Laboratory medicine最新文献

{"title":"Identification of biomarkers associated with pathological tumor staging and their utility in the diagnosis and prognosis of prostate cancer.","authors":"Shiquan Xu, He Shi, Yiran Liu, Jing Lin, Xia Wu, Ruichun Lu, Yu Fan, Weiqiang Tan","doi":"10.1093/labmed/lmae059","DOIUrl":"10.1093/labmed/lmae059","url":null,"abstract":"<p><strong>Objective: </strong>Pathological tumor (pT) staging plays a crucial role in prostate cancer (PCa) diagnosis. This study aimed to identify pT stage-associated biomarkers and explored their utility in PCa prognosis.</p><p><strong>Methods: </strong>GSE69223 was used to identify potential targets differentially expressed between level 2 of pT staging (pT2) and level 3 of pT staging (pT3). Quantitative reverse transcriptase-polymerase chain reaction and immunohistochemistry were performed on tissues from patients with PCa to screen the pT stage-associated targets and to explore the prognostic value of these targets in PCa.</p><p><strong>Results: </strong>CENPI and SLC38A11 were most significantly upregulated, whereas ANO6 and KANK2 were mostly decreased in pT3 tumors compared with pT2 staging. ANO6 levels were negatively associated with preoperative prostate-specific antigen (PSA) levels, lymph node staging (N staging), Gleason score, and overall survival (OS); CENPI was positively associated with preoperative PSA levels, N staging, and OS, but was not associated with the Gleason score; SLC38A11 and KANK2 were not associated with OS. ANO6 and KANK2 were correlated with neutrophil markers, whereas CENPI was correlated with macrophage M2 types.</p><p><strong>Conclusion: </strong>We identified 4 reliable PCa biomarkers associated with pT staging that would be valuable for diagnosing and determining PCa prognosis.</p>","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":"118-128"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular pathology and computational profiling of Janus kinase 2 (JAK2) mutation in acute lymphoblastic leukemia: insights from a Pakistani cohort.","authors":"Sidra Maqsood, Saqib Hussain Ansari, Mamona Mushtaq, Azhar Abbas, Ali Muhammad Waryah, Zaheer Ul- Haq","doi":"10.1093/labmed/lmae071","DOIUrl":"10.1093/labmed/lmae071","url":null,"abstract":"<p><strong>Background: </strong>JAK2 mutation plays a clinically significant role in the pathogenesis of acute lymphoblastic leukemia (ALL) by enhancing its oncogenicity. The study aimed to characterize the molecular pathology and computational profile of the JAK2 mutation in an ALL cohort of Pakistani origin.</p><p><strong>Methods: </strong>Ninety-three patients were enrolled in the current study. The disease diagnosis was confirmed via flow cytometry and karyotyping of bone marrow aspirate/blood. For the identification of causative gene variations and assessment of their potential impact, the JAK2 gene underwent direct sequencing and predictive computational and in silico structural analysis, respectively.</p><p><strong>Results: </strong>JAK2 mutations were detected in 10 (11%) patients. All mutations were missense with 1 being frameshift. Most mutations showed a similar pattern to the wild type but p.N673H+p.V674L+p.C675W (AAD699), p.V674F (AAD704), and p.V674L (AAD705) exhibited statistically significant stability loss. The triple mutation displayed reduced stability both globally and locally.</p><p><strong>Conclusion: </strong>The pattern of gene defects in JAK2 in the studied cohort showed a disruption in proper folding behavior, evident from increased gyration values, resulting in the hypothesis that these mutations may cause structural alterations in the JAK2 protein that lead to disease progression.</p>","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":"136-145"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lean methodology in health care practice: an example of application for clinical laboratory urinalysis processing.","authors":"Evaldas Kontautas, Ema Rajackaitė, Živilė Jacikė, Ramunė Šepetienė","doi":"10.1093/labmed/lmae072","DOIUrl":"10.1093/labmed/lmae072","url":null,"abstract":"<p><strong>Background: </strong>Improving quality and laboratory testing turnaround time (TAT) is a constant challenge for a clinical laboratory. The formulas that describe the best way to manage these goals are outlined in International Organization for Standardization standards. According to standards, improvement must be timely and continuous. Lean methodology is a tool to meet this requirement. One of the fundamental elements of Lean is a systematic approach to process improvement by removing waste to create value for the end-user (eg, patient) of the service. This methodology can be adapted in resource-limited settings.