Journal of the College of Physicians and Surgeons--Pakistan : JCPSP最新文献

{"title":"The Association Between Facial Ageing and Bone Mineral Density: A Mendelian Randomisation Study.","authors":"Yabo Wang, Chao Zhen, Ziyu Wang, Lu Zhang, Yunzhen Chen","doi":"10.29271/jcpsp.2025.06.797","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.06.797","url":null,"abstract":"<p><p>This article aimed to assess the causative association between facial ageing and bone mineral density (BMD) using Mendelian randomisation (MR). In this observational study, single-nucleotide polymorphisms (SNPs) linked to facial ageing and four different body regions, including total mineral density (TB-BMD, n = 56,284), femoral neck BMD (FN-BMD, n = 32,735), forearm BMD (FA-BMD, n = 8,143), and lumbar spine BMD (LS-BMD, n = 28,498), were employed as instrumental variables. A two-sample MR analysis was undertaken to scrutinise the causal association between the identified exposure and respective outcomes. The authors found there was no causal relationship between facial ageing and TB-BMD (Beta, -0.1238; 95% CI, -0.3125 to 0.0648; p = 0.1982), FN-BMD (Beta, 0.0720; 95% CI, -0.1728 to 0.3168; p = 0.5643), FA-BMD (Beta, 0.0582; 95% CI, -0.3803 to 0.4966; p = 0.7949), or LS-BMD (Beta, -0.0188; 95% CI, -0.3087 to 0.2711; p = 0.8987). Therefore, the degree of osteoporosis in a person cannot be inferred based on their facial ageing. Key Words: Bone mineral density, Causal relationship, Mendelian randomisation, Facial ageing, Osteoporosis.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 6","pages":"797-799"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Dermoscopy and Interpretation of Dermoscopic Findings in Stable and Progressing Lesions of Vitiligo.","authors":"Sara Shafqat, Atiya Rahman, Zarin Manzoor, Shakila Junaid, Sidra Anwer, Janta Kumari","doi":"10.29271/jcpsp.2025.06.693","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.06.693","url":null,"abstract":"<p><strong>Objective: </strong>To identify the various dermoscopic patterns present in vitiligo and its predictive value in determining the stability of the disease.</p><p><strong>Study design: </strong>Cross-sectional study. Place and Duration of the Study: Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan, from October 2023 to July 2024.</p><p><strong>Methodology: </strong>A total of 80 clinically diagnosed patients of vitiligo, of either gender, with stable and progressing vitiligo, having age ≥18 years, were included. Dermoscopic examination of vitiligo lesions was done to evaluate the clinical stability of the lesions. SPSS version 26 was used to analyse the data. The dermoscopic findings of stable and progressing vitiligo were compared using the Chi-square test and Fisher's exact test.</p><p><strong>Results: </strong>Out of the 80 patients who were clinically diagnosed with vitiligo, 56 (70%) were women and 24 (30%) were men. The patients' average age was 31.94 ± 8.185 years. Approximately 38 (47.5%) patients had stable vitiligo, while 42 (52.5%) had progressing vitiligo. The dermoscopic patterns included perifollicular depigmentation in 15%, perifollicular hyperpigmentation in 33%, perilesional/marginal hyperpigmentation in 8%, intra/perilesional erythema with telangiectasia in 19%, trichrome pattern in 26%, leucotrichia in 14%, starburst appearance in 24%, comet tail appearance in 26%, and minor Koebner's phenomenon in 33.75% cases. Comparison of findings between stable versus progressing vitiligo showed significant difference with a p-value of <0.05.</p><p><strong>Conclusion: </strong>Specific dermoscopic patterns can be utilised to ascertain disease activity and accordingly decide on the management protocol.</p><p><strong>Key words: </strong>Dermoscopy, Dermatoscopy, Dermoscopic patterns, Dermatoscopic patterns, Stable vitiligo, Progressing vitiligo.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 6","pages":"693-697"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Utility of Sonography and Magnetic Resonance Imaging in Evaluating Placenta Previa and Its Variants Using Intraoperative Findings as the Gold Standard.","authors":"Izza Shahid, Nadeem Ibrahim, Sadaf Shafique, Zunaira Zulfiqar","doi":"10.29271/jcpsp.2025.06.698","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.06.698","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the diagnostic utility of ultrasonography and magnetic resonance imaging (MRI) for the diagnosis of placenta previa (PP) with accurate grading, keeping peroperative findings as the gold standard.</p><p><strong>Study design: </strong>A cross-sectional study. Place and Duration of the Study: Department of Radiology, Combined Military Hospital, Gujranwala, Pakistan, from March 2023 to April 2024.