Syed Muzammil Shah, Sultan Ahmad, Noor Elahi, Muhammad Tariq, Shahid Alam, Tahir Shah
{"title":"Trends in Voluntary and Replacement Blood Donors: Seroprevalence of Transfusion-Transmitted Infections in Malakand Division, 2021-2024.","authors":"Syed Muzammil Shah, Sultan Ahmad, Noor Elahi, Muhammad Tariq, Shahid Alam, Tahir Shah","doi":"10.29271/jcpsp.2025.10.1340","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate trends in voluntary non-remunerated blood donors (VNRBD) versus replacement donors, and to investigate the prevalence of transfusion-transmitted infections (TTIs) among healthy blood donors in Malakand Division, Pakistan.</p><p><strong>Study design: </strong>Retrospective study. Place and Duration of the Study: Department of Health, Regional Blood Centre, Central Hospital Saidu Sharif, Swat, Pakistan, from 2021 to 2024.</p><p><strong>Methodology: </strong>This study analysed trends in VNRBD and replacement donors, along with the seroprevalence of TTIs (HCV, HBV, HIV, and Syphilis) using automated chemiluminescent microparticle immunoassay (CMIA). The Chi-square test in R-Studio was conducted to analyse trends in blood donor categories and TTIs over the four years.</p><p><strong>Results: </strong>A total of 94,716 healthy blood donors were screened during the study period. Male donors dominated both categories, with 80,105 (84.57%) in replacement and 14,526 (15.34%) in voluntary donations. Female participation remained minimal, with only 27 (0.03%) in replacement and 58 (0.06%) in voluntary donations. Most donors were in the age range of 18-33 years, totalling 71,107 (75.1%). Statistically significant changes (p <0.001) in voluntary and replacement donation trends were confirmed by the Chi-square test. A total of 2,292 (2.42%) TTIs were detected, including 873 (0.92%) cases of HCV, 637 (0.67%) cases of HBV, 220 (0.23%) cases of HIV, and 562 (0.59%) cases of syphilis.</p><p><strong>Conclusion: </strong>The study revealed a 2.42% TTIs prevalence among 94,716 donors, with male dominance (84.57%) and low female participation (0.03%). Syphilis and HIV cases increased in 2024 (p <0.001), highlighting the need for targeted blood donation campaigns and improved screening to reduce TTIs in Pakistan.</p><p><strong>Key words: </strong>Voluntary non-remunerated blood donation, Replacement blood donation, Transfusion-transmitted infections, HCV, HBV, HIV, Syphilis.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 10","pages":"1340-1344"},"PeriodicalIF":0.8000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29271/jcpsp.2025.10.1340","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To evaluate trends in voluntary non-remunerated blood donors (VNRBD) versus replacement donors, and to investigate the prevalence of transfusion-transmitted infections (TTIs) among healthy blood donors in Malakand Division, Pakistan.
Study design: Retrospective study. Place and Duration of the Study: Department of Health, Regional Blood Centre, Central Hospital Saidu Sharif, Swat, Pakistan, from 2021 to 2024.
Methodology: This study analysed trends in VNRBD and replacement donors, along with the seroprevalence of TTIs (HCV, HBV, HIV, and Syphilis) using automated chemiluminescent microparticle immunoassay (CMIA). The Chi-square test in R-Studio was conducted to analyse trends in blood donor categories and TTIs over the four years.
Results: A total of 94,716 healthy blood donors were screened during the study period. Male donors dominated both categories, with 80,105 (84.57%) in replacement and 14,526 (15.34%) in voluntary donations. Female participation remained minimal, with only 27 (0.03%) in replacement and 58 (0.06%) in voluntary donations. Most donors were in the age range of 18-33 years, totalling 71,107 (75.1%). Statistically significant changes (p <0.001) in voluntary and replacement donation trends were confirmed by the Chi-square test. A total of 2,292 (2.42%) TTIs were detected, including 873 (0.92%) cases of HCV, 637 (0.67%) cases of HBV, 220 (0.23%) cases of HIV, and 562 (0.59%) cases of syphilis.
Conclusion: The study revealed a 2.42% TTIs prevalence among 94,716 donors, with male dominance (84.57%) and low female participation (0.03%). Syphilis and HIV cases increased in 2024 (p <0.001), highlighting the need for targeted blood donation campaigns and improved screening to reduce TTIs in Pakistan.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
