Journal of the mechanical behavior of biomedical materials最新文献

{"title":"Coupled compressible flow and hyperelastic deformation in gas-driven channels within brain tissue with forensic applications.","authors":"Valentina Kosmerl, Alexander L Yarin","doi":"10.1016/j.jmbbm.2026.107686","DOIUrl":"https://doi.org/10.1016/j.jmbbm.2026.107686","url":null,"abstract":"<p><p>The present work is devoted to simulations of muzzle-gas/air penetration into bullet channels of different orientation in brain tissue in human skull after short-range shooting. This involves compressible gas penetration and flow in a channel created by a supersonic bullet. The gas presses onto the channel wall and the surrounding hyperelastic brain tissue yields. As a result, the channel expands manifesting the so-called cavitation. The expanding channel interacts with the nearby parts of the skull, which restricts the brain tissue motion and causes appearance of the overloaded sections of the channel and the loss of its original axial symmetry. Channel contraction is also observed. The results might be important as a forensic tool capable of distinguishing between genuine suicide or a homicide staged as a suicide.</p>","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"185 ","pages":"107686"},"PeriodicalIF":3.5,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical properties of Zr-2.5Nb porous structures with different porosities produced by electron beam powder bed fusion.","authors":"Huixia Li, Kangkang Cheng, Yu Wang, Jiamin Zou, Hong Wu, Changshu Xiang, Kaiyang Li, Naiqiang Zhang","doi":"10.1016/j.jmbbm.2026.107684","DOIUrl":"https://doi.org/10.1016/j.jmbbm.2026.107684","url":null,"abstract":"<p><p>Additive manufacturing enables the fabrication of porous metallic lattices with complex architectures. However, porous structures fabricated from conventional materials such as Ti-6Al-4V may exhibit limited ductility under certain loading conditions, motivating the exploration of alternative alloys. In this work, Zr-2.5Nb porous structures with a wide range of tailored porosities (64.4%-86.5%) were fabricated via electron beam powder bed fusion (EB-PBF). By adjusting the single-spot energy input, target porosities were systematically achieved, enabling a dedicated investigation of the porosity-property relationship. Mechanical properties were evaluated on samples within the porosity range of 64.4%-76.8%. Comprehensive mechanical evaluations (compression, bending, and tension) revealed that porosity serves as the dominant design variable: decreasing the porosity from 76.8% to 64.4% substantially enhanced the elastic modulus (0.81 to 2.36 GPa), compressive yield strength (21.9 to 64.7 MPa), bending yield strength (35.7 to 81.6 MPa), and tensile yield strength (14.0 to 45.9 MPa). These values fall within the range of human cancellous bone, suggesting potential relevance to bone replacement applications, though direct biological validation is required. Notably, the EB-PBF fabricated Zr-2.5Nb structures exhibited progressive compressive yielding without strut fracture, indicating sustained energy absorption capacity. The mechanical responses under all three loading modes were fitted using the Gibson-Ashby model, revealing a strong power-law dependence on relative density (exponents 2.19-2.54), which provides a quantitative framework for predicting mechanical behavior across the investigated porosity range. These results demonstrate that relative density governs the mechanical performance of EB-PBF Zr-2.5Nb porous lattices, establishing a porosity-centric design foundation for load-bearing orthopedic implants.</p>","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"185 ","pages":"107684"},"PeriodicalIF":3.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of right ventricular outflow tract material properties on simulated transcatheter pulmonary placement.","authors":"Jalaj Maheshwari, Wensi Wu, Christopher N Zelonis, Steve A Maas, Kyle Sunderland, Yuval Barak-Corren, Stephen Ching, Patricia Sabin, Andras Lasso, Matthew J Gillespie, Jeffrey A Weiss, Matthew A Jolley","doi":"10.1016/j.jmbbm.2026.107642","DOIUrl":"https://doi.org/10.1016/j.jmbbm.2026.107642","url":null,"abstract":"<p><p>Finite element (FE) simulations emulating transcatheter pulmonary valve (TPV) system deployment in patient-specific right ventricular outflow tracts (RVOT) assume material properties for the RVOT and adjacent tissues. Sensitivity of the deployment to variation in RVOT material properties is unknown. Moreover, the effect of a transannular patch stiffness and location on simulated TPV deployment has not been explored. A sensitivity analysis on the material properties of a patient-specific RVOT during TPV deployment, modeled as an uncoupled HGO material, was conducted using FEBioUncertainSCI. Further, the effects of a transannular patch during TPV deployment were analyzed by considering two patch locations and four patch stiffnesses. Visualization of results and quantification were performed using custom metrics implemented in SlicerHeart and FEBio. Sensitivity