Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan最新文献

{"title":"Antihypertensive effect of acupuncture involve reshaping gut microbiota and alleviating gut inflammation in spontaneously hypertensive rats.","authors":"Zheng Jie, Ding Zhimin, Chen Tingyu, Lü Zhuan, Zhang Lihong, Liu Yongtao, Zhang Yasu, Jin Xiaoqin, Wang Xinyu, Liu Bin, Feng Xiaodong","doi":"10.19852/j.cnki.jtcm.2026.04.011","DOIUrl":"10.19852/j.cnki.jtcm.2026.04.011","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the antihypertensive effect and mechanism of acupuncture at Renying (ST9) and Zusanli (ST36) from the perspective of gut microbiota.</p><p><strong>Methods: </strong>Eighteen male spontaneously hypertensive rats (SHRs) were randomly divided into the SHR group, the acupuncture group (SHR + A), the sham acupuncture group (SHR + SA), and six Wistar-Kyoto rats were set up as the normotensive control group. 16S ribosomal ribonucleic acid gene sequencing was performed to characterize changes in the gut microbiota. Blood samples were collected to measure inflammatory cytokines using enzyme-linked immunosorbent assay. Hematoxylin and eosin staining was used to assess the degree of colonic damage. Western blotting was performed to evaluate intestinal inflammation.</p><p><strong>Results: </strong>We observed that acupuncture at acupoints Renying (ST9) and Zusanli (ST36) reduced blood pressure in SHRs, modulated microbial beta diversity, increased the abundance of beneficial genera, and reshaped the composition of the intestinal microbiota. In addition, hypertension induced pathological changes in the intestine, along with inflammation and increased permeability. By contrast, acupuncture treatment decreased serum inflammatory cytokine levels and inhibited activation of the toll-like receptor 4/ nuclear factor-kappa B signaling pathway in SHRs, thereby restoring intestinal barrier integrity.</p><p><strong>Conclusions: </strong>Our experimental results indicate that acupuncture exerts a hypotensive effect that is associated with modulation of intestinal inflammation and microbiota, which may offer a new strategy for the prevention and treatment of hypertension.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"907-915"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13495073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baihe Dihuang decoction activates cannabinoid type 2 receptor to regulate microglial polarization and alleviate anxiety-like behavior in chronic restraint stress mice.","authors":"Luo Qiaoyun, Han Yuanshan, Liu Yang, Tang Lin, Wang Tianyu, Wang Yuhong, Zhao Hongqing","doi":"10.19852/j.cnki.jtcm.2026.04.003","DOIUrl":"10.19852/j.cnki.jtcm.2026.04.003","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the anxiolytic effects of Baihe Dihuang decoction (, BDD) and its underlying molecular mechanisms, focusing on cannabinoid type 2 receptor (CB2R)-mediated regulation of microglial polarization and the toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-kappa B (NF-κB) signaling pathway.</p><p><strong>Methods: </strong>A total of 60 male C57BL/6J mice were randomly divided into six groups (<i>n</i>= 10 per group): control group, model group, diazepam (2 mg/kg) group, high-dose BDD (16 g/kg) group, low-dose BDD (8 g/kg) group, and high-dose BDD (16 g/kg) combined with CB2R antagonist AM630 (1 mg/kg) group. Except for the control group, all other groups were subjected to chronic restraint stress (CRS) to establish an anxiety model. Anxiety-like behaviors were assessed using the open field test, light-dark box test, and elevated plus maze. Serum levels of interleukin (IL)-1β, IL-6, IL-10, and IL-4 and amygdala concentrations of 2-arachidonoylglycerol (2-AG) and anandamide (AEA) were quantified by enzyme-linked immunosorbent assay. Hematoxylin and eosin, Nissl, and terminal deoxynucleotidyl transferase dUTP nick-end labeling staining were used to evaluate neuronal damage in the amygdala. Immunofluorescence staining was employed to assess microglial polarization and CB2R expression. The expression levels of CB2R and downstream signaling molecules TLR4/MyD88/NF-κB in the amygdala were determined by quantitative polymerase chain reaction and Western blot.</p><p><strong>Results: </strong>BDD significantly alleviated CRS-induced anxiety-like behaviors and reduced neuronal damage in the amygdala. It downregulated pro-inflammatory cytokines IL-1β, IL-6 and upregulated anti-inflammatory cytokines IL-10, IL-4 in serum while increasing 2-AG and AEA levels in the amygdala. Furthermore, BDD promoted microglial polarization toward the M2 phenotype and enhanced CB2R expression, while suppressing the TLR4/MyD88/NF-κB signaling pathway. The administration of the CB2R antagonist AM630 reversed these effects, confirming the essential role of CB2R activation in the anxiolytic and neuroprotective effects of BDD.