Laboratory medicine最新文献_第9页

The antinuclear antibody HEp-2 indirect immunofluorescence harmonization and competency assessment program of the Society for Clinical Microbiologists of Türkiye: analysis of 7-year assessment results. 日本临床微生物学会抗核抗体HEp-2间接免疫荧光协调与能力评估项目：7年评估结果分析

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Laboratory medicine Pub Date : 2026-02-09 DOI: 10.1093/labmed/lmag001

Nilgun Kasifoglu, Neval Yurttutan Uyar, Ekrem Yasar, Nese Kaklikkaya, Tutku Taskinoglu, Burcin Sener

{"title":"The antinuclear antibody HEp-2 indirect immunofluorescence harmonization and competency assessment program of the Society for Clinical Microbiologists of Türkiye: analysis of 7-year assessment results.","authors":"Nilgun Kasifoglu, Neval Yurttutan Uyar, Ekrem Yasar, Nese Kaklikkaya, Tutku Taskinoglu, Burcin Sener","doi":"10.1093/labmed/lmag001","DOIUrl":"10.1093/labmed/lmag001","url":null,"abstract":"Introduction: Accurate and harmonized antinuclear antibody HEp-2 indirect immunofluorescence (IIF) reporting is essential for reliable communication between laboratories and clinicians. In Türkiye, a national online HEp-2 IIF competency assessment program has been operating since 2018, with 3 runs per year and participation of individual users representing clinical laboratories nationwide. The program evaluates the performance of participants and identifies training and reporting needs.Methods: Between 2018 and 2025, 21 runs were conducted; the accuracy of competent-level and expert-level fluorescence pattern identification was analyzed. Twenty-six to 64 participants took part in each run. Since 2021, reflex test recommendations have been incorporated.Results: The competent-level fluorescence patterns most accurately identified were AC-1, AC-3, AC-6/7, AC-8/9/10, AC-11/12, and AC-15/16/17, while AC-0 and AC-2/30 showed less than 80% accuracy in at least 1 run. Among expert-level patterns, accuracy was highest for pattern AC-27 and lowest for pattern AC-29, with low rates for AC-5, AC-6, AC-15, and AC-20. Reflex test recommendations were generally accurate (75.6%-100%).Discussion: The results revealed good performance for many competent-level nuclear and cytoplasmic patterns and satisfactory reflex test recommendations. Persistent challenges were recognized, however, for patterns AC-29, AC-5, AC-20, and AC-0. Competency self-assessment, combined with collective performance evaluation, may provide insight for the harmonization of HEp-2 IIF reporting and improvement of laboratory-clinician collaboration.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acquired bisalbuminemia associated with hepatobiliary disease: a two-case report and diagnostic implications. 获得性双白蛋白血症与肝胆疾病相关：两例报告及其诊断意义

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Laboratory medicine Pub Date : 2026-02-09 DOI: 10.1093/labmed/lmag002

Reda Karami, Fatima El Boukhrissi

{"title":"Acquired bisalbuminemia associated with hepatobiliary disease: a two-case report and diagnostic implications.","authors":"Reda Karami, Fatima El Boukhrissi","doi":"10.1093/labmed/lmag002","DOIUrl":"10.1093/labmed/lmag002","url":null,"abstract":"Introduction: Acquired bisalbuminemia is an uncommon qualitative albumin abnormality increasingly detected by capillary electrophoresis. It can be associated with several pathologic contexts.Methods: A retrospective analysis was performed on two cases of bisalbuminemia detected over a 10-year period in the biochemistry-toxicology laboratory of Moulay Ismail Military Hospital in Meknes, Morocco. Clinical, biochemical, electrophoretic, and histologic data were reviewed, with particular emphasis on serum albumin electrophoretic patterns.Results: Bisalbuminemia was identified in two distinct hepatobiliary contexts: an overlap syndrome between autoimmune hepatitis and primary sclerosing cholangitis and antibiotic exposure in a patient with cholangiocarcinoma. In both cases, the abnormal albumin fraction was temporary and resolved after treating the underlying condition or withdrawing the drug that was causing it.Discussion: Acquired bisalbuminemia represents a reversible laboratory finding that reflects underlying pathologic or pharmacologic processes. Capillary electrophoresis plays a pivotal role in the detection and follow-up of this condition.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of glycerol-related analytical bias in triglyceride estimation for patients with type 2 diabetes. 2型糖尿病患者甘油三酯评估中甘油相关分析偏差的评估