</p><p><strong>Methodology: </strong>Pregnant women aged 18-45 years in their third trimester with suspected PP were evaluated using transabdominal ultrasound and non-contrast MRI (1.5T). Perioperative findings during caesarean section served as the gold standard. Diagnostic accuracy was calculated for ultrasonography and MRI in diagnosing the accurate type of PP in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), keeping peroperative findings as the gold standard.</p><p><strong>Results: </strong>In a total of 110 cases, the mean and gestational ages were 30.56 ± 3.46 years and 33.25 ± 2.95 weeks, respectively. The sensitivity of ultrasound was 83.3%, while MRI demonstrated sensitivity at 95.0%. Ultrasound and MRI showed equally high specificity at 98.0%. The PPV was 98.0% for ultrasound and 98.3% for MRI. The NPV was 83.1% for ultrasound and 94.2% for MRI. The diagnostic accuracy of ultrasound was 90.0%, while MRI achieved a diagnostic accuracy of 96.4%. The diagnostic performance of USG and MRI did not reveal significant differences (p = 0.065).</p><p><strong>Conclusion: </strong>Ultrasonography can be a useful, cost effective, and safest initial assessment tool for diagnosis and grading of PP in the late pregnancy. It showed overall comparable results of USG and MRI.</p><p><strong>Key words: </strong>Diagnostic accuracy, Gold standard, Transabdominal ultrasound, Placenta previa, Ultrasonography.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 6","pages":"698-702"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Peripheral Blood CD4/CD8 Ratio with Efficacy and Prognosis in Patients with Non-Small Cell Lung Cancer Receiving PD-1/PD-L1 Inhibitors.","authors":"Guo-Xiang Li, Qi-Ming Zheng, Yuan-Yuan Li, Ye-Peng Wang, Min Zhang, Zhi-Gang Sun","doi":"10.29271/jcpsp.2025.06.800","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.06.800","url":null,"abstract":"<p><p>The aim of this study was to investigate the predictive role of the peripheral blood CD4/CD8 ratio in patients with non-small cell lung cancer (NSCLC) treated with PD-1/PD-L1 inhibitors therapy. Cochrane, Embase, Medline, PubMed, and Web of Science were searched until November 2023. Data were analysed using Stata MP 17.0 software. Outcome indicators included progression-free survival (PFS) and overall survival (OS). A total of five studies of the baseline CD4/CD8 ratio in peripheral blood strictly met the inclusion criteria. The pooled outcome indicator showed that high level of peripheral blood CD4/CD8 ratio in patients with NSCLC receiving PD-1/PD-L1 inhibitors was associated with better PFS (HR = 0.62, 95% CI: 0.49-0, 79, p <0.001), rather than OS (HR = 0.90, 95% CI: 0.53-1.51, p = 0.679). The results from this meta-analysis demonstrated that in patients with NSCLC receiving PD-1/PD-L1 inhibitors, a high baseline CD4/CD8 ratio in peripheral blood can predict better PFS. Key Words: CD4-CD8 Ratio, Immune checkpoint inhibitors, Non-small cell lung cancer, Peripheral blood, Prognosis, Survival.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 6","pages":"800-802"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic Radiomics Utilised to Predict Lateral Neck Lymph-Node Metastasis in Papillary Thyroid Carcinoma.","authors":"Xi Cai, Sichen Chen, Yan Ding, Fengsheng Zhou, Yu Zhang","doi":"10.29271/jcpsp.2025.06.742","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.06.742","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical significance of preoperative prediction for detecting metastasis in lateral neck lymph nodes (LNLN) among patients diagnosed with papillary thyroid carcinoma (PTC).</p><p><strong>Study design: </strong>Descriptive study. Place and Duration of the Study: Department of Medical Ultrasound, Wuxi People's Hospital of Nanjing Medical University, Wuxi, China, from March 2021 to March 2023.</p><p><strong>Methodology: </strong>Data from PTC patients with complete ultrasound and clinical records were collected, including 112 patients in the training group and 49 in the validation group. Based on pathological analysis, the individuals were categorised into the LNLN metastasis- positive group (50 cases) and the LNLN metastasis-negative group (111 cases). Logistic regression analysis showed that independent factors affected gender (OR = 3.167) as well as the maximum diameter of the tumour (OR = 1.177) and LNLN metastasis. Based on the above two independent influencing factors, the clinical model and ultrasound image feature model were constructed, respectively. A total of 6 non-zero coefficients of ultrasound radiomics features were screened by the LASSO regression dimensionality reduction to construct ultrasound radiomics models.