Journal of nuclear medicine : official publication, Society of Nuclear Medicine最新文献

{"title":"Noninvasive Characterization of Hepatic Lesions by Means of Glypican-3-Directed PET/CT.","authors":"Helen Scholtissek, Nic G Reitsam, Alexander Dierks, Thomas Kröncke, Bruno Märkl, Martin Trepel, Ralph A Bundschuh, Constantin Lapa","doi":"10.2967/jnumed.124.269290","DOIUrl":"10.2967/jnumed.124.269290","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"1314"},"PeriodicalIF":9.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embracing Flow: Exploring <i>Panta Rhei</i> in the Context of Nuclear Medicine.","authors":"David Taïeb, John O Prior, Rudi A J O Dierckx","doi":"10.2967/jnumed.125.270179","DOIUrl":"10.2967/jnumed.125.270179","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"1168"},"PeriodicalIF":9.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"¹⁷⁷Lu-PSMA Radiopharmaceutical Therapy or Cabazitaxel?\"","authors":"Mike Wenzel, Daniel Groener, Felix K H Chun, Philipp Mandel","doi":"10.2967/jnumed.125.270028","DOIUrl":"10.2967/jnumed.125.270028","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"1315"},"PeriodicalIF":9.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"¹⁷⁶Lu Radiation in Long-Axial-Field-of-View PET Scanners: A Nonissue for Patient Safety\".","authors":"Samaneh Mostafapour, Joyce van Sluis, Adriaan A Lammertsma, Charalampos Tsoumpas","doi":"10.2967/jnumed.125.270027","DOIUrl":"10.2967/jnumed.125.270027","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"1317"},"PeriodicalIF":9.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodistribution and Radiation Dosimetry for [⁶⁸Ga]Ga-LNTH-1363S, a Probe Targeting Fibroblast Activation Protein α.","authors":"Johanna S Enke, Bradley W Schuller, Lisa Glantschnig, Malte Kircher, Ralph A Bundschuh, Alexander Dierks, Marianne Patt, Eric J Fenn, Andreas Rinscheid, Christian H Pfob, Alejandro Amor Coarasa, John W Babich, Jacob Y Hesterman, Constantin Lapa","doi":"10.2967/jnumed.125.269793","DOIUrl":"10.2967/jnumed.125.269793","url":null,"abstract":"<p><p>The objective of this study is to evaluate the PET biodistribution and radiation dosimetry of the fibroblast activation protein (FAP)-targeted tracer [⁶⁸Ga]Ga-LNTH-1363S in cancer patients. <b>Methods:</b> Five patients with oncologic diseases (breast cancer, papillary thyroid carcinoma) were injected intravenously with 153-184 MBq of [⁶⁸Ga]Ga-LNTH-1363S. PET/CT imaging was performed at 10, 60, and 180 min after administration of [⁶⁸Ga]Ga-LNTH-1363S. Normal tissue dosimetry was performed following the MIRD dosimetry formalism. SUV analysis of normal tissues and tumors was performed. <b>Results:</b> The biodistribution of [⁶⁸Ga]Ga-LNTH-1363S demonstrated rapid tumor uptake and efficient clearance from nontarget tissues, resulting in high tumor-to-background ratios at all imaging time points. The kidneys received the highest absorbed dose among normal tissues (0.038 ± 0.01 mGy/MBq), followed by the pancreas and salivary glands. The tumor SUV_max peaked at 10 min after injection (18.6 ± 7.2) and remained high at later time points. No adverse events were observed during follow-up, and the effective dose (0.013 ± 0.002 mSv/MBq) was consistent with other FAP tracers. <b>Conclusion:</b> [⁶⁸Ga]Ga-LNTH-1363S offers favorable dosimetry and biodistribution profiles, comparable with other FAP-targeted tracers.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"1284-1290"},"PeriodicalIF":9.