Journal of the mechanical behavior of biomedical materials最新文献

{"title":"A modal analysis of implant-supported overdentures installed on differently positioned sets of dental implants.","authors":"Mika Tsuno, Hidemi Nakata, S. Kuroda, Munemitsu Miyasaka, T. Sasaki, S. Kasugai, E. Marukawa","doi":"10.2139/ssrn.4196941","DOIUrl":"https://doi.org/10.2139/ssrn.4196941","url":null,"abstract":"This study evaluated the three vibration characteristics, namely, natural frequency, damping ratio, and natural mode, together with maximum displacement of a two-implant-supported overdenture (IOD) at different locator attachment positions using experimental modal analysis (EMA). Edentulous mandibular models with a gingival thickness of 1 mm or 3 mm were prepared, into which dental implants were placed using a fully guided surgical template designed with simulation software, the locator abutments were fastened, and the IODs were then fabricated. The implant positions were bilaterally marked at the lateral incisor, first premolar, and first molar regions. EMA was performed by hammering the test structures to measure the impulse response and obtain the vibration characteristics (n = 5). The Kruskal-Wallis test was performed for natural frequency and maximum displacement, and the Games-Howell test for damping ratio. The significance level was set at α = 0.05. The study indicated that the gingival thickness had a significant effect on the vibration characteristics. Moreover, the natural frequency and damping ratio results showed that the vibration subsided faster when the attachment was placed on the molar implants in the thick gingival model. Furthermore, according to the effect of lateral force on IODs, the difference in maximum displacement between the anterior and posterior regions of the IOD was smaller when the attachments were designed on the pair of lateral incisors. Thus, within the limits of this experiment, our results suggested that two anterior implant-supported IODs are preferable treatment designs in terms of vibration engineering, especially when the gingiva is thick; the molar attachment design could be considered for thin gingival conditions. The differences in gingival thickness and abutment position affected the vibration characteristics of the IOD. Further in vivo studies would be necessary to validate the implant positions and their IOD designs for the mandibular edentulous shapes and the occlusal relationship.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"137 1","pages":"105492"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46021897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimum design requirements for a poroelastic mimic of articular cartilage.","authors":"W. Tan, A. Moore, M. Stevens","doi":"10.2139/ssrn.4207861","DOIUrl":"https://doi.org/10.2139/ssrn.4207861","url":null,"abstract":"The exceptional functional performance of articular cartilage (load-bearing and lubrication) is attributed to its poroelastic structure and resulting interstitial fluid pressure. Despite this, there remains no engineered cartilage repair material capable of achieving physiologically relevant poroelasticity. In this work we develop in silico models to guide the design approach for poroelastic mimics of articular cartilage. We implement the constitutive models in FEBio, a PDE solver for multiphasic mechanics problems in biological and soft materials. We investigate the influence of strain rate, boundary conditions at the contact interface, and fiber modulus on the reaction force and load sharing between the solid and fluid phases. The results agree with the existing literature that when fibers are incorporated the fraction of load supported by fluid pressure is greatly amplified and increases with the fiber modulus. This result demonstrates that a stiff fibrous phase is a primary design requirement for poroelastic mimics of articular cartilage. The poroelastic model is fit to experimental stress-relaxation data from bovine and porcine cartilage to determine if sufficient design constraints have been identified. In addition, we fit experimental data from FiHy™, an engineered material which is claimed to be poroelastic. The fiber-reinforced poroelastic model was able to capture the primary physics of these materials and demonstrates that FiHy™ is beginning to approach a cartilage-like poroelastic response. We also develop a fiber-reinforced poroelastic model with a bonded interface (rigid contact) to fit stress relaxation data from an osteochondral explant and FiHy™ + bone substitute. The model fit quality is similar for both the chondral and osteochondral configurations and clearly captures the first order physics. Based on this, we propose that physiological poroelastic mimics of articular cartilage should be developed under a fiber-reinforced poroelastic framework.