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Laboratory medicine Pub Date : 2026-02-09 DOI: 10.1093/labmed/lmag003

Mohini Rathore, Manoj Khokhar, Shelendra Kumar, Maya Gopalakrishnan, Shrimanjunath Sankanagoudar, Mithu Banerjee, Praveen Sharma, Sojit Tomo

{"title":"Assessment of glycerol-related analytical bias in triglyceride estimation for patients with type 2 diabetes.","authors":"Mohini Rathore, Manoj Khokhar, Shelendra Kumar, Maya Gopalakrishnan, Shrimanjunath Sankanagoudar, Mithu Banerjee, Praveen Sharma, Sojit Tomo","doi":"10.1093/labmed/lmag003","DOIUrl":"10.1093/labmed/lmag003","url":null,"abstract":"Introduction: Standard triglyceride assays may overestimate true triglyceride concentrations due to endogenous glycerol interference, particularly in type 2 diabetes, where enhanced lipolysis elevates circulating free glycerol. We compared glycerol-blanked and non-blanked triglyceride assays in patients with type 2 diabetes to quantify analytical bias and assess impact on cardiovascular risk indices.Methods: This cross-sectional study enrolled 200 patients with type 2 diabetes and 200 healthy control individuals. Serum triglyceride levels were measured using glycerol-blanked (Sekisui) and nonblanked (Beckman Coulter) enzymatic assays. Bias assessment, correlation analysis, and impact on atherogenic index of plasma were evaluated.Results: Median nonblanked triglyceride values were substantially higher than glycerol-blanked triglyceride values in control individuals (129.5 vs 120.95 mg/dL, P = .02) and patients with type 2 diabetes (158.5 vs 136.85 mg/dL, P = .0019). Overestimation was greater in patients (median difference, 16.1 mg/dL) than in control individuals (9.95 mg/dL, P = .0001). Bland-Altman analysis showed higher mean (SD) bias in patients with type 2 diabetes (-21.25 [41.51] mg/dL) than in control individuals (-13.26 [31.26] mg/dL). The triglyceride- glycerol-blanked triglyceride difference correlated with glycated hemoglobin values in individuals with type 2 diabetes (ρ = 0.141, P = .0473).Discussion: Glycerol-blanked triglyceride assays provide more accurate lipid assessment in type 2 diabetes, improving cardiovascular risk stratification and therapeutic decision-making.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EASIX as a new predictor of mortality in cerebrovascular diseases. EASIX作为脑血管疾病死亡率的新预测指标。

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Laboratory medicine Pub Date : 2026-02-09 DOI: 10.1093/labmed/lmaf082

Ökkeş Zortuk, Cihan Bedel, Günay Yıldız, Fatih Selvi, Yusuf Karancı

{"title":"EASIX as a new predictor of mortality in cerebrovascular diseases.","authors":"Ökkeş Zortuk, Cihan Bedel, Günay Yıldız, Fatih Selvi, Yusuf Karancı","doi":"10.1093/labmed/lmaf082","DOIUrl":"10.1093/labmed/lmaf082","url":null,"abstract":"Introduction: Cerebrovascular disease (CVD) represents a major global health concern that affects the blood vessels throughout the body and contributes to a considerable burden of mortality and morbidity. The Endothelial Activation and Stress Index (EASIX) has recently emerged as a promising biomarker for predicting many disease complications and outcomes. We aimed to investigate the relationship between EASIX and disease mortality in patients with CVD.Methods: The present study was conducted in a tertiary emergency department between January 6, 2023, and January 6, 2024, who were diagnosed with CVD. The mortality rate among patients within a 1-month period was analyzed. The EASIX was calculated using lactate dehydrogenase level (U/L) × creatinine level (mg/dL)/platelet count (×109/L). The parameters were then compared in relation to disease morbidity.Results: Following the exclusion of patients who met the preestablished exclusion criteria, the study included 74 participants. In the 1-month follow-up of 64 patients, no mortality was observed. The median EASIX score was 0.80 (IQR, 0.5-2.2) in the surviving patients, while the median EASIX score was 2.90 (IQR, 1.00-10.55) in the patients who died, indicating a statistically significantly higher score (P < .001).Discussion: EASIX has the potential to be a prognostic marker for mortality in patients with CVD.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of PAX1/JAM3 methylation analysis for triage of high-risk HPV-positive individuals. PAX1/JAM3甲基化分析在高危hpv阳性个体分诊中的应用

