Journal of the mechanical behavior of biomedical materials最新文献

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Material extrusion of thermoplastic acrylic for intraoral devices: Technical feasibility and evaluation. 口腔内装置用热塑性丙烯酸材料挤出:技术可行性和评价。
Journal of the mechanical behavior of biomedical materials Pub Date : 2023-06-01 DOI: 10.2139/ssrn.4354976
G. Ankit, Frank Alifui-Segbaya, S. Hasanov, Alan R. White, K. E. Ahmed, Robert M. Love, I. Fidan
{"title":"Material extrusion of thermoplastic acrylic for intraoral devices: Technical feasibility and evaluation.","authors":"G. Ankit, Frank Alifui-Segbaya, S. Hasanov, Alan R. White, K. E. Ahmed, Robert M. Love, I. Fidan","doi":"10.2139/ssrn.4354976","DOIUrl":"https://doi.org/10.2139/ssrn.4354976","url":null,"abstract":"With global demand for 3D printed medical devices on the rise, the search for safer, inexpensive, and sustainable methods is timely. Herein, we assessed the practicality of the material extrusion process for acrylic denture bases of which successful outcomes can be extended to implant surgical guides, orthodontic splints, impression trays, record bases and obturators for cleft palates or other maxillary defects. Representative materials comprising denture prototypes and test samples were designed and built with in-house polymethylmethacrylate filaments using varying print directions (PDs), layer heights (LHs) and reinforcements (RFs) with short glass fiber. The study undertook a comprehensive evaluation of the materials to determine their flexural, fracture, and thermal properties. Additional analyses for tensile and compressive properties, chemical composition, residual monomer, and surface roughness (Ra) were completed for parts with optimum parameters. Micrographic analysis of the acrylic composites revealed adequate fiber-matrix compatibility and predictably, their mechanical properties improved simultaneously with RFs and decreased LHs. Fiber reinforcement also improved the overall thermal conductivity of the materials. Ra, on the other hand, improved visibly with decreased RFs and LHs and the prototypes were effortlessly polished and characterized with veneering composites to mimic gingival tissues. In terms of chemical stability, the residual methyl methacrylate monomer contents are well below standards threshold for biological reactions. Notably, 5 vol% acrylic composites built with 0.05 mm LH in 0° on z-axis produced optimum properties that are superior to those of conventional acrylic, milled acrylic and 3D printed photopolymers. Finite element modeling successfully replicated the tensile properties of the prototypes. It may well be argued that the material extrusion process is cost-effective; however, the speed of manufacturing could be longer than that of established methods. Although the mean Ra is within an acceptable range, mandatory manual finishing and aesthetic pigmentation are required for long-term intraoral use. At a proof-of-concept level, it is evident that the material extrusion process can be applied to build inexpensive, safe, and robust thermoplastic acrylic devices. The broad outcomes of this novel study are equally worthy of academic reflection, and further translation to the clinic.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"143 1","pages":"105950"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47299822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effects of washing solution temperature on the biocompatibility and mechanical properties of 3D-Printed dental resin material. 洗液温度对3d打印牙科树脂材料生物相容性和力学性能的影响。
Journal of the mechanical behavior of biomedical materials Pub Date : 2023-05-01 DOI: 10.2139/ssrn.4388792
Rojee Oh, Jung-Hwa Lim, Chanhyeon Lee, Keun-Woo Lee, Sungyong Kim, Jong-Eun Kim