</p><p><strong>Conclusion: </strong>BDD treatment activated CB2R, which in turn modulated microglial polarization in the amygdala <i>via</i>the TLR4/MyD88/NF-κB signaling pathway, thereby alleviating anxiety-like behaviors and exerting neuro-protective effects.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"798-808"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture enhances CD8+ T cells recruitmentmodulating sympathetic nervous system to suppress tumor growth in mice bearing triple-negative breast cancer.","authors":"Tian Yehong, Zhang Qiaoli, Zhang Rui, Gao Tao, L I Nanzhi, Huang Jinchang, Jiang Xin, Qiu Xiaowei","doi":"10.19852/j.cnki.jtcm.2026.04.006","DOIUrl":"10.19852/j.cnki.jtcm.2026.04.006","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether peritumoral electroacupuncture (EA) suppresses tumor growth <i>via</i>CD8+ T cell infiltration mediated by sympathetic nervous system (SNS) regulation.</p><p><strong>Methods: </strong>Utilizing a mouse model of triple-negative breast cancer (TNBC), the SNS was activated through chronic restraint stress (CRS); chemical sympathetic denervation was induced by 6-hydroxydopamine (6-OHDA). The anti-tumor and immune regulatory effects of EA were evaluated by multidimensional methods, including <i>in vivo</i>bioluminescence imaging, flow cytometry, immunofluorescence, and enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Peritumoral EA decreased the volume and weight of tumors within 22 d after the implantation. Intratumoral CD8+ T cells significantly increased after EA. C-C motif chemokine ligand 5, as a chemokine that recruits effector T cells to the tumor microenvironment, also up-regulated. Meanwhile, EA reduced intratumoral sympathetic innervation and norepinephrine level. Subsequently, we found CRS significantly accelerates tumor growth and reduces the density of CD8+ T cell infiltration. However, EA reversed the tumor-promoting effect and immune suppression caused by CRS effectively. Furthermore, chemical sympathetic ablation with 6-OHDA revealed that the anti-tumor effect of EA was dependent on sympathetic integrity, as the ablation impaired both tumor-suppressing effect and CD8+ T cell recruitment mediated by EA.</p><p><strong>Conclusion: </strong>EA enhances anti-tumor immunity through SNS emphasizing the effective remodeling of the tumor immune microenvironment in mice with TNBC by neuro-immune interactions.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"832-843"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healing effects of Traditional Chinese Medicine plaster Heiyu Gao on refractory diabetic foot ulcers: a case series of ultra-elderly patients with surgical contraindications.","authors":"Zhang Danyu, W U Chengxiang, W U Yu, G U Jingyu","doi":"10.19852/j.cnki.jtcm.2026.04.021","DOIUrl":"10.19852/j.cnki.jtcm.2026.04.021","url":null,"abstract":"<p><p>Debridement surgery and revascularization are essential procedures for treating refractory diabetic foot ulcers (DFUs). However, a significant therapeutic gap exists for patients deemed at prohibitively high surgical risk. We report a case series of three nonagenarian patients (aged 95, 94, and 96 years) with Wagner grade 4 DFUs in whom conventional treatments had failed and surgery was absolutely contraindicated. Two proprietary Traditional Chinese Medicine (TCM) black plasters, designated as Heiyu Gao A and B based on century-old formulations, were externally applied to the ulcers and surrounding skin. The uniqueness of these cases lies in their extraordinary clinical challenges and remarkable treatment outcomes. Complete ulcer healing was achieved in all patients within 27, 105, and 96 d, respectively, without requiring revascularization or surgical debridement. Treatment demonstrated two novel features: tissue-intelligent selective autolytic debridement targeting only necrotic tissue, and concurrent regenerative repair at wound margins. All patients experienced significant pain reduction within three days of initiating treatment. The healing was characterized by absence of scarring and restoration of normal skin architecture. The follow-up periods ranged from 95 to 580 d, with no recurrence observed. These findings suggest that TCM black plasters may offer an effective alternative for high-risk patients currently relegated to palliative care pathways.