Journal of the College of Physicians and Surgeons--Pakistan : JCPSP最新文献_第7页

Pulmonary Embolism Risk Assessment in Acute Isolated Distal Deep Venous Thrombosis. 急性孤立远端深静脉血栓形成的肺栓塞风险评估。

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-09-01 DOI: 10.29271/jcpsp.2024.09.1127

Jingqiu Zhang, Jin Wang, Yongping Lu

{"title":"Pulmonary Embolism Risk Assessment in Acute Isolated Distal Deep Venous Thrombosis.","authors":"Jingqiu Zhang, Jin Wang, Yongping Lu","doi":"10.29271/jcpsp.2024.09.1127","DOIUrl":"10.29271/jcpsp.2024.09.1127","url":null,"abstract":"The clinical risk factors and risk of developing pulmonary embolism (PE) in patients with acute isolated distal deep venous thrombosis (IDDVT) were assessed using single complete-duplex ultrasound (CDUS) imaging to reduce over-testing and over-treatment. This observational study was conducted from January 2020 to December 2022. Retrospective analysis was performed on CT pulmonary angiography (CTPA), blood coagulation markers, myocardial injury markers, blood gas analysis, and CDUS imaging of the lower extremity blood vessels of 146 patients with newly diagnosed IDDVT. Binary logistic regression was used to evaluate the relationship between these indicators and PE. After stepwise regression analysis, the predictors included in the regression model were D-dimer (DD), the sum of the thrombus length, and the maximum value of the thrombus width, with odds ratios (ORs) of 1.307 (p <0.001), 1.018 (p = 0.005), and 1.613 (p = 0.018), respectively. The combined prediction model achieved an area under the receiver operating characteristic curve (AUC) of 0.832 [95% confidence interval (CI): 0.761, 0.902]. By balancing the sensitivity and specificity of DD, combined single CDUS improves the predictive value for PE in patients with IDDVT. Key Words: Venous thrombosis, Pulmonary embolism, Ultrasonography, D-dimer, Diagnosis.","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative Outcomes of the Awake Colorectal Surgery with Neuraxial Anaesthesia. 采用神经麻醉的清醒结直肠手术的术后效果。

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-09-01 DOI: 10.29271/jcpsp.2024.09.1009

Ayca Tuba Dumanli Ozcan, Serhat Ocakli, Ezgi Erkilic, Yasemin Yalniz, Sadettin Er, Cengiz Ceylan

{"title":"Postoperative Outcomes of the Awake Colorectal Surgery with Neuraxial Anaesthesia.","authors":"Ayca Tuba Dumanli Ozcan, Serhat Ocakli, Ezgi Erkilic, Yasemin Yalniz, Sadettin Er, Cengiz Ceylan","doi":"10.29271/jcpsp.2024.09.1009","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.09.1009","url":null,"abstract":"Objective: To determine the outcome of awake surgery with combined spinal epidural in geriatric colon cancer patients with advanced comorbidity.Study design: Quasi-experimental study. Place and Duration of the Study: Department of Anaesthesiology and Reanimation, Ankara Bilkent City Hospital, Ankara, Turkiye, from April 2022 to 2023.Methodology: Twenty-four American Society of Anaesthesiologists (ASA) I-II patients, aged 25-65 years and scheduled for colon cancer surgery were included in this research. All patients were observed preoperatively, at the operation room and at the postoperative surgery service. Spinal anaesthesia was planned for Group I and general anaesthesia for Group II. Ketofol (1:1) was administered to the combined spinal-epidural group, with a Ramsay sedation score of 3 after the spinal block. Epidural analgesia was planned for all patients. Patients' age, gender, weight, comorbidities, ASA risk scores, intraoperative haemodynamic parameters, bleeding amounts, colloid, crystalloid, and blood products were collected.Results: There was no significant difference between the demographic characteristics of both anaesthesia groups (p >0.05). The amount of bleeding was statistically lower in Group I than in the general anaesthesia group (p = 0.004). Oral intake, drain withdrawal, mobilisation, discharge times, and costs were similar in all groups (p >0.05).Conclusion: The regional anaesthesia applications facilitate compliance with routine mobilisation, discharge procedures and prevent complications in abdominal surgery and its positive perioperative effects in patients with poor respiratory parameters, poor general condition, and high comorbidity in advanced age.Key words: Regional anaesthesia, Spinal-epidural, Mobilisation, Pain, Colon cancer.","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Analysis of Gene Expression Profiles in Ovarian Clear Cell Carcinoma and High-Grade Serous Ovarian Cancer. 卵巢透明细胞癌和高级别浆液性卵巢癌基因表达谱的比较分析

