Journal of nuclear medicine : official publication, Society of Nuclear Medicine最新文献

{"title":"First-in-Human [⁶⁸Ga]Ga-DOTA-Folate PET/CT in a Patient with Ovarian Cancer.","authors":"Min Tan, Linwei Li, Yan Zhu, Hongyin Ding, Yueqi Zhao, Wei Wang, Yue Chen","doi":"10.2967/jnumed.125.271820","DOIUrl":"https://doi.org/10.2967/jnumed.125.271820","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are ⁶¹Cu, ⁶⁴Cu, and ⁶⁷Cu Really Happening?","authors":"Richard Zimmermann","doi":"10.2967/jnumed.126.272416","DOIUrl":"https://doi.org/10.2967/jnumed.126.272416","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[⁶⁸Ga]Ga-DOTA-5G PET/CT Detects Brain and Bone Metastases in a Patient with Metastatic Pancreatic Cancer.","authors":"Cameron C Foster, Tanushree Ganguly, Sven H Hausner, Edward Kim, Ebaa Al-Obeidi, Julie L Sutcliffe","doi":"10.2967/jnumed.126.272419","DOIUrl":"https://doi.org/10.2967/jnumed.126.272419","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiorgan Perfusion by PET: Potential Multiple Pathophysiology Interacting with the Heart to Guide Systemic and Cardiac Management.","authors":"K Lance Gould, Nils P Johnson","doi":"10.2967/jnumed.126.272071","DOIUrl":"https://doi.org/10.2967/jnumed.126.272071","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of LAT1 and CD98hc Expression on Tumor Cells of Diffuse Glioma: Revisiting the Molecular Basis for Amino Acid PET Imaging and Theranostics.","authors":"Jan-Michael Werner, Erwin Tomasich, Maximilian J Mair, Johannes A Hainfellner, Georg Widhalm, Marcus Hacker, Norbert Galldiks, Nathalie L Albert, Anna S Berghoff, Matthias Preusser","doi":"10.2967/jnumed.125.271348","DOIUrl":"https://doi.org/10.2967/jnumed.125.271348","url":null,"abstract":"<p><p>It is assumed that amino acid PET positivity of gliomas corresponds to tracer uptake by tumor cells via the amino acid transporter heterodimer CD98, consisting of a light (LAT1) and heavy subunit (CD98hc), but correlative studies of human tumor tissue samples and PET imaging are largely lacking. <b>Methods:</b> We evaluated a series of 31 patients with diffuse glioma (18 <i>IDH</i>-mutant, 13 <i>IDH</i>-wild type), of whom preoperative amino acid PET images and corresponding tumor tissue samples were available. LAT1 and CD98hc expression were immunohistochemically assessed and correlated to amino acid PET tracer uptake parameters. <b>Results:</b> LAT1 and CD98hc subunits were strongly and almost exclusively expressed on endothelial cells, with most tumor cells lacking immunostaining. There was no correlation of LAT1 or CD98hc expression with amino acid PET uptake parameters. <b>Conclusion:</b> Further studies to clarify the molecular basis of amino acid tracer uptake in diffuse glioma are warranted.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Widespread Prostate Cancer Osseous Metastases: Negative on ¹⁸F-Piflufolastat PET but Positive on ¹⁸F-Fluciclovine PET.","authors":"Gary A Ulaner, Richard Lam","doi":"10.2967/jnumed.125.272001","DOIUrl":"https://doi.org/10.2967/jnumed.125.272001","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Images on a Next-Generation Extended-Field-of-View Digital Bismuth Germanium Oxide Total-Body PET/CT.","authors":"Michael S Hofman, Alicia Corlett, Cameron Pain, Price Jackson, Ramin Alipour, Grace Kong, Aaron J N Wong, James Buteau, Tim Akhurst, Dulash Fernando, Shankar Siva, Declan G Murphy","doi":"10.2967/jnumed.125.271995","DOIUrl":"https://doi.org/10.2967/jnumed.125.271995","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Occipital Lobe Hypometabolism on [¹⁸F]FDG PET.","authors":"Debra A Dawson, Karine Provost, Jean-Paul Soucy, Peter George Maliha","doi":"10.2967/jnumed.125.271677","DOIUrl":"10.2967/jnumed.125.271677","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"826"},"PeriodicalIF":9.