</p><p><strong>Objective: </strong>The aim of this study was to test the application of Lean methodology in urinalysis.</p><p><strong>Methods: </strong>Lean has various collections of tools and concepts. We applied the most useful for the clinical laboratory: Gemba walk, Takt time, cycle time, and value-stream mapping. Finally, we created and approved workplace standards to improve the performance of urinalysis.</p><p><strong>Results: </strong>We compared the TATs of urinalysis tests before optimization, immediately after, and long after (~5 months). We found that TATs had significantly shortened. The TATs of emergency (STAT) urine tests immediately after optimization improved: automated microscopy to 16% (P =.194), fully automated test-strip to 23% (P = .0172), and standardized urine sediment examination to 20% (P =.0048). The TATs of routine urine tests also improved immediately after optimization: automated microscopy to 18% (P <.0001), fully automated test-strip to 11% (P =.0025), and standardized urine sediment examination to 18% (P =.0011). After 5 months of Lean application within the urinalysis laboratory, TATs of routine urine tests remained improved; however, the improvement of STAT urine test TATs dropped to approximately 4%.</p><p><strong>Conclusion: </strong>The application of the Lean methodology shows significant improvement in TATs of processes in our laboratory.</p>","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":"199-211"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The U-shaped association between hemoglobin concentrations and all-cause death risk in patients with community-acquired pneumonia.","authors":"Yilin Xu, Jianhua Fang, Xiuhua Kang, Tianxin Xiang","doi":"10.1093/labmed/lmae079","DOIUrl":"10.1093/labmed/lmae079","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of anemia in patients with community-acquired pneumonia (CAP) has been well described. However, few studies have explored its association with short-term and long-term mortality risk in CAP patients.</p><p><strong>Aim: </strong>We aimed to investigate the associations between hemoglobin concentrations at baseline and 14-day and 1-year mortality risk in a CAP population with a large sample size. Our data originated from the Dryad database, including a dataset from the study \"Incidence rate of community-acquired pneumonia in adults: a population-based prospective active surveillance study in 3 cities in South America.\" A total of 1463 study samples with follow-up data from the dataset were enrolled for our analysis.</p><p><strong>Results: </strong>During the follow-up period of 3 years, the 14-day risk and 1-year mortality risk were 206 (14.08%) and 401 (27.41%), respectively, among these CAP patients. Curve analysis indicated a strong U-shaped relationship between blood hemoglobin concentrations and 14-day mortality (r = -0.191, P < .001) and 1-year mortality (r = -0.220, P < .001). The blood hemoglobin level with the lowest point of mortality risk was 14.5 g/dL, suggesting that an increased hemoglobin concentration contributed to reduced 14-day and 1-year mortality risk in CAP patients when hemoglobin does not exceed 14.5 g/dL even if it is within the normal clinical range. In addition, we also observed significant associations of hemoglobin with 14-day mortality risk (odds ratio [OR] = 0.817; 95% CI, 0.742-0.899 P < .001) and 1-year mortality risk (OR = 0.834; 95% CI, 0.773-0.900; P < .001), but only in participants without risk factors for health care-associated pneumonia (HCAP) rather than in participants with risk factors for HCAP.