Cancer Cytopathology最新文献

{"title":"Intraoperative peritoneal cytology for cervical gastric-type adenocarcinoma: Cytopathology and clinical impact.","authors":"Waku Takigawa, Hiroshi Yoshida, Shoichi Kitamura, Chika Tokutake, Madoka Kondo, Mizuho Fujima, Yasuo Shibuki, Mayumi Kobayashi-Kato, Yasuhito Tanase, Masaya Uno, Mitsuya Ishikawa","doi":"10.1002/cncy.22915","DOIUrl":"10.1002/cncy.22915","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to elucidate the frequency and cytologic features of positive peritoneal washing cytology (PWC) in cervical gastric-type adenocarcinoma (GAS) and to clarify the clinical significance of positive PWC.</p><p><strong>Methods: </strong>The authors analyzed cases from their institution between 1991 and 2023 in which patients underwent surgery and PWC. The study included 62 patients who had cervical GAS (1991-2023; including seven patients with adenocarcinoma in situ and 26, 15, nine, and five patients with International Federation of Gynecology and Obstetrics 2018 stage I, II, III, and IV disease, respectively) and 100 patients who had usual-type endocervical adenocarcinoma (2007-2023; including 65, 15, and 20 patients with stage I, II, and III disease, respectively). The frequency of positive PWC results and cytologic features was assessed, and correlations between positive PWC results and clinicopathologic factors were examined, including prognosis, in the GAS group.</p><p><strong>Results: </strong>Positive PWC results were significantly more frequent in patients who had GAS at 24% (15 of 62 patients) compared with 7% (seven of 100 patients) in those who had usual-type endocervical adenocarcinoma. The cytologic features of GAS included distinct cellular atypia (enlarged nuclei, nuclear irregularity) and frequent formation of spherical clusters (10 of 15 cases) without the golden-yellowish mucus commonly seen in cervical smears. A positive PWC result in GAS was significantly correlated with larger tumor size, parametrium invasion, lymph node metastasis, and elevated carbohydrate antigen 19-9 levels. In patients with stage I GAS, the PWC-positive group had significantly shorter disease-free survival and overall survival compared with the PWC-negative group.</p><p><strong>Conclusions: </strong>Positive PWC findings are frequent in cervical GAS and are associated with pathologic factors indicative of tumor growth and progression. In patients who have stage I GAS, positive PWC results may indicate a poor prognosis, warranting further investigation.</p>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":" ","pages":"e22915"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid on-site evaluation using telecytology: Quality assurance study at a high-volume cancer center.","authors":"Mohamed Alhamar, Dorota Rudomina, Lu Wang, Rusmir Feratovic, Handy Oen, Oscar Lin, Xiao-Jun Wei","doi":"10.1002/cncy.22929","DOIUrl":"https://doi.org/10.1002/cncy.22929","url":null,"abstract":"<p><strong>Background: </strong>Telecytology-assisted rapid on-site evaluation (ROSE) offers a cost-effective method to enhance minimally invasive biopsies like fine needle aspiration and core biopsies with touch preparation. By reducing nondiagnostic sampling and the need for repeat procedures, ROSE via telecytology facilitates prompt triage for ancillary tests, improving patient management. This study examines cases initially deemed adequate for diagnosis during telecytology-assisted ROSE but later categorized as nondiagnostic at final evaluation (NDIS).</p><p><strong>Design: </strong>We performed a retrospective analysis of telecytology-assisted ROSE cases over 7 years at a major cancer center, focusing on fine needle aspiration and touch preparation of core biopsies. Each case was thoroughly reviewed, correlating with clinical data and concurrent core biopsies or subsequent excisions. The study identified leading factors contributing to NDIS.</p><p><strong>Results: </strong>The average NDIS rate was 0.06% (42/70,612). Misinterpretation of benign or reactive cells as neoplastic was the leading cause (76.2%) of discrepancies between original ROSE and final diagnosis. Kidney biopsies had the highest NDIS rate (0.90%), primarily because of misinterpreting nonneoplastic cells. Thyroid biopsies were linked to quantitative threshold issues (0.10%). NDIS events were most associated with misinterpretation in kidney, pancreas, gastrointestinal tract, and lung biopsies.</p><p><strong>Conclusion: </strong>In conclusion, the NDIS rate in telecytology-assisted ROSE is low, but quality assurance identified areas for improvement. Recognizing site-specific pitfalls during telecytology-assisted ROSE can enhance diagnostic accuracy and optimize patient care.