Journal of the College of Physicians and Surgeons--Pakistan : JCPSP最新文献

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Tracheobronchial Foreign Body in Children with an Insidious Medical History. 病史不详的儿童气管支气管异物。
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-06-01 DOI: 10.29271/jcpsp.2024.06.740
Xiaoxu Zhang, Qiulan Shi
{"title":"Tracheobronchial Foreign Body in Children with an Insidious Medical History.","authors":"Xiaoxu Zhang, Qiulan Shi","doi":"10.29271/jcpsp.2024.06.740","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.06.740","url":null,"abstract":"<p><p>This study explored the clinical features of tracheobronchial foreign bodies (TFB) in children lacking both a foreign body aspiration history and bronchial cut-off signs on imaging. This study was conducted between 2011 and 2021, including 45 children without a choking history or tracheal interruption on CT scans. Common symptoms were cough and wheezing (91.1%, 41 cases), followed by decreased breath sounds (55.6%, 25 cases), rales (48.9%, 22 cases), and wheezing (42.2%, 19 cases). Prior to TFB confirmation, bronchopneumonia was the prevalent diagnosis (88.9%, 40 cases). Vegetable matter was the most frequent foreign body type (75.6%, 34 cases), primarily located in the right main bronchus (31.1%) and left lower lobe bronchus (22.2%). TFB in children with obscure medical histories presents non-specifically, highlighting bronchoscopy's pivotal role in diagnosis and treatment. Key Words: Bronchoscope, Paediatrics, Tracheobronchial foreign body, Diagnosis.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of COVID-19 Infection in Operating Room Staff During Two COVID-19 Waves Using Different Preventive Strategies in a Tertiary Care Hospital in Pakistan. 巴基斯坦一家三甲医院在两次 COVID-19 浪潮中采用不同预防策略的手术室工作人员 COVID-19 感染情况比较。
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-06-01 DOI: 10.29271/jcpsp.2024.06.697
Samie Asghar Dogar, Tahir Munir, Ausaf Ahmed Khan, Saad Ilyas, Mohsin Nazir Butt, Asad Latif
{"title":"Comparison of COVID-19 Infection in Operating Room Staff During Two COVID-19 Waves Using Different Preventive Strategies in a Tertiary Care Hospital in Pakistan.","authors":"Samie Asghar Dogar, Tahir Munir, Ausaf Ahmed Khan, Saad Ilyas, Mohsin Nazir Butt, Asad Latif","doi":"10.29271/jcpsp.2024.06.697","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.06.697","url":null,"abstract":"<p><strong>Objective: </strong>To assess if limiting elective surgeries during specific pandemic phases significantly affected COVID-19 incidence among operating room (OR) staff.</p><p><strong>Study design: </strong>Retrospective cohort study. Place and Duration of the Study: Operation Theatre (OT), The Aga Khan University Hospital, Karachi, Pakistan, from May 2020 to 2021.</p><p><strong>Methodology: </strong>This retrospective study compared two pandemic waves: Wave 1, during which elective surgeries were restricted (REL), and Wave 2, during which elective surgeries were continued routinely (EL). Exposure levels were measured based on OR activity. Incidence rates were calculated per 100 OR staff, per 100 ORs, and per 100 surgeries for both Groups.</p><p><strong>Results: </strong>No statistically significant difference emerged in COVID-19 incidence among OR staff between REL (13.8 per 100 staff) and EL (14.4 per 100 staff) Groups (p = 0.825). However, the EL Group exhibited a significantly lower incidence risk per running OR (5.6 per 100 ORs vs. REL's 12 per 100 ORs, p <0.001). Additionally, the EL Group showed a lower incidence per 100 surgeries (1.5 vs. REL's 2.9, p <0.002).</p><p><strong>Conclusion: </strong>Restricting elective surgeries during the early pandemic phase did not significantly reduce COVID-19 incidence among OR staff. Infections were primarily linked to interactions with colleagues and the community, emphasising the need for a balanced pandemic response considering patient care and the consequences of surgery restrictions.</p><p><strong>Key words: </strong>COVID-19 infection, Operating room staff, COVID-19 waves, COVID-19 transmission, Hospital epidemiology, Pandemic response.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multisystem Inflammatory Syndrome in Neonates Associated with COVID-19 in Neonatal ICU of a Tertiary Care Hospital. 一家三甲医院新生儿重症监护室中与 COVID-19 相关的新生儿多系统炎症综合征