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PSMA PET/CT-Derived Indicators and Outcomes After [¹⁷⁷Lu]Lu-PSMA-617: A Multicenter Retrospective Analysis from the U.S. Expanded-Access Program.","authors":"Koichiro Kimura, Vishnu Murthy, Andrew F Voter, Lilja B Solnes, Abuzar Moradi Tuchayi, Surekha Yadav, Lela Theus, Andrew Nguyen, Vinicius Ludwig, Adrien Holzgreve, Lena M Unterrainer, Tristan R Grogan, Johannes Czernin, Thomas A Hope, Andrei Gafita, Jeremie Calais","doi":"10.2967/jnumed.125.270789","DOIUrl":"10.2967/jnumed.125.270789","url":null,"abstract":"<p><p>Pretherapeutic visual and quantitative indicators derived from prostate-specific membrane antigen (PSMA) PET/CT have been proposed as predictors of response to [¹⁷⁷Lu]Lu-PSMA-617 (¹⁷⁷Lu-PSMA) therapy in patients with metastatic castration-resistant prostate cancer. This study aimed to evaluate and compare the prognostic performance of these indicators in a cohort treated under the U.S. Expanded-Access Program. <b>Methods:</b> This retrospective analysis included 88 patients with metastatic castration-resistant prostate cancer from 3 U.S. institutions (University of California Los Angeles, University of California San Francisco, and Johns Hopkins) enrolled in the Expanded-Access Program who underwent baseline PSMA PET/CT before receiving ¹⁷⁷Lu-PSMA. We assessed visual indicators-such as the visual PSMA PET tumor-to-salivary gland ratio, tumor heterogeneity, and intensity scores-and quantitative metrics including total tumor volume (TTV), total tumor SUV_mean, total tumor SUV_max, total lesion uptake (TTV × total tumor SUV_mean), total lesion quotient (TTV ÷ total tumor SUV_mean), and the quantitative PSMA PET tumor-to-salivary gland score. Associations with clinical outcomes-a 50% or greater prostate-specific antigen decline (PSA50), prostate-specific antigen (PSA) progression-free survival (PFS), and overall survival (OS)-were analyzed using univariate and multivariate models. Predictive performance was evaluated via the concordance index from Cox proportional hazards regression. <b>Results:</b> After a median follow-up of 36.1 mo (95% CI, 33.8-37.8 mo), the PSA50 rate was 43%, the median PSA PFS was 4.5 mo (95% CI, 3.7-7.2 mo), and the 2-y PSA PFS rate was 7% (95% CI, 3-16%). The median OS was 12.5 mo (95% CI, 10.4-17.1 mo), and the 2-y OS rate was 29% (95% CI, 20-40%). Among the evaluated metrics, total tumor SUV_mean showed the highest predictive accuracy for PSA50 (area under the curve, 0.81; 95% CI, 0.73-0.90). In multivariate analyses adjusted for clinical factors, a higher total tumor SUV_mean was independently associated with improved PSA PFS (hazard ratio, 0.58; 95% CI, 0.39-0.86; <i>P</i> = 0.007) and OS (hazard ratio, 0.54; 95% CI, 0.34-0.86; <i>P</i> = 0.009). Total tumor SUV_mean also yielded higher concordance index values compared with models based on clinical variables alone (PSA PFS, 0.667 vs. 0.594; OS, 0.687 vs. 0.661, respectively). <b>Conclusion:</b> Baseline total tumor SUV_mean on PSMA PET/CT provides independent prognostic information beyond clinical parameters and may serve as a useful biomarker for patient selection and treatment personalization with ¹⁷⁷Lu-PSMA.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"731-738"},"PeriodicalIF":9.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Research Post.","authors":"Jeremie Calais, Johannes Czernin","doi":"10.2967/jnumed.126.272505","DOIUrl":"https://doi.org/10.2967/jnumed.126.272505","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":"67 5","pages":"663"},"PeriodicalIF":9.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147825180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}