Laboratory medicine最新文献_第7页

Association of ATP2B1 and STK39 gene variants with blood pressure levels in patients with essential hypertension. ATP2B1和STK39基因变异与原发性高血压患者血压水平的关系

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Laboratory medicine Pub Date : 2026-04-03 DOI: 10.1093/labmed/lmag025

Egemen Akgün, Ahmet Karagöz, Fadime Mutlu İçduygu, Ebru Alp

{"title":"Association of ATP2B1 and STK39 gene variants with blood pressure levels in patients with essential hypertension.","authors":"Egemen Akgün, Ahmet Karagöz, Fadime Mutlu İçduygu, Ebru Alp","doi":"10.1093/labmed/lmag025","DOIUrl":"10.1093/labmed/lmag025","url":null,"abstract":"Introduction: ATP2B1 and STK39 loci influence blood pressure in genome-wide association studies. We tested whether ATP2B1 rs2681472 and STK39 rs35929607 are associated with essential hypertension and blood pressure.Methods: We studied 194 untreated hypertensive adults and 191 normotensive control individuals. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. Logistic regression evaluated hypertension risk, and linear regression assessed systolic and diastolic blood pressure (BP) under genotypic, dominant, and additive models, with adjustment for clinical covariates; the false discovery rate was controlled.Results: The STK39 rs35929607 G allele was associated with hypertension (adjusted odds ratio [OR], 1.97 [95% CI, 1.21-3.21]; P = .007) and higher systolic BP (+8.02 mm Hg per G allele, 95% CI, 2.18-13.87; P = .007). Effects on diastolic BP were weaker (additive P = .10; dominant P = .06). ATP2B1 rs2681472 showed no statistically significant associations (hypertension per T allele OR, 1.18 [95% CI, 0.74-1.87]; P = .49). In sex-stratified analyses, STK39 associations were evident in men (hypertension OR, 3.22 [95% CI, 1.42-7.31]; P = .005; systolic BP, +15.88 mm Hg [95% CI, 5.95-25.80]; P = .002) but not in women.Discussion: In our study cohort, STK39 rs35929607 is associated with essential hypertension and higher systolic BP, with possible sex-specific effects. ATP2B1 rs2681472 is not associated with hypertension or BP traits.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13188984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Communication of newly diagnosed monoclonal gammopathy as a quasi-critical laboratory value. 新诊断的单克隆γ病作为准临界实验室价值的交流。

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Laboratory medicine Pub Date : 2026-04-03 DOI: 10.1093/labmed/lmaf067

Gurmukh Singh, Roni J Bollag, Natasha M Savage, Mei Zheng, Amany Keruakous

引用次数: 0

Leukocyte telomere length and chronic disease burden in an adult community sample: a cross-sectional study. 成人社区样本中的白细胞端粒长度和慢性疾病负担：一项横断面研究。

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Laboratory medicine Pub Date : 2026-04-03 DOI: 10.1093/labmed/lmag023

Jerome Alfred Q Tabajonda, Shang-Hsien Yang, Yi-Ling Shen, Flordeluna Z Mesina, Maureen B Sabit, Teresa T Sy Ortin, Carl Lexter B Tan, Cheng-Yoong Pang, Chi-Cheng Li, Liuh-Yow Chen, Pia Marie S P Albano