analysis revealed that the shear modulus of the ground matrix (c), fiber modulus (k₁), fiber dispersion (κ), and fiber mean orientation angle (γ) had the greatest effect on 95th %ile stress, whereas only c had the greatest effect on 95th %ile Lagrangian strain. First-order sensitivity indices contributed the greatest to the total-order sensitivity indices. Simulations using a transannular patch revealed that peak stress and strain were dependent on patch location and the underlying vessel geometry, with increasing patch stiffness modulating the magnitude of local stress concentrations. As stiffness of the patch increased, greater stress was observed at the interface connecting the patch to the RVOT, and stress in the patch itself increased while strain decreased. The total enclosed volume by the TPV device remained unchanged across all simulated patch cases. This study highlights that while uncertainties in tissue material properties and patch locations may influence functional outcomes, FE simulations provide a reliable framework for evaluating these outcomes in TPVR.</p>","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"185 ","pages":"107642"},"PeriodicalIF":3.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strontium oxide-functionalized 3D-printed polycaprolactone/β-tricalcium phosphate nanocomposite scaffolds with osteogenic microenvironment remodeling for accelerated bone regeneration.","authors":"Song Fuxiang, Ze Lalai A Di Li, Wang Zhili, Ling Yunxiao, Zhao Qianjuan, Liu Bin","doi":"10.1016/j.jmbbm.2025.107146","DOIUrl":"10.1016/j.jmbbm.2025.107146","url":null,"abstract":"<p><p>The repair of critical bone defects resulting from trauma, infection, tumors, and congenital malformations poses significant clinical challenges. The combination of medical-grade polycaprolactone (PCL) and β-tricalcium phosphate (β-TCP) is widely investigated for developing synthetic bone graft substitutes, attracting considerable interest in regenerative medicine. However, the material's inherent lack of osteogenic capacity remains a bottleneck to its widespread clinical application. This study synthesized a strontium oxide (SrO)-functionalized three-dimensional (3D)-printed polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) composite scaffold. Gradient SrO-doped (0-2.0 wt %) 3D printed scaffolds (3D PTSr) were fabricated by melt blending and direct ink writing (DIW) technology, and their physicochemical and biological properties were systematically characterized. Scanning electron microscopy (SEM) showed that the 3D PTSr scaffold had a precisely regulated macroscopic pore structure (pore size ∼ 1 mm) and uniformly distributed Sr element. When the doping amount of SrO was 1.5 wt %, the scaffold exhibited the best comprehensive performance: the surface contact angle was reduced to 64.78° ± 0.54°, and the weight loss rate was 42.83 ± 0.02 % after 4 weeks of in vitro degradation. At the same time, it showed the sustained release characteristics of Sr²⁺ for 56 days (cumulative release of 10.42 ppm). Mechanical tests showed that the compressive strength (5.64 ± 0.04 MPa) and tensile strength (2.75 ± 0.16 MPa) were significantly better than the control group (p < 0.05). In vitro biomimetic mineralization experiments confirmed that SrO functionalization facilitated dense calcium-phosphate composite layer formation. In vitro experiments demonstrated that the 3D PTSr1.5 scaffold significantly promoted the proliferation of MC3T3-E1 cells, and its osteogenic differentiation ability was verified by increasing alkaline phosphatase (ALP) activity and calcium nodule formation. Implantation of 3D PTSr1.5 scaffold into rat cranial defects significantly enhanced bone regeneration at 12 weeks versus controls. Histological analysis confirmed substantial regeneration of mature bone tissue and collagen fibers within the defect area. This study reveals the molecular mechanism of SrO functionalization promoting bone regeneration by regulating the synergistic effect of material degradation-ion release-topology, and provides a theoretical basis and technical reserve for the development of next-generation intelligent bone repair materials.</p>","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"172 ","pages":"107146"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An improved trabecular bone model based on Voronoi tessellation.","authors":"Yijun Zhou, P. Isaksson, C. Persson","doi":"10.2139/ssrn.4327657","DOIUrl":"https://doi.org/10.2139/ssrn.4327657","url":null,"abstract":"BACKGROUND AND OBJECTIVE\u0000Accurate numerical and physical models of trabecular bone, correctly representing its complexity and variability, could be highly advantageous in the development of e.g. new bone-anchored implants due to the limited availability of real bone. Several Voronoi tessellation-based porous models have been reported in the literature, attempting to mimic the trabecular bone. However, these models have been limited to lattice rod-like structures, which are only structurally representative of very high-porosity trabecular bone. The objective of this study was to provide an improved model, more representative of trabecular bone of different porosity.