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"1018-1025"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese Medicine related factors of planned dialysis in chronic kidney disease stage 5 patients with type 2 diabetes mellitus: a multicenter cross-sectional study.","authors":"Zhang Ruimin, L I Shuang, Q U Yilun, Wang Qian, Xie Huidi, Wang Xiaolong, Duan Shuwei, W U Jie, Wang Yong, Dong Zheyi, Chen Xiangmei","doi":"10.19852/j.cnki.jtcm.2026.04.018","DOIUrl":"10.19852/j.cnki.jtcm.2026.04.018","url":null,"abstract":"<p><strong>Objective: </strong>To clarify the distribution of Traditional Chinese Medicine (TCM) symptoms, syndrome elements and complications in chronic kidney disease stage 5 (CKD5) patients with type 2 diabetes mellitus (T2DM), and to analyze the correlation factors between dialysis and non-dialysis patients, so as to provide reference for clinical syndrome differentiation and treatment.</p><p><strong>Methods: </strong>The general information, laboratory indicators, and TCM syndrome factors of CKD5 patients with T2DM were obtained upon admission. The participants were divided into non-dialysis and dialysis groups according to the treatment methods used. Multivariate logistic regression was used for analysis. The probability of planned dialysis in CKD5 patients with T2DM was calculated by combining multiple TCM syndrome factors, and a receiver operating characteristic curve was drawn.</p><p><strong>Results: </strong>Approximately 77.2% of the study participants were men, with a median age of 59 years. A total of 277 and 95 patients comprised the non-dialysis and dialysis groups, respectively. The median duration of dialysis was 49.6 d. The dialysis group had a significantly higher serum creatinine level; a significantly lower estimated glomerular filtration rate, serum uric acid level, and 24-h urinary protein level; and a significantly lower proportion of patients with atherosclerosis (<i>P <</i> 0.01). The frequencies of Water stagnation pattern, Damp retention pattern, Heart deficiency pattern, and Lung deficiency pattern in the dialysis group were significantly higher (<i>P <</i> 0.01，<i>P</i> < 0.05), while the frequencies of Phlegm turbidity pattern and Kidney deficiency pattern were significantly lower (<i>P <</i> 0.01). Male sex [odds ratio (<i>OR</i>) = 1.780], Heart deficiency pattern (<i>OR</i> = 3.714), <i>Yin</i>deficiency pattern (<i>OR</i> = 2.262), and Water stagnation pattern (<i>OR</i> = 1.984) were factors related to planned dialysis in CKD5 patients with T2DM. The area under the receiver operating characteristic curve for planned dialysis in CKD5 patients with T2DM was 73.8% [95% confidence interval (0.680, 0.797), <i>P</i> < 0.001].</p><p><strong>Conclusions: </strong>Male sex, Heart deficiency pattern, <i>Yin</i>deficiency pattern, and Water stagnation pattern were correlated with planned dialysis in CKD5 patients with T2DM. Kidney deficiency pattern and Phlegm turbidity pattern were correlated with CKD5 patients with T2DM who had not yet started planned dialysis. The study of TCM syndrome elements provides therapeutic ideas for relieving the uncomfortable symptoms of CKD 5 patients with T2DM, and provides reference for clinical syndrome differentiation and treatment.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"982-989"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network pharmacology and experimental validation of asiaticoside protecting against diabetic kidney disease by regulating 11β-hydroxysteroid dehydrogenase type 2.","authors":"Zhu Qin, B I Peng, Zeng Jiali, Zhang Yang, H U Lidan, Cao Zhongkai, Zhu Jingyu, Jin Qinyang","doi":"10.19852/j.cnki.jtcm.2026.03.008","DOIUrl":"10.19852/j.cnki.jtcm.2026.03.008","url":null,"abstract":"<p><strong>Objective: </strong>To explore the protective effects and mechanisms of Asiaticoside (AC) against diabetic kidney disease (DKD) through network pharmacology combined with <i>in vitro</i> and <i>in vivo</i>experiments.</p><p><strong>Methods: </strong>Based on network pharmacology and RNA sequencing (RNA-Seq) analyses, combined with molecular docking, the core targets and signaling pathways of AC in the treatment of DKD were predicted and screened. Subsequently, the therapeutic effect of AC on DKD was validated in db/db mice and SV40-MES-13 cells, and its molecular mechanism was evaluated.