Journal of the College of Physicians and Surgeons--Pakistan : JCPSP最新文献

{"title":"Osteomyelitis of the Heel Due to Delayed Treatment of a Left Heel Fracture in a 5-Year Girl.","authors":"Zhiqi Zhang, Wendong Xie, Xiudong Liu, Chao Zhang","doi":"10.29271/jcpsp.2025.03.397","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.03.397","url":null,"abstract":"<p><p>Null.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 3","pages":"397-398"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Wnt10B/β-Catenin in Early Diagnosis, Lymph Node Metastasis, and Prognosis in Cervical Cancer.","authors":"Jingyun Wang, Yahong Wu","doi":"10.29271/jcpsp.2025.03.318","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.03.318","url":null,"abstract":"<p><strong>Objective: </strong>To assess the serum levels of Wnt10B and β-catenin for early diagnosis of the cervical cancer and their association with distant lymph node metastasis and prognosis.</p><p><strong>Study design: </strong>Observational study. Place and Duration of the Study: Department of Gynaecology, Hunan Provincial People's Hospital, The First Hospital Affiliated with Hunan Normal University, Changsha, Hunan, China, from September 2019 to 2023.</p><p><strong>Methodology: </strong>The cervical cancer group included 156 patients, while the control group comprised 96 healthy women. Serum samples were collected to compare the levels of β-catenin and Wnt10B. Univariate and multivariate analyses were used to explore the relationship between these biomarkers and clinical characteristics. The receiver Operating Characteristic (ROC) curve analysis was conducted to evaluate their diagnostic value.</p><p><strong>Results: </strong>The cervical cancer group exhibited significantly higher serum levels of β-catenin and Wnt10B compared to the control group (p <0.001). Univariate analysis revealed markedly elevated levels of Wnt10B and β-catenin (p <0.001) in patients with poor prognosis, lymph node metastasis, and advanced stages (III-IV). Multivariate analysis identified prognosis (p = 0.02) and lymph node metastasis (p <0.001) as independent risk factors for elevated Wnt10B and prognosis (p = 0.006) as a risk factor for increased β-catenin. According to ROC curve analysis, serum levels of Wnt10B (AUC = 0.77, p = 0.0003), β-catenin (AUC = 0.73, p = 0.0021), and the combined diagnostic approach (AUC = 0.79, p = 0.0001) could be used to predict the risk of postoperative recurrence.</p><p><strong>Conclusion: </strong>Serum levels of Wnt10B and β-catenin are valuable biomarkers for early cervical cancer diagnosis, lymph node metastasis, and prognosis of cervical cancer.</p><p><strong>Key words: </strong>Cervical cancer, Wnt10B, β-catenin, Early diagnosis, Prognostic biomarkers, Prognosis.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 3","pages":"318-323"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Attitudes of Medical Faculty Towards the Integration of Artificial Intelligence in Medical Education.","authors":"Khadija Farrukh Warraich","doi":"10.29271/jcpsp.2025.03.359","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.03.359","url":null,"abstract":"<p><strong>Objective: </strong>To explore the attitude of faculty members towards integration of artificial intelligence (AI) and to accelerate the appropriate adaptation of AI tools in medical education.</p><p><strong>Study design: </strong>A qualitative case study. Place and Duration of the Study: Department of Medical Education, Bahria University Health Sciences Campus, Karachi, Pakistan, from June to October 2023.</p><p><strong>Methodology: </strong>A qualitative case study design was employed using a social cognitive theory framework. Participants were selected using a purposive sampling technique. Inclusion criteria were faculty members with five years of teaching experience and who gave consent. Twenty-one participants were included in the study using purposive sampling technique. Data were collected using individual projective interviews and two focus group discussions using the photovoice methodology. Participants were given a presention on tools of AI which can be integrated in teaching and assessment. Pattern matching technique was used for data analysis.</p><p><strong>Results: </strong>Most of the participants had limited awareness of tools of AI that can be integrated in medical education to enhance teaching and assessment strategies. However, few participants had a good understanding of AI and its utility. However, there was great variation in the attitude of faculty members. Participants voiced on fostering partnerships between healthcare organisations, educational institutes, and technology companies to pool resources and expertise. Faculty members suggested that there should be more faculty development programmes on AI applications in medical education.</p><p><strong>Conclusion: </strong>Medical faculty needs to be trained as they have limited knowledge and awareness of the integration of AI in medical education.