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-06-01 DOI: 10.29271/jcpsp.2024.06.727
Asma Shabbir, Humaira Khurshid, Imran Mahmood Khan
{"title":"Multisystem Inflammatory Syndrome in Neonates Associated with COVID-19 in Neonatal ICU of a Tertiary Care Hospital.","authors":"Asma Shabbir, Humaira Khurshid, Imran Mahmood Khan","doi":"10.29271/jcpsp.2024.06.727","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.06.727","url":null,"abstract":"<p><strong>Objective: </strong>Neonatal multisystem inflammatory syndrome (MIS-N) is a unique disease of neonates described in several case reports from all over the world with a myriad of presentations and the emergence of new cases.</p><p><strong>Study design: </strong>Retrospective case series. Place and Duration of the Study: Department of Paediatrics, Fazaia Medical College, Pakistan Air Force Hospital, Islamabad, Pakistan, from December 2021 to November 2022.</p><p><strong>Methodology: </strong>The study was conducted on neonates who were managed as MIS-N in the neonatal ICU. Data were collected and analysed on SPSS version 24.</p><p><strong>Results: </strong>Patients in this study ranged from newborns to 13 days of age with a mean age of 3.27 ± 4.29 days and average gestational age of 35.18 ± 3.67 weeks. Among these neonates, 7 (63.6%) had bleeding diathesis, 11 (100%) had seizures, 8 (72.2%) presented with haemodynamic instability and shock, and 7 (63.3%) had signs of heart failure. All neonates (100%) had markedly raised SARS-CoV2 IgG antibodies, CRP, ferritin, D-dimers, interleukin 6, procalcitonin, 10 (90.9%) had hypoalbuminemia, and 7 (63.3%) had deranged coagulation profile. Cardiac involvement was seen in all neonates (100%) with raised proBNP and myocardial dysfunction on echocardiography. Pulmonary hypertension was present in 6 (54.4%) neonates. High mortality was observed at 6 (54.5%) among which 4 (66.6%) were premature neonates.</p><p><strong>Conclusion: </strong>MIS-N is a new disease entity which is still under research. There is a high propensity for cardiovascular system involvement and higher mortality among preterm neonates.</p><p><strong>Key words: </strong>Neonatal multisystem inflammatory syndrome (MIS-N), Multisystem inflammatory syndrome in children (MIS-C), SARS-CoV2 infection, SARS-CoV2 spike protein, SARS-CoV2 IgG antibodies.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colorectal Cancer Survival and Its Prognostic Factors in Karachi, Pakistan. 巴基斯坦卡拉奇的结直肠癌存活率及其预后因素
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-06-01 DOI: 10.29271/jcpsp.2024.06.688
Uzma Shamsi, Sajida Qureshi, Munira Moosaji, Iqbal Azam, Romana Idrees
{"title":"Colorectal Cancer Survival and Its Prognostic Factors in Karachi, Pakistan.","authors":"Uzma Shamsi, Sajida Qureshi, Munira Moosaji, Iqbal Azam, Romana Idrees","doi":"10.29271/jcpsp.2024.06.688","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.06.688","url":null,"abstract":"<p><strong>Objective: </strong>To determine the survival rates of colorectal cancer (CRC) in the Pakistani population and determine the prognostic factors for survival among the CRC patients.</p><p><strong>Study design: </strong>Retrospective cohort study. Place and Duration of the Study: The cancer registry of the Aga Khan University Hospital, Karachi, Pakistan, from 2010 to 2016.</p><p><strong>Methodology: </strong>The abstracted data from the cancer registry was cleaned and updated regarding the vital status at the last follow-up. Survival analyses were performed using the Kaplan-Meier method. Adjusted hazard ratios (aHR) and their 95% confidence intervals (CIs) were estimated using a cox regression model to assess the prognostic factors for survival.</p><p><strong>Results: </strong>The overall proportion of late-onset CRC (>50 years of age) was 55.3% and early-onset CRC (<=50 years of age) was higher than expected (45.7%). A high level of carcinoembryonic antigen (CEA) (>5 ng/ml) was associated with poor survival compared to patients with CEA levels of ≤5 ng/ml (aHR = 1.68, 95% CI = 1.04, 2.72). Patients, who experienced recurrence, showed poorer survival (aHR = 4.27, 95% CI = 2.55, 7.14). Patients, who did not undergo surgery, showed significantly poorer survival compared to those who underwent surgery (aHR = 5.53, 95% CI = 2.35, 13.03).</p><p><strong>Conclusion: </strong>The findings suggest that monitoring CEA levels, ensuring prompt surgical treatment and follow-up care for recurrent cases can improve survival outcomes in patients with colorectal cancer.</p><p><strong>Key words: </strong>Colorectal cancer (CRC), Surgery, Recurrence, Grade, Cancer registry.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Effect of Favipiravir on QT Intervals in COVID-19 Patients with and without Diabetes Mellitus. 评估 Favipiravir 对 COVID-19 糖尿病和非糖尿病患者 QT 间期的影响