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Peritoneal Lesions of Hepatocellular Carcinoma Using [⁶⁸Ga]Ga-RAYZ-8009.","authors":"Helen Scholtissek, Nic G Reitsam, Bruno Märkl, Alexander Dierks, Ralph A Bundschuh, Arthur J A T Braat, Thomas Kröncke, Constantin Lapa","doi":"10.2967/jnumed.125.270222","DOIUrl":"https://doi.org/10.2967/jnumed.125.270222","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization of PET/CT Performance Requirements for Whole-Body Quantitative Imaging: An International Proposal.","authors":"John J Sunderland, Ronald Boellaard, John C Dickson, Stephen A Graves, Dale L Bailey","doi":"10.2967/jnumed.124.269349","DOIUrl":"https://doi.org/10.2967/jnumed.124.269349","url":null,"abstract":"<p><p>Currently, PET scanner validation phantoms, methods, and acceptance criteria for clinical trials are not standardized. This situation generates substantial inefficiencies with many scanners being tested multiple times for different trials. Herein we propose a standardized PET scanner validation paradigm for clinical trials. <b>Methods:</b> At present, active PET scanner validation programs administered by the European Association of Nuclear Medicine Research Ltd. (EARL), the Society of Nuclear Medicine and Molecular Imaging Clinical Trials Network (CTN), and Australia New Zealand Society of Nuclear Medicine Australasian Radiopharmaceutical Trials Network are reviewed in detail to identify similarities, differences, strengths, and weaknesses. PET criteria that help define the quantitative performance characteristics most critical for clinical trials are identified. Historical quantitative scanner performance capabilities are reviewed, including increasing availability of primary and secondary standard activity measurements for calibration purposes. Methodologies for these phantom-based measurements are reviewed, and standardized approaches are recommended. <b>Results:</b> Phantom requirements, acquisitions, reconstruction, analysis, and acceptance criteria have all been developed to be reasonably aligned with current standard scanner validation approaches, while at the same time recommending improvements and clarifications where programmatic differences were identified. A scanner validation program based on the measurement of radionuclide specific scanner calibration and harmonized recovery coefficient performance is proposed. Quarterly calibration verification of ¹⁸F and annual calibration of other radionuclides are recommended. Accuracy of ±5% for ¹⁸F calibration and ±10% for other radionuclides are proposed acceptance criteria. Annual verification of EARL 2-concordant recovery coefficient performance using a National Electrical Manufacturers Association NU2 image quality phantom or CTN5 phantom imaged at an 8:1 target-to-background contrast is recommended, although contrast recovery coefficients, rather than recovery coefficients, are advised. <b>Conclusion:</b> An internationally standardized PET scanner validation paradigm is proposed. International adoption of such a system combined with a data-sharing system would create a more efficient, robust, uniform, and trustworthy scanner validation environment for clinical trials while improving clinical trial qualification efficiency, decreasing costs and mitigating duplication of testing.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charting the Future: Advancing Innovation and Impact.","authors":"Cathy Sue Cutler","doi":"10.2967/jnumed.124.667PresMessage","DOIUrl":"https://doi.org/10.2967/jnumed.124.667PresMessage","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":"66 7","pages":"7A-8A"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Routine Dosimetry: Proceed with Caution.","authors":"Oliver Sartor, Louise M Emmett, Ken Herrman","doi":"10.2967/jnumed.125.269867","DOIUrl":"10.2967/jnumed.125.269867","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"1155"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptomatic Prostate-Specific Membrane Antigen PET-Positive Radionecrosis After Multimodality Brain Metastasis-Directed Treatment Including [¹⁷⁷Lu]Lu-PSMA-617.","authors":"Brandon S Imber, Kenny Kwok Hei Yu, Wassim Abida, Luke R G Pike, Milan Grkovski, Thomas J Kaley, Michael J Morris, Lisa Bodei, Anton Nosov, Mark P S Dunphy, Heiko Schöder, Josef J Fox, Marc Rosenblum, Tejus Bale, Simone Krebs","doi":"10.2967/jnumed.124.269175","DOIUrl":"10.2967/jnumed.124.269175","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"1153-1154"},"PeriodicalIF":9.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}