{"title":"Leukocyte telomere length and chronic disease burden in an adult community sample: a cross-sectional study.","authors":"Jerome Alfred Q Tabajonda, Shang-Hsien Yang, Yi-Ling Shen, Flordeluna Z Mesina, Maureen B Sabit, Teresa T Sy Ortin, Carl Lexter B Tan, Cheng-Yoong Pang, Chi-Cheng Li, Liuh-Yow Chen, Pia Marie S P Albano","doi":"10.1093/labmed/lmag023","DOIUrl":"10.1093/labmed/lmag023","url":null,"abstract":"Introduction: Telomere length is a biomarker of cellular aging and chronic disease risk, but its population-level correlates and disease-specific patterns remain unclear. This study examined telomere length associations and its contribution to disease prediction.Methods: Leukocyte telomere length measured using quantitative polymerase chain reaction was analyzed in 615 Filipino adults. Associations with sociodemographic, lifestyle, and physiologic factors were evaluated among healthy participants using variance-robust methods and Welch tests. Linear support vector classifiers with SHapley Additive exPlanations interpretation predicted cancer, cardiovascular disease (CVD), mental health disorders, allergy, and diabetes using 5-fold cross-validation.Results: Postgraduate participants had shorter telomere lengths than did high school graduates (mean difference, 2.740; P = .02) and college graduates (mean difference, 2.884; P = .01). Telomere length did not differ between individuals without CVD and CVD alone; however, CVD-only cases had shorter telomere lengths than did those with additional comorbidities (mean difference, -3.253; P = .009). Single allergy cases had shorter telomere lengths (P = .03), whereas cancer-only cases had longer telomere lengths (P = .003). Model accuracies ranged from 85.37% to 93.47%, with telomere length contributing mainly to cancer prediction.Discussion: Telomere length showed disease-specific associations and improved cancer prediction but had limited links with measured exposures. Longitudinal studies are needed to clarify causality and refine telomere length-based risk stratification.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an in-house control standard for quantitative polymerase chain reaction-based diagnosis of leprosy. 制定麻风病定量聚合酶链反应诊断的内部控制标准。

IF 1

Laboratory medicine Pub Date : 2026-04-03 DOI: 10.1093/labmed/lmag020

Selfu Girma, Mesfin Tafesse Gemeda, Adugna Abdi Woldesemayat, Kidist Bobosha, Endalamaw Gadisa

{"title":"Development of an in-house control standard for quantitative polymerase chain reaction-based diagnosis of leprosy.","authors":"Selfu Girma, Mesfin Tafesse Gemeda, Adugna Abdi Woldesemayat, Kidist Bobosha, Endalamaw Gadisa","doi":"10.1093/labmed/lmag020","DOIUrl":"10.1093/labmed/lmag020","url":null,"abstract":"Introduction: To develop an in-house reference control DNA standard targeting the RLEP region of Mycobacterium leprae for use in quantitative polymerase chain reaction (qPCR) diagnostics, aiming to reduce dependence on animal models and external sources.Method: Previously characterized DNA samples from patients with leprosy were used to amplify and sequence the 450-base pair RLEP region. A specific 131-base pair segment within this region was targeted for qPCR assay development. The amplified products were purified; sequenced using Illumina next-generation sequencing technology; and validated through bioinformatics analyses, including Basic Local Alignment Search Tool (BLAST; National Institutes of Health) alignment and copy number assessment.Results: The consensus sequence aligned perfectly with the known RLEP region. The BLAST analysis revealed 37 copies of the target sequence throughout the genome, confirming the sequence's utility as a sensitive diagnostic marker. The qPCR assay successfully detected the target in both reference and clinical samples, with melting curve analysis indicating high specificity.Discussion: An in-house M leprae RLEP control standard was successfully developed that provides a reliable, ethical, and resource-efficient alternative to traditional animal-derived controls for leprosy diagnosis using qPCR.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemoglobin Hekinan II (HBA1:c.84G>T): an electrophoretically silent α-globin variant missed by routine screening in northern Thailand. 血红蛋白血红蛋白II （HBA1:c）84G>T)：泰国北部常规筛查遗漏的一种电泳沉默α-珠蛋白变体。

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Laboratory medicine Pub Date : 2026-04-03 DOI: 10.1093/labmed/lmag028

