Journal of the College of Physicians and Surgeons--Pakistan : JCPSP最新文献

{"title":"Doppler Ultrasonography Findings Before and After Progesterone Therapy in Abortus Imminens.","authors":"Hilal Gulsum Turan Ozsoy, Gultekin Adanas Aydin, Serhat Unal, Behiye Oral","doi":"10.29271/jcpsp.2026.10.1305","DOIUrl":"https://doi.org/10.29271/jcpsp.2026.10.1305","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of vaginal micronised progesterone on uteroplacental haemodynamics in first-trimester pregnancies complicated by abortus imminens.</p><p><strong>Study design: </strong>A descriptive study. Place and Duration of the Study: Department of Obstetrics and Gynaecology, University of Health Sciences, Bursa City Hospital, Bursa, Turkiye, from October to December 2024.</p><p><strong>Methodology: </strong>This retrospective study included 27 women with singleton first-trimester pregnancies diagnosed with abortus imminens. Patients received vaginal micronised progesterone 400 mg/day for 14 days. Uterine and spiral artery Doppler ultrasound (DUS) indices, including pulsatility index (PI) and resistive index (RI), were measured before treatment, at 48 hours, and on Day 14 post-treatment. A paired-samples t-test was used to compare DUS indices, analysed in SPSS (version 26.0).</p><p><strong>Results: </strong>The mean age of the mothers was 30.30 ± 5.36 years; the mean body mass index was 24.51 ± 3.55 kg/m2. Mean gestational age was 9.4 ± 3.5 weeks. Significant decreases were observed in the spiral artery PI and RI and the right uterine artery indices at Assessments 2 and 3 compared with the pre-treatment values. High intra-observer agreement was observed for the uterine arteries (p <0.0001). Clinical follow-up showed successful term live births in 24 (88.9%) patients, while late miscarriage occurred in 3 (11.1%).</p><p><strong>Conclusion: </strong>Vaginal micronised progesterone therapy for first-trimester abortus imminens produces a rapid, significant reduction in uterine and spiral artery Doppler indices within 48 hours, persisting at 14 days, indicating acute and sustained improvement in uteroplacental perfusion.</p><p><strong>Key words: </strong>Progesterone, Uteroplacental circulation, Doppler velocimetry, Abortus imminens, Vaginal progesterone.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"36 10","pages":"1305-1311"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149140107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting MMPs in Ovarian Cancer: A New Frontier for Antibiotic Repurposing.","authors":"Durga Devi, Fatima Bibi, Shama Chaudhry","doi":"10.29271/jcpsp.2026.10.1233","DOIUrl":"https://doi.org/10.29271/jcpsp.2026.10.1233","url":null,"abstract":"<p><p></p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"36 10","pages":"1233-1235"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Sympathetic Denervation Plus Pulmonary Vein Isolation for Atrial Fibrillation in Patients with Hypertension: A Meta-Analysis of Randomised Controlled Trials.","authors":"Kun Wang, Na Yi, Yong Cai Liang, Jie Xiong, Ting Wan","doi":"10.29271/jcpsp.2026.10.1318","DOIUrl":"10.29271/jcpsp.2026.10.1318","url":null,"abstract":"<p><p>To assess the efficacy and safety of adding adjuvant renal sympathetic denervation (RSDN) to pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF). A search of multiple electronic databases was conducted using a comprehensive strategy to identify randomised controlled trials (RCTs) evaluating the impact of RSDN combined with PVI compared with PVI alone in patients with AF and hypertension. The search results were imported to Covidence for article eligibility screening. Six RCTs were included, involving a total of 516 patients. The rate of AF recurrence [RR: 0.58, 95% CI (0.40; 0.82), p = 0.002, I2 = 28%] was significantly lower with RSDN+PVI compared to PVI alone at 12 months, whereas no significant difference was found at 24 months (p = 0.93). RSDN+PVI significantly reduced systolic blood pressure (SBP) at 12 months (MD: -13.41, 95% CI = -15.59; -11.22, p <0.001, I2 = 88%) and diastolic blood pressure (DBP) at 12 months (MD: -4.54, 95% CI -7.66; -1.42, p = 0.004, I2 = 81%) compared to PVI alone. This meta-analysis demonstrated that SBP and DBP, as well as AF recurrence, were lower at 12 months in the PVI plus adjunctive RSDN therapy group than in the PVI-alone group. Key Words: Renal sympathetic denervation, Pulmonary vein isolation, Atrial fibrillation, Hypertension, Catheter ablation, Antiarrhythmic therapy.