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-06-01 DOI: 10.29271/jcpsp.2024.06.659
Mustafa Dogan, Derya Baykiz, Ibrahim Yilmaz, Fatma Bahar Hacioglu Kasim, Betul Ekiz Bilir, Bulent Bilir
{"title":"Evaluation of the Effect of Favipiravir on QT Intervals in COVID-19 Patients with and without Diabetes Mellitus.","authors":"Mustafa Dogan, Derya Baykiz, Ibrahim Yilmaz, Fatma Bahar Hacioglu Kasim, Betul Ekiz Bilir, Bulent Bilir","doi":"10.29271/jcpsp.2024.06.659","DOIUrl":"10.29271/jcpsp.2024.06.659","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of favipiravir administered to diabetic and non-diabetic COVID-19 patients on the QT/QTc interval.</p><p><strong>Study design: </strong>Analytical study. Place and Duration of the Study: Republic of Turkey, Ministry of Health, State Hospital, Corlu, Tekirdag, Turkiye, from March to September 2021.</p><p><strong>Methodology: </strong>Electrocardiogram (ECG) analysis was performed on all participants (n=180) divided into four groups. Group 1 included only healthy volunteers. Group 2 included only cases diagnosed with T2DM. Group 3 included only severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) cases. Group 4 included cases diagnosed with both SARS and T2DM. Favipiravir was administered only to the cases in Group 3 and Group 4. In the cases that were administered favipiravir, the QT/QTc interval was calculated and recorded at different time intervals on the first and fifth days of the therapy. The difference between groups was determined by Tukeye's test after ANOVA. Pearson's correlation test was used to determine whether there was a linear relationship between two numericals. The alpha significance value was determined to be <0.05 in all statistical analyses.</p><p><strong>Results: </strong>When all groups were compared, it was seen that both QT and QTc values ​​increased in Groups 3 and 4, which were administered favipiravir (p <0.05). Favipiravir may cause an increased risk of ventricular and atrial arrhythmias.</p><p><strong>Conclusion: </strong>Favipiravir may cause QT interval prolongation, particularly in SARS-Cov-2 patients diagnosed with T2DM.</p><p><strong>Key words: </strong>COVID-19, Drug-induced long QT syndrome, Intra-infarct haemorrhage; Favipiravir, Type 2 diabetes mellitus.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast Cancer Management During the COVID Pandemic. COVID 大流行期间的乳腺癌管理。
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-06-01 DOI: 10.29271/jcpsp.2024.06.732
Gulcin Turkmen Sariyildiz, Fikriye Figen Ayhan
{"title":"Breast Cancer Management During the COVID Pandemic.","authors":"Gulcin Turkmen Sariyildiz, Fikriye Figen Ayhan","doi":"10.29271/jcpsp.2024.06.732","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.06.732","url":null,"abstract":"<p><strong>Objective: </strong>To explore the impact of COVID-19 among both the newly diagnosed patients and patients under follow-up for breast cancer by focusing on patients' accessibility to management and comparing the distribution of them before and during pandemic.</p><p><strong>Study design: </strong>Single-centric retrospective study. Place and Duration of the Study: Department of General Surgery and Department of Physical Medicine and Rehabilitation, Atilim University, Medicana International Ankara Hospital, Ankara, Turkiye, from March 2018 to 2022.</p><p><strong>Methodology: </strong>The data were collected to analyse numbers and distributions of physician visits regarding breast cancer.</p><p><strong>Results: </strong>The mean age of patients was 55.98 ± 12.60 years. The percentages of newly diagnosed cases showed similarity (7.37% vs. 9.79%) before and during the pandemic (p = 0.18).  