Moe Theingi, Chedtapak Ruengdit, Manoo Punyamung, Sakorn Pornprasert

{"title":"Hemoglobin Hekinan II (HBA1:c.84G>T): an electrophoretically silent α-globin variant missed by routine screening in northern Thailand.","authors":"Moe Theingi, Chedtapak Ruengdit, Manoo Punyamung, Sakorn Pornprasert","doi":"10.1093/labmed/lmag028","DOIUrl":"10.1093/labmed/lmag028","url":null,"abstract":"Introduction: This study aimed to characterize the molecular and hematologic features of hemoglobin (Hb) Hekinan II in northern Thailand and to evaluate its phenotypic expression when co-inherited with other hemoglobinopathies.Methods: In total, 2314 blood samples were drawn for routine Hb analysis using high-performance liquid chromatography and capillary electrophoresis, and common α0-thalassemia deletions were detected by multiplex real-time polymerase chain reaction with high-resolution melting analysis. Targeted next-generation sequencing using DNA nanoball sequencing technology was applied to identify variations in the HBA1, HBA2, and HBB genes.Results: Routine laboratory screening failed to detect Hb Hekinan II in all cases. Molecular analysis identified 13 (0.6%) carriers. Individuals with heterozygous Hb Hekinan II showed normal Hb profiles and near-normal red blood cell indices, confirming its clinically silent nature. Co-inheritance with HbE resulted in mild microcytosis resembling the HbE trait, while more complex genotypes involving β0-thalassemia, α+-thalassemia, or additional α-globin variants produced variable hematologic phenotypes. All cases were detected only by molecular methods and were missed by conventional Hb typing.Discussion: Hemoglobin Hekinan II is a clinically benign but diagnostically challenging α-globin variant that cannot be reliably identified by routine screening. Integrating targeted molecular diagnostics is essential for accurate detection and genetic counseling.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet transfusion refractoriness in Glanzmann thrombasthenia: a case report with literature review. 血小板输注难治性格兰兹曼血栓性贫血1例并文献复习。

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Laboratory medicine Pub Date : 2026-04-03 DOI: 10.1093/labmed/lmag007

Zeineb Ben Lamine, Imen Jarray, Houda Romdhane, Wafa Chenbah, Yosra Ben Youssef, Batoul Houissa

{"title":"Platelet transfusion refractoriness in Glanzmann thrombasthenia: a case report with literature review.","authors":"Zeineb Ben Lamine, Imen Jarray, Houda Romdhane, Wafa Chenbah, Yosra Ben Youssef, Batoul Houissa","doi":"10.1093/labmed/lmag007","DOIUrl":"10.1093/labmed/lmag007","url":null,"abstract":"Introduction: Glanzmann thrombasthenia (GT) is a rare inherited platelet function disorder characterized by a deficiency or dysfunction of the αIIbβ3 integrin, leading to impaired platelet aggregation. Platelet transfusion refractoriness (PTR) represents a therapeutic challenge, often resulting from alloimmunization against HLA antigens or the αIIbβ3 complex.Methods: We report the case of a patient with type I GT, who presented with recurrent mucosal hemorrhages and chronic anemia requiring repeated transfusions.Results: By the age of 8 years, the patient developed transfusion refractoriness, with hemorrhagic episodes unresponsive to platelet transfusions. Immunologic investigations revealed anti-HLA and anti-αIIbβ3 antibodies. At 14 years of age, a severe hemorrhagic episode with rapid hemoglobin decline was successfully managed with recombinant activated factor VII (rFVIIa).Discussion: Management of PTR in GT represents a major clinical challenge, frequently associated with anti-HLA or anti-αIIbβ3 antibodies. In high-resource settings, transfusion strategies are guided by antibody specificity: HLA-compatible or human platelet antigen-compatible platelets are used for patients with anti-HLA or anti-human platelet antigen antibodies, respectively, while rFVIIa is reserved for individuals with anti-αIIbβ3 antibodies. In LMIC such as Tunisia, prevention of alloimmunization through systematic leukoreduction is essential. When PTR occurs, donor selection by crossmatching, when feasible, and judicious use of rFVIIa for life-threatening hemorrhage remain key therapeutic options.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HScore as a diagnostic tool in ERBB2 equivocal (immunohistochemistry 2+) breast cancer. HScore作为ERBB2模棱两可（免疫组化2+）乳腺癌的诊断工具。

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Laboratory medicine Pub Date : 2026-04-03 DOI: 10.1093/labmed/lmag006

