Journal of the College of Physicians and Surgeons--Pakistan : JCPSP最新文献

{"title":"Simultaneous Bilateral Carotid Artery Stenting on Elderly Patients.","authors":"Sisi Zhao, Pengfei Hu, Lingtao Tang","doi":"10.29271/jcpsp.2025.08.1075","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.08.1075","url":null,"abstract":"<p><p>Null.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 8","pages":"1075-1076"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic and Genotypic Association of the Duffy Blood Group Antigens (Fy^a, Fy^b) in Healthy Blood Donors.","authors":"Sadia Ali, Fahim Akhtar, Rehan Ahmad Khan Lodhi, Nargis Sabir","doi":"10.29271/jcpsp.2025.08.953","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.08.953","url":null,"abstract":"<p><strong>Objective: </strong>To determine the Duffy blood group antigens (Fya, Fyb) phenotypic and genotypic distribution among blood donors reporting in a tertiary care transfusion centre in the northern region of Pakistan.</p><p><strong>Study design: </strong>A cross-sectional study. Place and Duration of the Study: Department of Immunohaematology and Molecular Biology, Armed Forces Institute of Transfusion, Rawalpindi, Pakistan, from August 2023 to March 2024.</p><p><strong>Methodology: </strong>The total number of blood donors recruited was 287, using the WHO sample size calculator. ABO, Rhesus (Rh), and Duffy blood group phenotyping were performed using commercially available antisera. Genotyping of the Duffy blood group was carried out using polymerase chain reaction specific sequence of primers (PCR-SSP). Statistical Package for the Social Sciences (SPSS) version 22 was used to analyse the data. For association analysis, the Chi-square test was used.</p><p><strong>Results: </strong>The most common phenotype observed was (a+ b-), found in 53.3% of all Duffy phenotypes, followed by a+ b+ (31.7%), a- b+ (13.2%), and a- b- (1.7%). The frequency of Duffy genotypes showed a non-significant correlation with Duffy phenotypes.</p><p><strong>Conclusion: </strong>In the catchment area of the studied centre in Northern Pakistan, the phenotypic frequency of (a+ b-) is the highest of all Duffy phenotypes i.e., (53.3%), followed by a+ b+, a- b+, and a- b-, respectively. Serological and PCR-SSP methods were found to be in complete agreement. PCR could serve as an alternative approach for identifying the Duffy blood group, especially in individuals with low antigen expression.</p><p><strong>Key words: </strong>Duffy blood group, Alloimmunisation, Genotype, Phenotype, Transfusion.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 8","pages":"953-957"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levels of Serum Vitamin D in Oral <em>Lichen Planus </em>Patients in the Twin Cities of Pakistan: A Cross-Sectional Study.","authors":"Kanwal Sohail, Maryam Rehman, Haris Ahtasham","doi":"10.29271/jcpsp.2025.08.969","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.08.969","url":null,"abstract":"<p><strong>Objective: </strong>To demonstrate a probable association of the levels of vitamin D with the occurrence and severity of oral lichen planus (OLP).</p><p><strong>Study design: </strong>A cross-sectional, descriptive study. Place and Duration of the Study: Department of Dermatology, Pak-Emirates Military Hospital, Rawalpindi, Pakistan, from October 2023 to February 2024.</p><p><strong>Methodology: </strong>Respondents diagnosed with OLP were recruited, comprising 44 patients. The severity of the disease was noted via the White-Erosive-Atrophic Modified (WEA-MOD) scoring system. Patients' serum vitamin D levels were checked. To evaluate the relationship between vitamin D levels and disease severity, the Kruskal-Wallis test was applied. The types of OLP were also compared regarding clinical and laboratory characteristics using the Mann-Whitney U test and the Chi-square test.</p><p><strong>Results: </strong>The WEA-MOD scoring, that shows severity of disease, showed a mean value of 3.39 ± 0.99. The mean value of Vitamin D levels was 33.64 ± 22.77 ng/ml. With the rising WEA-MOD score indicating increase in disease severity, vitamin D levels tended to fall; however, the interrelation between vitamin D levels and the severity of the pathology was not statistically significant (p-value 0.730). Moreover, the types of oral lichen planus (OLP) also showed no significant association to vitamin D levels, although a slightly lower vitamin D levels was observed.