</p><p><strong>Results: </strong>Network pharmacology and protein-protein interaction analyses identified 11-beta hydroxysteroid dehydrogenase type 2 (<i>HSD11B2</i>) as a potential key target for AC treatment of DKD. Molecular docking indicated strong affinity between AC derivative and HSD11B2. RNA-Seq analysis showed that AC significantly regulated steroid metabolism under diabetic conditions. In db/db mice, AC reduced urinary protein excretion, improved renal morphology, and protected renal function. AC also dose-dependently inhibited excessive proliferation of SV40-MES-13 cells in a high-glucose environment. Further validation showed that AC upregulated <i>Hsd11b2</i> mRNA expression and HSD11B2 protein levels.</p><p><strong>Conclusion: </strong>AC may alleviate DKD-related pathological processes by regulating <i>Hsd11b2</i> gene expression and HSD11B2 protein levels.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"641-651"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of adolescents and young adults with type 2 diabetes and Traditional Chinese Medicine therapies: a single-center experience in China from 2011 to 2023.","authors":"W U Jing, Wang Le, Guo Xiangyu, Gao Kuo, Liu Jinmin","doi":"10.19852/j.cnki.jtcm.2026.03.010","DOIUrl":"10.19852/j.cnki.jtcm.2026.03.010","url":null,"abstract":"<p><strong>Objective: </strong>To clarify the clinical characteristics of type 2 diabetes in adolescents and young adults (T2DMY) patients, and their treatment strategies involving Traditional Chinese Medicine (TCM) and Western Medicine.</p><p><strong>Methods: </strong>This study was conducted at Dongfang Hospital of Beijing University of TCM. Clinical data of outpatients and inpatients from 2011 to 2023 were retrieved from the electronic medical record database with type 2 diabetes mellitus (T2DM) as the first diagnosis.</p><p><strong>Results: </strong>A total of 405 outpatients and 570 inpatients with T2DMY were included in the analysis. Compared with middle aged and elderly T2DM patients (T2DME), T2DMY patients have a higher proportion of diabetes family history and higher body mass index, poorer control of blood glucose, blood lipid, liver and kidney function, and a higher incidence of non-alcoholic fatty liver disease and gout. In terms of anti-diabetes treatment, T2DMY patients are more likely to receive metformin and insulin drugs. In terms of TCM diagnosis and treatment, compared with T2DME patients, T2DMY patients are more frequently diagnosed with the syndrome of phlegm damp trapped spleen, and more herbs such as Fuling (<i>Poria</i>) and Chenpi (<i>Pericarpium Citri Reticulatae</i>) are more frequently used to invigorate the spleen and dispel dampness.</p><p><strong>Conclusion: </strong>Compared with T2DME patients, T2DMY patients have worse metabolism. In the treatment of TCM, more attention can be paid to the function of the spleen, and the herbal medicine can be used to enhance the function of the spleen and dispell dampness when it is compatible with <i>Qi</i>tonifying drugs.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"706-714"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture-driven exosomes: an emerging therapy.","authors":"Jian Jiawei, Ding Zhimin, Zhuang Yueyang, Wang Junzi, Yang Minguang, Liu Weilin","doi":"10.19852/j.cnki.jtcm.2026.03.017","DOIUrl":"10.19852/j.cnki.jtcm.2026.03.017","url":null,"abstract":"<p><p>Acupuncture, as a significant component of Traditional Chinese Medicine (TCM), has attracted increased attention for its mechanism of controlling the physiological functions of the human body and promoting the recovery of diseases by stimulating specific acupoints. Despite its long history and wide clinical application, the mechanism of action of acupuncture is still not fully understood. More research needs to be done on how acupuncture affects molecular communication and cellular function. Exosomes are nanoscale vesicles that rely on cellular multivesicular bodies (MVBs) fused with cell membranes to be released into the extracellular matrix. They are crucial for information transfer between cells and are currently a hot research topic in the world's cutting-edge life sciences. Previous research has demonstrated that the therapeutic effect of acupuncture may be related to stimulating certain cells to secrete exosomes, that exosomes released may contain \"acupuncture information\", and that manipulating the back-injection of exosomes to produces \"acupuncture-like\" effects. These findings suggest that exosomes could serve as a bridge between conventional acupuncture therapy and modern precision medicine. They also offer fresh prospects and difficulties for acupuncture translational medicine research. To better define the relationship between exosomes and acupuncture, we reviewed and systematized the literature on past studies related to exosomes and acupuncture. This paper provides a significant theoretical and experimental foundation for applying exosomes in precision medicine by summarizing and analyzing the relationship between acupuncture stimulation and exosome function. This is expected to promote the combination of traditional acupuncture therapy and modern biotechnology and bring innovation and progress to future medical practice.