Tasnem Alsebai, Muhammed Yaman Swied, Ricardo Cossyleon, Kathy Robinson, Kristin Delfino, John Gao, Krishna Rao

{"title":"HScore as a diagnostic tool in ERBB2 equivocal (immunohistochemistry 2+) breast cancer.","authors":"Tasnem Alsebai, Muhammed Yaman Swied, Ricardo Cossyleon, Kathy Robinson, Kristin Delfino, John Gao, Krishna Rao","doi":"10.1093/labmed/lmag006","DOIUrl":"10.1093/labmed/lmag006","url":null,"abstract":"Introduction: ERBB2 is amplified or overexpressed in 15% to 20% of primary invasive breast cancers. Despite the aggressive nature of ERBB2-positive breast cancers, the development of anti-ERBB2 therapy has resulted in better prognoses. HScore is a scoring system that broadens immunohistochemistry (IHC) results into a quantitative range. The aim of this retrospective study was to evaluate whether the HScore can be used to predict all ERBB2 IHC-equivocal cases as positive or negative without the need for fluorescence in situ hybridization confirmation.Methods: Image acquisition and processing tools were used on previously collected tissue slides from patients with ERBB2 IHC 2+ breast cancer from 2014 to 2023. After image acquisition, HScore values were calculated using variables from image analysis software.Results: The mean HScore values in ERBB2-positive cases were higher (3.06) than in ERBB2-negative cases (2.62). Receiver operating characteristic curve analysis yielded an area under the curve of 0.668 (95% CI, 0.523-0.812), indicating poor predictive accuracy. The optimal HScore cutoff of 2.6007 provided moderate sensitivity (0.77) but limited specificity (0.58).Discussion: Although the HScore showed moderate predictive accuracy, it lacked the reliability to replace fluorescence in situ hybridization as the gold standard. Future research should focus on refining the methodology and integrating it with other diagnostic approaches to enhance accuracy and clinical utility.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the benefits of industry clinical placements for medical laboratory science academics. 为医学化验学专业人员研究行业临床实习的好处。

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Laboratory medicine Pub Date : 2026-04-03 DOI: 10.1093/labmed/lmag027

Dodie Pouniotis, Lynda Sharp, Ross Vlahos, Sapha Shibeeb

{"title":"Examining the benefits of industry clinical placements for medical laboratory science academics.","authors":"Dodie Pouniotis, Lynda Sharp, Ross Vlahos, Sapha Shibeeb","doi":"10.1093/labmed/lmag027","DOIUrl":"10.1093/labmed/lmag027","url":null,"abstract":"Introduction: Industry placements are central to Medical Laboratory Science (MLS) student training, yet their value as professional development for MLS academics has not been well described.Methods: A cross-sectional survey was conducted across Australian universities offering Australian Institute of Medical and Clinical Scientists-accredited MLS programs. Two online surveys captured MLS academics' and program leaders' perceptions of the benefits, feasibility, and implementation considerations of academic clinical placements.Results: Among 29 academics (35% response rate) and 10 program leaders (83% response rate), hematology was the most common teaching area (30%). Most (79%) academics reported prior clinical pathology experience, with more than half reporting at least 10 years of experience. Maintaining clinical currency was rated extremely important, and placements were perceived as beneficial for teaching and student learning. Preferences centered on short placements (≤2 weeks), conducted annually or biannually, and participation likelihood increased with departmental support and short durations. Program leaders expressed unanimous support for placements to enhance curriculum alignment, student engagement, and technological currency. They also recognized the benefit for university-industry partnerships and skill development.Discussion: Academic clinical placements are widely perceived by both academics and program leaders as educationally valuable, enhancing teaching, student learning, and curriculum alignment with industry practices.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13157342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report of meningeal carcinomatosis presenting as rapidly progressive dementia: cytological diagnosis with ancillary immunohistochemistry of cerebrobrospinal fluid cells. 以快速进展性痴呆为表现的脑膜癌病1例：脑脊液细胞辅助免疫组化的细胞学诊断。

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Laboratory medicine Pub Date : 2026-04-03 DOI: 10.1093/labmed/lmag008