</p>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"133 1","pages":"e22929"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the sensitivity of high-grade squamous intraepithelial lesion Pap diagnosis and interobserver variability with the Hologic Genius Digital Diagnostics System.","authors":"Lakshmi Harinath, Esther Elishaev, Yuhong Ye, Jonee Matsko, Amy Colaizzi, Stephanie Wharton, Rohit Bhargava, Liron Pantanowitz, Chengquan Zhao","doi":"10.1002/cncy.22918","DOIUrl":"10.1002/cncy.22918","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI)-based systems are transforming cytopathology practice. The aim of this study was to evaluate the sensitivity of high-grade squamous intraepithelial lesion (HSIL) Papanicolaou (Pap) diagnosis assisted by the Hologic Genius Digital Diagnostics System (GDDS).</p><p><strong>Methods: </strong>A validation study was performed with 890 ThinPrep Pap tests with the GDDS independently. From this set, a subset of 183 cases originally interpreted as HSIL confirmed histologically were included in this study. The sensitivity for detecting HSIL by three cytopathologists was calculated.</p><p><strong>Results: </strong>Most HSIL cases were classified as atypical glandular cell/atypical squamous cell-high grade not excluded (AGC/ASC-H) and above by all cytopathologists. Of these cases, 11.5% were classified as low-grade squamous intraepithelial lesion (LSIL) by pathologist A (P-A), 6% by pathologist B (P-B), and 5.5% by pathologist C (P-C); 3.8%, 2.7%, and 1.6% of these cases were classified as atypical squamous cell of unknown significance (ASC-US) by P-A, P-B, and P-C, respectively. The sensitivity for detection of cervical intraepithelial neoplasia 2 and above (CIN2+) lesions was 100% if ASC-US and above (ASC-US+) abnormalities were counted among all three pathologists. The sensitivity for detection of CIN2+ lesions was 84.7%, 91.3%, and 92.9% by P-A, P-B, and P-C, respectively, for ASC-H and above abnormalities. The Kendall W coefficient was 0.722, which indicated strong agreement between all pathologists.</p><p><strong>Conclusions: </strong>New-generation AI-assisted Pap test screening systems such as the GDDS have the potential to transform cytology practice. In this study, the GDDS aided in interpreting HSIL in ThinPrep Pap tests, with good sensitivity and agreement between the pathologists who interacted with this system.</p>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":" ","pages":"e22918"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of different HPV genotype viral loads and cervical lesions: A retrospective analysis of 1585 cases.","authors":"Yilu Zhou, Jiaxin Liu, Shuai Chen, Xianzhen Xin, Mohan Xiao, Xian Qiang, Lina Zhang","doi":"10.1002/cncy.22920","DOIUrl":"10.1002/cncy.22920","url":null,"abstract":"<p><strong>Background: </strong>To reduce unnecessary examinations and treatments, an effective detection method for differentiating human papillomavirus (HPV)-positive patients is urgently needed. This study aimed to explore the differences in HPV viral loads across various cervical lesions and identify the optimal cutoff value for high-grade squamous intraepithelial lesions (HSILs).</p><p><strong>Methods: </strong>This retrospective study included patients with varying degrees of cervical lesions admitted to a hospital between January 1, 2023, and March 1, 2024. The HPV genotype and viral load were determined using BioPerfectus multiplex real-time assay. The differences in HPV genotype viral loads among cervical lesion classifications were analyzed to identify the most applicable type of viral load.</p><p><strong>Results: </strong>The viral loads of HPV16, HPV31, HPV33, HPV35, and HPV58 were significantly associated with the grade of cervical lesions (p < .05), with the HPV16 group exhibiting the strongest correlation (p < .01). The HPV16 viral load demonstrated good sensitivity (Se) and specificity (Sp) for predicting HSIL (Se = 81.52%, Sp = 64.13%). The three most prevalent HPV genotypes associated with negative, low-grade squamous intraepithelial lesions (LSILs) and HSILs were HPV16, HPV52, and HPV58. HPV33 exhibited the highest prevalence of HSILs, followed by HPV16.</p><p><strong>Conclusions: </strong>High-risk HPV viral load is associated with cervical lesion classification. HPV16 viral load can effectively differentiate HSIL from LSIL with good Se and Sp.</p>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":" ","pages":"e22920"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fine-needle aspiration and effusion cytology of thoracic SMARCA4-deficient undifferentiated tumor and SMARCA4-deficient non-small cell lung carcinoma: A multi-institutional experience with 27 patients.","authors":"Nicole Zalles, Sanjay Mukhopadhyay, Swati Satturwar, Sigfred Lajara, Samer Khader, Liron Pantanowitz, Tarik M Elsheikh","doi":"10.1002/cncy.22919","DOIUrl":"10.1002/cncy.22919","url":null,"abstract":"<p><strong>Background: </strong>Thoracic switch/sucrose nonfermentable-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4 (SMARCA4)-deficient (SD) malignancies, including SD undifferentiated tumor (SD-UT) and SD non-small cell lung carcinoma (SD-NSCLC), have been recently described. The cytologic features of these neoplasms in fine-needle aspiration (FNA) and effusion specimens have rarely been reported in the literature. This study aimed to describe and compare the spectrum of cytologic, immunohistochemical, and clinical features of these high-grade malignancies recently encountered at the participating institutions.