{"title":"Effects of washing solution temperature on the biocompatibility and mechanical properties of 3D-Printed dental resin material.","authors":"Rojee Oh, Jung-Hwa Lim, Chanhyeon Lee, Keun-Woo Lee, Sungyong Kim, Jong-Eun Kim","doi":"10.2139/ssrn.4388792","DOIUrl":"https://doi.org/10.2139/ssrn.4388792","url":null,"abstract":"The use of digital manufacturing, particularly additive manufacturing using three-dimensional (3D) printing, is expanding in the field of dentistry. 3D-printed resin appliances must undergo an essential process, post-washing, to remove residual monomers; however, the effect of the washing solution temperature on the biocompatibility and mechanical properties remains unclear. Therefore, we processed 3D-printed resin samples under different post-washing temperatures (without temperature control (N/T), 30 °C, 40 °C, and 50 °C) for different durations (5, 10, 15, 30, and 60 min) and evaluated the degree of conversion rate, cell viability, flexural strength, and Vickers hardness. Increasing the washing solution temperature significantly improved the degree of conversion rate and cell viability. Conversely, increasing the solution temperature and time decreased the flexural strength and microhardness. This study confirmed that the washing temperature and time influence the mechanical and biological properties of the 3D-printed resin. Washing 3D-printed resin at 30 °C for 30 min was most efficient to maintain optimal biocompatibility and minimize changes of mechanical properties.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"143 1","pages":"105906"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46103480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Y-TZP/MWCNT-SiO2 nanocomposite for dental protheses. 牙科假体用Y-TZP/MWCNT-SiO2纳米复合材料的研制。
Journal of the mechanical behavior of biomedical materials Pub Date : 2023-05-01 DOI: 10.2139/ssrn.4388790
L. H. Da Silva, Laura Ajamil Rinaldi, D. Lazar, V. Ussui, R. Tango, R. Belli, U. Lohbauer, P. Cesar
{"title":"Development of Y-TZP/MWCNT-SiO2 nanocomposite for dental protheses.","authors":"L. H. Da Silva, Laura Ajamil Rinaldi, D. Lazar, V. Ussui, R. Tango, R. Belli, U. Lohbauer, P. Cesar","doi":"10.2139/ssrn.4388790","DOIUrl":"https://doi.org/10.2139/ssrn.4388790","url":null,"abstract":"Y-TZP/MWCNT-SiO2 nanocomposite was synthesized by co-precipitation and hydrothermal treatment methods. After the characterization of the MWCNT-SiO2 powder, specimens were obtained from the synthesized material Y-TZP/MWCNT-SiO2 by uniaxial pressing for a second characterization and later comparison of its optical and mechanical properties with the conventional Y-TZP. The MWCNT-SiO2 was presented in bundles of carbon nanotubes coated by silica (mean length: 5.10 ± 1.34 μm /D90: 6.9 μm). The composite manufactured was opaque (contrast ratio: 0.9929 ± 0.0012) and had a white color with a slightly difference from the conventional Y-TZP (ΔE00: 4.4 ± 2.2) color. The mechanical properties of Y-TZP/MWCNT-SiO2: vickers hardness (10.14 ± 1.27 GPa; p = 0.25) and fracture toughness (4.98 ± 0.30 MPa m1/2; p = 0.39), showed no significant difference from the conventional Y-TZP (hardness: 8.87 ± 0.89; fracture toughness: 4.98 ± 0.30 MPa m1/2). However, for flexural strength (p = 0.003), a lower value was obtained for Y-TZP/MWCNT-SiO2 (299.4 ± 30.5 MPa) when compared to the control Y-TZP (623.7 ± 108.8 MPa). The manufactured Y-TZP/MWCNT-SiO2 composite presented satisfactory optical properties, however the co-precipitation and hydrothermal treatment methods need to be optimized to avoid the formation of porosities and strong agglomerates, both from Y-TZP particles and MWCNT-SiO2 bundles, which lead to a significant decrease in the material flexural strength.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"143 1","pages":"105888"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45096493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A finite porous-viscoelastic model capturing mechanical behavior of human cervix under multi-step spherical indentation. 一个有限多孔粘弹性模型捕捉了人类宫颈在多步球形压痕下的力学行为。
Journal of the mechanical behavior of biomedical materials Pub Date : 2023-05-01 DOI: 10.2139/ssrn.4348162
Lei Shi, K. Myers