\u0000\u0000\u0000METHODS\u0000Boolean operations were utilized to merge scaled Voronoi cells, thereby introducing different structural patterns, controlling porosity and to some extent anisotropy. The mechanical properties of the structures were evaluated using analytical estimations, numerical simulations, and experimental compression tests of 3D-printed versions of the structures. The capacity of the developed models to represent trabecular bone was assessed by comparing some key geometric features with trabecular bone characterized in previous studies.\u0000\u0000\u0000RESULTS\u0000The models gave the possibility to provide pore interconnectivity at relatively low porosities as well as both plate- and rod-like structures. The mechanical properties of the generated models were predictable with numerical simulations as well as an analytical approach. The permeability was found to be better than Sawbones at the same porosity. The models also showed the capability of matching e.g. some vertebral structures for key geometric features.\u0000\u0000\u0000CONCLUSIONS\u0000An improved numerical model for mimicking trabecular bone structures was successfully developed using Voronoi tessellation and Boolean operations. This is expected to benefit both computational and experimental studies by providing a more diverse and representative structure of trabecular bone.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"62 1","pages":"106172"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91177604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-specific finite element analysis of human corneal lenticules: An experimental and numerical study.","authors":"M. Nambiar, Layko Liechti, Harald P. Studer, A. S. Roy, T. Seiler, P. Büchler","doi":"10.2139/ssrn.4378257","DOIUrl":"https://doi.org/10.2139/ssrn.4378257","url":null,"abstract":"The number of elective refractive surgeries is constantly increasing due to the drastic increase in myopia prevalence. Since corneal biomechanics are critical to human vision, accurate modeling is essential to improve surgical planning and optimize the results of laser vision correction. In this study, we present a numerical model of the anterior cornea of young patients who are candidates for laser vision correction. Model parameters were determined from uniaxial tests performed on lenticules of patients undergoing refractive surgery by means of lenticule extraction, using patient-specific models of the lenticules. The models also took into account the known orientation of collagen fibers in the tissue, which have an isotropic distribution in the corneal plane, while they are aligned along the corneal curvature and have a low dispersion outside the corneal plane. The model was able to reproduce the experimental data well with only three parameters. These parameters, determined using a realistic fiber distribution, yielded lower values than those reported in the literature. Accurate characterization and modeling of the cornea of young patients is essential to study better refractive surgery for the population undergoing these treatments, to develop in silico models that take corneal biomechanics into account when planning refractive surgery, and to provide a basis for improving visual outcomes in the rapidly growing population undergoing these treatments.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"147 1","pages":"106141"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44775455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical characterisation of commercial artificial skin models.","authors":"Antony S. K. Kho, Steve Béguin, E. O’Cearbhaill, A. N. Annaidh","doi":"10.2139/ssrn.4378258","DOIUrl":"https://doi.org/10.2139/ssrn.4378258","url":null,"abstract":"Understanding of the mechanical properties of skin is crucial in evaluating the performance of skin-interfacing medical devices. Artificial skin models (ASMs) have rapidly gained attention as they are able to overcome the challenges in ethically sourcing consistent and representative ex vivo animal or human tissue models. Although some ASMs have become commercialised, a thorough understanding of the mechanical properties of the skin models is crucial to ensure that they are suitable for the purpose of the study. In the present study, skin and fat layers of ASMs (Simulab®, LifeLike®, SynDaver® and Parafilm®) were mechanically characterised through hardness, needle insertion, tensile and compression testing. Different boundary constraint conditions (minimally and highly constrained) were investigated for needle insertion testing, while anisotropic properties of the skin models were investigated through different specimen orientations during tensile testing. Analysis of variance (ANOVA) tests were performed to compare the mechanical properties between the skin models. Properties of the skin models were compared against literature to determine the suitability of the skin models based on the material property of interest. All skin models offer relatively consistent mechanical performance, providing a solid basis for benchtop evaluation of skin-interfacing medical device performance. Through prioritising models with mechanical properties that are consistent with human skin data, and with limited variance, researchers can use the data presented here as a toolbox to select the most appropriate ASM for their particular application.