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"137 1","pages":"105528"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48556889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manufacturing hydroxyapatite scaffold from snapper scales with green phenolic granules as the space holder material.","authors":"A. Indra, I. Hamid, Jerry Farenza, Nofriady Handra, Anrinal, A. Subardi","doi":"10.2139/ssrn.4208687","DOIUrl":"https://doi.org/10.2139/ssrn.4208687","url":null,"abstract":"Hydroxyapatite (HA) scaffold was made using the powder metallurgy with an use of a space holder method with a pore-forming agent from green phenolic (GP) granules. The novelty of this study was the use of GP granules as an agent that does not melt at high temperatures to avoid damaging the tangential contact between the HA powder during the sintering process. HA from snapper scales was added and mixed with polyvinyl alcohol (PVA) and ethanol to form a slurry. The ethanol content was then removed by drying at room temperature. The HA, which contained PVA, was added with GP granules as a pore-forming agent in various amounts to get the desired porosity. The green body was made using a stainless steel mold with the uniaxial pressing process under a pressure of 100 MPa. To make a scaffold sintered body, a sintering process ran at 1200 °C with a holding time of 2 h while maintaining the heating and cooling rates at 5 °C/min. The physical properties of the scaffold sintered body were characterized through linear shrinkage test, pore measurement, porosity test, phase observation by X-ray diffraction (XRD), and microstructure observation by scanning electron microscopy (SEM) and digital microscopy (DM). So were the mechanical ones through a compressive strength test. The results showed that the sintered body had a compressive strength value of 1.6 MPa at a porosity of 60.7% with a pore size of 129-394 μm. The scaffold contained interconnections between pores at a HA:GP ratio of 55:45 wt%, which matched the condition required for cell tissue growth. The conclusion is that GP granules are good enough to be used as a pore-making agent on scaffolds using the space holder method because they do not damage the tangential contact between the HA powder during the sintering process. However, efforts are needed to remove the remaining GP ash on the scaffold.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"136 1","pages":"105509"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49098107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fracture toughness determination of porcine muscle tissue based on AQLV model derived viscous dissipated energy.","authors":"Othniel J. Aryeetey, Martin Frank, A. Lorenz, D. Pahr","doi":"10.2139/ssrn.4061495","DOIUrl":"https://doi.org/10.2139/ssrn.4061495","url":null,"abstract":"The ability of soft collagenous tissue (SCT) to withstand propagation of a defect in the presence of a macroscopic crack is termed the 'fracture toughness parameter'. In soft tissues not undergoing significant plastic deformation, it is purported that a considerable amount of additional energy is dissipated during failure processes, due to viscoelasticity. Hence the total work, measured experimentally during failure, is the sum of fracture and viscoelastic energies. Previous authors have aimed to apply constitutive modeling to describe viscoelastic hysteresis for fracture toughness determination with a tendency of models to either over or underestimate the viscous energy. In this study, the fracture toughness of porcine muscle tissue is determined using two strategies. Firstly, it was determined experimentally by calculation of the difference in dissipated energy of notched and unnotched tissue specimens undergoing cyclic 'triangular wave' excitation with increasing strain levels in uniaxial tension. The second strategy involved the extension and use of the adaptive quasi-linear viscoelastic model (AQLV) to model cyclic loading (model parameters were obtained from a previous study) and sequentially the dissipated energy was calculated. The mean value of the dissipated energy based on the AQLV approach was then subtracted from the total dissipated energy of notched porcine muscle tissue samples to determine the fracture toughness. The mean experimental viscous dissipated energy ratio was 0.24 ± 0.04 in the experimental approach, compared to 0.28 ± 0.03 for the AQLV model. Fracture toughness determined experimentally yielded 0.84 ± 0.80 kJ/m2, and 0.71 ± 0.76 kJ/m2 for the AQLV model, without a significant difference (p = 0.87). Hence, the AQLV model enables a reasonable estimation of viscous dissipated energy in porcine muscle tissue with the advantage to perform tests only on notched specimens, instead of testing additional unnotched samples. Moreover, the AQLV model will help to better understand the constitutive viscoelastic behaviour of SCTs and might also serve as a basis for future fracture toughness determination with constitutive model simulations.