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-09-01 DOI: 10.29271/jcpsp.2024.09.1066

Chen Ye, Gang Hu, Xiaoni Zhou, Wen Deng, Kai Hu, Minglei Fu

{"title":"Comparative Analysis of Gene Expression Profiles in Ovarian Clear Cell Carcinoma and High-Grade Serous Ovarian Cancer.","authors":"Chen Ye, Gang Hu, Xiaoni Zhou, Wen Deng, Kai Hu, Minglei Fu","doi":"10.29271/jcpsp.2024.09.1066","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.09.1066","url":null,"abstract":"Objective: To evaluate disparities in gene expression profiles between Ovarian Clear Cell Carcinoma (OCCC) and High-Grade Serous Ovarian Carcinoma (HGSOC).Study design: A descriptive study. Place and Duration of the Study: The Second People's Hospital of Jingdezhen, Jiangxi, China, between 31st December 2017 and December 2023.Methodology: Basic and clinical diagnostic information, along with genetic test reports, were compiled from all patients within the included groups. Differential gene expression between the two cohorts was scrutinised to elucidate its clinical significance.Results: Comparative analysis revealed nine differentially expressed genes in OCCC relative to HGSOC, with six exhibiting significant disparities (p <0.05). These genes are implicated in pivotal cellular processes including the cell cycle, apoptosis, DNA damage repair, and the PI3K pathway. Notably, aberrant expression patterns, such as overexpression of MET and downregulation of PTEN and SMARCA4, correlated with adverse prognosis and survival outcomes in selected patients.Conclusion: Distinctive gene expression profiles between OCCC and HGSOC underscore disparate tumorigenic mechanisms, thereby laying a foundation for the tailored therapeutic interventions. Further elucidation of the identified differentially expressed genes is warranted to delineate their role in OCCC pathogenesis and prognostic significance.Key words: Ovarian clear cell carcinoma, High-grade serous ovarian cancer, Gene expression profiles, Homologous recombination repair.","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Power of Patient-Reported Outcomes in Oncology Practice. 患者报告结果在肿瘤学实践中的作用。

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-09-01 DOI: 10.29271/jcpsp.2024.09.1007

Waqas Ahmed Khan, Saad Salim Naviwala

引用次数: 0

Metabolomics in Pakistan: A Comprehensive Analysis of Availability, Practices, and Challenges in Clinical Laboratories. 巴基斯坦的代谢组学：全面分析临床实验室的可用性、实践和挑战。

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-09-01 DOI: 10.29271/jcpsp.2024.09.1117

Hafsa Majid, Aamir Ijaz, Lena Jafri, Imran Siddiqui, Sibtain Ahmed, Aysha Habib Khan

{"title":"Metabolomics in Pakistan: A Comprehensive Analysis of Availability, Practices, and Challenges in Clinical Laboratories.","authors":"Hafsa Majid, Aamir Ijaz, Lena Jafri, Imran Siddiqui, Sibtain Ahmed, Aysha Habib Khan","doi":"10.29271/jcpsp.2024.09.1117","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.09.1117","url":null,"abstract":"Objective: To comprehensively analyse the current state of metabolomics in clinical laboratories across Pakistan.Study design: Cross-sectional survey. Place and Duration of the Study: Section of Chemical Pathology, Department of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, Pakistan, from June to November 2022.Methodology: This survey assessed metabolomics availability, computational methods, and resources in Pakistani clinical laboratories. The survey questionnaire was distributed within the chemical pathology community via Google Forms, and responses were garnered from 44 chemical pathologists across 17 laboratories in 10 cities.Results: Among respondents, 11 had formal metabolomics training, with three having less than 1 year, five more than 1 year, and 33 lacking any experience. Primary clinical applications included inherited metabolic disorders, bio-informatics, microbiology, therapeutic drug monitoring, toxicology, and nutritional and environmental science. Thirty-three labs reported no omics-related technology; LC-MS and GC-MS were present in eight labs and capillary spectroscopy, direct infusion mass spectroscopy, and Fourier transform infrared-spectroscopy were predominantly used for metabolite identification. Challenges identified in implementing metabolomics included lack of awareness, limited expertise, low volume, restricted applicability, high instrument costs, and insufficient funding.Conclusion: Metabolomics in Pakistan faces limitations, but the chemical pathology community expresses strong interest, emphasising the need for intensified efforts in education and training in this emerging field.Key words: Metabolomics, Chemical pathology, Pakistan, Clinical laboratories, Genetics, Survey.","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the Vast Landscape of Academic Research Databases: A Guide for Researchers. 探索学术研究数据库的广阔天地：研究人员指南》。