</p><p><strong>Methods: </strong>This study documented clinical and imaging characteristics of tumors from 27 patients. Sixteen cytomorphologic features and immunohistochemical findings were compared between SD-UT and SD-NSCLC samples.</p><p><strong>Results: </strong>Twenty three FNAs, two bronchial brushings, and two pleural fluids were evaluated, including 17 SD-UT cases (mean patient age, 70 years) and 10 SD-NSCLC cases (mean patient age, 62 years). Both malignancies presented with large thoracic masses and/or hilar/mediastinal lymphadenopathy. All SD-UT cytologic samples had a discohesive or mixed cohesive-discohesive architecture, and most (13 of 17) showed predominant rhabdoid or mixed rhabdoid-epithelioid features. Most SD-NSCLC cytologic samples (nine of 10) were either cohesive or mixed cohesive-discohesive and had a predominantly epithelioid morphology (eight of 10). Keratins and claudin-4 were negative or focally positive in SD-UT samples, whereas they were diffusely positive in SD-NSCLC samples. Both malignancies were negative for TTF-1 and p40/p63 and showed loss of expression of SMARCA4.</p><p><strong>Conclusions: </strong>Although there is considerable clinical and cytopathologic overlap between SD-UT and SD-NSCLC, some key features allow for their distinction. SD-UT is mostly discohesive with rhabdoid or mixed rhabdoid-epithelioid features, whereas SD-NSCLC often has cohesive epithelioid morphology. The combination of clinical presentation, cytomorphology, and immunohistochemistry is essential for a definitive diagnosis.</p>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":" ","pages":"e22919"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rapid turnaround time workflow for a cytological liquid biopsy assay using FNA supernatant specimens","authors":"Mohamed H. Maher PharmD, PhD,&nbsp;Dzifa Y. Duose PhD,&nbsp;Ignacio I. Wistuba MD,&nbsp;Rajyalakshmi Luthra MD,&nbsp;Srividya Arjuna PhD,&nbsp;Sinchita Roy Chowdhuri MD, PhD","doi":"10.1002/cncy.22925","DOIUrl":"10.1002/cncy.22925","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Genomic profiling is essential in the management of non–small cell lung cancer. However, this may often be challenging because of limited cytological tissue and extended turnaround time (TAT) for next-generation sequencing (NGS). This study aims to describe a rapid TAT workflow for molecular profiling using fine-needle aspiration (FNA) supernatants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A fully automated total nucleic acid extraction using the Genexus Integrated System was compared to a manual extraction using FNA supernatants from 50 patients with non–small cell lung cancer. Molecular profiling using the 50 gene Oncomine Precision Assay GX panel was performed and NGS results were compared with those of paired tissue samples.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The FNA samples processed using the automated Genexus purification system (<i>n</i> = 42) and the manual extraction method (<i>n</i> = 8) showed comparable quality control metrics with a median total nucleic acid yield of 1230 ng (18–17720 ng) and 1068 ng (777–1740 ng), respectively. The Genexus purification system reduced the hands-on time from 120 to 30 minutes, enhancing workflow efficiency and decreasing the overall TAT. Of the 50 samples extracted, NGS was performed on 26 samples: seven via manual extraction and 19 using automated extraction. NGS quality control metrics were also comparable between both extraction methods. The overall TAT of the automated NGS workflow from specimen received to test result was 24 hours, providing rapid and reliable molecular results for timely clinical decision-making and improved patient outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"133 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The deadliness of loneliness","authors":"Bryn Nelson PhD,&nbsp;William Faquin MD, PhD","doi":"10.1002/cncy.22924","DOIUrl":"https://doi.org/10.1002/cncy.22924","url":null,"abstract":"&lt;p&gt;In May 2023, US Surgeon General Vivek Murthy, MD, MBA, issued a stark health advisory. “Our epidemic of loneliness and isolation has been an underappreciated public health crisis that has harmed individual and societal health,” he asserted. Dr Murthy cited research suggesting that poor social connections increase the risk of depression, anxiety, heart disease, stroke, dementia in older adults, and premature death. The World Health Organization likewise declared loneliness a global health threat in 2023, and other countries have raised the alarm on a problem likely exacerbated by social distancing during the coronavirus disease 2019 pandemic.