Cancer Cytopathology最新文献

{"title":"Utility and performance of cell blocks in cerebrospinal fluid cytology: Experience at two teaching hospitals","authors":"Hyeji Yoon CT,&nbsp;Constance V. Chen MD,&nbsp;Vimal Krishnan MD,&nbsp;Jill Grochowski CT,&nbsp;Gioia Iezza MD,&nbsp;Poonam Vohra MD,&nbsp;Ronald Balassanian MD,&nbsp;Nancy Y. Greenland MD PhD","doi":"10.1002/cncy.22836","DOIUrl":"10.1002/cncy.22836","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cytology cell blocks (CBs) are not routinely made for cerebrospinal fluid (CSF) specimens. The goal of this study was to identify when CSF CB preparation improves diagnostic performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Under institutional review board approval, a retrospective review of CSF cytology cases was conducted at a tertiary university-based hospital and an affiliated county hospital. Patient history, CSF volume, final diagnosis, use of stains, and whether the CB was contributory was determined from the cytopathology report. CSF nucleated cell count data was obtained from the medical record.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 69 CSF specimens with CBs from January 2006 to March 2023 were identified from 61 patients. The median CSF volume was 8 mL (interquartile range, 4–13 mL; range, 1–800 mL), with immunohistochemical stains performed on 29 (42%) cases. Per cytology report, CB was contributory in 23 cases (33%), not contributory in 34 cases (49%), and not discussed in 12 cases (17%). The median volume was 8 mL for cases in which CB was contributory, not contributory, or not discussed. There was no difference in average nucleated cell counts between cases in which CB was contributory versus not contributory (73.9 vs. 40.0, <i>p</i> = .175).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>CBs for CSF samples were contributory in a subset (33%) of cases. The authors were unable to identify any specific pre-analytic factors, including specimen volume and average nucleated cell counts, for cases in which CB was contributory. Further evaluation is needed to identify if there are scenarios in which CSF CBs should be routinely prepared.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 10","pages":"621-628"},"PeriodicalIF":2.6,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cncy.22836","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research and scholarly mentoring: A guide for pathology faculty and program directors","authors":"R. Lane Coffee Jr. PhD, MS,&nbsp;Stephen John Cico MD, MEd","doi":"10.1002/cncy.22835","DOIUrl":"10.1002/cncy.22835","url":null,"abstract":"","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 10","pages":"605-608"},"PeriodicalIF":2.6,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant risk of pediatric Bethesda category III thyroid nodules subcategorized by nuclear atypia and other: A single institution experience","authors":"Xiaobing Jin MD,&nbsp;Xin Jing MD,&nbsp;Brian Smola BS,&nbsp;Amer Heider MD","doi":"10.1002/cncy.22831","DOIUrl":"10.1002/cncy.22831","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The 2023 Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) divides AUS diagnoses into two major subcategories: atypia of undetermined significance (AUS) nuclear atypia (AUS-N) and other (AUS-O). This study aims to compare the histological outcome and malignant rate of pediatric AUS thyroid nodules classified into AUS-N and AUS-O subcategories.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>A search of our institutional electronic pathology database for the period from January 2012 to July 2023 was conducted to identify pediatric (&lt;21 years old) thyroid nodules that were interpreted as AUS and subsequently had surgery. Cases were further divided into AUS-N and AUS-O subcategories. Results of follow-up surgical resections were collected. The malignant rate was calculated and compared between AUS-N and AUS-O groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study identified 62 thyroid nodules from 58 pediatric patients. Among these nodules, 29 and 33 were subcategorized as AUS-N and AUS-O, respectively. Both groups exhibited a female predominance and displayed a similar nodule size distribution. Histological analysis revealed 15 carcinomas in AUS-N nodules, including 11 cases of classic papillary thyroid carcinoma (PTC) and four cases of follicular type of PTC. In contrast, in the AUS-O group, a total of five carcinomas were documented, including two PTCs and three oncocytic thyroid carcinomas. Notably, the malignant rate of AUS-N nodules (52%) is significantly higher than that of AUS-O nodules (15%) (<i>p</i> = .002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In pediatric AUS thyroid nodules, the malignant risk in AUS-N is significantly higher than that in AUS-O. These findings may guide more appropriate clinical triage and/or improve management of pediatric patients with AUS thyroid nodules.