{"title":"A finite porous-viscoelastic model capturing mechanical behavior of human cervix under multi-step spherical indentation.","authors":"Lei Shi, K. Myers","doi":"10.2139/ssrn.4348162","DOIUrl":"https://doi.org/10.2139/ssrn.4348162","url":null,"abstract":"The cervix is a soft tissue exhibiting time-dependent behavior under mechanical loads. The cervix is a vital mechanical barrier to protect the growing fetus. The remodeling of the cervical tissue, characterized by an increase in time-dependent material properties, is necessary for a safe parturition. The failure of its mechanical function and accelerated tissue remodeling is hypothesized to lead to preterm birth, which is birth before 37 weeks of gestation. To understand the mechanism of the time-dependent behavior of the cervix under compressive states, we employ a porous-viscoelastic material model to describe a set of spherical indentation tests performed on nonpregnant and term pregnant tissue. A genetic algorithm-based inverse finite element analysis is used to fit the force-relaxation data by optimizing the material parameters, and the statistical analysis of the optimized material parameters is conducted on different sample groups. The force response is captured well using the porous-viscoelastic model. The indentation force-relaxation of the cervix is explained by the porous effects and the intrinsic viscoelastic properties of the extracellular matrix (ECM) microstructure. The hydraulic permeability obtained from the inverse finite element analysis agrees with the trend of the value directly measured previously by our group. The nonpregnant samples are found significantly more permeable than the pregnant samples. Within nonpregnant samples, the posterior internal os is found significantly less permeable than the anterior and posterior external os. The proposed model exhibits the superior capability to capture the force-relaxation response of the cervix under indentation, as compared to the conventional quasi-linear viscoelastic framework (range of r2 of the porous-viscoelastic model 0.88-0.98 vs. quasi-linear model: 0.67-0.89). As a constitutive model with a relatively simple form, the porous-viscoelastic framework has the potential to be used to understand disease mechanisms of premature cervical remodeling, model contact of the cervix with biomedical devices, and interpret force readings from novel in-vivo measurement tools such as an aspiration device.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"143 1","pages":"105875"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48954781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tensile properties of freeze-cast collagen scaffolds: How processing conditions affect structure and performance in the dry and fully hydrated states. 冷冻铸造胶原支架的拉伸性能:加工条件如何影响干燥和完全水合状态下的结构和性能。
Journal of the mechanical behavior of biomedical materials Pub Date : 2023-05-01 DOI: 10.2139/ssrn.4340647
Isabella Caruso, Kaiyang Yin, P. Divakar, U. Wegst
{"title":"Tensile properties of freeze-cast collagen scaffolds: How processing conditions affect structure and performance in the dry and fully hydrated states.","authors":"Isabella Caruso, Kaiyang Yin, P. Divakar, U. Wegst","doi":"10.2139/ssrn.4340647","DOIUrl":"https://doi.org/10.2139/ssrn.4340647","url":null,"abstract":"Tensile properties of directionally freeze-cast biopolymer scaffolds are rarely reported, even though they are of interest from a fundamental science perspective and critical in applications such as scaffolds for the regeneration of nerves or when used as ureteral stents. The focus of this study is on collagen scaffolds freeze-cast with two different applied cooling rates (10 °C/min and 1 °C/min) in two freezing directions (longitudinal and radial). Reported are the results of a systematic structural characterization of dry scaffolds by scanning electron microscopy and the mechanical characterization in tension of both dry and fully hydrated scaffolds. Systematic structure-property-processing correlations are obtained for a comparison of the tensile performance of longitudinally and radially freeze-cast collagen scaffolds with their performance in compression. Collated, the correlations, obtained both in tension in this study and in compression for collagen and chitosan in two earlier reports, not only enable the custom-design of freeze-cast biopolymer scaffolds for biomedical applications but also provide new insights into similarities and differences of scaffold and cell-wall structure formation during the directional solidification of \"smooth\" and \"fibrillar\" biopolymers.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"144 1","pages":"105897"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46201433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of swelling and anatomical location on the viscoelastic behavior of the porcine urinary bladder wall. 肿胀和解剖位置对猪膀胱壁粘弹性行为的影响。