The number of imaging studies decreased by 53.33% in patients under follow-up (p = 0.006), despite screening tests showed a similar trend (p = 0.145). General surgery visits marked up (+44.6%), in contrast to plastic surgery visits (-42.04%, p <0.001). Patients' admissions decreased in many COVID-19 related clinics (pulmonology, emergency, internal medicine, and intensive care), but cardiology (+96.59%) and rehabilitation (+75%) admissions increased during the pandemic (p <0.001). The number of medical oncology and radiation oncology visits did not change (p >0.05).</p><p><strong>Conclusion: </strong>Total number of physician visits was similar before and during the pandemic despite the changing distribution. While COVID-19 led to markedly rising trends of surgical, cardiological, and rehabilitative management in patients with breast cancer, falling trends were seen in other specialities except oncology which showed a plateau during two years. The falling trends of visits to pulmonology, emergency, internal medicine, and intensive care clinics may be explained by crowded COVID-19 cases.</p><p><strong>Key words: </strong>Breast cancer, COVID-19, Surgery, Oncology, Rehabilitation.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Mid-Urethral Sling and Urethral Dilation for Stress Urinary Incontinence Combined with Urethral Stricture in Women. 尿道中段吊带和尿道扩张术治疗女性压力性尿失禁合并尿道狭窄的疗效。
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-06-01 DOI: 10.29271/jcpsp.2024.06.702
Yan Qin, Peng Qiao, Xing Guan, Biao Wang
{"title":"Efficacy of Mid-Urethral Sling and Urethral Dilation for Stress Urinary Incontinence Combined with Urethral Stricture in Women.","authors":"Yan Qin, Peng Qiao, Xing Guan, Biao Wang","doi":"10.29271/jcpsp.2024.06.702","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.06.702","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the potential clinical benefits of mid-urethral sling (MUS) and urethral dilatation (UD) operations for the treatment of stress urinary incontinence (SUI) combined with urethral stricture.</p><p><strong>Study design: </strong>Descriptive study. Place and Duration of the Study: Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China, from January 2017 to 2022.</p><p><strong>Methodology: </strong>Patients with Qmax <15ml/s or PVR >50ml, and video urodynamic study (VUDS) capable of confirming the presence and position of urethral stricture were included. The clinical efficacy was evaluated by International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) questionnaire, maximum flow rate (Qmax), and postvoid residual (PVR) urine. ICIQ-SF, Qmax, and PVR were measured presurgery, on postoperative 2-week, and 1-month postsurgery.</p><p><strong>Results: </strong>There were total 19 patients with an average age of 61.37 ± 11.28 years (range 39-84) with SUI and urethral stricture. ICIQ-SF scores were decreased significantly at one month postoperatively compared with the preoperative [5.0 (0.0, 7.0) vs. 14.0 (13.0, 15.0), p <0.001]. Qmax was increased dramatically compared with the preoperative [21.3 (14.0, 28.4) vs. 13.0 (8.7,18.0), p <0.001], and PVR was decreased remarkably than the preoperative [0.0 (0.0,0.0) vs. 0.0 (0.0,60.0), p = 0.018]. Of 19 patients primarily managed with MUS and UD, two patients experienced recurrence requiring repetitive dilation till sling excision surgery was conducted, and improvement was evident in one patient after repeating UD.</p><p><strong>Conclusion: </strong>The overall incidence of SUI combined with urethral stricture in women is low. With a success rate of 89.5%, MUS and UD were effective therapies for the co-existence of SUI with urethral stricture, and repeated UD can be performed safely if necessary in long-term follow-up.</p><p><strong>Key words: </strong>Stress urinary incontinence, Urethral stricture, Mid-urethral sling, Urethral dilatation.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frequency of Inferior Alveolar Nerve Injury During Third Molar Extraction. 第三磨牙拔除术中下牙槽神经损伤的频率。
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-06-01 DOI: 10.29271/jcpsp.2024.06.723
Sehrish Maqbool, Najia Sajjad Khan, Iram Abbas, Alamgir Khan
