以鲷鱼鳞为原料,以绿色酚醛颗粒为支架材料制备羟基磷灰石支架。

A. Indra, I. Hamid, Jerry Farenza, Nofriady Handra, Anrinal, A. Subardi
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引用次数: 1

摘要

羟基磷灰石(HA)支架采用粉末冶金方法,采用空间保持器法,用绿色酚醛(GP)颗粒制备成孔剂。这项研究的新颖之处在于使用GP颗粒作为一种在高温下不熔化的试剂,以避免在烧结过程中破坏HA粉末之间的切向接触。加入来自鲷鱼鳞片的HA并与聚乙烯醇(PVA)和乙醇混合以形成浆料。然后通过在室温下干燥来去除乙醇含量。将含有PVA的HA加入不同量的GP颗粒作为成孔剂,以获得所需的孔隙率。生坯体使用不锈钢模具在100MPa的压力下进行单轴压制工艺制成。为了制造支架烧结体,烧结过程在1200°C下进行,保持时间为2小时,同时将加热和冷却速率保持在5°C/分钟。通过线性收缩试验、孔隙测量、孔隙率试验、X射线衍射(XRD)相观察以及扫描电子显微镜(SEM)和数字显微镜(DM)微观结构观察,对支架烧结体的物理性能进行了表征。通过抗压强度测试得到的力学模型也是如此。结果表明,烧结体的抗压强度值为1.6MPa,孔隙率为60.7%,孔径为129-394μm。支架包含孔之间的互连,HA:GP比率为55:45wt%,这与细胞组织生长所需的条件相匹配。结论是,GP颗粒足够好,可以用作空间支架法支架上的造孔剂,因为它们在烧结过程中不会破坏HA粉末之间的切向接触。然而,需要努力清除脚手架上残留的GP灰。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Manufacturing hydroxyapatite scaffold from snapper scales with green phenolic granules as the space holder material.
Hydroxyapatite (HA) scaffold was made using the powder metallurgy with an use of a space holder method with a pore-forming agent from green phenolic (GP) granules. The novelty of this study was the use of GP granules as an agent that does not melt at high temperatures to avoid damaging the tangential contact between the HA powder during the sintering process. HA from snapper scales was added and mixed with polyvinyl alcohol (PVA) and ethanol to form a slurry. The ethanol content was then removed by drying at room temperature. The HA, which contained PVA, was added with GP granules as a pore-forming agent in various amounts to get the desired porosity. The green body was made using a stainless steel mold with the uniaxial pressing process under a pressure of 100 MPa. To make a scaffold sintered body, a sintering process ran at 1200 °C with a holding time of 2 h while maintaining the heating and cooling rates at 5 °C/min. The physical properties of the scaffold sintered body were characterized through linear shrinkage test, pore measurement, porosity test, phase observation by X-ray diffraction (XRD), and microstructure observation by scanning electron microscopy (SEM) and digital microscopy (DM). So were the mechanical ones through a compressive strength test. The results showed that the sintered body had a compressive strength value of 1.6 MPa at a porosity of 60.7% with a pore size of 129-394 μm. The scaffold contained interconnections between pores at a HA:GP ratio of 55:45 wt%, which matched the condition required for cell tissue growth. The conclusion is that GP granules are good enough to be used as a pore-making agent on scaffolds using the space holder method because they do not damage the tangential contact between the HA powder during the sintering process. However, efforts are needed to remove the remaining GP ash on the scaffold.
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