{"title":"Antibiotic exposure and cancer risk: an umbrella review elucidating the direction of risk across 14 malignancies.","authors":"Tu Xu, Qing Xin, Jiacheng Li, Yiyan Pei, Zheran Liu, Xingchen Peng","doi":"10.1093/pubmed/fdag051","DOIUrl":"10.1093/pubmed/fdag051","url":null,"abstract":"<p><strong>Background: </strong>Antibiotics are among the most frequently prescribed medications worldwide. However, previous studies have yielded inconsistent findings regarding the association between antibiotic exposure and the risk of various cancers, and the credibility of the available evidence remains uncertain.</p><p><strong>Methods: </strong>We conducted an umbrella review based on published meta-analyses and systematic reviews to evaluate the association between past or current antibiotic exposure and cancer risk. PubMed, Embase, Cochrane Library, and Web of Science were searched from inception to November 2025. Pooled effect sizes were obtained utilizing random-effects models. The credibility of evidence was evaluated utilizing the GRADE framework. All analyses were analyzed utilizing the R package \"metaumbrella\".</p><p><strong>Results: </strong>10 articles encompassing 14 cancer types and 66 distinct associations were included. 9 associations were classified as highly suggestive evidence, 7 as suggestive evidence, and 21 as weak evidence. Among associations for which the evidence reached the highly suggestive level, antibiotic exposure was associated with increased risks of proximal colon cancer, pancreatic cancer, kidney cancer, and bladder cancer.</p><p><strong>Conclusions: </strong>Antibiotic exposure may be related to cancer risk in a cancer type-specific manner. These findings provide a higher-level evidence synthesis to inform future research directions and hypothesis generation in this field.</p>","PeriodicalId":94107,"journal":{"name":"Journal of public health (Oxford, England)","volume":" ","pages":"661-669"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Garth Reid, Glenna Nightingale, Nason Maani, Mike Smith, Mark Petticrew
{"title":"Addressing challenges in reviewing e-cigarette evidence: proposing a new 'Test for Dominance' in systematic reviews.","authors":"Garth Reid, Glenna Nightingale, Nason Maani, Mike Smith, Mark Petticrew","doi":"10.1093/pubmed/fdaf149","DOIUrl":"10.1093/pubmed/fdaf149","url":null,"abstract":"<p><strong>Background: </strong>Current systematic review evidence on e-cigarettes as a smoking cessation tool is contested. Part of the reason for this is the difficulty of objectively assessing the limited and heterogeneous evidence base.The study aim was to develop a novel approach to testing the validity of systematic reviews and assessing the extent of the dominance of included primary studies.</p><p><strong>Methods: </strong>Leave-one-out meta-analysis was used to measure dominance. The systematic review on e-cigarettes as a smoking cessation tool by Hanewinkel et al. was used as a proof of concept.</p><p><strong>Results: </strong>The Hajek et al. study dominates the Hanewinkel et al. systematic review, exerting a disproportionate influence on the overall pooled effect.</p><p><strong>Conclusions: </strong>This research has identified a gap in current approaches to validity testing in systematic reviews. The Test for Dominance could supplement existing testing, including tests for heterogeneity, sensitivity analysis, and subgroup analysis. When a single study dominates a systematic review, the findings of that review should be interpreted with caution and further randomised controlled trials undertaken to reduce such distortion.</p>","PeriodicalId":94107,"journal":{"name":"Journal of public health (Oxford, England)","volume":" ","pages":"739-744"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148427392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How conditions within immigration removal centres in the United Kingdom affect the mental wellbeing of detainees: a scoping review.","authors":"Niamh Gallagher, Tristan Price, Matthew Griggs","doi":"10.1093/pubmed/fdag044","DOIUrl":"10.1093/pubmed/fdag044","url":null,"abstract":"<p><strong>Background: </strong>Immigration Removal Centres (IRCs) are used to detain people for immigration control by the UK government. This scoping review aims to examine the experiences of detainees within UK IRCs, specifically how conditions within them, including the regime, affect their mental wellbeing.</p><p><strong>Methods: </strong>The Joanna Briggs Institute guideline for scoping reviews was followed. Six bibliographic databases and additional grey literature sources were searched for quantitative and qualitative evidence. Descriptive analyses and quality assessments were conducted.</p><p><strong>Results: </strong>Fifteen research studies and nine pieces of grey literature were included, comprising a total of 1353 participants and 11 IRCs. The majority of data was qualitative in methodology and published after 2015. Main findings from articles were charted according to Maslow's (1943) Hierarchy of Needs, revealing persistent failings across all dimensions (physiological, safety, belongingness, esteem, and self-actualization). The regime within the IRCs as well as the psychosocial environment led to emotional distress and feelings of disempowerment, dehumanization, and criminality.</p><p><strong>Conclusions: </strong>This review highlights the negative impact of IRCs within the UK on the mental wellbeing of detainees and the need for urgent policy reform. Changes addressing temporal uncertainty of detention and use of community-based settings are proposed for UK governmental review.</p>","PeriodicalId":94107,"journal":{"name":"Journal of public health (Oxford, England)","volume":" ","pages":"767-779"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiuling Li, Mohammad Javad Koohsari, Jing Zhao, Mohammad Sabbir Hossain Khan, Koichiro Oka, Gavin R McCormack
