Journal of nuclear medicine : official publication, Society of Nuclear Medicine最新文献

{"title":"Changing Career Focus: Owen Witte Talks with Caius Radu and Johannes Czernin About a Life Dedicated to Science and Discovery.","authors":"Owen Witte, Caius Radu, Johannes Czernin","doi":"10.2967/jnumed.125.270520","DOIUrl":"https://doi.org/10.2967/jnumed.125.270520","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [¹⁸F]MK6240.","authors":"Ye Xia, Maeva Dhaynaut, Yanis Chemli, Cristina Lois, Bernard J Hanseeuw, Emma Thibault, Colin Groot, Rik Ossenkoppele, Keith Johnson, Georges El Fakhri, Marc D Normandin, Nicolas J Guehl","doi":"10.2967/jnumed.125.270165","DOIUrl":"10.2967/jnumed.125.270165","url":null,"abstract":"<p><p>This study aimed to test and validate a dual-time-window (DTW) protocol for 6-(fluoro-¹⁸F)-3-(¹H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([¹⁸F]MK6240) dynamic PET imaging in experimental datasets acquired in human subjects. <b>Methods:</b> DTW protocols were tested and validated in datasets previously collected in 25 participants: 13 were cognitively normal, 10 had mild cognitive impairment, and 2 had Alzheimer disease. Participants underwent full 120-min [¹⁸F]MK6240 dynamic PET scans as well as structural MRI. Intermediary 3-dimensional volumes were removed from the acquired dynamic PET images to emulate DTW acquisitions consisting of an early phase and a late phase. Five break durations (30, 40, 50, 60, and 70 min) were investigated to determine the optimal break for 2 study durations (120 and 110 min). Regional brain time-activity curves were extracted using atlases available in the Montreal Neurologic Institute template space and using the FreeSurfer parcellation. Interpolation strategies were tested to recover the missing time points. Distribution volume ratio (DVR) estimates obtained from the DTW time-activity curves were compared with those obtained from the full time-activity curves as reference. Parametric maps were generated for the selected protocol and evaluated. <b>Results:</b> The correlation and agreement between DVR values obtained from the DTW method and the full time-activity curves were overall very good. The DTW protocol with a 60-min break using a biexponential model fit as the interpolation method provided the best compromise between practicality and quantitative accuracy. The mean differences between this DTW and the full acquisition, averaged across brain regions and all subjects, were less than 1% with a corresponding SD of less than 4%, and DVR estimates were not statistically different from those obtained from the full acquisition (<i>P</i> > 0.05). DVR parametric images were visually and quantitatively consistent with those obtained from the full acquisition. <b>Conclusion:</b> This study presents strong support for the use of a DTW protocol with [¹⁸F]MK6240. Such a protocol would be well suited to allow for both quantification of tau and derivation of an index of cerebral perfusion while reducing patient discomfort and increasing scanning efficiency in comparison to a full dynamic acquisition.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated Total-Body Perfusion Imaging with ¹⁵O-Water PET Using Basis Functions and Organ-Specific Model Selection.","authors":"Anna Åhlström, Elin Lindström, Teemu Maaniittyy, Hidehiro Iida, Henri Kärpijoki, Jens Sörensen, Juhani Knuuti, Mark Lubberink","doi":"10.2967/jnumed.124.269409","DOIUrl":"https://doi.org/10.2967/jnumed.124.269409","url":null,"abstract":"<p><p>Long-axial-field-of-view PET with ¹⁵O-water allows perfusion to be measured in the whole body simultaneously. The purpose of this work was to describe a method for automated computation of total-body parametric perfusion images using PET information only and to validate the perfusion and volume of distribution (<i>V</i> _T) values obtained by comparing them with the gold standard (nonlinear regression analysis). <b>Methods:</b> Data from 10 subjects at Turku PET Centre were evaluated. Each subject underwent a 4-min 40-s dynamic PET/CT scan starting simultaneously with a controlled bolus administration of 350 MBq of ¹⁵O-water. Arterial and venous blood curves were defined using cluster analysis. Delay correction was performed by down-sampling the PET volume, using nonlinear regression for estimation of the delay for each subvolume, interpolation of delay values to the original matrix, and delay correction of all voxel time-activity curves, allowing for linearization of the model. Total-body perfusion images were calculated using several basis function implementations of the single-tissue-compartment model, considering the variations in blood supply to different organs. Model selection for each voxel was performed using cluster analysis to identify different organs. Perfusion and <i>V</i> _T values based on the automated parametric imaging method were validated by comparison of mean organ values with nonlinear regression of the appropriate compartment models to whole-organ time-activity curves. <b>Results:</b> The results showed good agreement between the parameters achieved from the automated parametric images and nonlinear regression. Correlation (<i>R</i> ²) and agreement between linear and nonlinear analyses were high, with an <i>R</i> ² of 0.99 for both perfusion and <i>V</i> _T, with a slope of 0.98 and 1.01 for perfusion and <i>V</i> _T, respectively. <b>Conclusion:</b> Perfusion and <i>V</i> _T values based on automated total-body parametric analysis agreed well with those based on nonlinear regression of whole-organ time-activity curves.