Journal of the mechanical behavior of biomedical materials Pub Date : 2023-05-01 DOI: 10.2139/ssrn.4326307
Tyler G. Tuttle, D. McClintock, S. Roccabianca
{"title":"Effects of swelling and anatomical location on the viscoelastic behavior of the porcine urinary bladder wall.","authors":"Tyler G. Tuttle, D. McClintock, S. Roccabianca","doi":"10.2139/ssrn.4326307","DOIUrl":"https://doi.org/10.2139/ssrn.4326307","url":null,"abstract":"The ability of the urinary bladder to perform its physiological function depends largely on its mechanical characteristics. Understanding the mechanics of this tissue is crucial to the development of accurate models of not just this specific organ, but of the pelvic floor overall. In this study, we tested porcine bladder to identify variations in the tissue's viscoelastic characteristics associated with anatomical locations and swelling. We investigated this relationship using a series of stress-relaxation experiments as well as a modified Maxwell-Wiechert model to aid in the interpretation of the experimental data. Our results highlight that tissue located near the neck of the bladder presents significantly different viscoelastic characteristics than the body of the organ. This supports what was previously observed and is a valuable contribution to the understanding of the location-specific properties of the bladder. We also tested the effect of swelling, revealing that the bladder's viscoelastic behavior is mostly independent of solution osmolarity in hypoosmotic solutions, but the use of a hyperosmotic solution can significantly affect its behavior. This is significant, since several urinary tract pathologies can lead to chronic inflammation and disrupt the urothelial barrier causing increased urothelial permeability, thus subjecting the bladder wall to non-physiologic osmotic challenge.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"143 1","pages":"105926"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45092487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reinforcement of resin-modified glass-ionomer cement with glass fiber and graphene oxide. 用玻璃纤维和氧化石墨烯增强树脂改性玻璃离聚物水泥。
Journal of the mechanical behavior of biomedical materials Pub Date : 2023-04-01 DOI: 10.2139/ssrn.4372928
F. Sari, M. Ugurlu
{"title":"Reinforcement of resin-modified glass-ionomer cement with glass fiber and graphene oxide.","authors":"F. Sari, M. Ugurlu","doi":"10.2139/ssrn.4372928","DOIUrl":"https://doi.org/10.2139/ssrn.4372928","url":null,"abstract":"OBJECTIVE\u0000To evaluate the effect of adding glass fiber and graphene oxide to a resin-modified glass ionomer cement (RMGIC).\u0000\u0000\u0000METHODS\u0000Experimental RMGICs were prepared by adding separately and simultaneously glass fibers (5, 10, and 20 wt%) and graphene oxide (1, 3, and 5 wt%) to the powder of RMGIC with different ratios. The samples were examined under SEM and XRD. The surface roughness, flexural strength, Vickers microhardness, water sorption, and solubility were investigated. Data were analyzed using ANOVA and Tukey tests (p = 0.05).\u0000\u0000\u0000RESULTS\u0000Adding fiber and graphene oxide to RMCIS increased the surface roughness, flexural strength, and microhardness. The highest surface roughness value was obtained in the 20% fiber+5% graphene oxide adding group and the lowest in the control group (p < 0.05). The highest microhardness and flexural strength values were acquired in the 20% fiber-adding group and the lowest in the control group (p < 0.05). 10% and 20% fiber addition increased water sorption and solubility (p < 0.05). Adding 3%, 5% graphene oxide, and 20% fiber+5% graphene oxide reduced water sorption (p < 0.05). The highest water sorption was found in the 20% fiber-adding group and the lowest in the 5% graphene oxide and %20 fiber+5% graphene oxide-adding groups (p < 0.05). Graphene oxide alone and together with fiber did not affect the solubility (p > 0.05).\u0000\u0000\u0000CONCLUSION\u0000The results show that reinforcement of RMGIC with glass fiber and graphene oxide may improve the mechanical properties. But the glass fibers may cause more water sorption and solubility. Graphene oxide may decrease water sorption of RMGIC and fiber-reinforced RMGIC.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"142 1","pages":"105850"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47904838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The practical process of manufacturing poly(methyl methacrylate)-based scaffolds having high porosity and high strength. 介绍了制备高孔隙率、高强度聚甲基丙烯酸甲酯基支架的实用工艺。