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Laboratory medicine Pub Date : 2026-02-09 DOI: 10.1093/labmed/lmaf096

Qin Guo, Huaguo Wang, Xue Diao, Yinghong Liu, Yanling Chen, Qiyun Long, Zejiang Liu, Xing Qi, Sheng Lin, Xuhui Song

{"title":"Utility of PAX1/JAM3 methylation analysis for triage of high-risk HPV-positive individuals.","authors":"Qin Guo, Huaguo Wang, Xue Diao, Yinghong Liu, Yanling Chen, Qiyun Long, Zejiang Liu, Xing Qi, Sheng Lin, Xuhui Song","doi":"10.1093/labmed/lmaf096","DOIUrl":"10.1093/labmed/lmaf096","url":null,"abstract":"Introduction: We sought to assess the clinical utility of methylation detection of paired box gene 1 (PAX1) and junctional adhesion molecule 3 (JAM3) in the triage of individuals testing positive for high-risk human papillomavirus (HPV).Methods: Cervical secretions from 312 high-risk HPV-positive patients were analyzed for dual-gene methylation of PAX1 and JAM3 (PAX1m/JAM3m). Methylation levels were compared across histologically confirmed cervical lesions. Using histopathology as the reference standard, the triage performance of PAX1m/JAM3m was evaluated against cytology and HPV-16/18 genotyping.Results: Methylation positivity increased in statistical significance with lesion severity (P < .001 for trend). For the detection of cervical intraepithelial neoplasia (CIN) 2 or more severe lesions (CIN2+), PAX1m/JAM3m yielded a sensitivity of 91.8% (95% CI, 84.1%-96.2%), specificity of 90.7% (95% CI, 85.7%-94.1%), and an area under the receiver operating characteristic curve of 0.912 (95% CI, 0.874-0.951), outperforming cytology, HPV-16/18 genotyping, and their combinations. Using PAX1m/JAM3m positivity as a criterion for colposcopy referral, 1 CIN2+ case was detected per 1.22 referrals, reducing the colposcopy referral rate by approximately 19.2% and increasing the CIN2+ detection rate by 39.4% compared with cytology at the atypical squamous cells of undetermined significance threshold.Discussion: PAX1m/JAM3m levels are strongly associated with cervical lesion severity and represent a promising triage strategy for high-risk HPV-positive individuals.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146196057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and pedigree analysis of a hidden partial D antigen with rare RHD*DV.1 allele. 一种罕见RHD*DV隐性D部分抗原的鉴定及家系分析。1等位基因。

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Laboratory medicine Pub Date : 2026-02-09 DOI: 10.1093/labmed/lmag005

Xiaohua Yuan, Xuefeng Shao, Chunzi Xu, Jing Wang, Xiaoye Sun, Kecheng Wang

{"title":"Identification and pedigree analysis of a hidden partial D antigen with rare RHD*DV.1 allele.","authors":"Xiaohua Yuan, Xuefeng Shao, Chunzi Xu, Jing Wang, Xiaoye Sun, Kecheng Wang","doi":"10.1093/labmed/lmag005","DOIUrl":"10.1093/labmed/lmag005","url":null,"abstract":"Introduction: An 85-year-old O D-positive male with a history of multiple D-positive RBC transfusions (10.5 units in 2020, 5.5 units in 2023) presented with severe anemia in June 2024. Unexpected antibodies were found in his plasma, and crossmatching was incompatible with all O D-positive donor RBCs. In this article, we document the methodology for confirming a hidden partial D antigen with rare RHD*DV.1 allele variant, with the objectives of elucidating the characteristics of this rare allele and establishing evidence-based transfusion guidelines.Methods: This partial D antigen was identified using column agglutination and tube methods for the patient in this case. Subsequent adsorption-elution assays characterized the antibody mixture in the his plasma. RHD gene sequencing confirmed the specific mutations and zygosity.Results: Compared with the 4+ agglutination observed in column agglutination testing for the patient in this instance, a much weaker reaction (2+ agglutination) was noted in tube testing. RHD gene sequencing revealed 2 variations in exon 5-c.667T>G and c.697G>C-consistent with the RHD*DV.1 allele. Both of the patient's sons were genotyped as RHD*DV.1/RHD*01, confirming the inheritance of this allele from their father. Analysis of the patient's haplotypes showed only 1 single-nucleotide variation (formerly single-nucleotide polymorphism) difference (c.801 + 108G>A) located in intron 5. This finding demonstrates that the 2 exon 5 variations reside on separate haplotypes, confirming that this patient was a definitive homozygote for RHD*DV.1.Discussion: For women of childbearing potential, pretransfusion screening using the tube method remains a vital component in the early detection of D antigen variants and is essential for preventing alloimmunization.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical utility of C-reactive protein in evaluating infection patterns and disease severity in respiratory viral infections: a retrospective single-center analysis, 2020-2025. c反应蛋白在评估呼吸道病毒感染感染模式和疾病严重程度中的临床应用：2020-2025年回顾性单中心分析