</p><p><strong>Key words: </strong>Artificial intelligence, Medical education, Medical faculty.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 3","pages":"359-362"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Rectus Femoris Muscle Cross-Sectional Area and Severity of Acute Exacerbations of Chronic Obstructive Pulmonary Disease.","authors":"Wei Wang, Hongju Bao, Feng Zhu, Lingyun Dong, Xiaoyun Hu, Weizhen Song","doi":"10.29271/jcpsp.2025.03.331","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.03.331","url":null,"abstract":"<p><strong>Objective: </strong>To assess the correlation between rectus femoris muscle cross-sectional area (RFCSA) and the severity of acute exacerbations of chronic obstructive pulmonary disease (ECOPD).</p><p><strong>Study design: </strong>Observational study. Place and Duration of the Study: Respiratory and Critical Care Medicine Ward, Suzhou Ninth Hospital affiliated to Soochow University, Suzhou, Jiangsu, China, from May 2021 to April 2024.</p><p><strong>Methodology: </strong>Data of seventy-two ECOPD patients were collected regarding their gender, age, height, and weight. The patients' RFCSA, the Forced Expiratory Volume in 1 second predicted (FEV1% predicted), the COPD assessment test (CAT), and the modified Medical Research Council (mMRC) Dyspnoea Scale were determined. To analyse the data, the patients were divided into four groups, the groups were classified as: Mild group (the value of FEV1% predicted 80% or more), moderate group (the value of FEV1% predicted between 50% and 79%), severe group (the value of FEV1% predicted between 30% and 49%), and very severe group (the value of FEV1% predicted 30% or less).</p><p><strong>Results: </strong>There were significant differences in RFCSA (H 41.80, p <0.001), FEV1% predicted (H 63.91, p <0.001), and CAT (H 24.50, p <0.001) among the four groups. RFCSA, FEV1% predicted, and CAT varied significantly among the groups. In ECOPD patients, RFCSA showed positive relationship with FEV1% predicted (r = 0.75, p <0.001). A strong negative correlation was obtained between RFCSA and CAT in ECOPD patients (r = -0.69, p <0.001).</p><p><strong>Conclusion: </strong>RFCSA may be an indicator for evaluating the severity of ECOPD.</p><p><strong>Key words: </strong>Rectal muscle cross-sectional area, Forced expiratory volume in 1 second predicted, Exacerbations of chronic obstructive pulmonary disease, COPD assessment test, Modified medical research council.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 3","pages":"331-334"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Lactate Clearance Useful in Predicting Cardiopulmonary Resuscitation Outcome and 48-Hour Mortality?","authors":"Erdinc Senguldur, Mehmet Cihat Demir, Kudret Selki","doi":"10.29271/jcpsp.2025.03.267","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.03.267","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the predictive value of lactate clearance (ΔL) in witnessed cardiac arrest patients in the emergency department (ED) at two time points: Cardiopulmonary resuscitation (CPR) outcome and 48-hour mortality.</p><p><strong>Study design: </strong>Observational study. Place and Duration of the Study: Department of Emergency Medicine, Duzce University, Duzce, Turkiye, from July 1 to December 31, 2023.</p><p><strong>Methodology: </strong>Patients aged 18 years and older presenting with cardiac arrest in the ED, whose relatives signed the informed consent form, were included. Out-of-hospital cardiac arrest, trauma-related cardiac arrest, major bleeding, and known malignancy were excluded from the study. All patients who met the criteria were included. All data were recorded prospectively. Receiver operating characteristic (ROC) analysis and risk analysis were performed for lactate clearance (ΔL) and 20-minut Results: The predictive power of ΔL at 10 minutes (ΔL 0-10), 20 minutes (ΔL0-20), and between 10 and 20 minutes (ΔL10-20) was found to be significantly high for both the likelihood of no-ROSC (return of spontaneous circulation) and 48-hour mortality across all patients. The AUC values for ΔL at first 10 minutes, 20 minutes, and within 10-20 minutes were 0.991, 0.997, and 0.944, respectively for the no-ROSC group, and 0.942, 0.947, and 0.882, respectively for 48-hour mortality in the ROSC group. ROSC was not achieved in any patient with ΔL0-20 value of ≤-0.15. ΔL below the calculated thresholds increased the risk of not achieving ROSC and 48-hour mortality by tenfold.</p><p><strong>Conclusion: </strong>ΔL during CPR is a useful tool to predict the outcome of CPR and 48-hour mortality. The ΔL0-20 value was evaluated as a valuable parameter that can be used after the 20th minute of CPR when deciding whether to continue or terminate CPR.</p><p><strong>Key words: </strong>Emergency department, In-hospital cardiac arrest, Lactate clearance, Mortality, CPR outcome.