{"title":"Neighbourhood street patterns and residents' health amongst adults in Calgary: differences by socioeconomic status and exposure.","authors":"Jiuling Li, Mohammad Javad Koohsari, Jing Zhao, Mohammad Sabbir Hossain Khan, Koichiro Oka, Gavin R McCormack","doi":"10.1093/pubmed/fdag048","DOIUrl":"10.1093/pubmed/fdag048","url":null,"abstract":"<p><strong>Background: </strong>Street layout is a key urban design element that influences a neighbourhood's street connectivity, providing opportunities for physical activity, social interaction, and risk of environmental exposures. However, its effects across different socioeconomic contexts and varying durations of exposure to the neighbourhood are less explored.</p><p><strong>Methods: </strong>This study aims to address these gaps by employing ordinal logistic regression models to examine the associations between neighbourhood street patterns and residents' physical and mental health. It also investigates whether these associations vary by neighbourhood socioeconomic status (SES) and length of residence.</p><p><strong>Results: </strong>The findings showed that grid street patterns were positively associated with self-assessed physical health, particularly in low SES neighbourhoods and amongst longer-term residents. However, no significant associations were observed between street pattern and self-assessed mental health.</p><p><strong>Conclusions: </strong>Our findings underscore the importance of considering both the social context and duration of residence when investigating the influence of urban design on health.</p>","PeriodicalId":94107,"journal":{"name":"Journal of public health (Oxford, England)","volume":" ","pages":"797-805"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148298151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cheuk Him Michael Lam, Thomas Mason, Bruce Hollingsworth
{"title":"Measuring performance in cancer services during COVID-19 and beyond: a novel case throughput metric using NHS Cancer Waiting Times data.","authors":"Cheuk Him Michael Lam, Thomas Mason, Bruce Hollingsworth","doi":"10.1093/pubmed/fdag041","DOIUrl":"10.1093/pubmed/fdag041","url":null,"abstract":"<p><strong>Background: </strong>Cancer Waiting Times (CWT) targets are a central instrument of cancer policy in England, yet conventional performance indicators often obscure changes in service throughput. The COVID-19 pandemic exposed limitations in existing monitoring approaches, particularly for assessing disruption and recovery across cancer pathways.</p><p><strong>Methods: </strong>A novel case throughput metric (CTM) was developed by extracting National Health Service (NHS) England CWT data spanning 2017-23, covering 334 trusts and an average of 300 000 patients annually. The metric defines service throughput as the ratio of patient volumes meeting waiting time standards during defined periods of investigation normalized to a pre-pandemic baseline, enabling meaningful comparison across trusts while accounting for variation in trust sizes and pre-existing differences in service provision.</p><p><strong>Results: </strong>The metric revealed substantial heterogeneity in both disruption and recovery across cancer pathways, with diagnostic and referral routes experiencing greater and more persistent throughput loss than treatment pathways. Recovery trajectories also varied markedly between regions, with exploratory analyses suggesting associations with sociodemographic factors.</p><p><strong>Conclusion: </strong>The CTM provides a policy-relevant complement to existing CWT indicators by making changes in service throughput explicit. It offers a practical tool for monitoring cancer system resilience and informing recovery planning during and beyond major system shocks.</p>","PeriodicalId":94107,"journal":{"name":"Journal of public health (Oxford, England)","volume":" ","pages":"754-758"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amy Wilcock, Davara Bennett, David Taylor-Robinson, Philip McHale
{"title":"Assessing the impact of social determinants of health on rising preterm birth trends in England. A longitudinal ecological study, 2012-17.","authors":"Amy Wilcock, Davara Bennett, David Taylor-Robinson, Philip McHale","doi":"10.1093/pubmed/fdag045","DOIUrl":"10.1093/pubmed/fdag045","url":null,"abstract":"<p><strong>Background: </strong>Preterm birth (PTB) is the UK's leading cause of neonatal morbidity and mortality. There is international evidence of socioeconomic inequalities in PTB. Between 2012 and 2017, the proportion of live births occurring prematurely increased in England. This study explores how changes to major social determinants of health (SDH) may have contributed to recent trends.</p><p><strong>Methods: </strong>We analysed PTB trends and their correlation with contemporaneous trends in major SDH predictors (socioeconomic status, income, and unemployment) for English Local Authorities. We used both fixed-effects and mixed-effects modelling to estimate the association between SDH and PTB rates between 2012 and 2017.</p><p><strong>Results: </strong>The gap in PTB inequalities widened over the study period, with the absolute difference in PTB rates between most and least disadvantaged communities rising by 35%. Mixed-effects analysis demonstrated an association between the proportion of children living in low-income households and PTB; for each percentage point increase in child poverty, an estimated additional 0.24 per 1000 births was preterm.</p><p><strong>Conclusion: </strong>We provide evidence of rising PTB rates in England prior to the pandemic, which disproportionately affected the poorest areas of the country. Policies targeting areas with higher child poverty rates are likely to reduce inequalities in PTB in England.</p>","PeriodicalId":94107,"journal":{"name":"Journal of public health (Oxford, England)","volume":" ","pages":"780-787"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chris White, Daniel Bloyce, Miranda Thurston, Paul Bissell