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"147 1","pages":"106090"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42559157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multistep deformation of helical fiber electrospun scaffold toward cardiac patches development.","authors":"A. Alattar, E. Gkouti, A. Czekanski","doi":"10.2139/ssrn.4340642","DOIUrl":"https://doi.org/10.2139/ssrn.4340642","url":null,"abstract":"The scaffolds used for cardiac patches must mimic the viscoelastic behavior of the native tissue, which expands up to high deformation levels of its sedentary size during the systole segment of pumping blood. In our study, we exposed fabricated electrospun samples to repeated multistep tension by applying and removing deformation to mimic the mechanical behavior of helical fibered cardiac scaffolds. Since the fiber-based specimens exhibit viscoelastic behavior, the transient responses to constant deformation caused stress relaxation and stress recovery. However, these transient viscoelastic operations performed at high strain enable unpredictable phenomena, usually hidden behind stress softening and folding (plasticity) phenomena; the material significantly reduces the required stress, and remaining deformation occurs. Thus, by regulating the fabrication (electrospinning parameters) process and preconditioning before setting, the actual viscoelastic behavior of the electrospun scaffolds will be evident, as well as their limitations towards their application to cardiac patches development.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"147 1","pages":"106157"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42096387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication and characterisation of bioglass and hydroxyapatite-filled scaffolds.","authors":"Laura Mendoza-Cerezo, J. Rodríguez-Rego, Anabel Soriano-Carrera, Alfonso C. Marcos-Romero, A. Macías-García","doi":"10.2139/ssrn.4388787","DOIUrl":"https://doi.org/10.2139/ssrn.4388787","url":null,"abstract":"Tissue engineering is a continuously evolving field. One of the main lines of research in this field focuses on the replacement of bone defects with materials designed to interact with the cells of a living organism in order to provide the body with a structure on which new tissues can easily grow. Among the most commonly used materials are bioglasses, which are frequently used due to their versatility and good properties. This article discusses the results of the production of an injectable paste of Bioglass® 45S5 and hydroxyapatite on a 3D printed porous structure by additive manufacturing, using a thermoplastic (PLA). The results were evaluated in a specific application of the paste, so the mechanical and bioactive properties were studied to show the multiple possibilities of using this combination for its application in regenerative medicine and more specifically in bone implants.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"144 1","pages":"105937"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42538234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strength and ductility loss of Magnesium-Gadolinium due to corrosion in physiological environment: Experiments and modeling.","authors":"D. Steglich, J. Besson, Inken Reinke, H. Helmholz, M. Luczak, V. Garamus, B. Wiese, D. Höche, C. Cyron, R. Willumeit-Römer","doi":"10.2139/ssrn.4385334","DOIUrl":"https://doi.org/10.2139/ssrn.4385334","url":null,"abstract":"We propose a computational framework to study the effect of corrosion on the mechanical strength of magnesium (Mg) samples. Our work is motivated by the need to predict the residual strength of biomedical Mg implants after a given period of degradation in a physiological environment. To model corrosion, a mass-diffusion type model is used that accounts for localised corrosion using Weibull statistics. The overall mass loss is prescribed (e.g., based on experimental data). The mechanical behaviour of the Mg samples is modeled by a state-of-the-art Cazacu-Plunkett-Barlat plasticity model with a coupled damage model. This allowed us to study how Mg degradation in immersed samples reduces the mechanical strength over time. We performed a large number of in vitro corrosion experiments and mechanical tests to validate our computational framework. Our framework could predict both the experimentally observed loss of mechanical strength and the ductility due to corrosion for both tension and compression tests.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"144 1","pages":"105939"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43713158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}