</p><p><strong>Conclusion: </strong>The greatest discovery is that our findings indicated a significant U-shaped relationship between hemoglobin levels and 14-day and 1-year mortality risk in CAP patients. However, a significant relationship was only discovered in subjects without risk factors for HCAP. More evidence is needed to support this finding.</p>","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":"178-186"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142368079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and hematological profile of patients with pancytopenia at a tertiary medical center in Ethiopia.","authors":"Girum Tesfaye Kiya, Ebissa Dandena, Wondimagegn Adissu, Estifanos Kebede","doi":"10.1093/labmed/lmae077","DOIUrl":"10.1093/labmed/lmae077","url":null,"abstract":"<p><strong>Background: </strong>Pancytopenia is an important hematological problem encountered in routine clinical practice associated with a multitude of disease states. The possible causes of pancytopenia can be influenced by geography, socioeconomic conditions, and endemic illnesses. Information regarding the underlying clinical conditions and morphologic features of blood cells of pancytopenia is limited and varied across different regions. Thus, this study was designed to assess the peripheral morphologic features of blood cells and the underlying clinical causes of pancytopenia.</p><p><strong>Methods: </strong>A facility-based cross-sectional study was conducted at the Jimma Medical Center hematology laboratory from June 13 to November 13, 2022. A total of 3 mL of whole blood was collected from each subject for complete blood count analysis and peripheral blood morphology examination. Data on sociodemographic and clinical conditions were collected from medical records using a checklist. The data were analyzed using Statistical Package for the Social Sciences version 26.</p><p><strong>Results: </strong>A total of 163 patients with pancytopenia were identified within the 5 months. Hyper-reactive malarial splenomegaly was the most prevalent cause (29.4%), followed by megaloblastic anemia (20.2%), chronic liver disease (10.4%), and acute leukemia (8.6%). Anisocytosis was the predominant peripheral blood morphology finding (82.2%), along with microcytosis (49.7%), ovalocytosis (31.3%), and macrocytosis (30.7%). Severe anemia was observed in 57% of cases, whereas the majority (92%) exhibited moderate leukopenia. A significant proportion (42.3%) had a platelet count below 50,000/μL.</p><p><strong>Conclusion: </strong>Unlike previous studies conducted in other parts of the world, this study showed that hyperreactive malarial splenomegaly was the leading cause of pancytopenia. This emphasizes the necessity of considering this condition as a possible cause for pancytopenia, particularly in malaria-endemic areas. The findings of the hematological profiles and peripheral blood morphology strongly suggest that early identification and prompt management of patients with pancytopenia require collaboration between clinical and laboratory investigations.</p>","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":"164-170"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of immunoglobulin preparations on anti-HLA antibody specificity analysis.","authors":"Rie Nakagawa, Hideaki Matsuura, Hayato Kojima, Yuko Abe, Ayuna Yamada, Hiroki Doi, Yasuo Miura","doi":"10.1093/labmed/lmae078","DOIUrl":"10.1093/labmed/lmae078","url":null,"abstract":"<p><strong>Background: </strong>Donor-specific antibodies (DSAs) targeting human leukocyte antigens (HLAs) substantially reduce the longevity of transplanted organs. Desensitization of DSA-positive renal transplant recipients is achieved through intravenous administration of immunoglobulin (IVIg). However, the presence and detectability of anti-HLA antibodies in IVIg preparations following administration are not fully understood. We aimed to assess whether immunoglobulin preparations contain anti-HLA antibodies that can be detected as passive antibodies when administered into the body.</p><p><strong>Methods: </strong>We evaluated 3 immunoglobulin preparations from different pharmaceutical companies, using anti-HLA class I and II antibody specificity tests and immunocomplex capture fluorescence analysis (ICFA).