</p><p><strong>Conclusion: </strong>While serum vitamin D levels appeared to decline with increasing disease severity, as indicated by higher WEA-MOD scores, the association was not statistically significant. Similarly, no significant difference in vitamin D levels was observed among various clinical types of OLP. Patients with the erosive form of OLP tended to exhibit lower serum vitamin D levels compared to those with the reticular form, suggesting a possible but inconclusive link between disease subtype and vitamin D status.</p><p><strong>Key words: </strong>Cross-sectional studies, Deficiency, Dermatology, Lichen planus, Pathology, Vitamin D.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 8","pages":"969-974"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolution of Nuclear Medicine from Unclear to 'Precision' Medicine.","authors":"Nosheen Fatima","doi":"10.29271/jcpsp.2025.08.945","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.08.945","url":null,"abstract":"<p><p>Null.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 8","pages":"945-946"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Cancer Diagnostic Decisions from Multi-Source Data.","authors":"Ling Xu, Xiangyun Zeng, Boyuan Xing","doi":"10.29271/jcpsp.2025.08.964","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.08.964","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of support vector machines (SVM) in diagnostic decisions on the benign or malignant nature of the ultrasound Breast Imaging Reporting and Data System (BI-RADS) category 4 breast nodules in a multi-source diagnostic context.</p><p><strong>Study design: </strong>An experimental study. Place and Duration of the Study: Department of Ultrasound Imaging, Yichang Central People's Hospital, Yichang, China, from January 2020 to November 2023.</p><p><strong>Methodology: </strong>This study involved patients with ultrasound BI-RADS category 4 breast nodules. Conventional ultrasound diagnostics, S-Detect technology, and medical quasi-intelligent software were used to analyse the pre-treatment ultrasound results with pathological diagnoses serving as the reference standard for accuracy. Principal component analysis (PCA) was applied to extract the principal components from the multi-source breast imaging parameters, which were then integrated with SVM for evaluating its feasibility in classifying category 4 breast nodules as benign or malignant across various breast imaging modalities.</p><p><strong>Results: </strong>PCA extracts two principal components from a 12-dimensional feature parameter matrix measured from the multi-source breast imaging. The SVM, when combined with PCA, demonstrated a high level of reliability in multi-source breast cancer diagnostics, achieving a decision accuracy rate of 94.5%.</p><p><strong>Conclusion: </strong>The integration of SVM with PCA principal component analysis has proven to be highly valuable in the diagnostic decision- making process for the multi-source breast cancer diagnostics, offering a robust method for distinguishing between benign and malignant category 4 breast nodules.</p><p><strong>Key words: </strong>Support vector machine, Principal component analysis, Breast imaging, Multi-source diagnostics.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 8","pages":"964-968"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Cysticercosis Manifesting 20 Years after Primary Cutaneous Disease.","authors":"Yang Cui, Bingheng Wang","doi":"10.29271/jcpsp.2025.08.1073","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.08.1073","url":null,"abstract":"<p><p>Null.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 8","pages":"1073-1074"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environment-Conscious Imaging: Clinicians Must Lead the Change.","authors":"Farooq Azam Rathore","doi":"10.29271/jcpsp.2025.08.1071","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.08.1071","url":null,"abstract":"<p><p></p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 8","pages":"1071-1072"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Extracorporeal Shock Wave Lithotripsy Outcomes Using Machine Learning and the Triple-/Quadruple-D Scores.","authors":"Mucahit Gelmis, Sina Kardas, Ali Ayten, Oguzhan Cura, Serkan Gonultas, Mustafa Gokhan Kose","doi":"10.29271/jcpsp.2025.08.1007","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.08.1007","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the predictive performance of the triple-D and quadruple-D scores integrated with machine learning (ML) models in determining stone-free outcomes after extracorporeal shock wave lithotripsy (ESWL), and to compare ML model performance and identify its key predictors influencing ESWL success.