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extravasation Frequency of [¹⁷⁷Lu]Lu-DOTATATE: Insights and Implications Derived from 1,314 Cycles of Treated Patients-A Single-Site Analysis.","authors":"Gunjan Kayal, Finn Augensen, Lisa Bodei, Bae Chu, Harry Marquis, Lukas M Carter, John Humm, Adam L Kesner","doi":"10.2967/jnumed.124.269411","DOIUrl":"https://doi.org/10.2967/jnumed.124.269411","url":null,"abstract":"<p><p>Extravasation of radiopharmaceuticals raises potential concerns, including adverse tissue reactions and reduction in both quantitative accuracy and therapeutic efficacy. This study presents a single-center experience reviewing extravasation events during [¹⁷⁷Lu]Lu-DOTATATE administration in peptide receptor radionuclide therapy, assessing their frequency, impact on patient care, and dosimetric effects. <b>Methods:</b> [¹⁷⁷Lu]Lu-DOTATATE was administered intravenously to outpatients following standard peptide receptor radionuclide therapy protocols. Whole-body planar imaging was performed 3-4 h after injection to confirm administration and assess extravasation, indicated by focal increased uptake at the infusion site. Qualitative image reviews by nuclear medicine physicians or technologists flagged potential extravasations. For these cases, regions of interest were delineated over the infused and contralateral arm and on the thighs. Extravasated activity was quantified relative to injected and whole-body activity. Absorbed dose calculations were performed using the MIRD formalism, assuming a monoexponential clearance model and accounting for varying extravasate volumes, with infiltration depths ranging from 2 to 7 mm. Statistical analyses compared retained activity and dosimetric parameters between extravasation and control groups. <b>Results:</b> Among 1,314 administrations in 365 outpatients, 14 cases (1.1%) had increased uptake at the infusion site, suggesting extravasation. The maximum radiopharmaceutical retention at the infused site was less than 1% of total injected activity and less than 2.1% whole-body activity (accounting for bladder voiding). The corresponding extravasated activity related to administered activity was 0.07% and 0.01% in the extravasation and control groups, respectively (<i>P</i> < 0.001). The extravasation group had higher absorbed dose estimates at the infusion site than did the control group (median, 0.53 Gy [range, 0.12-1.23 Gy] vs. 0.32 Gy [range, 0.17-0.71 Gy]; <i>P</i> = 0.3), with a significantly higher median extravasated dose (0.14 Gy [range, 0.03-0.67 Gy] vs. 0.02 Gy [range, 0.0-0.19 Gy]; <i>P</i> < 0.001). We did not observe any radiogenic tissue reactions. <b>Conclusion:</b> Extravasation during [¹⁷⁷Lu]Lu-DOTATATE therapy was rare and resulted in minimal dosimetric consequences, with absorbed doses at the infusion site well below the thresholds for deterministic effects and soft-tissue necrosis. These findings indicate that extravasation had a negligible impact on treatment efficacy and patient safety in this patient cohort, reinforcing the safety of [¹⁷⁷Lu]Lu-DOTATATE administration protocols and emphasizing the low clinical risk associated with radiopharmaceutical extravasation during therapy.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 SNMMI Highlights Lecture: Neurosciences.","authors":"Richard Carson","doi":"10.2967/jnumed.125.270521","DOIUrl":"https://doi.org/10.2967/jnumed.125.270521","url":null,"abstract":"<p><p><i>The Highlights Lecture, presented at the closing session of each SNMMI Annual Meeting, was originated and presented for more than 30 y by Henry N. Wagner, Jr., MD. Beginning in 2010, the duties of summarizing selected significant presentations at the meeting were divided annually among 4 distinguished nuclear and molecular medicine subject matter experts. The 2024 Highlights Lectures were delivered on June 11, 2024, at the SNMMI Annual Meeting in Toronto, Canada. Presented here is the lecture by Richard Carson, PhD, Professor of Radiobiology and Biomedical Imaging and of Biomedical Engineering at Yale School of Medicine (New Haven, CT), who spoke on neuroscience topics presented at the meeting. Note that in the following presentation summary, numerals in brackets represent abstract numbers as published in</i> The Journal of Nuclear Medicine <i>(2024;65[suppl 2]).