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 9","pages":"564-568"},"PeriodicalIF":2.6,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cncy.22831","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current role of cytopathology in the molecular and computational era: The perspective of young pathologists","authors":"Alessandro Caputo MD,&nbsp;Pasquale Pisapia MD, PhD,&nbsp;Vincenzo L'Imperio MD","doi":"10.1002/cncy.22832","DOIUrl":"10.1002/cncy.22832","url":null,"abstract":"<p>Cytopathology represents a well established diagnostic approach because of its limited cost, reliability, and minimal invasiveness with respect to other methodologies. The evolving complexity of the different classifications systems and the implementation of ancillary techniques to refine the diagnosis is progressively helping in the risk of malignancy stratification, and the adoption of next-generation sequencing techniques contributes to enrich this valuable tool with predictive information, which is always more essential in the tailored medicine era. The recent introduction of digital and computational pathology is further boosting the potentialities of cytopathology, aiding in the interpretation of samples to improve the cost effectiveness of large screening programs and the diagnostic efficiency within intermediate/atypical categories. Moreover, the adoption of artificial intelligence tools is promising to complement molecular investigations, representing a stimulating perspective in the cytopathology field. In this work, the authors tried to summarize the multifaceted nature of this complex and evolving field of pathology, synthesizing the most recent advances and providing the young pathologists’ perspective on this fascinating world.</p>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 11","pages":"678-685"},"PeriodicalIF":2.6,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review on performance characteristics of FNA of renal lesions: It is time for a standardized classification system","authors":"Kübra Katipoglu MD,&nbsp;Irem Kilic MD,&nbsp;Olcay Kurtulan MD,&nbsp;Yasemin Akdas PhD, MPH,&nbsp;Güliz A. Barkan MD","doi":"10.1002/cncy.22826","DOIUrl":"10.1002/cncy.22826","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The incidence of renal tumors has steadily increased over the past decade. In this study, the authors performed a systematic review and analysis of the literature on renal fine-needle aspiration (FNA) to determine its performance and explore whether a standardized classification system can be used for reporting renal FNA cytology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic search of published articles on <i>renal FNA</i> was conducted. The data on FNA and histologic diagnosis were extracted and categorized, and the risk of malignancy was calculated. Different scenarios were used to estimate FNA performance statistics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 3766 potentially relevant studies, 23 met the inclusion criteria of the study. The 2231 FNA cases included were re-categorized according to the classification system, rendering 142 (6.36%) <i>nondiagnostic</i>, 270 (12.1%) <i>nonneoplastic</i>, 271 (12.14%) <i>benign neoplasm</i>, 65 (2.91%) <i>renal neoplasm with unknown malignant potential, oncocytic type</i>, 25 (1.12%) <i>atypia of undetermined significance</i>, 60 (2.68%) <i>suspicious for malignancy</i>, and 1398 (62.66%) <i>malignant</i> FNA diagnoses. The risk of malignancy in these cases was 65.4%, 18.1%, 16.6%, 16.9%, 60%, 73.3%, and 96.9%, respectively. According to the classification system, the study indicated that the accuracy of renal FNA was between 91% and 95%, the sensitivity was 90.9%–96.7%, and the specificity was 82%–92% in different scenarios.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There is a need for a standardized reporting in renal cytology that will improve the sensitivity and accuracy of renal cytology, reduce the rate of indeterminate diagnoses, and alter the management strategies of renal lesions. Based on the available literature, a new reporting system is proposed, including categories with an associated risk of malignancy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 8","pages":"510-524"},"PeriodicalIF":2.6,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic germ cell tumors in serous cavities and cerebrospinal fluid: A single-center experience","authors":"Tieying Hou MD, PhD,&nbsp;Katrina Collins MD,&nbsp;Guohua Liang MD, PhD,&nbsp;Sheila E. Segura MD,&nbsp;Thomas M. Ulbright MD,&nbsp;Hector Mesa MD, PhD,&nbsp;Harvey M. Cramer MD","doi":"10.1002/cncy.22827","DOIUrl":"10.1002/cncy.22827","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Metastatic germ cell tumors (GCTs) involving body cavity effusions and cerebrospinal fluid (CSF) are rare. Diagnosis is challenging because of limited morphological and clinicopathological information in the literature.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A database search of our institution from 1990 to 2024 identified 27 cases of metastatic GCTs, comprising five pediatric and 22 adolescent and adult patients, in serous cavities or the CSF, including peritoneal (15), pleural (nine), CSF (two), and pericardial (one) fluid.