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-09-01 DOI: 10.29271/jcpsp.2024.09.1143

Muhammad Farooq, Hafsa Majid, Muhammad Umer Naeem Effendi

引用次数: 0

Well-Differentiated Neuroendocrine of Left Kidney. 左肾分化良好的神经内分泌。

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-09-01 DOI: 10.29271/jcpsp.2024.09.1137

Asif Husain Osmani, Anis Hussain Jaffery

引用次数: 0

Diagnostic Value of Pericholedochal Hypointense Ring Sign in MRI T2W Images in Cases of Pancreatic Ductal Adenocarcinoma. MRI T2W 图像中胰腺导管腺癌病例胆总管周围高密度环征的诊断价值

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-09-01 DOI: 10.29271/jcpsp.2024.09.1101

Ozlem Akinci, Ercan Inci, Mustafa Orhan Nalbant, Ozkan Oner, Elif Hocaoglu

{"title":"Diagnostic Value of Pericholedochal Hypointense Ring Sign in MRI T2W Images in Cases of Pancreatic Ductal Adenocarcinoma.","authors":"Ozlem Akinci, Ercan Inci, Mustafa Orhan Nalbant, Ozkan Oner, Elif Hocaoglu","doi":"10.29271/jcpsp.2024.09.1101","DOIUrl":"10.29271/jcpsp.2024.09.1101","url":null,"abstract":"Objective: To determine the value of hypointense pericholedocal ring sign in magnetic resonance imaging (MRI) T2W sequence images in the diagnosis of pancreatic ductal adenocarcinoma (PDA).Study design: Retrospective observational study. Place and Duration of the Study: Department of Radiology, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkiye, from January 2016 and March 2022.Methodology: Retrospective analysis of MRI scans was performed on 70 patients with postoperative histopathological confirmation of a diagnosis of periampullary cancer. The patients' demographic information, the results of their histopathological examinations, and the findings of their MRIs were recorded. The results of the MRI were statistically analysed and compared between the PDA and the non-PDA groups.Results: The study included 43 (61.4%) male and 27 (38.5%) female patients, with a mean age of 62.2 ± 8.4 years. The means of Wirsung diameter and tumour diameter were significantly higher in PDA group (p = 0.034, p = 0.010, respectively). A progressive contrast enhancement pattern of 95.3% was observed in PDA group, while 40.7% rapid contrast enhancement pattern was observed in the non-PDA group. Hypointense pericholedochal ring sign, observed in T2W sequences, was detected in 74.2% (n = 32) of the PDA group and 11.1% (n = 3) of the non-PDA group, and the findings were statistically significant (p <0.001).Conclusion: Hypointense pericholedochal ring sign in axial T2W sequences in periampullary tumours is a complementary MRI finding in the distinction between the PDA and the non-PDA groups.Key words: Magnetic resonance imaging, Pancreatic ductal adenocarcinoma, Periampullary tumours, Pericholedochal ring sign.","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Accuracy of Polymerase Chain Reaction Against Giemsa Staining on Tissue Biopsy for Cutaneous Leishmaniasis. 聚合酶链式反应对皮肤利什曼病组织活检革兰氏染色的诊断准确性。

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-09-01 DOI: 10.29271/jcpsp.2024.09.1024