</p><p><strong>Results: </strong>Significant differences existed in Rad scores (RS) between the LNLN metastasis-positive group and the LNLN metastasis-negative group in the training set (p <0.05). The ROC curve indicated that the combined model exhibited a significantly higher area under the curve (AUC) compared to the ultrasound radiomics model. The calibration curve demonstrated high calibration for both the ultrasound radiomics model and the combined model, in good consistency with the actual results.</p><p><strong>Conclusion: </strong>The clinical-ultrasonic feature-radiomics model holds significant clinical value in predicting LNLN metastasis in PTC patients.</p><p><strong>Key words: </strong>Radiomics, Lateral neck lymph node, Papillary thyroid carcinoma, Preoperative prediction, Logistic regression analysis.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 6","pages":"742-748"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes Between Fresh Embryo and First Frozen-Thawed Embryo Transfer in Donor Sperm In-Vitro Fertilisation.","authors":"Jiayao Chen, Zhiping Zhang, Wenjing Shi, Qin Yan, Shimin Wang, Xueqing Wu","doi":"10.29271/jcpsp.2025.06.703","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.06.703","url":null,"abstract":"<p><strong>Objective: </strong>To compare the pregnancy outcomes of embryo transfer (ET) and frozen-thawed embryo transfer (FET) after controlling for maternal confounding factors.</p><p><strong>Study design: </strong>Descriptive analytical study. Place and Duration of the Study: Reproductive Medicine Centre, Children's Hospital of Shanxi and Women Health Centre of Shanxi, Affiliated Hospital of Shanxi Medical University, Taiyuan, China, from January 2015 to September 2022.</p><p><strong>Methodology: </strong>Clinical data and pregnancy outcomes of 1,051 sperm-donor in-vitro fertilisation IVF/ICSI embryo-transfer cycles, divided into initial FET and fresh ET groups, were compared. Primary outcomes included clinical pregnancy rate, miscarriage rate, and live birth rate.</p><p><strong>Results: </strong>Significant differences were observed in clinical pregnancy and live birth rates (44.02% vs. 53.63%, p = 0.018; 34.78% vs. 44.87%, p = 0.012) but not in miscarriage or ectopic pregnancy rates (18.52% vs. 14.41%, p = 0.339; 2.47% vs. 1.94%, p = 0.752) between the groups.</p><p><strong>Conclusion: </strong>In 1,065 sperm-donor IVF cycles, frozen-thawed embryos yielded higher clinical pregnancy and live birth rates, particularly with single ET. FET is a successful, safe, and preferable option for couples using donor sperm in assisted reproductive technologies.</p><p><strong>Key words: </strong>Donor sperm, Fresh embryo transfer, Frozen-thawed embryo transfer, Pregnancy outcome, Assisted reproductive technique.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 6","pages":"703-707"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Combined MPFL Reconstruction and Lateral Retinacular Release in Lateral Patellar Instability.","authors":"Muhammad Usama, Hafiz Umair Hussain, Faraz Ahmad Khan, Bilal Zaib, Abid Ullah, Muhammad Basharat","doi":"10.29271/jcpsp.2025.06.730","DOIUrl":"10.29271/jcpsp.2025.06.730","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of the combined medial patellofemoral ligament (MPFL) and reconstruction release in lateral patellar instability in terms of radiological and functional outcomes following the procedure.</p><p><strong>Study design: </strong>A retrospective observational study. Place and Duration of the Study: Department of Orthopaedics, Ghurki Trust Teaching Hospital, Lahore, Pakistan, from January 2019 to January 2024.</p><p><strong>Methodology: </strong>Forty-seven patients with lateral patellar instability that underwent MPFL reconstruction and lateral retinacular release were studied, and the average follow-up duration was 17.5 (12-26) months. The patellar tilt, lateral patellar, and congruence angles were determined. Globally accepted scoring systems-such as Kujala, Lyshom, and Nelitz scores-were computed and compared.</p><p><strong>Results: </strong>Congruence angle improved from 18.7 ± 4.8 to a value of -4.9 ± 1.37 postoperatively. On the last follow-up, the lateral patellar angle had improved from 7.9 ± 3.9 to 6.1 ± 2 which was statistically significant (p <0.05) according to the paired samples t-test evaluation. Additionally, the patellar tilt angle improved, going from 27.6 ± 6.7 to 6.1 ± 0.9. In addition to the radiological improvement, an increase in each of the three measured scores indicated physiological improvement. The postoperative mean Lyshom score increased considerably from 43.82 ± 11.3 to 87.74 ± 8.85 (p <0.001). Likewise, the average Kujala score increased significantly from 45.42 ± 9.29 points to 89.42 ± 6.99 (p <0.001). Eighteen (38%) patients reported as being satisfied, four (9%) patients were partially satisfied, and only one (2%) patient was not satisfied.