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"135 1","pages":"105429"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48844356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimisation of the additive manufacturing parameters of polylactic acid (PLA) cellular structures for biomedical applications.","authors":"David E. Myers, A. Abdel-Wahab, F. Hafeez, K. Essa, Nikolina Kovacev","doi":"10.2139/ssrn.4115315","DOIUrl":"https://doi.org/10.2139/ssrn.4115315","url":null,"abstract":"Fused deposition modelling (FDM) is an additive manufacturing technology used to create functional and complex geometries directly from computer-generated models. This technique can be utilised to generate cellular structures with controllable pore size, pore shape, and porosity. Cellular structures are fundamental in orthopaedics scaffolds because of its low elastic modulus, high compressive strength, and adequate cell accommodation spaces. This paper aims at investigating and optimising the FDM additive manufacturing process parameters of polylactic Acid (PLA) for two lattice structures namely Schoen Gyroid and Schwarz Primitive. The effect of additive manufacturing critical process parameters including layer height, flow rate, and print speed on the geometrical accuracy and compressive strength of the specimens were analysed. In addition, other parameters that have minimal effect on the geometrical accuracy of the printed parts were discussed. A Full Factorial Analysis (FFA) using Minitab software was undertaken to identify the perfect combination of printing parameters to provide the most geometrically accurate structure. In this study, samples of the Schoen Gyroid and the Schwarz Primitive lattices and a solid control cylinder were 3D printed using the ideal printing combination to assess the manufacturability, the geometrical accuracy, and the mechanical behaviour of both designs. It was found that the optimised FDM process parameters for the studied cellular structures were a layer height of 0.16 mm, a printing speed of 50 mm/s and a flow rate of 90%. As a result of using these parameters, the solid, Schoen Gyroid and Schwarz Primitive specimens demonstrated elastic moduli values of 951 MPa, 264 MPa, and 221 MPa, respectively. In addition, the Schoen Gyroid and the Schwarz Primitive have reached their stress limits at around 8.68 MPa and 7.06 MPa, respectively. It was noticed that the Schoen Gyroid structure exhibited ∼ 18% higher compressive strength and ∼ 16% higher elastic modulus compared to the Schwarz Primitive structure for the same volume fraction of porosity, overall dimensions, and the manufacturing process parameters. Although both structures revealed mechanical properties that fall within the range of the human trabecular bone, but Schoen Gyroid exhibited improved structural integrity performance that is evident by its post-yield behaviour.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"136 1","pages":"105447"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46084998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composition optimization of PLA/PPC/HNT nanocomposites for mandibular fixation plate using single-factor experimental design.","authors":"I. Haneef, Y. Buys, N. Shaffiar, A. A. Abdul Hamid, S. I. S. Shaharuddin, Fitriani","doi":"10.2139/ssrn.4148312","DOIUrl":"https://doi.org/10.2139/ssrn.4148312","url":null,"abstract":"The need to overcome the secondary surgery to remove implanted metal fixation plate leads to the idea of replacing the material with degradable bionanocomposite. In this research, polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %) were considered as the candidate material for mandibular fixation plate. A single-factor design using Design Expert software was used to determine 20 different compositions of PLA/PPC/HNT nanocomposites and their mechanical properties were then measured. The optimization of the PLA/PPC/HNT nanocomposite composition was performed based on the nanocomposite's response to Young's modulus, tensile strength, and elongation at break. Further analysis suggested an optimum composition of 92.5/7.5 PLA/PPC with 6 wt % of HNT. The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"135 