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"36 10","pages":"1318-1325"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Probiotics on Oral Microbiological Environment, Gingival Health, and Dental Plaque: A Meta-Analysis.","authors":"Mehwash Kashif, Mahmooda Kazmi, Asfahan Shah, Syeda Nimra Qadri","doi":"10.29271/jcpsp.2026.10.1326","DOIUrl":"10.29271/jcpsp.2026.10.1326","url":null,"abstract":"<p><p>This meta-analysis was conducted to assess the effects of probiotics on dental plaque, gingival health, and the oral microbiological environment. PubMed and Google Scholar were searched, and the Cochrane Collaboration's Risk of Bias tool was used to assess the risk of bias in the included studies. Thirteen randomised clinical trials were included, enrolling 321 participants. Probiotics had positive effects on gingival index (GI) scores (p = 0.04), with no statistically significant improvement in plaque index scores (p = 0.64) or bleeding on probing (p = 0.92). No significant differences were observed in IL-1β levels; Prevotella intermedia (p = 0.37), Fusobacterium nucleatum (p = 0.11), Porphyromonas gingivalis (p = 0.13), Aggregatibacter actinomycetemcomitans (p = 0.16) counts; or gingival crevicular fluid volumes (p = 0.94). The probiotics intervention had a substantial impact on GI score. These findings suggest that probiotics may improve gingival health and offer adjunctive treatment for gingivitis and periodontal disease. Key Words: Dental plaque, Gingival health, Microbiological environment, Oral, Probiotics.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"36 10","pages":"1326-1333"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149140099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting Postoperative Lactate Differences Following Modified Del Nido Cardioplegia in Adult Coronary Artery Bypass Grafting.","authors":"Bedirhan Bugra Bayici, Fatih Kizilyel","doi":"10.29271/jcpsp.2026.10.1368","DOIUrl":"https://doi.org/10.29271/jcpsp.2026.10.1368","url":null,"abstract":"<p><p></p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"36 10","pages":"1368-1369"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Hepatitis B Virus Ribonucleic Acid with Type 2 Diabetes Mellitus in Chronic Hepatitis B.","authors":"Xinyuan Chen, Huanzheng Li, Liling Chen","doi":"10.29271/jcpsp.2026.10.1260","DOIUrl":"https://doi.org/10.29271/jcpsp.2026.10.1260","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether serum hepatitis B virus (HBV) ribonucleic acid (RNA) positivity, compared with HBV deoxyribonucleic acid (DNA), is independently associated with type 2 diabetes mellitus (T2DM) in patients with chronic hepatitis B (CHB).</p><p><strong>Study design: </strong>A descriptive study. Place and Duration of the Study: Department of Clinical Laboratory, Wenzhou Central Hospital, Wenzhou, China, from October 2023 to May 2025.</p><p><strong>Methodology: </strong>This study included 1,843 patients with CHB. The relationships between HBV markers and T2DM were examined in 239 patients. The association between T2DM and different HBV RNA/DNA stratifications was assessed using multivariate logistic regression.</p><p><strong>Results: </strong>Among 1,843 patients, there was a moderate positive correlation between HBV RNA and HBV DNA levels (r = 0.452, p <0.001). Among 239 patients, the prevalence of T2DM was significantly higher in the HBV RNA-positive group than in the RNA-negative group (p = 0.021). By contrast, there was no statistically significant difference in T2DM prevalence between the HBV DNA-positive and DNA-negative groups (p = 0.242). Multivariate analysis showed that HBV DNA was not significantly associated (p > 0.05), whereas RNA positivity was an independent risk factor for T2DM (odds ratio [OR] = 2.091, 95% confidence interval [CI] = 1.127-3.881, p = 0.019). Stratified analysis showed that patients with HBV DNA-negative/RNA-positive status had the highest risk of T2DM (OR = 2.981, 95% CI = 1.316-6.755, p = 0.009) compared with the HBV DNA-negative/RNA-negative reference group. Furthermore, male gender was independently associated with T2DM (OR range = 3.480-3.764, p < 0.001).