</i></p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Association of PET-Derived Rest and Stress Myocardial Blood Flow with Cardiovascular Outcomes.","authors":"Ahmed Sayed, Mahmoud Al Rifai, Mouaz Al-Mallah","doi":"10.2967/jnumed.125.269457","DOIUrl":"https://doi.org/10.2967/jnumed.125.269457","url":null,"abstract":"<p><p>Although there is strong evidence for the prognostic value of myocardial flow reserve (MFR), there are fewer data on the prognostic implications of its constituents: myocardial blood flow at rest (MBF_rest) and stress (MBF_stress). <b>Methods:</b> Consecutive patients undergoing ⁸²Rb PET imaging with regadenoson stress testing at a tertiary care center between August 2019 and August 2024 were included in this study. The 2 coprimary outcomes were a composite of death or heart failure (HF) hospitalization and a composite of myocardial infarction (MI) or late revascularization. Multivariable Andersen-Gill Cox models with robust variance estimators were used to incorporate recurrent events. Outcomes were modeled as a smooth function of MBF_stress and MBF_rest, with restricted cubic splines to allow nonlinearity. <b>Results:</b> The analysis included 8,131 consecutive patients (median age of 68 y; 46.1% were women; median follow-up of 520 d (interquartile range, 186-921 d), among whom 471 deaths, 828 HF hospitalizations, 164 MIs, and 429 late revascularizations occurred. After adjusting for the relevant covariates, an MFR of 2 achieved through a lower MBF_rest was associated with a significantly lower incidence of death and HF hospitalization, whereas an MFR of 2 achieved through a greater MBF_stress was associated with a significantly lower incidence of MI and late revascularization. Assessments of the partial χ² statistic, which measures the importance of predictors, similarly confirmed that MBF_rest was more important for predicting death or HF hospitalization whereas MBF_stress was more important for predicting MI or late revascularization. <b>Conclusion:</b> Measurements of absolute myocardial blood flow offer complementary prognostic value to MFR. A diminished MBF_stress may signal a greater risk of future ischemic outcomes, whereas an elevated MBF_rest may signal a greater risk of future death or HF hospitalization.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodistribution and Radiation Dosimetry for [⁶⁸Ga]Ga-LNTH-1363S, a Probe Targeting Fibroblast Activation Protein α.","authors":"Johanna S Enke, Bradley W Schuller, Lisa Glantschnig, Malte Kircher, Ralph A Bundschuh, Alexander Dierks, Marianne Patt, Eric J Fenn, Andreas Rinscheid, Christian H Pfob, Alejandro Amor Coarasa, John W Babich, Jacob Y Hesterman, Constantin Lapa","doi":"10.2967/jnumed.125.269793","DOIUrl":"https://doi.org/10.2967/jnumed.125.269793","url":null,"abstract":"<p><p>The objective of this study is to evaluate the PET biodistribution and radiation dosimetry of the fibroblast activation protein (FAP)-targeted tracer [⁶⁸Ga]Ga-LNTH-1363S in cancer patients. <b>Methods:</b> Five patients with oncologic diseases (breast cancer, papillary thyroid carcinoma) were injected intravenously with 153-184 MBq of [⁶⁸Ga]Ga-LNTH-1363S. PET/CT imaging was performed at 10, 60, and 180 min after administration of [⁶⁸Ga]Ga-LNTH-1363S. Normal tissue dosimetry was performed following the MIRD dosimetry formalism. SUV analysis of normal tissues and tumors was performed. <b>Results:</b> The biodistribution of [⁶⁸Ga]Ga-LNTH-1363S demonstrated rapid tumor uptake and efficient clearance from nontarget tissues, resulting in high tumor-to-background ratios at all imaging time points. The kidneys received the highest absorbed dose among normal tissues (0.038 ± 0.01 mGy/MBq), followed by the pancreas and salivary glands. The tumor SUV_max peaked at 10 min after injection (18.6 ± 7.2) and remained high at later time points. No adverse events were observed during follow-up, and the effective dose (0.013 ± 0.002 mSv/MBq) was consistent with other FAP tracers. <b>Conclusion:</b> [⁶⁸Ga]Ga-LNTH-1363S offers favorable dosimetry and biodistribution profiles, comparable with other FAP-targeted tracers.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summary: Appropriate Use Criteria for ¹⁸F-FDG PET/CT for Initial Staging of Malignant Disease.","authors":"Hossein Jadvar, Michael B Atkins, Twyla Bartel, Lioe-Fee de Geus-Oei, Elizabeth H Dibble, Balazs Halmos, Rathan M Subramaniam, Gary A Ulaner, Sofia Carrilho Vaz, Helen Nadel, Katherine Zukotynski, Landis K Griffeth","doi":"10.2967/jnumed.125.270429","DOIUrl":"https://doi.org/10.2967/jnumed.125.270429","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiopharmaceutical Therapy: Balancing Absorbed Dose and Antitumor Immunity.","authors":"Jiangtao Yue, Yue Zhang, Yue Miu, Yaqi Zhao, Yue Li, Yicheng Ni, Guanghai Fei","doi":"10.2967/jnumed.125.269868","DOIUrl":"https://doi.org/10.2967/jnumed.125.269868","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>JNM</i> Editors' Choice Awards for 2024.","authors":"Johannes Czernin","doi":"10.2967/jnumed.125.270522","DOIUrl":"https://doi.org/10.2967/jnumed.125.270522","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}