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 3","pages":"267-273"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of the Declining Trend in Fluoroscopy Use: Addressing a Diagnostic Challenge in Patient Care.","authors":"Muhammad Haseeb Malik","doi":"10.29271/jcpsp.2025.03.393","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.03.393","url":null,"abstract":"<p><p>Null.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 3","pages":"393"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis on the Impact of Screen-Time on the Social-Emotional Development of Children Under Five Years.","authors":"Areesha Ahmer, Mohammad Raza, Maha Azhar, Abdur Rahman, Jai Kumar das, Sidra Kaleem Jafri","doi":"10.29271/jcpsp.2025.03.351","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.03.351","url":null,"abstract":"<p><p>Given the rising consumption of electronic media by children under five years of age, it is crucial to study the impact of screen time (ST) on the social-emotional development (SED) of children. Heterogenous past studies have reported emotional and behavioural problems, delayed language and motor milestones, and increased peer victimisation due to increasing ST. This review consolidates existing literature on the link between ST and children's SED, providing a comprehensive analysis of its impact. A detailed literature search across PubMed, Scopus, CINAHL, Cochrane Database of Systematic Review, and manual citation searching was conducted. Inclusion criteria were studies from 2012 up till July 2023, participants under age 5 years, and studies reporting the impact of ST on SED of children. This systematic review was performed using the PRISMA guidelines. Meta-analysis was conducted on articles that reported OR and used the strengths and difficulties questionnaire (SDQ) as the assessment tool. This review included 12 studies from 7 countries. The methodological quality of studies was good (n = 2), fair (n = 9), and poor (n = 1). Descriptive analysis revealed that ST was generally associated with poorer SED. The meta-analysis revealed that ST was significantly related to SED in children with an overall OR (using a random-effects model) of 1.24 (95% CI: 1.16-1.33). ST had a significant positive impact on hyperactivity and emotional problems with an OR of 1.39 (95% CI: 1.15-1.67) and 1.21 (95% CI: 1.15-1.27), respectively. These findings support the recommendations outlined by the AAP to limit ST for children. Caregivers and policymakers need to be recruited to prevent harmful impacts on SED outcomes of children. Key Words: Child, Infant, Social, Emotional, Development, Screen-time, Technology.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 3","pages":"351-358"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blazing the Trail for Diagnosis of Infectious Diseases: Why Microbial Infection Imaging Should Be a Pressing Priority in Pakistan.","authors":"Moiz Ahmed Khan","doi":"10.29271/jcpsp.2025.03.396","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.03.396","url":null,"abstract":"<p><p>Null.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 3","pages":"396"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Need for a Multidimensional Approach to Mortality Prediction in COVID-19: A Critical Review of Recent Findings.","authors":"Muhammad Khawar Ul Hassan Gillani, Muhammad Kashan Sajid","doi":"10.29271/jcpsp.2025.03.394","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.03.394","url":null,"abstract":"<p><p>Null.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 3","pages":"394-395"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing a Newborn Screening Programme: A Success Story from a Low-Resource Setting.","authors":"Hafsa Majid, Lena Jafri, Sibtain Ahmed, Khadija Nuzhat Humayun, Salman Kirmani, Aysha Habib Khan","doi":"10.29271/jcpsp.2025.03.387","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.03.387","url":null,"abstract":"<p><p>The purpose of this communication was to assess the clinical effectiveness of a newborn screening (NBS) programme for congenital hypothyroidism (CH) in a tertiary care centre. This cross-sectional study was conducted from January 2019 to December 2023. Thyroid-stimulating hormone (TSH) on dried blood spot (DBS) specimens collected after 24 hours of birth with >10 mIU/L was further confirmed by testing serum TSH and FT4, and CH cases were referred to a paediatric endocrinologist for management. During the study period, coverage of NBS was tracked. Over a four-year period, 30,402 newborns were screened, with 96.2% coverage (total births-31610). Positive screening results (TSH>10 mIU/L) were found in 1.9% of neonates (n = 586), with confirmatory tests performed in 63.13% (n = 370) of these cases. CH was confirmed in 27 cases, with an incidence of 1:1126. This study demonstrated that NBS for CH was successfully implemented and highly effective. However, there is a need to further improve recall rates. Key Words: Congenital hypothyroidism, Dried blood spot testing, Newborn screening, Clinical efficacy.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 3","pages":"387-389"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}