</p><p><strong>Conclusion: </strong>HBV RNA (especially DNA-negative) better assesses T2DM risk in patients with CHB.</p><p><strong>Key words: </strong>Type q2 diabetes mellitus, Hepatitis B virus, Hepatitis B virus ribonucleic acid, Hepatitis B virus deoxyribonucleic acid, Risk factors.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"36 10","pages":"1260-1265"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149140060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-High-Burden TP53 Mutation (VAF 92%) in Acute Myeloid Leukaemia: A Fatal Case with Rapid Clinical Progression.","authors":"Rongli Xu, Zixuan Zhang, Shaojin Wen","doi":"10.29271/jcpsp.2026.10.1372","DOIUrl":"https://doi.org/10.29271/jcpsp.2026.10.1372","url":null,"abstract":"<p><p></p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"36 10","pages":"1372"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriasis Metabolism-Immune Regulation Network Analysis Based on Blood and Skin Tissue Transcriptome Data.","authors":"Huihuang He, Xuesong Xiang, Yanfang Zhang, Wenhong Qiu, Kaiwen Guo","doi":"10.29271/jcpsp.2026.10.1242","DOIUrl":"https://doi.org/10.29271/jcpsp.2026.10.1242","url":null,"abstract":"<p><strong>Objective: </strong>To identify pivotal genes involved in the metabolic-immune crosstalk of psoriasis and evaluate their utility as biomarkers for diagnosis and targeted therapy.</p><p><strong>Study design: </strong>A bioinformatics-based experimental study. Place and Duration of the Study: Department of Immunology, School of Medicine, Jianghan University, Wuhan, China, from September 2024 to October 2025.</p><p><strong>Methodology: </strong>Transcriptomic data from peripheral blood neutrophils (GSE106087) and skin lesions (GSE30999) were integrated. Differentially expressed genes were screened, followed by protein-protein interaction (PPI) network analysis and LASSO regression. Validation employed ROC analysis, Gene Set Enrichment Analysis (GSEA), immune infiltration assessment, qRT-PCR in an LPS-induced HaCaT model, and single-cell RNA sequencing.</p><p><strong>Results: </strong>CD36, IL1B, and CREB1 were identified as core regulatory factors. GSEA linked CD36 to tricarboxylic acid cycle impairment, and CREB1 to altered potassium ion transport and energy metabolism. qRT-PCR confirmed that all three genes were upregulated in vitro. Single-cell analysis showed that CD36 and IL1B expression in various cell types in psoriatic skin lesions was increased. Immune infiltration analysis showed that CD36 expression in patients with psoriasis was strongly negatively correlated with the abundance of neutrophils, whereas the abundances of CD8+ T cells and mast cells were increased.</p><p><strong>Conclusion: </strong>This study outlines a psoriasis-specific metabolic-immune imbalance network with CD36, IL1B, and CREB1 as the core. Multidimensional validation supports their potential for patient stratification and targeted treatment and provides a basis for future drug development.</p><p><strong>Key words: </strong>Psoriasis, CD36, CREB1, IL1B, LASSO regression model, Gene expression profiling, Single-cell gene expression analysis, Biomarker, Metabolic-immune network.