</p><p><strong>Results: </strong>Direct testing for anti-HLA antibodies resulted in high background errors, particularly for Venoglobulin. Diluting Venoglobulin to physiological concentrations revealed the presence of anti-HLA class I antibodies; however, no common alleles were found between the specificity identification test and ICFA.For Glovenin and Venilon, anti-HLA class I and II antibodies were detected; however, variability was observed across different test reagent lots. Moreover, dilution of the globulin formulation revealed a prozone phenomenon.</p><p><strong>Conclusion: </strong>The administration of IVIg complicates the accurate detection of anti-HLA antibodies, underscoring the need for careful interpretation of test results post-IVIg administration.</p>","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":"171-177"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferritin-based biomarkers and their prognostic value in Vietnamese patients with sepsis.","authors":"Phung Thanh Huong, Huu Huy Nguyen, Thi Minh Huyen Pham","doi":"10.1093/labmed/lmae112","DOIUrl":"https://doi.org/10.1093/labmed/lmae112","url":null,"abstract":"<p><strong>Introduction: </strong>Sepsis remains a critical global health challenge because of its high mortality rates and complex pathophysiology. Early and accurate diagnosis and prognosis is pivotal for enhancing clinical outcomes in sepsis management. This study investigates the prognostic implications of serum ferritin, the ferritin index (FI), and the ferritin to lymphocyte ratio (FLR) on septic shock and 28-day mortality among Vietnamese patients with sepsis.</p><p><strong>Methods: </strong>We conducted a retrospective cohort analysis using data from medical records of 89 patients with sepsis.</p><p><strong>Results: </strong>The study establishes FI and procalcitonin cutoffs for discriminating septic shock at 2.29 and 37.15 µg/mL, respectively, with sensitivities of 71.9% and 54.4% and specificities of 56.3% and 77.4%, respectively. Combining FI and procalcitonin enhances predictive capability. Predicting 28-day mortality, serum ferritin, FLR, and Sequential Organ Failure Assessment scores have cutoffs of 828.45 µg/L, 901.41 mg/G, and 10.5, respectively, with varying sensitivities and specificities. Integration of serum ferritin value and FLR with Sequential Organ Failure Assessment score substantially improves predictive accuracy (area under the curve approaching 0.8). Subgroup analysis revealed pronounced associations, particularly serum ferritin, with acute kidney injury (odds ratio = 10.00) and anemia (odds ratio = 11.27) in predicting mortality.</p><p><strong>Discussion: </strong>This study underscores FLR's novel mortality prediction utility and reinforces ferritin biomarkers' prognostic relevance in sepsis, highlighting implications for tailored sepsis management strategies.</p>","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of soluble neural cell adhesion molecule, soluble IL-2 receptor ɑ, and IL-2 in pelvic pain severity and their association with endometriosis in infertile women.","authors":"Fadhil Ahsan, Nanda Yuli Rahmawati, Budi Santoso, Fidyah Nanda Alditia, Alfin Firasy Mufid, Ashon Sa'adi, Sri Ratna Dwiningsih, Arif Tunjungseto, M Y Ardianta Widyanugraha","doi":"10.1093/labmed/lmae107","DOIUrl":"https://doi.org/10.1093/labmed/lmae107","url":null,"abstract":"<p><strong>Introduction: </strong>Pelvic pain, often associated with endometriosis, significantly affects women's quality of life. This study explored the soluble neural cell adhesion molecules (sNCAM), soluble interleukin 2 receptor α (sIL-2Rα), and IL-2 levels in the serum and peritoneal fluid of infertile women with pelvic pain.</p><p><strong>Methods: </strong>We enrolled 86 infertile women aged 24 to 41 years undergoing diagnostic laparoscopy: 44 women with endometriosis and 42 women who acted as controls. Pain intensity was assessed using the visual analog scale. The soluble molecules were measured using enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Serum and peritoneal sNCAM, sIL-2Rα, and IL-2 levels were statistically significantly higher in women with pelvic pain. Both serum and peritoneal sNCAM levels correlated with visual analog scale scores, indicating a relationship between these markers and pain severity. Elevated peritoneal sIL-2Rα levels were also associated with pelvic pain. Receiver operating characteristic curve analysis showed the potential of serum sNCAM in distinguishing between mild and moderate to severe pain.