{"title":"Marginalising prevention during Health Devolution in Greater Manchester? A qualitative study of the perceptions and experiences of public health professionals.","authors":"Chris White, Daniel Bloyce, Miranda Thurston, Paul Bissell","doi":"10.1093/pubmed/fdag050","DOIUrl":"10.1093/pubmed/fdag050","url":null,"abstract":"<p><strong>Background: </strong>There are increasing moves across the globe towards devolution of various state services, including health. However, Greater Manchester (GM) is the only region in England with fully devolved health powers. A key feature of the policies supporting devolution in GM was a proposed uplift in focus and funding for prevention of ill-health. This was deemed important for supporting people's health and wellbeing, and economic stability. This study explores the experiences of people working in public health during devolution in GM, and seeks to understand the constraints and opportunities of this novel approach.</p><p><strong>Methods: </strong>Forty two semi-structured interviews were conducted with people in public health roles in GM, examining how relational processes contributed to how prevention was perceived and enacted.</p><p><strong>Results: </strong>Prevention work was considered less of a priority than treatment-centred activities in GM, both in terms of planning and practice. Some plans for increased prevention were neglected, and lacking direction, which tended to lead to stagnation of genuinely innovative prevention-based plans.</p><p><strong>Conclusions: </strong>Continued marginalization of prevention could be explained through processes such as lifestyle drift and the enduring prestige attached to treatment work. Despite the intentions behind the policies, there were instances where devolution seemed to exacerbate these tendencies.</p>","PeriodicalId":94107,"journal":{"name":"Journal of public health (Oxford, England)","volume":" ","pages":"806-817"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"United Kingdom pandemic preparedness: lessons from hantavirus and Ebola for public health readiness.","authors":"Sam Ghebrehewet, Ting Shi","doi":"10.1093/pubmed/fdag060","DOIUrl":"10.1093/pubmed/fdag060","url":null,"abstract":"","PeriodicalId":94107,"journal":{"name":"Journal of public health (Oxford, England)","volume":" ","pages":"621-622"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148852257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Koser Khan, Natalija Atas, Daniel Clarkson, Linda Heaton, Becky Shaw, Adele Thomas
{"title":"Voices from the foodbank: experiencing food insecurity in North-West England during the cost-of-living crisis.","authors":"Koser Khan, Natalija Atas, Daniel Clarkson, Linda Heaton, Becky Shaw, Adele Thomas","doi":"10.1093/pubmed/fdag036","DOIUrl":"10.1093/pubmed/fdag036","url":null,"abstract":"<p><strong>Background: </strong>The current cost of living crisis in the UK has exacerbated food insecurity and the associated impacts on people's health and well-being. There is limited understanding of the extent and depth of the health impacts on those facing food insecurity. This qualitative study examines lived experiences of food bank users facing food insecurity in the North-West of England and the impacts on their mental health.</p><p><strong>Methods: </strong>18 semi-structured interviews were conducted with participants recruited from three food banks in North-West of England. Thematic analysis was used to analyze interview data. Two public advisors also reviewed analysis.</p><p><strong>Results: </strong>Participants described the challenges of being food insecure while accessing support from a food bank and how this had detrimental impacts on their mental health. Four main themes of mental health impacts emerged from the interviews: precarious circumstances, loss of self-worth and dignity, loss of agency, and parental guilt.</p><p><strong>Conclusions: </strong>Individuals accessing food banks face severe and detrimental impacts on their mental health and wellbeing. Food bank users commonly reported increased anxiety, stress, and depression, along with feelings of parental guilt and loss of dignity. Consideration of mental health needs is required and how perceptions of shame and stigma can be reduced.</p>","PeriodicalId":94107,"journal":{"name":"Journal of public health (Oxford, England)","volume":" ","pages":"759-766"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147966280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to: A cross-sectional study on national cancer screening participation among people with physical disabilities: focus on health screening experience and perceptions.","authors":"","doi":"10.1093/pubmed/fdag063","DOIUrl":"10.1093/pubmed/fdag063","url":null,"abstract":"","PeriodicalId":94107,"journal":{"name":"Journal of public health (Oxford, England)","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}