the preference for using type O blood in emergency situations because they may induce complex or multiple alloimmunization in special circumstances.Methods: A subgroup of 77 type O blood Tunisian donors were genotyped for 19 common blood alleles using the single specific primer-polymerase chain reaction method. The statistical analysis was done using HaploView software.Results: The study showed the dominance of the alleles RH*5, KEL*2, FY*2, and CO*1 and the absence of the homozygous state of the KEL*1 and CO*2 alleles. Furthermore, a complete linkage disequilibrium between the RH*2/RH*4 and RH*3/RH*5 loci and the FY*Null/FY*Exp and FY*A/FY*B loci was detected. Additionally, it seems that sensitization to MNS:3, FY:1, and RH:3 may constitute a potential factor for alloimmunization after transfusion with O blood type units: the probabilities of simple alloimmunizations are 24.5 per 100, 18.5 per 100, and 18 per 100, respectively. Multiple alloimmunization against RH:1;KEL:1 or RH:1;KEL:1;RH:3 phenotypes may occur, with probabilities of 7 per 1000 and 2 per 1000, respectively.Conclusion: Some O-type RBC units may contain blood with very immunogenic phenotypes, the use of which in an emergency requires great caution because it can be a step towards subsequent alloimmunization.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":"44-48"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LEP rs7799039 and LEPR rs1137101 gene variants are not associated with clinical features in patients with metabolic syndrome in the Turkish population. LEP rs7799039 和 LEPR rs1137101 基因变异与土耳其人群中代谢综合征患者的临床特征无关。

Laboratory medicine Pub Date : 2025-01-06 DOI: 10.1093/labmed/lmae061

Marjan Jabbarli, Naci Senkal, Fatima Ceren Tuncel, Yasemin Oyaci, Merve Guzel Dirim, Murat Kose, Sacide Pehlivan, Alpay Medetalibeyoglu

{"title":"LEP rs7799039 and LEPR rs1137101 gene variants are not associated with clinical features in patients with metabolic syndrome in the Turkish population.","authors":"Marjan Jabbarli, Naci Senkal, Fatima Ceren Tuncel, Yasemin Oyaci, Merve Guzel Dirim, Murat Kose, Sacide Pehlivan, Alpay Medetalibeyoglu","doi":"10.1093/labmed/lmae061","DOIUrl":"10.1093/labmed/lmae061","url":null,"abstract":"Objectives: Genetic predisposition plays a role in the etiology of metabolic syndrome (MetS), an important health problem worldwide. Leptin (LEP), produced by adipose tissue, plays a crucial role in the development of MetS. In this study, we evaluated the effects of LEP and LEP receptor (LEPR) variants on clinical findings and risk of developing MetS in the Turkish population.Methods: A total of 320 patients were included in the study, of whom 150 were patients with MetS and 170 were healthy controls. DNA was extracted from blood samples. LEP rs7799039 and LEPR rs1137101 variants were genotyped using the polymerase chain reaction-based restriction fragment length polymorphism method. The genotype distributions of these variants and clinical and laboratory findings were compared.Results: The LEP rs7799039 GA and AA genotypes and A allele frequencies were higher in participants with MetS than in the control group. For LEP rs7799039, the genotype AA-GA was higher in males, and the GG genotype was higher in females. On analyzing the clinical outcomes associated with these variants, it was observed that individuals possessing LEP rs7799039 GA and AA genotypes displayed elevated levels of triglycerides. In addition, those with the AG-GG genotype of LEPR rs1137101 had lower mean hemoglobin levels.Conclusion: Our results showed that the LEP rs7799039 and LEPR rs1137101 variants may be associated with both the risk of MetS development and clinical findings. Among the various contributors to MetS, a genetic predisposition is commonly recognized as the primary cause.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":"37-43"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic plasma exchange for hyperviscosity syndrome in IgA multiple myeloma. 治疗性血浆置换用于治疗 IgA 多发性骨髓瘤的高粘滞性综合征。

Laboratory medicine Pub Date : 2025-01-06 DOI: 10.1093/labmed/lmae054

Nalan Yurtsever, Thomas C Binns, Jeanne E Hendrickson, Christopher A Tormey, Edward S Lee

引用次数: 0