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The most common primary site was the testis (<i>n</i> = 10), followed by the ovaries (<i>n</i> = 7), mediastinum (<i>n</i> = 4), retroperitoneum (<i>n</i> = 3), pineal gland (<i>n</i> = 2), and sacrum/coccyx (<i>n</i> = 1). The primary tumors in 14 patients were mixed GCTs (six with a seminoma component), followed by immature teratomas (six), yolk sac tumors (three), embryonal carcinomas (two), pure seminomas (one), and postpubertal teratomas (one). The median interval between primary tumor diagnosis and diagnosis of fluid positivity was 7 months (range: 0–134 months). In nine cases, the malignant fluid was diagnosed simultaneously with or within 1 month of the primary tumor. GCT subtyping was performed on 23 of the 27 cytological specimens. Twenty-four patients (89%) also had metastases to other sites. Thirteen patients died of the disease (48%), with a median survival time of 4 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Metastatic GCTs in serous effusions and CSF are often associated with disseminated disease and poor prognosis. Subtyping can be performed by cytomorphology combined with immunohistochemistry.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 9","pages":"549-555"},"PeriodicalIF":2.6,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cncy.22827","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The World Health Organization Reporting System for Pancreaticobiliary Cytopathology: Overview and Summary","authors":"Barbara A. Centeno MD,&nbsp;Mauro Saieg MD, PhD,&nbsp;Momin T. Siddiqui MD,&nbsp;Miguel Perez-Machado MD, PhD,&nbsp;Lester J. Layfield MD,&nbsp;Birgit Weynand,&nbsp;Michelle D. Reid MD,&nbsp;Edward B. Stelow MD,&nbsp;Maria D. Lozano MD, PhD,&nbsp;Noriyoshi Fukushima MD, PhD,&nbsp;Ian A. Cree,&nbsp;Ravi Mehrotra MD,&nbsp;Fernando C. Schmitt MD, PhD,&nbsp;Andrew S. Field MBBS (Hons),&nbsp;Martha B. Pitman MD","doi":"10.1002/cncy.22806","DOIUrl":"10.1002/cncy.22806","url":null,"abstract":"<p>The recently published <i>WHO Reporting System for Pancreaticobiliary Cytopathology</i> (World Health Organization [WHO] System) is an international approach to the standardized reporting of pancreaticobiliary cytopathology, updating the <i>Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology</i> (PSC System). Significant changes were made to the categorization of benign neoplasms, intraductal neoplasms, mucinous cystic neoplasms, and malignant neoplasms considered low grade. Benign neoplasms, such as serous cystadenoma, categorized as Neoplastic: benign in the PSC system, are categorized as Benign/negative for malignancy in the WHO system. Pancreatic neuroendocrine tumor, solid-pseudopapillary neoplasm, and gastrointestinal stromal tumor, categorized as Neoplastic: other in the PSC system, are categorized as Malignant in the WHO System in accord with their classification in the 5th edition WHO Classification of Digestive System Tumours (2019). The two new categories of Pancreaticobiliary Neoplasm Low-risk/grade and Pancreaticobiliary Neoplasm High-risk/grade are mostly limited to intraductal neoplasms and mucinous cystic neoplasms. Low-risk/grade lesions are mucinous cysts, with or without low-grade epithelial atypia. High-risk/grade lesions contain neoplastic epithelium with high-grade epithelial atypia. Correlation with clinical, imaging, and ancillary studies remains a key tenet. The sections for each entity are written to highlight key cytopathological features and cytopathological differential diagnoses with the pathologist working in low resource setting in mind. Each section also includes the most pertinent ancillary studies useful for the differential diagnosis. Sample reports are provided for each category. Finally, the book provides a separate section with risk of malignancy and management recommendations for each category to facilitate decision-making for clinicians.</p>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 7","pages":"396-418"},"PeriodicalIF":2.6,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cncy.22806","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate change is threatening access to cancer care","authors":"Bryn Nelson PhD,&nbsp;William Faquin MD, PhD","doi":"10.1002/cncy.22828","DOIUrl":"https://doi.org/10.1002/cncy.22828","url":null,"abstract":"&lt;p&gt;After a natural disaster, the danger is far from over for residents with health concerns, whether cancer or other conditions. An extreme event may disrupt access to shelter, food, and water while also destroying medications, health supplies, roads, and health care facilities. Because power and telecommunications are often knocked out, telehealth can be difficult or impossible.&lt;/p&gt;&lt;p&gt;Extreme events are not new hazards. With a hotter planet fueling stronger and more unpredictable storms, flooding, wildfires, and heatwaves, however, researchers are having to rethink how they approach disaster preparedness and response and risk communication for increasingly vulnerable communities. “The same people who are at risk of flooding also may live in a fenceline community where the flooding could cause the redistribution of chemical contaminants that could also impact their health,” says Jennifer Horney, PhD, a professor of epidemiology at the University of Delaware in Newark.