Journal of the mechanical behavior of biomedical materials Pub Date : 2023-04-01 DOI: 10.2139/ssrn.4372929
A. Indra, Rivaldo Razi, Riri Jasmayeti, Alfi Fauzan, Didit Wahyudi, Nofriady Handra, A. Subardi, I. Susanto, Iswandi, M. J. Purnomo
{"title":"The practical process of manufacturing poly(methyl methacrylate)-based scaffolds having high porosity and high strength.","authors":"A. Indra, Rivaldo Razi, Riri Jasmayeti, Alfi Fauzan, Didit Wahyudi, Nofriady Handra, A. Subardi, I. Susanto, Iswandi, M. J. Purnomo","doi":"10.2139/ssrn.4372929","DOIUrl":"https://doi.org/10.2139/ssrn.4372929","url":null,"abstract":"Poly(methyl methacrylate) (PMMA)-based scaffolds have been produced using the granule casting method with grain sizes M80-100 and M100-140. The novelty of this study was the application of the cold-cutting method (CCm) to reduce the PMMA granule size. PMMA granule shape, granule size (mesh), and sintering temperature were the primary variables in manufacturing PMMA scaffolds. CCm was applied to reduce the granule size of commercial PMMA, which was originally solid cylindrical, by lowering the temperature to 3.5 °C, 0 °C, and-8.3 °C. PMMA granules that had been reduced were sieved with mesh sizes M80-100 and M100-140. Green bodies were made by the granule casting method using an aluminum mold measuring 8 × 8 × 8 mm3. The sintering process was carried out at temperatures varying from 115 °C to 140 °C, a heating rate of 5 °C/min, and a holding time of 2 h, the cooling process was carried out in a furnace. The characterization of the PMMA-based scaffolds' properties was carried out by observing the microstructure with SEM, analyzing the distribution of pore sizes with ImageJ software, and testing the porosity, the phase, with XRD, and the compressive strength. The best results from the overall analysis were the M80-100 PMMA scaffold treated at a sintering temperature of 130 °C with compressive strength, porosity, and pore size distribution values of 8.2 MPa, 62.0%, and 121-399 μm, respectively, and the M100-140 one treated at a sintering temperature of 135 °C with compressive strength, porosity, and pore size distribution values of 12.1 MPa, 61.2%, and 140-366 μm, respectively. There were interconnected pores in the PMMA scaffolds, as evidenced by the SEM images. There was no PMMA phase change between before and after the sintering process.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"142 1","pages":"105862"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48815010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A multi-scale computational model for the passive mechanical behavior of right ventricular myocardium. 右心室心肌被动力学行为的多尺度计算模型。
Journal of the mechanical behavior of biomedical materials Pub Date : 2023-03-01 DOI: 10.2139/ssrn.4177757
David S. Li, Emilio A. Mendiola, R. Avazmohammadi, F. Sachse, Michael S. Sacks
{"title":"A multi-scale computational model for the passive mechanical behavior of right ventricular myocardium.","authors":"David S. Li, Emilio A. Mendiola, R. Avazmohammadi, F. Sachse, Michael S. Sacks","doi":"10.2139/ssrn.4177757","DOIUrl":"https://doi.org/10.2139/ssrn.4177757","url":null,"abstract":"We have previously demonstrated the importance of myofiber-collagen mechanical interactions in modeling the passive mechanical behavior of right ventricle free wall (RVFW) myocardium. To gain deeper insights into these coupling mechanisms, we developed a high-fidelity, micro-anatomically realistic 3D finite element model of right ventricle free wall (RVFW) myocardium by combining high-resolution imaging and supercomputer-based simulations. We first developed a representative tissue element (RTE) model at the sub-tissue scale by specializing the hyperelastic anisotropic structurally-based constitutive relations for myofibers and ECM collagen, and equi-biaxial and non-equibiaxial loading conditions were simulated using the open-source software