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Imaging and Fluid Biomarkers of Alzheimer Disease: Complementation Rather Than Competition. 阿尔茨海默病的成像和液体生物标志物：互补而非竞争。
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-06-06 DOI: 10.2967/jnumed.125.270152
Alexander Drzezga, Henryk Barthel
{"title":"Imaging and Fluid Biomarkers of Alzheimer Disease: Complementation Rather Than Competition.","authors":"Alexander Drzezga, Henryk Barthel","doi":"10.2967/jnumed.125.270152","DOIUrl":"https://doi.org/10.2967/jnumed.125.270152","url":null,"abstract":"<p><p>With the introduction of the new causal amyloid targeting therapies, the role of biomarker-assisted diagnosis of Alzheimer disease (AD) has received a further boost. In addition to the well-established gold standard, amyloid PET imaging, cerebrospinal fluid diagnostics are currently being suggested for therapy inclusion and patient selection. In addition, new types of blood-based biomarkers are being introduced, holding diagnostic potential together with potentially easy and broad accessibility in the future. In addition to the introduction of new biomarkers and new therapeutic approaches, the guidelines for biomarker-based classification of AD are also in flux, sometimes clustering biomarker classes and neglecting their individual characteristics, leading to divergent or controversial discussions. It is difficult to keep pace with these rapid developments, and the respective roles of the various AD biomarkers have not yet been clearly defined. Thus, in this paper, we attempt to discuss the strengths and weaknesses of the various imaging and fluid biomarkers of AD and classify what we consider to be their complementary, nonredundant value for various diagnostic questions. We propose an integrated biomarker algorithm for the purpose of reliable AD patient selection for amyloid targeting therapies.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":"66 Suppl 2","pages":"S32-S44"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and Efficacy of 20 Cycles of [177Lu]Lu-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer. [177Lu]Lu-PSMA-617治疗转移性去势抵抗性前列腺癌的安全性和有效性
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-06-02 DOI: 10.2967/jnumed.124.269447
Kerry E Jewell, James P Buteau, Elizabeth Medhurst, Edmond M Kwan, Shahneen Sandhu, Arun A Azad, Michael S Hofman
{"title":"Safety and Efficacy of 20 Cycles of [<sup>177</sup>Lu]Lu-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer.","authors":"Kerry E Jewell, James P Buteau, Elizabeth Medhurst, Edmond M Kwan, Shahneen Sandhu, Arun A Azad, Michael S Hofman","doi":"10.2967/jnumed.124.269447","DOIUrl":"10.2967/jnumed.124.269447","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"981-982"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDA Reconsiders Rules Around Radiation Dosimetry for First-in-Human Studies of Investigational PET Radiopharmaceuticals. FDA重新考虑关于PET放射性药物首次人体研究的辐射剂量学规则。
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-06-02 DOI: 10.2967/jnumed.125.269885
Marianna Dakanali, Steven S Zigler, Sally W Schwarz, Michael L Nickels, Reiko Oyama, Henry F VanBrocklin, Peter J H Scott
{"title":"FDA Reconsiders Rules Around Radiation Dosimetry for First-in-Human Studies of Investigational PET Radiopharmaceuticals.","authors":"Marianna Dakanali, Steven S Zigler, Sally W Schwarz, Michael L Nickels, Reiko Oyama, Henry F VanBrocklin, Peter J H Scott","doi":"10.2967/jnumed.125.269885","DOIUrl":"10.2967/jnumed.125.269885","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"986-988"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to "The Randomized, Phase 2 LuCAP Study". 回复“随机二期LuCAP研究”。
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-06-02 DOI: 10.2967/jnumed.125.270026
Swayamjeet Satapathy, Ashwani Sood
{"title":"Reply to \"The Randomized, Phase 2 LuCAP Study\".","authors":"Swayamjeet Satapathy, Ashwani Sood","doi":"10.2967/jnumed.125.270026","DOIUrl":"10.2967/jnumed.125.270026","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"986"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient-Specific Dosimetry-Driven PRRT: Time to Move Forward! 患者特异性剂量学驱动的PRRT：是时候向前迈进了！
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-06-02 DOI: 10.2967/jnumed.124.268880
Emmanuel Deshayes, Ioannis Karfis, Lore Santoro, Magdalena Mileva, Rachele Danieli, Kévin Hebert, Marco Maccauro, Carlo Chiesa, Manuel Bardiès