</p><p><strong>Study design: </strong>An observational study. Place and Duration of the Study: Department of Urology, Gaziosmanpasa Training and Research Hospital, Istanbul, Turkiye, from October 2020 to November 2024.</p><p><strong>Methodology: </strong>A total of 309 patients who underwent ESWL were analysed. The patients were categorised into stone-free and non-stone- free groups based on post-treatment imaging. Clinical parameters, including quadruple-D score (stone volume, density, skin-to-stone distance [SSD], and location), were recorded. Three ML models‒random forest (RF), logistic regression (LR), and neural network (NN)‒were trained on 80% of the dataset and tested on 20%. Model performance was assessed using accuracy, area under the curve (AUC), precision, recall, and F1 score.</p><p><strong>Results: </strong>The quadruple-D score (AUC: 0.724) demonstrated superior predictive power compared to the Triple-D score (AUC: 0.700). Among ML models, RF achieved the highest accuracy (82.9%, AUC: 0.91), followed by NN (80.9%, AUC: 0.87) and LR (79.6%, AUC: 0.85). Significant predictors of ESWL success were stone density, volume, SSD, and the quadruple-D score, while age and body mass index (BMI) were not significant.</p><p><strong>Conclusion: </strong>Integrating the quadruple-D score with ML models, particularly RF, enhances the prediction of ESWL outcomes. Combining clinical expertise with computational intelligence can refine patient selection and optimise treatment strategies. However, prospective studies are needed to validate these findings.</p><p><strong>Key words: </strong>Extracorporeal shock wave lithotripsy, Quadruple-D score, Machine learning, Random forest, Stone-free prediction.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 8","pages":"1007-1013"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Severe Diabetic Foot Ulcers and Progressive Gangrene.","authors":"Cailing He, Hong Yin, Shoubao Wang","doi":"10.29271/jcpsp.2025.07.937","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.07.937","url":null,"abstract":"<p><p>Null.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 7","pages":"937-938"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of Carpal Tunnel Release with Longitudinal Mini Incision: A Prospective Cohort.","authors":"Muhammad Ahsan Sulaiman, Muhammad Ahmad Ghazni, Marij Zahid, Muhammad Omer Farooq, Muhammad Saad Iqbal, Pervaiz Mehmood Hashmi","doi":"10.29271/jcpsp.2025.07.848","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.07.848","url":null,"abstract":"<p><strong>Objective: </strong>To determine the outcome of longitudinal mini incision (1.5 cm) for carpal tunnel release (CTR), using the Boston carpal tunnel questionnaire (BCTQ) to measure symptomatic relief, functional recovery, and postoperative complications.</p><p><strong>Study design: </strong>Experimental study. Place and Duration of the Study: Department of Orthopaedic Surgery, The Aga Khan University Hospital, Karachi, Pakistan, from October 2023 to September 2024.</p><p><strong>Methodology: </strong>A prospective analysis was conducted on 77 patients who underwent CTR with longitudinal mini incision. Parameters evaluated were the outcome with BCTQ symptoms and functional scores for patients who underwent mini-incision CTR. This was recorded preoperatively and at six months post release with the questionnaire.</p><p><strong>Results: </strong>Seventy-five patients showed significant improvement (score value + p-value) in BCTQ symptom and functional score post- release at six months after the release of CT via mini-incision technique. The only complications 6 (8%) recorded were pillar pain 2 (2.7%) and complex regional pain syndrome 4 (5.3%), which resolved at 6 months postoperatively. There were no injuries to the median nerve using the mini-incision technique, and no recurrence was recorded.</p><p><strong>Conclusion: </strong>Mini-incision technique was safe and effective for median nerve release in carpal tunnel syndrome (CTS), along with excellent outcomes at six months when evaluated with the BCTQ symptoms and functional scores.</p><p><strong>Key words: </strong>Carpal tunnel syndrome, Mini incision carpal tunnel release, Boston carpal tunnel questionnaire.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 7","pages":"848-853"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}