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Laboratory medicine Pub Date : 2026-02-09 DOI: 10.1093/labmed/lmaf095

Yonghee Lee, Jae-Sik Jeon, Jae Kyung Kim

{"title":"Clinical utility of C-reactive protein in evaluating infection patterns and disease severity in respiratory viral infections: a retrospective single-center analysis, 2020-2025.","authors":"Yonghee Lee, Jae-Sik Jeon, Jae Kyung Kim","doi":"10.1093/labmed/lmaf095","DOIUrl":"10.1093/labmed/lmaf095","url":null,"abstract":"Introduction: Acute respiratory tract infections remain a major global health concern, and advances in molecular diagnostics have improved viral detection. The clinical interpretation of C-reactive protein (CRP) levels in viral respiratory infections, however, remains insufficiently defined. This study aimed to analyze CRP profiles in patients with respiratory viral infections to clarify their epidemiologic and clinical significance.Methods: A retrospective analysis was conducted in 7639 respiratory specimens tested by multiplex reverse transcription-polymerase chain reaction between July 2020 and March 2025, with concurrent CRP measurement. C-reactive protein values below 0.5 mg/dL were imputed as 0.25 mg/dL for analysis.Results: Among the 7639 specimens analyzed, 965 (12.63%) tested positive for respiratory viruses, with a peak observed during the winter-spring season. Viral positivity was slightly higher in women than in men. Children younger than 5 years of age exhibited the highest positivity (54.33%) but lower CRP values, whereas CRP levels increased substantially with age, reaching 12.10 mg/dL in individuals 70 years of age and older. Co-infections (13.2%) were strongly associated with lower CRP levels.Discussion: Distinct CRP distributions were observed according to age and infection complexity. These findings support the use of CRP as a supplemental marker for interpreting viral respiratory tract infections and identifying atypical inflammatory responses, particularly in co-infections.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of platelet-related parameters and autoantibodies in patients with autoimmune bullous diseases. 自身免疫性大疱性疾病患者血小板相关参数与自身抗体的相关性

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Laboratory medicine Pub Date : 2026-02-09 DOI: 10.1093/labmed/lmaf094

Zhijun Zhou, Hua Qian, Huicheng Li, Dantong Chen, Xiaohua Tao, Yun Jin, Mingxue Zhu, Xiaoguang Li

{"title":"Correlation of platelet-related parameters and autoantibodies in patients with autoimmune bullous diseases.","authors":"Zhijun Zhou, Hua Qian, Huicheng Li, Dantong Chen, Xiaohua Tao, Yun Jin, Mingxue Zhu, Xiaoguang Li","doi":"10.1093/labmed/lmaf094","DOIUrl":"10.1093/labmed/lmaf094","url":null,"abstract":"Introduction: Autoimmune bullous diseases (AIBDs) are rare, tissue-specific autoimmune diseases of the skin, and corresponding autoantibodies have been proved to be pathogenic. Recently, we reported that variations in platelet-related parameters may reflect the fluctuations of circulating AIBD-correlated antibody titers during the disease progression of 1 patient with AIBD. The purpose of this article is to further investigate the possible correlation between autoantibody titers and platelet-related parameters in patients with AIBD.Methods: This study collected data on autoantibody titers and platelet-related parameters from 136 patients with bullous pemphigoid positive for anti-BP180 antibodies, 54 patients with pemphigus foliaceus positive for anti-desmoglein (Dsg) 1 antibody, 55 patients with pemphigus vulgaris positive for both anti-Dsg1 and Dsg3 antibodies, and 16 patients with pemphigus vulgaris positive for anti-Dsg3 antibody alone. Two groups of healthy individuals served as controls.Results: Comparative analyses revealed clinically significantly elevated platelet-related parameters, such as platelet count and thrombocytocrit, in the autoantibody-positive patient groups relative to control individuals. Correlation analyses demonstrated statistically significant positive associations between autoantibody titers and specific platelet-related parameters.Discussion: These findings represent the first documented evidence of a positive correlation between autoantibody titers and platelet-related parameters in patients with AIBDs. The data implied that platelets may contribute to the disease pathophysiology and progression of AIBDs.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of serum amyloid A as a biomarker for sepsis diagnosis compared with C-reactive protein, procalcitonin, and presepsin. 血清淀粉样蛋白A作为败血症诊断的生物标志物与c反应蛋白、降钙素原和胃蛋白酶的比较