&lt;/p&gt;&lt;p&gt;That dual risk was laid bare by the 2017 flooding of the heavily industrialized Houston Ship Canal and surrounding neighborhoods by Hurricane Harvey, says Dr Horney, a core faculty member of the University of Delaware’s Disaster Research Center. Access, safety concerns, and other pressure points can likewise be magnified by extreme events. “If you have housing that’s not safe or a lack of transportation, those things are really important in non-disaster times to your health, but they’re really, &lt;i&gt;really&lt;/i&gt; important in disaster times,” Dr Horney says.&lt;/p&gt;&lt;p&gt;For patients with cancer, the need for specialized care can compound the threat. “When you think about it in the context of access to care and extreme weather events disrupting that access, access to cancer care is really critical,” says Eva Rawlings Parker, MD, assistant professor of dermatology at Vanderbilt University Medical Center in Nashville, Tennessee. “It’s one thing if you miss your routine physical and can reschedule that. It’s quite another thing if you miss your chemotherapy infusion: It can have much more significant consequences.”&lt;/p&gt;&lt;p&gt;A 2019 study led by researchers at the American Cancer Society found that hurricane disasters were associated with worse overall survival for patients with locally advanced non–small cell lung cancer who were undergoing daily radiotherapy.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; The longer the disaster declaration was, the worse their survival was, for disasters lasting up to a month. Because even short radiotherapy delays can decrease lung cancer survival rates, the authors recommended that disaster mitigation planning include strategies for identifying at-risk patients with cancer, arranging for their transfer to other treatment centers, and eliminating out-of-network insurance charges.&lt;/p&gt;&lt;p&gt;The growing urgency to develop contingency plans could be aided by lessons learned from vulnerable facilities and populations, notes Leticia Nogueira, PhD, MPH, scientific director of health service","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 5","pages":"266-267"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cncy.22828","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140817269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is molecular testing of salivary gland FNA specimens ready for prime time?","authors":"Marc P. Pusztaszeri MD","doi":"10.1002/cncy.22825","DOIUrl":"10.1002/cncy.22825","url":null,"abstract":"","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 7","pages":"393-395"},"PeriodicalIF":2.6,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140810875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of International System for Reporting Serous Fluid Cytopathology: A systematic review and meta-analysis in malignancy diagnosis","authors":"Sana Ahuja MD,&nbsp;Rhea Ahuja MD,&nbsp;Shivam Pandey PhD,&nbsp;Sufian Zaheer MD","doi":"10.1002/cncy.22822","DOIUrl":"10.1002/cncy.22822","url":null,"abstract":"<p>This study conducts the first meta-analysis to assess the aggregated risk of malignancy associated with each category of the International System for Reporting Serous Fluid Cytopathology (ISRSFC) for reporting serous effusion cytology, while also evaluating diagnostic accuracy. PubMed/MEDLINE and Embase were systematically searched using the keywords “(pleural, peritoneal, and pericardial effusions) AND (serous effusion cytology) OR (International System for Reporting Serous Fluid Cytopathology)”. Articles underwent risk of bias assessment using the QUADAS-2 tool. After excluding inadequate samples, a meta-analysis determined sensitivity and specificity for different cutoff points, including \"atypical considered positive,\" \"suspicious of malignancy considered positive,\" and \"malignant considered positive.\" Summary receiver operating characteristic curves assessed diagnostic accuracy, and the diagnostic odds ratio was pooled. Sixteen retrospective cross-sectional studies, totaling 19,128 cases, were included. Sensitivity and specificity for the “atypical and higher risk categories” considered positive were 77% (95% confidence interval [CI], 68%–84%) and 95% (95% CI, 93%–97%) respectively. For the “suspicious for malignancy and higher risk categories” considered positive, sensitivity and specificity were 57% (95% CI, 49%–65%) and 100% (95% CI, 99%–100%) respectively. Sensitivity and specificity for the “malignant” category considered positive for malignancy were 70% (95% CI, 60%–77%) and 99% (95% CI, 98%–99%), respectively. The pooled area under the curve ranged from 85% to 89.5% for each cutoff. This meta-analysis underscores the ISRSFC's accuracy in reporting serous fluid cytology. It emphasizes the diagnostic importance of the \"suspicious\" and \"malignant\" categories in identifying malignancy, and the role of the \"benign\" category in ruling out malignancy.</p>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 10","pages":"609-620"},"PeriodicalIF":2.6,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}