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"36 10","pages":"1242-1253"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mind-Motor Mat Training as an Early Adjunct to Antihypertensive Therapy for Cognitive Preservation.","authors":"Sana Bashir, Arzoo Bashir, Mehreen Baig","doi":"10.29271/jcpsp.2026.10.1353","DOIUrl":"10.29271/jcpsp.2026.10.1353","url":null,"abstract":"<p><p>Hypertension affects over 1.28 billion adults globally and remains a critical contributor to cardiovascular complications, mortality, and cognitive decline. Its prevalence approaches 25% in Pakistan, with many cases remaining undiagnosed or uncontrolled. Chronic elevation in blood pressure damages cerebral vasculature, disrupts the blood-brain barrier, and accelerates white matter degeneration, leading to impairments in attention, memory, and executive functions, enhancing dementia risk. This commentary synthesises the current evidence linking hypertension-related cerebrovascular pathology with cognitive deterioration, exploring mind-motor mat training (MMMT) as a potential early, non-pharmacological adjunct to antihypertensive therapy. It integrates structured stepping sequences with concurrent cognitive challenges-such as memory recall, pattern recognition, and decision-making-to enhance neurovascular coupling, neuroplasticity, and functional balance. Based on the reviewed literature, this practice proposal supports integrating MMMT into routine hypertension management to promote cognitive preservation, reduce fall risk, and improve overall quality of life. Such an approach extends hypertension care beyond pharmacological control toward comprehensive neuroprotective and rehabilitative strategies. Key Words: Hypertension, Cognitive decline, Mind-motor mat training.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"36 10","pages":"1353-1355"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Spine Surgery for the Treatment of Degenerative Lumbar Spondylolisthesis with Spinal Stenosis in Elderly Patients.","authors":"Zheng Li, Chongchao Yan, Na Zhong, Zhongxu Bai, Jianpeng Zhang, Wenkui Zhao","doi":"10.29271/jcpsp.2026.09.1205","DOIUrl":"https://doi.org/10.29271/jcpsp.2026.09.1205","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical outcomes of endoscopic lumbar interbody fusion in elderly patients with degenerative lumbar spondylolisthesis (DLS) and spinal stenosis.</p><p><strong>Study design: </strong>A descriptive study. Place and Duration of the Study: Department of Orthopaedics, Baoding No.1 Hospital, Baoding, China, from June 2023 to June 2024.</p><p><strong>Methodology: </strong>A descriptive review of 40 patients with single-segment DLS and spinal stenosis was carried out. Patients were classified into a control group and an observation group according to the surgical method. Perioperative indicators, pain measured using the Visual Analogue Scale (VAS), Oswestry Disability Index (ODI) scores, and Japanese Orthopaedic Association (JOA) scores at 6 months postoperatively were used for efficacy evaluation based on the modified MacNab criteria. Lumbar MRI measured the dura mater cross-sectional area to assess the decompression effect. The t-test and chi-square (c²) test were employed to analyse the outcomes.</p><p><strong>Results: </strong>Incision length, blood loss, and hospital stay were significantly reduced in the observation group (p < 0.05). At 6 months postoperatively, both groups showed significant improvements in VAS, JOA, and ODI scores compared with preoperative values (p <0.05). The observation group demonstrated significantly greater improvement than the control group (p <0.05). The excellent surgical outcomwe rate in the observation group was significantly higher than in the control group (c2 = 4.329, p = 0.037). The dura mater cross-sectional areas in the two groups significantly increased relative to preoperative measurements (p <0.05); however, these two groups did not exhibit a statistical difference (p >0.05).</p><p><strong>Conclusion: </strong>Spinal endoscopic surgery for elderly patients with degenerative spondylolisthesis combined with spinal stenosis has a definite therapeutic effect and has unique advantages in improving patients' symptoms and enhancing their quality of life.</p><p><strong>Key words: </strong>Endoscopic spine, Elderly, Degenerative lumbar spondylolisthesis, Spinal stenosis, Clinical efficacy.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"36 9","pages":"1205-1209"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}