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Laboratory medicine Pub Date : 2026-02-09 DOI: 10.1093/labmed/lmaf054

Myeong Hee Kim, So Young Kang, Woo-In Lee, Min Young Lee

{"title":"Evaluation of serum amyloid A as a biomarker for sepsis diagnosis compared with C-reactive protein, procalcitonin, and presepsin.","authors":"Myeong Hee Kim, So Young Kang, Woo-In Lee, Min Young Lee","doi":"10.1093/labmed/lmaf054","DOIUrl":"10.1093/labmed/lmaf054","url":null,"abstract":"Introduction: Several biomarkers have been developed for rapid and accurate diagnosis of sepsis. This study aimed to evaluate the potential of serum amyloid A (SAA) as a biomarker for sepsis diagnosis compared with C-reactive protein (CRP), procalcitonin (PCT), and presepsin.Methods: Biomarker levels were measured in 193 patients. Blood and microbial cultures were obtained from 69 and 94 patients, respectively. Based on the culture results and clinical symptoms, patients were classified into groups with sepsis, local infection, inflammatory disease, or other conditions to evaluate the differences in the values of the 4 biomarkers.Results: Serum amyloid A, CRP, and PCT levels were high in both the sepsis and localized infection groups, whereas SAA also showed increased levels in the inflammatory disease group. The area under the curve for diagnostic ability of SAA, CRP, PCT, and presepsin were 82.6%, 82.0%, 90.3%, and 85.7%, respectively. In the statistical association analysis, SAA showed a positive correlation with the 3 other biomarkers, with the best correlation observed with CRP.Discussion: The application of SAA in the early diagnosis of sepsis holds substantial clinical promise, particularly when employed alongside established biomarkers such as PCT, CRP, and presepsin. This combinatory approach may enhance diagnostic accuracy.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central nervous system toxoplasmosis with atypical neurologic findings in an immunocompetent patient. 免疫功能正常患者中枢神经系统弓形虫病伴非典型神经系统表现。

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Laboratory medicine Pub Date : 2026-01-07 DOI: 10.1093/labmed/lmaf068

Alexandros Giannakis, Miltiadis Makridimas, Eirini Christaki, Anastasia K Zikou, Spiridon Konitsiotis

{"title":"Central nervous system toxoplasmosis with atypical neurologic findings in an immunocompetent patient.","authors":"Alexandros Giannakis, Miltiadis Makridimas, Eirini Christaki, Anastasia K Zikou, Spiridon Konitsiotis","doi":"10.1093/labmed/lmaf068","DOIUrl":"10.1093/labmed/lmaf068","url":null,"abstract":"Introduction: Central nervous system toxoplasmosis usually occurs in immunocompromised patients and is associated with severe clinical findings. It is rare in immunocompetent individuals.Methods: A young patient presented with mild neurologic findings. Brain magnetic resonance imaging (MRI) with intravenous gadolinium contrast revealed a calcified lesion with mixed signal intensity in the cerebellum surrounded by mild edema and showing mild enhancement. Elevated immunoglobulin G and M titers for Toxoplasma gondii were found. A comprehensive diagnostic workup for other infectious, autoimmune, malignant, and immunosuppressive conditions yielded no clinically significant findings. Other common sites of toxoplasmosis involvement were excluded.Results: Treatment with sulfamethoxazole-trimethoprim resulted in improvement of headaches and neurologic signs. At the 2-year follow-up, serial brain MRI scans showed no clinically significant changes apart from the absence of contrast enhancement. Clinically, the patient reports intermittent migraine-like headaches and a mild tremor in both upper limbs. No evidence of immunodeficiency was identified, supporting a final diagnosis of central nervous system toxoplasmosis in an immunocompetent patient.Discussion: Central nervous system toxoplasmosis can occur in immunocompetent individuals, even with mild or atypical neurologic presentations. Brain MRI and serum serology are crucial for diagnosing these cases.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0