{"title":"Frequency of Inferior Alveolar Nerve Injury During Third Molar Extraction.","authors":"Sehrish Maqbool, Najia Sajjad Khan, Iram Abbas, Alamgir Khan","doi":"10.29271/jcpsp.2024.06.723","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.06.723","url":null,"abstract":"<p><strong>Objective: </strong>To determine the frequency of inferior alveolar nerve injury during third molar extraction and the associated factors.</p><p><strong>Study design: </strong>Descriptive study. Place and Duration of the Study: Department of Oral and Maxillofacial Surgery, Ayub Teaching Hospital, Abbottabad, Pakistan, from July to December 2021.</p><p><strong>Methodology: </strong>A total of 163 patients with third molar surgery were included. Patients were followed up after one week, one month, and three months of duration. The frequency of inferior alveolar nerve injury was determined as well as its relationship with other surgical variables like age, gender, type of impaction, buccal flap retraction, bone cutting, tooth splitting, and duration of surgery via Chi-square test.</p><p><strong>Results: </strong>The frequency of inferior alveolar nerve injury was found to be 1.2% (n = 02). None of the surgical variables had a statistically significant association with it (p >0.05).</p><p><strong>Conclusion: </strong>The frequency of nerve injury of the inferior alveolar nerve during extraction of the third molar was 1.2%. Proper treatment planning, using advanced radiography, experienced surgeon, and proper technique can help in lowering nerve injury risk.</p><p><strong>Key words: </strong>Inferior alveolar nerve injuries, Molar, Tooth extraction, Paraesthesia.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Various Therapeutic Approaches to Manage Infertility in Polycystic Ovarian Syndrome. 多囊卵巢综合症患者不孕症的各种治疗方法比较。
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-06-01 DOI: 10.29271/jcpsp.2024.06.654
Sameena Ahmed, Samia Perwaiz Khan, Safia Izhar, Sadia Rashid, Rizwana S Waraich, Fadieleh A Sohail
{"title":"Comparison of Various Therapeutic Approaches to Manage Infertility in Polycystic Ovarian Syndrome.","authors":"Sameena Ahmed, Samia Perwaiz Khan, Safia Izhar, Sadia Rashid, Rizwana S Waraich, Fadieleh A Sohail","doi":"10.29271/jcpsp.2024.06.654","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.06.654","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacies of common therapeutic regimens and their combinations, used in polycystic ovarian syndrome (PCOS) to improve fertility in reproductive-age women.</p><p><strong>Study design: </strong>A descriptive study. Place and Duration of the Study: Department of Obstetric Gynaecologist, Medicare Cardiac and General Hospital, Karachi, Pakistan, from November 2022 to July 2023.</p><p><strong>Methodology: </strong>Out of 300 patients with the symptoms of menstrual irregularities and infertility, 152 were diagnosed as PCOS patients based on the ultrasound and hormonal assays and selected for study purpose. They were divided according to their therapeutic regimen into four treatment groups, treated by different therapeutic agents. Group A received metformin 500 mg/day (n = 38); Group B received metformin + myo-inositol 1g (n = 49); Group C received metformin + letrozole 2.5 mg (n = 36), and Group D received metformin + letrozole + myo-inositol (n = 29), orally for three months. All continuous variables, such as body mass index (BMI), FSH, LH, FT4, and FSI were analysed by applying t-test to all therapeutic groups, keeping p ≤0.05 as the level of significance.</p><p><strong>Results: </strong>HCG-positive was found as 86% (n = 33) in Group A, 63% (n = 31) in Group B, 52% (n = 19) in Group C, and 27% (n = 08) in Group D. There were statistically significant (p <0.001) changes in BMI, FSH, LH, FT4, and FSI as well. Metformin alone and metformin plus myo-inositol came out to be more effective than other regimens.</p><p><strong>Conclusion: </strong>Metformin alone and myo-inositol plus metformin are effective therapeutic options in PCOS-induced infertility problems.</p><p><strong>Key words: </strong>Polycystic ovarian syndrome, Infertility, Metformin, Myo-inositol, Letrozole, Menstrual irregularities.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Elderly's Limited Awareness of Advanced-Way Dental Procedures Hinders Access to Treatment, Resulting in Persistent Pain and Unmet Dental Needs in Pakistan. 在巴基斯坦,老年人对先进牙科治疗方法的认识有限,阻碍了他们接受治疗,导致疼痛持续存在,牙科需求得不到满足。
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-06-01 DOI: 10.29271/jcpsp.2024.06.742
Raahim Salman Abdul Ghaffar, Abdullah Nawaz Baloch, Tazeen Saeed Ali
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