{"title":"Patient-Specific Dosimetry-Driven PRRT: Time to Move Forward!","authors":"Emmanuel Deshayes, Ioannis Karfis, Lore Santoro, Magdalena Mileva, Rachele Danieli, Kévin Hebert, Marco Maccauro, Carlo Chiesa, Manuel Bardiès","doi":"10.2967/jnumed.124.268880","DOIUrl":"10.2967/jnumed.124.268880","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"983"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Business Model Beats Science and Logic: Dosimetry and Paucity of Its Use. 商业模式胜过科学和逻辑：剂量学及其应用的匮乏。
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-06-02 DOI: 10.2967/jnumed.125.269865
Michael D F Goldenberg, Taranjit S Gill, Jitesh Dhingra
{"title":"Business Model Beats Science and Logic: Dosimetry and Paucity of Its Use.","authors":"Michael D F Goldenberg, Taranjit S Gill, Jitesh Dhingra","doi":"10.2967/jnumed.125.269865","DOIUrl":"10.2967/jnumed.125.269865","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"988"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[68Ga]Ga-RAYZ-8009: A Peptide PET Tracer for Targeting HCC in Humans. [68Ga]Ga-RAYZ-8009：一种靶向肝癌的PET示踪剂。
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-06-02 DOI: 10.2967/jnumed.124.269294
Yue Zhang, Jiangtao Yue, Xuhong Yang, Guanghai Fei, Yicheng Ni, Yue Li
{"title":"[<sup>68</sup>Ga]Ga-RAYZ-8009: A Peptide PET Tracer for Targeting HCC in Humans.","authors":"Yue Zhang, Jiangtao Yue, Xuhong Yang, Guanghai Fei, Yicheng Ni, Yue Li","doi":"10.2967/jnumed.124.269294","DOIUrl":"10.2967/jnumed.124.269294","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"984"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Radiopharmaceutical Trial Design: Is It Time to Change Nomenclature? 诊断性放射性药物试验设计：是时候改变命名法了吗？
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-06-02 DOI: 10.2967/jnumed.125.269496
Rodney J Hicks
{"title":"Diagnostic Radiopharmaceutical Trial Design: Is It Time to Change Nomenclature?","authors":"Rodney J Hicks","doi":"10.2967/jnumed.125.269496","DOIUrl":"10.2967/jnumed.125.269496","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"848-850"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDA Approval of 18F-Flurpiridaz for PET: Stepping into a New Era of Myocardial Perfusion Imaging? FDA批准18f -氟吡达用于PET：进入心肌灌注成像的新时代？
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-06-02 DOI: 10.2967/jnumed.124.269154
Thomas H Schindler, Timothy M Bateman, Daniel S Berman, Panithaya Chareonthaitawee, Lorraine E De Blanche, Vasken Dilsizian, Sharmila Dorbala, Robert J Gropler, Leslee L Shaw, Prem Soman, David E Winchester, Hein J Verberne, Sukhjeet Ahuja, Rob Beanlands, Marcelo Di Carli, Venkatesh L Murthy, Terrence D Ruddy, Ronald G Schwartz
{"title":"FDA Approval of <sup>18</sup>F-Flurpiridaz for PET: Stepping into a New Era of Myocardial Perfusion Imaging?","authors":"Thomas H Schindler, Timothy M Bateman, Daniel S Berman, Panithaya Chareonthaitawee, Lorraine E De Blanche, Vasken Dilsizian, Sharmila Dorbala, Robert J Gropler, Leslee L Shaw, Prem Soman, David E Winchester, Hein J Verberne, Sukhjeet Ahuja, Rob Beanlands, Marcelo Di Carli, Venkatesh L Murthy, Terrence D Ruddy, Ronald G Schwartz","doi":"10.2967/jnumed.124.269154","DOIUrl":"10.2967/jnumed.124.269154","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"862-864"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Funding Reductions Threaten the Future of Medical Innovation. 资金削减威胁着医疗创新的未来。
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-06-02 DOI: 10.2967/jnumed.125.270157
Johannes Czernin, Carolyn J Anderson, Ramsey Derek Badawi, Henryk Barthel, Frank M Bengel, Thomas Beyer, Irene Buvat, Jérémie Calais, Sharmila Dorbala, Alexander E Drzezga, Ken Herrmann, Thomas A Hope, Hossein Jadvar, David A Mankoff, Heinrich R Schelbert, Wolfgang A Weber
{"title":"Funding Reductions Threaten the Future of Medical Innovation.","authors":"Johannes Czernin, Carolyn J Anderson, Ramsey Derek Badawi, Henryk Barthel, Frank M Bengel, Thomas Beyer, Irene Buvat, Jérémie Calais, Sharmila Dorbala, Alexander E Drzezga, Ken Herrmann, Thomas A Hope, Hossein Jadvar, David A Mankoff, Heinrich R Schelbert, Wolfgang A Weber","doi":"10.2967/jnumed.125.270157","DOIUrl":"10.2967/jnumed.125.270157","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"829"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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