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"768-778"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese Medicine for the prevention and treatment of adolescent idiopathic scoliosis: scientific understanding and a multimodal therapeutic approach.","authors":"Lin Kaifeng, Zeng Zhongliao, Sun Yan, Sun Fangzhou, Zhang Han, Sun Jing, Jiang Ling, Jeffrey D Deng, L I Min, Liang Bocheng","doi":"10.19852/j.cnki.jtcm.2026.03.015","DOIUrl":"10.19852/j.cnki.jtcm.2026.03.015","url":null,"abstract":"<p><p>Adolescent Idiopathic Scoliosis (AIS) is a common spinal disorder characterized by deviations in the coronal, sagittal, and axial planes. As AIS progresses with age, it compromises biomechanical function and increasingly impacts pulmonary function and psychological well-being. Bracing and Physiotherapeutic Scoliosis-Specific Exercises (PSSE) are commonly used conservative treatments for AIS. However, Traditional Chinese Medicine (TCM) has been gaining increasing attention in conservative AIS management. This study examines the effectiveness of TCM and its integrative therapies in AIS treatment, with particular emphasis on the foundational TCM concept of \"preventive treatment of disease\". A three-level prevention strategy is proposed, highlighting the importance of early detection, timely treatment, and proactive intervention. This framework aims to promote a scientific understanding of TCM approaches and their synergistic use with other therapies in AIS management, offering new perspectives and potential directions for future.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"745-756"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the anti-apoptotic, anti-platelet aggregation, and pro-angiogenic properties of Naoshuantong capsule in ischemic stroke: insights from network pharmacology and animal experiments.","authors":"L I Chuanpeng, Yao Yaoyao, X U Yingzhi, Jiang Ping, Feng Luda, Gao Ying, Dong Xinglu","doi":"10.19852/j.cnki.jtcm.20260304.001","DOIUrl":"10.19852/j.cnki.jtcm.20260304.001","url":null,"abstract":"<p><strong>Objective: </strong>To explore the complex molecular mechanisms of Naoshuantong capsule (, NST), a Traditional Chinese Medicine formula, against ischemic stroke (IS) using network pharmacology and various experimental verifications.</p><p><strong>Methods: </strong>This study employed an integrative approach that combined network pharmacology with experimental validation. Specifically, a network pharmacology model was developed to clarify the fundamental mechanisms and essential NST targets against IS. The core targets and pathways were verified using molecular docking and animal experiments. Additionally, the predicted effects of NST were confirmed by a series of experimental techniques, including hematoxylin-eosin staining, platelet aggregation, flow cytometry, and Western blotting.</p><p><strong>Results: </strong>A total of 299 targets for overlap of compounds-disease targets were predicted. Protein-protein interaction (PPI) network analysis revealed that the top 30 core targets. Subsequent molecular docking analysis demonstrated that serine-threonine protein kinase 1 (AKT1), phosphoinositide 3-kinase (PI3K), and vascular endothelial growth factor A (VEGFA) have significant binding abilities with these compounds. Gene ontology (GO) enrichment analysis indicated that NST mechanisms against IS involved anti-apoptosis, antiplatelet-aggregation, and angiogenesis ability, confirmed by animal experiments. GO pathway analysis further showed that the mechanism of NST in treating IS was associated PI3K-AKT signaling. Ultimately, this study determined that NST downregulated cleaved-caspase-3 expression while upregulated phosphorylated AKT (P-AKT)/AKT, phosphatidylinositol-4,5-Bisphosphate 3-kinase/PI3K, B-cell lymphoma-2 (Bcl-2)/Bcl-2-associated X protein, and VEGFA expressions.</p><p><strong>Conclusion: </strong>The analysis utilizing multiple approaches manifested that NST has anti-apoptotic, antiplatelet-aggregation, and pro-angiogenic properties in managing IS, offering a systemic outlook for investigating the impact of NST on IS.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"629-640"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}