&lt;/p&gt;&lt;p&gt;Studies of people who are lonely, socially isolated, or living alone have expanded the potential consequences to include a higher risk of developing and dying of cancer, increasing the urgency of understanding the problem, its contributing factors, and the potential solutions.&lt;/p&gt;&lt;p&gt;Despite the flurry of attention, Frank Infurna, PhD, a professor of psychology at Arizona State University in Tempe, says that the loneliness “epidemic” has been more of an endemic but growing problem in the United States, particularly within the Baby Boomer and Gen X generations. “We’re seeing over multiple generations, over multiple cohorts, that loneliness levels within the US are elevated. So, it’s been a problem not just recently; it’s been a problem for a while,” he says.&lt;/p&gt;&lt;p&gt;Kerri Winters-Stone, PhD, an exercise scientist and professor in the Division of Oncological Sciences at the Oregon Health &amp; Science University in Portland, began shifting her work to focus on loneliness among cancer survivors a few years ago. “I think it’s a bigger problem than we’re acknowledging,” she says. If loneliness and isolation should be treated as cancer-abetting threats akin to smoking and the human papillomavirus, however, studies have not yet settled on how to similarly tamp down the danger.&lt;/p&gt;&lt;p&gt;The problem is complicated by related but different kinds of “aloneness.” &lt;i&gt;Social isolation&lt;/i&gt;, for example, refers to a small or nonexistent social network or a lack of meaningful engagement with others, whereas &lt;i&gt;loneliness&lt;/i&gt; refers to a mismatch between desired and actual social connections—the unwanted feeling of being alone or not close to others. “A person can be socially isolated but may not feel lonely, and vice versa,” says Hyunjung Lee, PhD, MS, MPP, MBA, a principal scientist on the American Cancer Society’s Cancer Disparities Research Team (the American Cancer Society publishes &lt;i&gt;Cancer Cytopathology&lt;/i&gt;).&lt;/p&gt;&lt;p&gt;Living alone, by contrast, is a more objective measure “that can be easily assessed with a single question on the number of people in the household,” Dr Lee says. “People who live alone are more likely to be socially isolated or feel lonely, although this is not always the case.” Research also suggests that older people are more likely to live alone in the United States than elsewhere around the world—in ","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 12","pages":"736-737"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cncy.22924","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer-aiding elements begin illuminating the genome’s “dark matter”","authors":"Bryn Nelson PhD,&nbsp;William Faquin MD, PhD","doi":"10.1002/cncy.22917","DOIUrl":"10.1002/cncy.22917","url":null,"abstract":"&lt;p&gt;When researchers set out to identify every protein-encoding gene in the human genome, initial estimates suggested that they might find up to 100,000. In reality, scientists have uncovered fewer than 20,000, which account for only 2% of the 3.1 billion letters of DNA.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;The remaining 98% has been referred to as “junk DNA” or “dark matter,” which reflects the once-common assumption that it was little more than genomic filler. An estimated 14,000 pseudogenes, or defective copies of genes, may fall into that category, albeit with some exceptions. Recent studies, however, have cast a new spotlight on a menagerie of other molecules, including some with a lineage far older than the human species, that may play significant roles in the development and progression of cancer and other diseases.&lt;/p&gt;&lt;p&gt;Martin Taylor, MD, PhD, assistant professor of pathology and laboratory medicine at the Brown University Center on the Biology of Aging and the Legorreta Cancer Center in Providence, Rhode Island, began studying one kind of genomic dark matter, LINE-1 retrotransposons, approximately 15 years ago. “The overwhelming evidence says that these are just parasitic sequences that we’ve been evolving with for billions of years,” he says of the mobile elements. “They’re actually older than multicellular organisms.” The virus-like, self-copying sequences, in fact, may have given rise to viruses.&lt;/p&gt;&lt;p&gt;Astoundingly, LINE-1 has effectively written at least one-third of the human genome through its copy-and-paste mechanism. Most of its own 500,000 copies are “fossils” from when humans mutated and defeated the once full-length retrotransposons. However, an estimated 6000 elements are more or less still intact; of those, maybe 100–150 are still functional and capable of hopping around and inserting themselves into other sequences, Dr Taylor says. They are repressed in healthy tissues but can become activated in the event of diseases such as cancer and autoimmune diseases.