1","pages":"105423"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48368000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explant analysis of a Discocerv cervical disc: A case study for a ceramic-on-ceramic cervical disc.","authors":"Göksu Kandemir, A. Bowey, C. Jensen, T. Joyce","doi":"10.2139/ssrn.4101074","DOIUrl":"https://doi.org/10.2139/ssrn.4101074","url":null,"abstract":"Explant analyses are key to better understanding the effectiveness of medical implants in replacing natural joints. For the first time, an explanted Discocerv cervical disc was examined. The implant utilised the articulation of a caudal zirconia cup (inferior component) and a cephalic alumina head (superior component). The articulating surface of the superior alumina head had an average surface roughness of 0.016 ± 0.003 μm (Sa) and the articulating surface of the inferior zirconia cup had an average surface roughness of 0.015 ± 0.002 μm (Sa). Both articulating surfaces had negative skewness, indicating the removal of local peaks. The difference between the average surface roughness of the components was not significant (p-value: 0.741). Dark grey marks were observed on both of the articulating surfaces, which were found to be adhered titanium debris that was generated due to component impingement. This titanium debris may explain the small amount of metallosis that was reported at explantation. Some transfer of zirconium to the alumina articulating surface was also seen.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"135 1","pages":"105473"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48037162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of biodegradable Zn-1Mg-1Mn and Zn-1Mg-1Mn-1HA composites with a polymer-ceramics coating of PLA/HA/TiO2 for orthopaedic applications.","authors":"N. Anand, K. Pal","doi":"10.2139/ssrn.4039434","DOIUrl":"https://doi.org/10.2139/ssrn.4039434","url":null,"abstract":"Zn is a promising biodegradable metal that shows huge potential as bioresorbable implant material as it possesses outstanding biocompatibility and high corrosion resistance than Mg. However, the low value of mechanical strength and hardness has hugely restricted its application. Moreover, incorporating alloying elements have typically magnified its mechanical properties. In the current study, the effect of the alloying component Mn and HA on the Zn-Mg composite and also the effect of polymer-ceramics nanofiber coating on the composite sample was studied. The result shows that the current studied samples were mainly comprised of a primary Zn matrix and a secondary phase of Mg2Zn11. The prepared sample shows very high compressive yield strength (CYS 228 MPa) and hardness (83 HV). The value of corrosion rates of the as-cast Zn-1Mg-1Mn-1HA sample was higher in comparison to that of the as-cast Zn-1Mg-1Mn sample, but after the polymer-ceramics nanofiber coating formation of PLA/HA/TiO2, the values were reduced to a more significant extent and achieved values of 0.01484 mm/year from 0.01892 mm/year in electrochemical tests. Moreover, the coated and uncoated sample shows outstanding hemocompatibility for both samples, but the minimum value is obtained for coated Zn-1Mg-1Mn-1HA sample (2.251%). The viability of MG63 cells cultured in different diluted extracts (25% and 50% extract) of the coated Zn-1Mg-1Mn-1HA sample reached a value greater than 90%, which displayed no possible cytotoxicity for biomedical applications.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"136 1","pages":"105470"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49430558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of build orientation in accuracy, flexural modulus, flexural strength, and microhardness of 3D-Printed resins for provisional restorations.","authors":"E. F. de Castro, G. Nima, F. Rueggeberg, M. Giannini","doi":"10.2139/ssrn.4153617","DOIUrl":"https://doi.org/10.2139/ssrn.4153617","url":null,"abstract":"PURPOSE\u0000This study evaluated the effects of 3D-printing build orientation on accuracy, flexural modulus (FM), flexural strength (FS), and microhardness of selected, commercial 3D-printed provisional resins (3DRs).