Xiaoxuan Xu, Chang Su, Dongming Zheng

{"title":"A case report of meningeal carcinomatosis presenting as rapidly progressive dementia: cytological diagnosis with ancillary immunohistochemistry of cerebrobrospinal fluid cells.","authors":"Xiaoxuan Xu, Chang Su, Dongming Zheng","doi":"10.1093/labmed/lmag008","DOIUrl":"10.1093/labmed/lmag008","url":null,"abstract":"Introduction: Meningeal carcinomatosis (MC) is a severe complication of systemic cancers. Although typical presentations involve meningeal irritation or cranial nerve deficits, its manifestation as rapidly progressive dementia (RPD) in the absence of classic signs is exceedingly rare. This complication poses a substantial diagnostic challenge, especially when the primary tumor remains occult.Methods: We present the case of a 56-year-old man with a 4-month history of progressive cognitive decline, behavioral changes, and visual hallucinations culminating in stupor. The diagnostic evaluation consisted of a comprehensive neurologic examination, contrast-enhanced brain magnetic resonance imaging, cerebrospinal fluid (CSF) analysis, and whole-body 18F-fludeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) imaging.Results: Brain magnetic resonance imaging revealed diffuse leptomeningeal enhancement. FDG-PET/CT demonstrated abnormal FDG uptake localized to the cerebellar cortex and basal meninges; however, no primary tumor was identified. A CSF analysis showed elevated opening pressure, pleocytosis, and increased protein; cytology confirmed malignant cells. Immunohistochemical profiling (CK7+, TTF1+, MOC31+, Ki-67 40%+, BerEp4+, EMA+) indicated adenocarcinoma of probable pulmonary origin, confirming MC.Discussion: This case underscores that RPD can be a rare but dominant initial feature of MC and highlights the essential role of CSF cytology combined with immunohistochemistry in achieving a definitive diagnosis, especially when neuroimaging is nonspecific and a primary tumor is not detected.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the first call: unveiling the gray areas in reactive donor notification and counseling in lower-middle-income countries-a systematic scoping review. 超越第一项呼吁：揭示中低收入国家被动捐助者通知和咨询中的灰色地带——系统的范围审查。

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Laboratory medicine Pub Date : 2026-04-03 DOI: 10.1093/labmed/lmag022

Rishiraj Sinha, Richard Gammon

{"title":"Beyond the first call: unveiling the gray areas in reactive donor notification and counseling in lower-middle-income countries-a systematic scoping review.","authors":"Rishiraj Sinha, Richard Gammon","doi":"10.1093/labmed/lmag022","DOIUrl":"10.1093/labmed/lmag022","url":null,"abstract":"Introduction: Donor notification and counseling after reactive screening for transfusion-transmitted infections (TTIs) are critical to transfusion safety and public health, yet practices in low- and middle-income countries (LMIC) remain inconsistent and poorly evaluated.Methods: A Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for scoping reviews-guided scoping review was conducted to map evidence on TTI-reactive donor notification and follow-up in LMIC. We searched PubMed, EMBASE, Scopus, and Web of Science for English-language studies published between January 2005 and June 2025. Eligible studies reported notification strategies, donor psychological factors, linkage-to-care outcomes, digital health interventions, or system-level integration. Data were extracted and narratively synthesized across 5 thematic domains, as mentioned in the \"Results\" section.Results: Notification success and donor response varied widely. Telephone-based notification consistently achieved higher return rates than letters or text messaging, while replacement donors demonstrated lower follow-up than did voluntary donors. Stigma, fear, and inaccurate contact information were major barriers to counseling. Evidence on linkage to confirmatory testing and treatment was limited; digital health approaches were largely absent. No studies evaluated cost-effectiveness or workforce impact.Discussion: Overall, TTI-reactive donor notification in LMIC remains fragmented, with critical gaps in digital innovation, psychosocial support, and linkage-to-care evaluation. Strengthening system-integrated, technology-enabled, culturally sensitive notification models is essential to improve donor and public health outcomes.","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":"57 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0