&lt;/p&gt;&lt;p&gt;By sequencing cancers, researchers have found that LINE-1, on rare occasion, can insert itself into a tumor suppressor gene such as APC or P10 and promote cancer. Work by Dr Taylor and others suggests that LINE-1 also may contribute to cancer in other ways. Those cancer-abetting mechanisms, he says, “have to do with the fact that when LINE-1 gets turned on, the cell thinks it’s infected with a virus—or at least has a virus-like response—and that causes inflammation.” The defensive response, research suggests, can manipulate the tumor microenvironment and alter cell signaling pathways to promote carcinogenesis.&lt;/p&gt;&lt;p&gt;In addition, Dr Taylor says, “The transposons cause a huge amount of DNA damage, and the thinking in the field now is that they may contribute to the chromosomal instability that we see as a hallmark of cancer.” He sees LINE-1 not as a classic cancer driver but rather as an accelerator that more broadly contributes to cancer development and progression, thoug","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 11","pages":"671-672"},"PeriodicalIF":2.6,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cncy.22917","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thank You to Reviewers 2024","authors":"","doi":"10.1002/cncy.22913","DOIUrl":"https://doi.org/10.1002/cncy.22913","url":null,"abstract":"","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 12","pages":"809-810"},"PeriodicalIF":2.6,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Researchers confront a rising tide of cancer misinformation","authors":"Bryn Nelson PhD,&nbsp;William Faquin MD, PhD","doi":"10.1002/cncy.22909","DOIUrl":"10.1002/cncy.22909","url":null,"abstract":"&lt;p&gt;Some online articles have suggested, without evidence, that high-dose infusions of vitamin C can cure cancer. Others have promised, falsely, that baking soda can cure prostate cancer or that cannabis oil can cure breast or lung cancer. Well before ivermectin was infamously touted as an (ineffective) intervention for the coronavirus disease 2019, a podcast wrongly asserted that the antiparasitic medication offered a cancer cure.&lt;/p&gt;&lt;p&gt;Experts have long warned of the noxious effects of online misinformation aimed at swaying elections and public opinion. The swirl of misinformation around cancer treatment and prevention may be less well studied, but researchers have begun raising alarms about the considerable harm that can come from advice that is, in some cases, literally toxic.&lt;/p&gt;&lt;p&gt;Skyler Johnson, MD, an assistant professor of radiation oncology at the University of Utah’s Huntsman Cancer Institute in Salt Lake City, experienced the phenomenon firsthand when his wife was diagnosed with cancer in 2011 while he was still in medical school. The couple encountered so many fact-free claims and false assertions online that Dr Johnson decided to study the effects of this flood of bad advice. Even after his wife was declared cancer-free, he realized that such misinformation, even from well-meaning friends and relatives, can lead to serious and avoidable harm.&lt;/p&gt;&lt;p&gt;Most disturbingly, he discovered, it can kill. In a highly cited study, Dr Johnson and his colleagues found that patients who relied entirely on unproven alternative cancer therapies were significantly more likely to die within 5 years than patients who used conventional treatments, such as chemotherapy, radiation, immunotherapy, and surgery.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; For a subset of patients with breast or colorectal cancer who used alternative medicine, the mortality risk jumped roughly 5-fold. No matter how advanced cancer treatments might be, he says, “if patients aren’t willing to take those treatments, then we’ve done no good.”&lt;/p&gt;&lt;p&gt;When she read Dr Johnson’s study, Briony Swire-Thompson, PhD, director of the Psychology of Misinformation Lab in the Network Science Institute at Northeastern University in Boston, Massachusetts, had an epiphany. The cognitive psychologist had previously studied general and political misinformation, but she immediately understood the unique challenge posed by cancer misinformation. “That was, I think, an aha moment where I realized this is a topic where belief really has impact in people’s lives,” she says.&lt;/p&gt;&lt;p&gt;Dr Swire-Thompson characterizes &lt;i&gt;misinformation&lt;/i&gt; as an umbrella term for all false information and &lt;i&gt;disinformation&lt;/i&gt; as a subset of false information that is spread deliberately. The high anxiety accompanying a cancer diagnosis, coupled with cognitive fatigue and the fear of side effects from chemotherapy, radiation, or surgery, she notes, can make a patient more susceptible to a huckster trying to capitalize financially. “People are wi","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 10","pages":"603-604"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cncy.22909","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}