\u0000\u0000\u0000MATERIAL AND METHODS\u0000PMMA CAD/CAM provisional material (Vita Temp/Vita) served as Control. Four 3DRs (Cosmos-SLA/Yller, Cosmos-DLP/Yller, PriZma-Bioprov/Makertech, Nanolab/Wilcos) were used in three printing orientations (0°, 45°, and 90°). Printed samples were cleaned with isopropyl alcohol prior to post-curing in specific post-curing units. For each group, 20 bar-shaped samples (25 × 2x2 mm) and ten disc-shaped samples (15-mm diameter, 2.5-mm thick) were obtained. The dimensions of bar samples were measured and the mean percent errors were compared to the reference (digital) values to obtain \"accuracy\" (n = 20). Samples were then aged in distilled water at 37 °C and half were submitted to a three-point bend test in a universal testing machine after 24 h and the other half after 1 year (n = 10). Disc samples were polished prior to microhardness evaluation (n = 10). Microstructure and elemental composition of filler particles in the 3DRs were analyzed using scanning electron microscopy (SEM) and energy dispersive x-ray spectroscopy (EDS) (n = 3). Accuracy and microhardness were submitted to two way-, and FM and FS to three way-ANOVA, followed by Tukey's tests. Results of experimental groups were compared to a milled PMMA Control using Dunnett's tests, and Student's t-tests compared FM and FS to Control at different aging periods (α = 0.05).\u0000\u0000\u0000RESULTS\u0000Except for Cosmos-DLP, the 90° orientation demonstrated the best overall accuracy in all dimensions evaluated. The overall accuracy of Cosmos-SLA was not significantly different from Control and higher than other 3DRs. The FM of all 3DRs was lower than Control, regardless of orientation and aging period. After 1 year of aging, FS of 45°-Cosmos-SLA and all orientations of PriZma were not different from Control, while 90°-Cosmos-SLA was higher. Build orientation had no influence on microhardness of the 3DRs: Nanolab was the only resin harder than Control. Very few nanometric spherical filler particles were found in Cosmos-SLA, Cosmos-DLP, and PriZma, while Nanolab presented higher number of particles having irregular shapes and sizes.\u0000\u0000\u0000CONCLUSIONS\u0000In general, although build orientation did not influence microhardness results, the 90° -orientation resulted in the best overall accuracy for most 3DRs. After 1-year water storage, Cosmos-SLA printed vertically showed the highest FS, while the PMMA Control obtained the highest FM for both aging periods.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"136 1","pages":"105479"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48771715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silver-loaded mesoporous silica nanoparticles enhanced the mechanical and antimicrobial properties of 3D printed denture base resin.","authors":"Sultan Aati, Seerat Aneja, Michael Kassar, Ryan Leung, A. Nguyen, Susan Tran, Barsha Shrestha, A. Fawzy","doi":"10.2139/ssrn.4166940","DOIUrl":"https://doi.org/10.2139/ssrn.4166940","url":null,"abstract":"The aim of this study is to develop a novel 3D printed denture base resin material modified with mesoporous silica nanocarrier loaded with silver (Ag/MSN) to enhance mechanical and antimicrobial properties. Acrylate resin-based was incorporated with various proportion of Ag/MSN (0.0-2.0 wt%). Specimens with different geometry were printed and characterized accordingly for the effect of modification on properties such as: mechanical and physical properties, chemical composition and degree of conversion, as well as biological response in term of biocompatibility and antimicrobial against oral fibroblast and candida biofilm (C. albicans), respectively. The consecutive addition of Ag/MSN improved significantly surface hardness and crack propagation resistance, while flexural strength remained similar to control; however, a negligible decrease was observed with higher concentrations ≥1 wt%. No significant difference was noticed with water sorption, while water solubility had a remarkable trend of reduction associated with filler content. The surface roughness significantly increased when concentration of Ag/MSN was ≥1.0 wt%. A significant reduction in C. albicans biofilm mass, as the inhibition proficiency was correlated with the proportion of the filler. With respect to the amount of Ag/MSN, the modification was compatible toward fibroblast cells. The sequential addition of Ag/MSN enhanced significantly the mechanical and antimicrobial properties of the 3D printed resin-based material without affecting adversely compatibility. The acrylic resin denture base material has susceptibility of microbial adhesion which limits its application. Silver loaded MSN showed a significant performance to enhance antimicrobial activity against C. albicans which is the main cause of denture stomatitis. The proposed invention is a promise technique for clinical application to provide an advanced prosthesis fabrication and serve as long-term drug delivery.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"134 1","pages":"105421"},"PeriodicalIF":0.0,"publicationDate":"2022-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46143750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}