Aleena Khalid, Maria Mushtaq Gill, Irfan Ali Mirza, Sakeenah Hussain Naqvi, Syed Adeel Hussain Gardezi, Rabia Sajjad

{"title":"Diagnostic Accuracy of Polymerase Chain Reaction Against Giemsa Staining on Tissue Biopsy for Cutaneous Leishmaniasis.","authors":"Aleena Khalid, Maria Mushtaq Gill, Irfan Ali Mirza, Sakeenah Hussain Naqvi, Syed Adeel Hussain Gardezi, Rabia Sajjad","doi":"10.29271/jcpsp.2024.09.1024","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.09.1024","url":null,"abstract":"Objective: To evaluate the diagnostic accuracy of a commercial real-time polymerase chain reaction (PCR) kit targeting 18S rRNA against Giemsa-stained tissue slides in patients clinically suspected of cutaneous leishmaniasis (CL).Study design: Cross-sectional analytical study. Place and Duration of the Study: Department of Microbiology, Armed Forces Institute of Pathology / National University of Medical Sciences, Rawalpindi, Pakistan, from July to December 2022.Methodology: Samples of skin tissue in 98 patients suspected of CL were evaluated. These samples were subjected to Giemsa-staining for microscopy and real-time PCR. Sensitivity, specificity, and accuracy of the PCR were calculated keeping Giemsa-stained tissue slide microscopy as gold standard.Results: Out of the 98 tissue samples, 37 were found positive for leishmaniasis on PCR while 13 were found Leishmania positive on microscopy of Giemsa-stained slides. The sensitivity, specificity, and accuracy of the PCR for the detection of Leishmania species were 100%, 71.8%, and 91.8%, respectively with 100% negative predictive value.Conclusion: This study demonstrates that the commercial PCR is a reliable diagnostic test for the diagnosis of CL. The ease, rapidity, and reliability of the PCR make it a dependable tool in diagnostic repertoire of CL.Key words: Giemsa stain, Leishmania spp., Polymerase chain reaction, Viasure.","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Teaching Methods on Clinical Reasoning in Forensic Medicine: A Quasi-Experimental Study. 教学方法对法医学临床推理的影响：一项准实验研究。

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Pub Date : 2024-09-01 DOI: 10.29271/jcpsp.2024.09.1096

Mehreen Fatima, Arshad Khan, Ramlah Naz, Muhammad Yahya Noori

{"title":"Impact of Teaching Methods on Clinical Reasoning in Forensic Medicine: A Quasi-Experimental Study.","authors":"Mehreen Fatima, Arshad Khan, Ramlah Naz, Muhammad Yahya Noori","doi":"10.29271/jcpsp.2024.09.1096","DOIUrl":"https://doi.org/10.29271/jcpsp.2024.09.1096","url":null,"abstract":"Objective: To compare the effectiveness of flipped classroom and video-assisted learning techniques with didactic lectures in promoting clinical reasoning skills in Forensic Medicine.Study design: Quasi-experimental study. Place and Duration of the Study: Department of Forensic Medicine, Dow International Medical College and Dow University of Health Sciences, Karachi, Pakistan, from May to October 2023.Methodology: The study included 114 third-year medical students divided into three predefined tutorial groups. Over four weeks, within the Forensic Medicine respiratory module, each group was taught one topic per week using a distinct teaching strategy: Traditional lectures (TL) for the first group, flipped classroom (FC) method for the second group, and video-assisted teaching (VAT) for the third group. Students' learning achievements and clinical reasoning skills were assessed through a pre-test, post-test, and revision post-test.Results: Pre-test scores showed no significant differences among the groups (p = 0.655). However, post-test scores differed significantly (F2:111 = 11.93, p <0.001). Tukiye's test indicated that the mean score for the FC group was significantly different from the TL group (p = 0.003) and the VAT group (p <0.001), but there was no significant difference between the TL and VAT groups (p = 0.422). The revision post-test indicated a significant decrease in mean scores across all groups, regardless of the instructional approach (p <0.001).Conclusion: The FC approach for teaching clinical reasoning in Forensic Medicine shows promising results, effectively improving student performance and learning experience.Key words: Flipped classroom, Video-assisted teaching, Clinical reasoning, Forensic Medicine teaching.","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0