</p><p><strong>Conclusion: </strong>Improvements in both radiological and functional outcomes occur with MPFL reconstruction and lateral retinacular release; nonetheless, further higher-level evidence-generating research on the topic is recommended.</p><p><strong>Key words: </strong>Lateral retinacular release, Medial patello-femoral ligament reconstruction, Patellar instability.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 6","pages":"730-734"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Nicorandil in Heart Failure: A Meta-Analysis.","authors":"Tongge Mu, Kaixuan Tang, Yan Sun","doi":"10.29271/jcpsp.2025.06.755","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.06.755","url":null,"abstract":"<p><p>This meta-analysis aims to evaluate the effectiveness of nicorandil in treating heart failure by synthesising evidence from diverse studies. The study period spanned from 12/01/2023 to 28/02/2024. Observational and randomised controlled trials have been conducted to study the cardiovascular outcomes associated with nicorandil. The findings consistently show that nicorandil, administered either intravenously or orally, significantly reduces major adverse cardiovascular events (MACEs), lowers NT-proBNP levels, and improves left ventricular ejection fraction, indicating enhanced cardiac function. Nicorandil emerges as a promising adjunctive therapy in heart failure management, potentially improving patient outcomes and decreasing the risk of MACEs. However, the exact role of this therapy in heart failure treatment requires further research. Key Words: Nicorandil, Heart failure, Major adverse cardiovascular events (MACEs), Cardiac function, Meta-analysis.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 6","pages":"755-760"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hashimoto's Encephalopathy Co-Occurring with Graves' Disease in a Paediatric Patient: Efficacy of Early Plasma Exchange.","authors":"Yan Wang, Peisen Ruan, Hehe Chen","doi":"10.29271/jcpsp.2025.06.805","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.06.805","url":null,"abstract":"<p><p>Null.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 6","pages":"805-806"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FOXQ1 Suppressing Apoptosis in Colorectal Cancer Cells by P53 Deacetylation.","authors":"Guisong Yang, Huanjie Chen, Xiaolei Ma, Fugang Wang, Guiliang Ma, Hong Qi","doi":"10.29271/jcpsp.2025.06.722","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.06.722","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the impact of Forkhead box Q1 (FOXQ1) expression on platinum-based chemoresistance in colorectal cancer (CRC) cells, and to examine the regulatory function of FOXQ1 on Sirtuin 1 (SIRT1) protein expression and P53 protein deacetylation levels during the DNA damage response (DDR).</p><p><strong>Study design: </strong>An experimental study. Place and Duration of the Study: Second Department of Gastrointestinal Surgery, General Surgery Centre, Qingdao Municipal Hospital, Affiliated to Qingdao Medical College, Qingdao University, Qingdao, China, from October 2023 to December 2024.</p><p><strong>Methodology: </strong>Gene expression levels of FOXQ1 in CRC cells and SW620 cells treated with cisplatin (CDDP) were evaluated using quantitative real-time polymerase chain reaction (qRT-PCR). The t-test was used to compare the gene expression levels between the two groups. Three gene-edited SW620 cell models were established: FOXQ1 overexpression (oe-FOXQ1), FOXQ1 RNA interference (sh- FOXQ1), and a negative control (NC). CCK-8 assays measured CDDP's half-inhibitory concentration (IC50), while flow cytometry, calcein-AM/PI staining, and colony formation evaluated cell apoptosis and survival. Western blot analysed SIRT1 and acetylated p53, and the SIRT1 inhibitor (S)-Selisistat explored FOXQ1-related pathways.</p><p><strong>Results: </strong>FOXQ1 was highly expressed in CRC. CDDP treatment further increased its expression in SW620 cells. FOXQ1 overexpression enhanced CDDP resistance, elevated SIRT1 levels, and promoted P53 deacetylation. (S)-Selisistat reversed P53 deacetylation and reduced CDDP resistance in oe-FOXQ1 cells.</p><p><strong>Conclusion: </strong>FOXQ1 promotes chemoresistance in CRC by upregulating SIRT1 expression and promoting P53 deacetylation, thereby inhibiting apoptosis triggered by DDR.</p><p><strong>Key words: </strong>Colorectal cancer, Forkhead Box Q1, Sirtuin 1, P53 Acetylation, Apoptosis.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 6","pages":"722-729"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}