</p><p><strong>Discussion: </strong>Elevated levels of sNCAM, sIL-2Rα, and IL-2 in serum and peritoneal fluid correlate with pelvic pain severity in infertile women, suggesting their involvement in disease pathogenesis and potential as objective biomarkers for pain assessment in endometriosis. Further research is needed to validate these findings for clinical use.</p>","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic stewardship of procalcitonin testing by implementation of computer-based decision support.","authors":"Gina M Belfiore, Christopher A Jankowski, Carmen L Isache, Scott Smith, Matthew Feldhammer","doi":"10.1093/labmed/lmae108","DOIUrl":"https://doi.org/10.1093/labmed/lmae108","url":null,"abstract":"<p><strong>Introduction: </strong>Appropriate test utilization strategies are paramount in preventing the overuse of antibiotics, which can contribute to antimicrobial resistance. Biomarkers such as procalcitonin (PCT) are frequently ordered upon suspicion of infection, but current pneumonia and sepsis guidelines recommend against using PCT alone when initiating antibiotic therapy. The purpose of this study was to evaluate the effectiveness of standardized, guideline-based computerized decision support in curbing the inappropriate ordering of PCT testing.</p><p><strong>Methods: </strong>This study was a retrospective, single-center cohort of hospitalized adult patients with at least 1 available PCT serum level over a 27-month period. Secondary outcomes included the total number of PCT orders, the number of days on antibiotics, and the appropriate antibiotic response rate based on the PCT result.</p><p><strong>Results: </strong>A total of 300 patients met our inclusion criteria for this study. The rate of appropriate PCT ordering increased in the postimplementation group (2% vs 10%), with an increased rate of appropriate ordering in patients with community-acquired pneumonia (4.3% vs 18.4%) and no change in patients with sepsis (0% vs 3.3%). Overall, PCT orders dropped by 78% after implementation of decision support.</p><p><strong>Discussion: </strong>This study demonstrated that the addition of guideline-based computerized clinical decision support increased the rate of diagnostic stewardship for PCT orders.</p>","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serologic detection of regenerating protein I alpha by time-resolved fluoroimmunoassay and its clinical value in gastric cancer.","authors":"Zhongyi Xiang, Xiaoyan Wang, Akao Zhu, Xindong Chen, Yuan Qin, Xiumei Zhou, Xueqin Zhao, Yigang Wang, Biao Huang, Hongming Fang, Pengfei Liu","doi":"10.1093/labmed/lmae106","DOIUrl":"https://doi.org/10.1093/labmed/lmae106","url":null,"abstract":"<p><strong>Background: </strong>Regenerating protein I alpha (REG Iα) plays a key role in the progression of gastric cancer (GC). However, the clinical application value of serum REG Iα in GC remains largely unknown.</p><p><strong>Methods: </strong>Serum REG Iα levels were analyzed through time-resolved fluoroimmunoassay (TRFIA) in healthy controls (HCs) and patients with benign gastric disease (BGD) and GC.</p><p><strong>Results: </strong>The REG Iα levels of patients with GC were significantly higher than those of HCs and patients with BGD (P < .0001). The REG Iα levels were higher in patients with GC with poor pathological differentiation type; tumor, node, and metastasis stages III-IV; deep tumor invasion (T3-T4); and distant metastasis (P < .05). The diagnostic efficiency of the combined REG Iα, carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) tests improved compared with that of the single-indicator test for the diagnosis of patients with GC.</p><p><strong>Conclusion: </strong>REG Iα-TRFIA may facilitate the ancillary diagnosis of GC and have a monitoring role for further progression of GC. It can also help elucidate the possible diagnostic role of serum REG Iα as a noninvasive tool.</p>","PeriodicalId":94124,"journal":{"name":"Laboratory medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}