FEniCS to compute the effective stress-strain response of the RTE. To estimate the model parameters of the RTE model, we first fitted a 'top-down' biaxial stress-strain behavior with our previous structurally based (tissue-scale) model, informed by the measured myofiber and collagen fiber composition and orientation distributions. Next, we employed a multi-scale approach to determine the tissue-level (5 x 5 x 0.7 mm specimen size) RVFW biaxial behavior via 'bottom-up' homogenization of the fitted RTE model, recapitulating the histologically measured myofiber and collagen orientation to the biaxial mechanical data. Our homogenization approach successfully reproduced the tissue-level mechanical behavior of our previous studies in all biaxial deformation modes, suggesting that the 3D micro-anatomical arrangement of myofibers and ECM collagen is indeed a primary mechanism driving myofiber-collagen interactions.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"142 1","pages":"105788"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45357584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Development of biodegradable customized tibial scaffold with advanced architected materials utilizing additive manufacturing. 利用增材制造技术开发具有先进建筑材料的可生物降解定制胫骨支架。
Journal of the mechanical behavior of biomedical materials Pub Date : 2023-03-01 DOI: 10.2139/ssrn.4354973
N. Kladovasilakis, P. Charalampous, A. Boumpakis, T. Kontodina, K. Tsongas, D. Tzetzis, I. Kostavelis, P. Givissis, D. Tzovaras
{"title":"Development of biodegradable customized tibial scaffold with advanced architected materials utilizing additive manufacturing.","authors":"N. Kladovasilakis, P. Charalampous, A. Boumpakis, T. Kontodina, K. Tsongas, D. Tzetzis, I. Kostavelis, P. Givissis, D. Tzovaras","doi":"10.2139/ssrn.4354973","DOIUrl":"https://doi.org/10.2139/ssrn.4354973","url":null,"abstract":"In the last decade, the development of customized biodegradable scaffolds and implants has attracted increased scientific interest due to the fact that additive manufacturing technologies allow for the rapid production of implants with high geometric complexity constructed via commercial biodegradable polymers. In this study, innovative designs of tibial scaffold in form of bone-brick configuration were developed to fill the bone gap utilizing advanced architected materials and bio-inspired diffusion canals. The architected materials and canals provide high porosity, as well as a high surface area to volume ratio in the scaffold facilitating that way in the tissue regeneration process and in withstanding the applied external loads. The cellular structures applied in this work were the Schwarz Diamond (SD) and a hybrid SD&FCC hybrid cellular material, which is a completely new architected material that derived from the combination of SD and Face Centered Cubic (FCC) structures. These designs were additively manufactured utilizing two biodegradable materials namely Polylactic acid (PLA) and Polycaprolactone (PCL), using the Fused Filament Fabrication (FFF) technique, in order to avoid the surgery, for the scaffold's removal after the bone regeneration. Furthermore, the additively manufactured scaffolds were examined in terms of compatibility and assembly with the bone's physical model, as well as, in terms of mechanical behavior under realistic static loads. In addition, non-linear finite element models (FEMs) were developed based on the experimental data to accurately simulate the mechanical response of the examined scaffolds. The Finite Element Analysis (FEA) results were compared with the experimental response and afterwards the stress concentration regions were observed and identified. Τhe proposed design of scaffold with SD&FCC lattice structure made of PLA material with a relative density of 20% revealed the best overall performance, showing that it is the most suitable candidate for further investigation (in-vivo test, clinical trials, etc.) and commercialization.","PeriodicalId":94117,"journal":{"name":"Journal of the mechanical behavior of biomedical materials","volume":"141 1","pages":"105796"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41449719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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